journal
https://read.qxmd.com/read/38826140/the-social-media-paradox-unravelling-the-impact-of-digital-networks-on-pathology
#1
JOURNAL ARTICLE
Archit Goel, Gargi Kapatia, Amber Parwaiz, Shruti Gupta
No abstract text is available yet for this article.
June 3, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38780094/artificial-intelligence-and-lung-pathology
#2
JOURNAL ARTICLE
Emanuel Caranfil, Kris Lami, Wataru Uegami, Junya Fukuoka
This manuscript provides a comprehensive overview of the application of artificial intelligence (AI) in lung pathology, particularly in the diagnosis of lung cancer. It discusses various AI models designed to support pathologists and clinicians. AI models supporting pathologists are to standardize diagnosis, score PD-L1 status, supporting tumor cellularity count, and indicating explainability for pathologic judgements. Several models predict outcomes beyond pathologic diagnosis and predict clinical outcomes like patients' survival and molecular alterations...
May 23, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38736358/morphologic-features-of-invasion-in-lung-adenocarcinoma-diagnostic-pitfalls
#3
JOURNAL ARTICLE
Erik Thunnissen, Masayuki Noguchi, Sabina Berezowska, Mauro Giulio Papotti, Federica Filipello, Yuko Minami, Hans Blaauwgeers
Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains...
May 13, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38717587/from-morphology-to-molecules-advances-in-the-distinction-of-multiple-primary-lung-cancers-from-intrapulmonary-metastases-in-non-small-cell-lung-cancer
#4
JOURNAL ARTICLE
Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic
The increasing incidence of multiple lung nodules underscores the need for precise differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary metastases (IPMs). This distinction impacts patient prognosis and treatment strategies. The prevalence of multiple lung nodules, ranging from 19.7% to 55.5%, highlights the clinical significance of this challenge. Historically, the role of histopathology, particularly comprehensive histology assessment (CHA), has been pivotal in differentiating MPLCs and IPMs...
May 8, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38712814/igg4-related-sclerosing-disease-of-the-gallbladder-incidental-malignancy-mimicker-associated-with-cholelithiasis
#5
JOURNAL ARTICLE
Domenika Ortiz Requena, Julio Poveda, Oliver G McDonald, Nemencio Ronquillo, Monica Garcia-Buitrago, Elizabeth A Montgomery
No abstract text is available yet for this article.
May 7, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38695284/the-international-system-for-reporting-serous-fluid-cytopathology-a-systematic-review-and-meta-analysis-of-diagnostic-test-accuracy-studies
#6
JOURNAL ARTICLE
Fatima E Jamal, Johannes A Vey, Tanja Proctor, Angela Ishak, Fernando C Schmitt, Ilias P Nikas
This is the first systematic review and meta-analysis of The International System (TIS) for reporting serous fluid cytopathology. Our aims were to present the pooled malignancy rate of each TIS reporting category and the diagnostic accuracy of cytology using this system. Database search using a predefined strategy was followed by study selection, data extraction, study quality assessment, and statistical analysis. Data derived from 16 eligible studies were pooled. The pooled rates of malignancy were as follows: 27% (95% CI; 16%-41%) for "nondiagnostic" (ND), 11% (95% CI; 7%-18%) for negative for malignancy" (NFM), 49% (95% CI; 37%-61%) for "atypia of undetermined significance" (AUS), 90% (95% CI; 81%-95%) for "suspicious for malignancy" (SFM), and 100% (95% CI; 98%-100%) for "positive for malignancy" (MAL)...
May 2, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38666775/the-grading-system-for-lung-adenocarcinoma-brief-review-of-its-prognostic-performance-and-future-directions
#7
JOURNAL ARTICLE
Jose G Mantilla, Andre L Moreira
Histologic grading of tumors is associated with prognosis in many organs. In the lung, the most recent grading system proposed by International association for the Study of Lung Cancer (IASLC) and adopted by the World Health Organization (WHO) incorporates the predominant histologic pattern, as well as the presence of high-grade architectural patterns (solid, micropapillary, and complex glandular pattern) in proportions >20% of the tumor surface. This system has shown improved prognostic ability when compared with the prior grading system based on the predominant pattern alone, across different patient populations...
April 26, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38666761/immunohistochemistry-of-lung-cancer-biomarkers
#8
JOURNAL ARTICLE
Mary Beth Beasley
Immunohistochemical (IHC) staining represents a comparatively inexpensive testing method that is attractive as a potential alternative to molecular sequencing methods or fluorescence in situ hybridization for pulmonary biomarker testing. While a variety of IHC tests directed at actionable genetic alterations have been developed and evaluated since the advent of targeted therapy, specific antibody clones for anaplastic lymphoma kinase, ROS-1, and potentially neurotrophic tropmyosin receptor kinase have been the primary antibodies that provide sufficiently robust results to be utilized as either a primary testing or screening method to direct targeted therapy...
April 26, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38647238/uterine-smooth-muscle-tumors-an-overview
#9
JOURNAL ARTICLE
Andre Pinto
Uterine smooth muscle tumors are a heterogeneous group of mesenchymal neoplasms with multiple histologic variants and distinct biological behaviors. Pathologic classification (benign, uncertain malignant potential, malignant) relies on the evaluation of mitotic index, necrosis, and degree of cytologic atypia, with different thresholds based on each subtype. Immunohistochemistry and other ancillary studies may be necessary to establish the diagnosis in a subset of cases, given the morphologic overlap with other mesenchymal neoplasms, including low-grade and high-grade endometrial stromal tumors, inflammatory myofibroblastic tumors, and PEComa...
April 19, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38627880/gastric-leiomyosarcoma-in-post-gastrointestinal-stromal-tumor-era-revisit
#10
JOURNAL ARTICLE
Tengfei Wang, Bing Leng
Primary gastric leiomyosarcoma is an exceptionally rare disease. This review covers 41 post-gastrointestinal stromal tumor (GIST) era gastric leiomyosarcoma cases that are supported by immunohistochemistry markers. Other spindle cell lesions are also excluded through histological and immunohistochemistry evaluations. The patients range from 3 to 82 years old, with an average age of 54.6 years. The male-to-female ratio is 1.4:1, from diverse geographic areas. Patients may experience abdominal symptoms, and tumor sizes vary between 1 cm and 22 cm...
April 17, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38623604/the-other-uterine-mesenchymal-neoplasms-recent-developments-and-emerging-entities
#11
JOURNAL ARTICLE
Jennifer A Bennett, Andre Pinto
Uterine mesenchymal neoplasms are a challenging group of tumors that often show overlapping morphologic features and immunohistochemical profiles. The increasing use of molecular testing in these tumors has enabled a better appreciation of their pathobiology, resulting in a wave of emerging neoplasms and improved characterization of ones previously considered exceptionally rare. Identification of specific molecular alterations has permitted targeted therapy options in tumors that were typically unresponsive to conventional therapies, as well as recognition that a subset can have a hereditary basis...
April 16, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38595110/pathology-of-surgically-resected-lung-cancers-following-neoadjuvant-therapy
#12
JOURNAL ARTICLE
Sabina Berezowska, Mark Keyter, Hasna Bouchaab, Annikka Weissferdt
In around 30% of patients, non-small cell lung cancer is diagnosed at an advanced but resectable stage. Adding systemic therapy has shown clear benefit over surgery alone in locally advanced disease, and currently, chemo-immunotherapy in the adjuvant or neoadjuvant setting is the new standard for patients without targetable mutations. One major advantage of the neoadjuvant approach is the possibility of an immediate evaluation of the treatment effect, highlighting the role of pathology as an important contributor at the forefront of clinical decision-making and research...
April 9, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38525660/contemporary-diagnostic-reporting-for-prostatic-adenocarcinoma-morphologic-aspects-molecular-correlates-and-management-perspectives
#13
JOURNAL ARTICLE
Selvaraj Muthusamy, Steven Christopher Smith
The diagnosis and reporting of prostatic adenocarcinoma have evolved from the classic framework promulgated by Dr Donald Gleason in the 1960s into a complex and nuanced system of grading and reporting that nonetheless retains the essence of his remarkable observations. The criteria for the "Gleason patterns" originally proposed have been continually refined by consensuses in the field, and Gleason scores have been stratified into a patient-friendly set of prognostically validated and widely adopted Grade Groups...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38525603/nkx3-1-expression-in-non-prostatic-tumors-and-characterizing-its-expression-in-esophageal-gastroesophageal-adenocarcinoma
#14
JOURNAL ARTICLE
Ansa Mehreen, Kiran G Manjee, Divyangi Paralkar, Gladell P Paner, Thanh Lan
The NKX3.1 immunohistochemical stain is widely recognized as a highly sensitive and specific marker for prostate adenocarcinoma. Nevertheless, its expression has been documented in various nonprostatic tissues and malignancies. This review aims to provide an overview of NKX3.1 expression in diverse tumor types, with a specific focus on its aberrant expression in esophageal/gastroesophageal adenocarcinoma (E/GE-ADC). In our investigation, we explored the expression of NKX3.1 in a series of E/GE-ADC to shed light on its prevalence in this tumor category...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38525552/cystic-features-in-renal-epithelial-neoplasms-and-their-increasing-clinical-and-pathologic-significance
#15
JOURNAL ARTICLE
Maria Tretiakova, Jung Woo Kwon, Gladell P Paner
Most cystic renal tumors after resection (Boniak IIF to IV cysts) have an indolent course despite the significantly higher proportion of malignant [ie, renal cell carcinoma (RCC)] diagnosis. Most cystic renal tumors have clear cell histology that include cystic clear cell RCC and multilocular cystic renal neoplasm of low malignant potential (MCNLMP). There is growing evidence to suggest that MCNLMP, cystic clear cell RCC, and noncystic clear cell RCC form a cystic-to-solid biological spectrum with MCNLMP representing the most indolent form and with cystic clear cell RCC behaving better than noncystic (solid) clear cell RCC...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38525515/evolution-of-testicular-germ-cell-tumors-in-the-molecular-era-with-histogenetic-implications
#16
JOURNAL ARTICLE
Irem Kilic, Andres M Acosta, Muhammad T Idrees
The current WHO classification of testicular germ cell tumors is based on the pathogenesis of the tumors driven by different genomic events. The germ cell neoplasia in situ is the precursor lesion for all malignant germ cell tumors. The current understanding of pathogenesis is that the developmental and environmental factors with the erasure of parental genomic imprinting lead to the development of abnormal gonocytes that settle in the "spermatogonial Niche" in seminiferous tubules. The abnormal primordial germ cells in the seminiferous tubules give rise to pre-GCNIS cells under the influence of TPSY and OCT4 genes...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38523484/updates-on-urinary-bladder-tumors-with-neuroendocrine-features
#17
JOURNAL ARTICLE
Dilara Akbulut, Hikmat Al-Ahmadie
The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and remains ill-defined but is increasingly recognized. Well-differentiated neuroendocrine tumor and paraganglioma can arise in the bladder but are very rare in this location. Recent advances in molecular characterization allowed for better classification and may offer improved stratification of these tumors...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38512018/novel-and-emerging-concepts-in-genitourinary-tumors-empowered-in-the-multidisciplinary-and-molecular-era
#18
JOURNAL ARTICLE
Gladell P Paner
No abstract text is available yet for this article.
March 21, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38420747/sex-cord-stromal-tumors-of-the-ovary-an-update-and-review-part-ii-pure-sex-cord-and-sex-cord-stromal-tumors
#19
REVIEW
Kyle M Devins, Robert H Young, Esther Oliva
We review the time honored but still frequently challenging features of ovarian sex cord-stromal tumors and also emphasize new developments, including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part to the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr...
July 1, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38369847/sex-cord-stromal-tumors-of-the-ovary-an-update-and-review-part-i-pure-ovarian-stromal-tumors
#20
REVIEW
Kyle M Devins, Robert H Young, Esther Oliva
In two separate reviews, we review the time-honored but still frequently challenging features of ovarian sex cord-stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E...
July 1, 2024: Advances in Anatomic Pathology
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