journal
https://read.qxmd.com/read/38602586/a-novel-%C3%AE-%C3%AE-unsaturated-ketone-inhibits-leukemia-cell-growth-as-parp1-inhibitor
#1
JOURNAL ARTICLE
Weijia Zhao, Min Mo, Jia Yu, Sha Cheng, Guiping Long, Zhiqiong Luo, Wei Liang, Chen Yan, Heng Luo, Baofei Sun
Leukemia is a malignant disease of the hematopoietic system, in which clonal leukemia cells accumulate and inhibit normal hematopoiesis in the bone marrow and other hematopoietic tissues as a result of uncontrolled proliferation and impaired apoptosis, among other mechanisms. In this study, the anti-leukemic effect of a compound (SGP-17-S) extracted from Chloranthus multistachys, a plant with anti-inflammatory, antibacterial and anti-tumor effects, was evaluated. The effect of SGP-17-S on the viability of leukemic cell was demonstrated by MTT assay, cell cycle, and apoptosis were assessed by flow cytometry using PI staining and Annexin V/PI double staining...
April 11, 2024: Medical Oncology
https://read.qxmd.com/read/38592576/combination-of-ifn-gamma-with-sting-agonist-and-pd-1-immune-checkpoint-blockade-a-potential-immunotherapy-for-gastric-cancer
#2
JOURNAL ARTICLE
Shahnaz Hosseinzadeh, Mahsa Imani, Farhad Pourfarzi, Narjes Jafari, Saeid AbedianKenari, Elham Safarzadeh
Suppression of the cGAS-STING pathway is an immune escape mechanism in cancer cells. The critical role of this pathway in gastric cancer (GC) is not fully understood. Herein, we evaluated the effect of the interferon-gamma (IFN-gamma), STING agonist, PD-1 immune checkpoint blockade, and their combination on the cGAS-STING pathway in GC. Expression of cGAS and STING in tumor tissue samples and adjacent normal tissue (ANT) biopsies of fifty new GC patients was evaluated by quantitative real-time PCR (qRT-PCR)...
April 9, 2024: Medical Oncology
https://read.qxmd.com/read/38592567/study-of-the-effect-of-sfrp1-protein-on-molecules-involved-in-the-regulation-of-dna-methylation-in-cml-cell-line
#3
JOURNAL ARTICLE
Nazli Demirkiran, Bengusu Aydin, Melek Pehlivan, Zeynep Yuce, H Ogun Sercan
Wnt-signaling pathway plays a crucial role in the pathogenesis and progression of Chronic Myeloid Leukemia (CML). sFRP1 is involved in the suppression of the Wnt-signaling pathway and has been shown to be epigenetically silenced by promoter hypermethylation during CML progression. DNMT3A plays a crucial role in promoter hypermethylation and is responsible for establishing methylation patterns. We aimed to analyze the relationship between sFRP1 expression and DNMT3A, TET1, TET2 and TET3 proteins that are responsible for maintaining cellular methylation patterns; along with miRNAs miR144-3p and miR-767-5p that are known to be associated with these proteins...
April 9, 2024: Medical Oncology
https://read.qxmd.com/read/38592510/recent-developments-in-targeting-breast-cancer-stem-cells-bcscs-a-descriptive-review-of-therapeutic-strategies-and-emerging-therapies
#4
REVIEW
Khubaib Ali, Muhammad Nabeel, Fatima Mohsin, Mehwish Iqtedar, Muhammad Islam, Muhammad Fawad Rasool, Furqan K Hashmi, Syed Ahmed Hussain, Hamid Saeed
Despite recent advancements in the diagnosis and treatment of breast cancer (BC), patient outcomes in terms of survival, recurrence, and disease progression remain suboptimal. A significant factor contributing to these challenges is the cellular heterogeneity within BC, particularly the presence of breast cancer stem cells (BCSCs). These cells are thought to serve as the clonogenic nexus for new tumor growth, owing to their hierarchical organization within the tumor. This descriptive review focuses on the evolving strategies to target BCSCs, which have become a pivotal aspect of therapeutic development...
April 9, 2024: Medical Oncology
https://read.qxmd.com/read/38592504/coadministration-of-doxorubicin-with-vitamin-d3-lactobacillus-acidophilus-and-lactobacillus-casei-in-the-4t1-mouse-model-of-breast-cancer-anticancer-and-enteroprotective-effects
#5
JOURNAL ARTICLE
Mohammad Ali Mirzadeh, Majid Eslami, Ali Ghanbari, Sam Zarbakhsh, Sedighe Yosefi, Abbas Pakdel
The use of doxorubicin (Dox) in the treatment of breast cancer negatively affects the intestines and other tissues. Many studies have proven that probiotics and vitamin D3 have antitumor and intestinal tissue-protecting properties. To achieve effectiveness and minimize side effects, the current study aims to administer Dox together with probiotics (Lactobacillus acidophilus and Lactobacillus casei) and vitamin D3. Forty-two female BALB/c inbred mice were divided into six groups: Group 1 (Control), Group 2 (Dox), Group 3 (Dox and probiotics), Group 4 (Dox and vitamin D3), Group 5 (Dox, probiotics, and vitamin D3), and Group 6 (probiotics and vitamin D3)...
April 9, 2024: Medical Oncology
https://read.qxmd.com/read/38592406/increased-v-atpase-activity-can-lead-to-chemo-resistance-in-oral-squamous-cell-carcinoma-via-autophagy-induction-new-insights
#6
REVIEW
Ahmadreza Lagzian, Marziye Askari, Melika Sadat Haeri, Nastaran Sheikhi, Sara Banihashemi, Mohsen Nabi-Afjadi, Yalda Malekzadegan
Oral squamous cell carcinoma (OSCC) is a cancer type with a high rate of recurrence and a poor prognosis. Tumor chemo-resistance remains an issue for OSCC patients despite the availability of multimodal therapy options, which causes an increase in tumor invasiveness. Vacuolar ATPase (V-ATPase), appears to be one of the most significant molecules implicated in MDR in tumors like OSCC. It is primarily responsible for controlling the acidity in the solid tumors' microenvironment, which interferes with the absorption of chemotherapeutic medications...
April 9, 2024: Medical Oncology
https://read.qxmd.com/read/38580762/immunomodulatory-effects-of-diospyros-peregrina-fruit-preparation-dfp-in-non-small-cell-lung-cancer-nsclc-by-utilizing-dendritic-cell-mediated-antigen-presentation-and-t-helper-th-cell-differentiation
#7
JOURNAL ARTICLE
Nawaneetan Sriraman, Ankita Sarkar, Sohom Naskar, Nitika Mahajan, Oishi Mukherjee, R Pradeep, Melvin George, Koustav Sarkar
Diospyros peregrina is a dioecious plant which is native to India. It belongs to the family of Ebenaceae and is extensively used to treat various ailments, such as leucorrhoea and other uterine-related problems. Though few studies have been on D. peregrina for their anti-tumour response, little is known. Therefore, this intrigued us to understand its immunomodulator capabilities on various types of cancer extensively. Our primary focus is on NSCLC (Non-Small Cell Lung Cancer), which is ranked as the second largest form of cancer in the world, and the treatments demand non-invasive agents to target NSCLC effectively...
April 5, 2024: Medical Oncology
https://read.qxmd.com/read/38575697/probiotic-derived-silver-nanoparticles-target-mtor-mmp-9-bcl-2-dependent-ampk-activation-for-hepatic-cancer-treatment
#8
JOURNAL ARTICLE
Alaa Elmetwalli, Mohamed O Abdel-Monem, Ali H El-Far, Gehad S Ghaith, Noaf Abdullah N Albalawi, Jihan Hassan, Nadia F Ismail, Tarek El-Sewedy, Mashael Mashal Alnamshan, Nouf K ALaqeel, Ibtesam S Al-Dhuayan, Mervat G Hassan
Recent advances in nanotechnology have offered novel ways to combat cancer. By utilizing the reducing capabilities of Lactobacillus acidophilus, silver nanoparticles (AgNPs) are synthesized. The anti-cancer properties of AgNPs have been demonstrated in previous studies against several cancer cell lines; it has been hypothesized that these compounds might inhibit AMPK/mTOR signalling and BCL-2 expression. Consequently, the current research used both in vitro and in silico approaches to study whether Lactobacillus acidophilus AgNPs could inhibit cell proliferation autophagy and promote apoptosis in HepG2 cells...
April 4, 2024: Medical Oncology
https://read.qxmd.com/read/38573558/citalopram-an-antipsychotic-agent-induces-g1-g0-phase-cell-cycle-arrest-and-promotes-apoptosis-in-human-laryngeal-carcinoma-hep-2-cells
#9
JOURNAL ARTICLE
Mohammed Salama, Abeer Ali, Fawziya A R Ibrahim, Seham Elabd
Human laryngeal squamous carcinoma (LSCC) is a common malignant tumor in the head and neck. Despite the recently developed therapies for the treatment of LSCC, patients' overall survival rate still did not enhance remarkably; this highlights the need to formulate alternative strategies to develop novel treatments. The antitumor effects of antidepressant drugs such as citalopram have been reported on several cancer cells; however, they have yet to be investigated against LSCC. The current study was directed to explore the possible antitumor effects of citalopram on human laryngeal carcinoma cell lines (HEP-2)...
April 4, 2024: Medical Oncology
https://read.qxmd.com/read/38573420/unlocking-the-potential-phenylboronic-acid-as-a-nuclear-targeting-boron-agent-for-neutron-capture-therapy
#10
JOURNAL ARTICLE
Jiejian Chen, Yonghao Li, Xiaoning Gan, Chengyin Weng, Xisheng Fang, Guolong Liu
It has been proposed that boron neutron capture therapy (BNCT) holds promise as a treatment modality for melanoma. However, the effectiveness of boron agents in delivery remains a critical issue to be addressed for BNCT. To this end, phenylboronic acid, which exhibits good water solubility and low cytotoxicity similar to BPA, has been investigated as a potential nuclear-targeting boron agent. The boron concentration of phenylboronic acid was found to be 74.47 ± 12.17 ng/106 B16F10 cells and 45...
April 4, 2024: Medical Oncology
https://read.qxmd.com/read/38553593/regulation-of-hippo-signaling-mediated-apoptosis-by-rauvolfia-tetraphylla-in-triple-negative-breast-cancer
#11
JOURNAL ARTICLE
B Balavaishnavi, M Kamaraj, T G Nithya, P Santhosh, S GokilaLakshmi, Mohammed Rafi Shaik
Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional medicine for various disease treatments. However, the tumor suppressor activity of R. tetraphylla and its phytocompounds were not explored against triple-negative breast cancer. The current research investigated the impact of R. tetraphylla methanolic extract (RTE) and its isolated compounds Ajmaline (RTC1) and Reserpine (RTC2) on triple-negative breast cancer cell line (MDA-MB-231) focusing on anti-proliferative effects...
March 29, 2024: Medical Oncology
https://read.qxmd.com/read/38546893/investigating-the-correlation-between-prominent-viruses-and-hematological-malignancies-a-literature-review
#12
REVIEW
Arian Haghtalab, Milad Hejazi, Naeem Goharnia, Ali Yekanlou, Kousha Hazhir, Asma Barghi, Zahra Bazzaz, Iman Allahverdizadeh, Ataollah GhalibafSabbaghi
Extensive research has been conducted on the correlation between viral infections and hematological cancers ever since the identification of the Rous Sarcoma Virus as a cancer-causing agent. Numerous viruses, such as the Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human T-lymphotropic virus 1, and severe acute respiratory syndrome-related coronavirus 2, have been identified as potential contributors to the development and progression of cancer by disrupting normal cellular processes...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546811/structure-based-multitargeted-docking-screening-pharmacokinetics-dft-and-dynamics-simulation-studies-reveal-mitoglitazone-as-a-potent-inhibitor-of-cellular-survival-and-stress-response-proteins-of-lung-cancer
#13
JOURNAL ARTICLE
Abdulkarim S Binshaya, Omar Saad Alkahtani, Fahad M Aldakheel, Ahmed Hjazi, Hassan H Almasoudi
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is responsible for more than 1.8 million deaths yearly and is expected to rise to 2.2 million by 2030. The most common type of lung cancer is non-small cell lung cancer (NSCLC), which accounts for about 80% and small cell lung cancer (SCLC), which is more aggressive than NSCLC and is often diagnosed later and accounts for 20% of cases...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38538985/effect-of-capecitabine-as-monotherapy-for-her2-normal-metastatic-breast-cancer
#14
JOURNAL ARTICLE
Anne-Dorthe Mosgaard Knudsen, Mikala Wej Modvig, Marianne Vogsen, Annette Raskov Kodahl
This study aimed to evaluate the efficacy of capecitabine monotherapy for patients with human epidermal growth factor receptor-2 (HER2) normal metastatic breast cancer (MBC). The primary endpoint was progression-free survival (PFS), and secondary endpoints included overall survival (OS) and PFS according to treatment line and estrogen receptor (ER) status. Patients who received capecitabine as monotherapy for HER2 normal MBC from 2010 to 2020 were included in this retrospective study. ER status, treatment line, number of treatments, and dates of progression and death were registered...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38538804/ywhag-promotes-colorectal-cancer-progression-by-regulating-the-cttn-wnt-%C3%AE-catenin-signaling-axis
#15
JOURNAL ARTICLE
Yuanben Wang, Yulin Cao, Ying Chen, Han Cheng, Zhiang Liu, Mengna Wang, Yuyang Feng, Bojian Fei, Kaisa Cui, Zhaohui Huang
Colorectal cancer (CRC) ranks as the third most prevalent cancer type globally. Nevertheless, the fundamental mechanisms driving CRC progression remain ambiguous, and the prognosis for the majority of patients diagnosed at an advanced stage is dismal. YWHA/14-3-3 proteins serve as central nodes in several signaling pathways and are closely related to tumorigenesis and progression. However, their exact roles in CRC are still poorly elucidated. In this study, we revealed that YWHAG was the most significantly upregulated member of the YWHA/14-3-3 family in CRC tissues and was associated with a poor prognosis...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38536512/potential-role-of-immune-cell-therapy-in-gynecological-cancer-and-future-promises-a-comprehensive-review
#16
REVIEW
Sandipan Dasgupta, Sakuntala Gayen, Tania Chakraborty, Naureen Afrose, Ranita Pal, Sutapa Mahata, Vilas Nasare, Souvik Roy
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer cells are killed by the invasion of immune system. In recent year, immunotherapy has mostly an advanced treatment approach to repressing the tumor cells survival, proliferation, and invasion via the activation of immune systems. Moreover, various types of immune cells including T-cells, B-cells, and dendritic cells are associated with the immunotherapeutic strategy in cancer treatment...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38532150/exploring-the-combined-anti-cancer-effects-of-sodium-butyrate-and-celastrol-in-glioblastoma-cell-lines-a-novel-therapeutic-approach
#17
JOURNAL ARTICLE
Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) in two glioblastoma cell lines. SB, a histone deacetylase inhibitor, and CEL, derived from the tripterygium wilfordii plant, act as mTOR and proteasome inhibitors. Both can cross the blood-brain barrier, and they exhibit chemo- and radiosensitive properties in various cancer models. GB cell lines LN-405 and T98G were treated with SB and CEL...
March 26, 2024: Medical Oncology
https://read.qxmd.com/read/38526769/estrogen-receptor-status-determines-differential-regulation-of-%C3%AE-1-and-%C3%AE-2-adrenoceptor-mediated-cell-survival-angiogenesis-and-intracellular-signaling-responses-in-breast-cancer-cell-lines
#18
JOURNAL ARTICLE
Hannah P Priyanka, Uday P Pratap, Rahul S Nair, Ramasamy Vasantharekha, Srinivasan ThyagaRajan
Psychosocial stress promotes cancer pathogenesis involving angiogenesis through alterations in neuroendocrine-immune functions that may involve adrenoceptor (AR)-dependent signaling mechanisms in the brain, lymphoid organs, and cancerous cells. Various concentrations of α1 - and α2 - AR-specific agonists and antagonists were incubated in vitro with estrogen receptor-positive (ER +) MCF-7, and ER (-) MDA MB-231 cells to examine the secretions of VEGF-A, VEGF-C, and nitric oxide (NO), and expression of signaling molecules- p-ERK, p-CREB, and p-Akt on the proliferation of breast cancer cell lines...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526657/physical-characterization-and-bioavailability-assessment-of-5-fluorouracil-based-nanostructured-lipid-carrier-nlc-in-vitro-drug-release-hemolysis-and-permeability-modulation
#19
JOURNAL ARTICLE
Mainuddin, Anoop Kumar, Ratneshwar Kumar Ratnesh, Jay Singh, Shweta Dumoga, Nitin Sharma, Amulya Jindal
5-Fluorouracil (5-FU) is an anticancer agent belonging to BCS Class III that exhibits poor release characteristics and low retention in the biological system. The main objective of this investigation was to develop a drug delivery system, i.e., Nanostructure Lipid Carriers (NLCs) loaded with 5-FU to prolong its biological retention through 5-FU-loaded NLCs (5-FUNLC) were designed to manipulate physicochemical characteristics and assessment of in vitro and in vivo performance. The developed NLCs underwent comprehensive characterization, including assessments for particle size, zeta potential, morphological evaluation, and FT-IR spectroscopy...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526643/investigation-of-cellular-communication-and-signaling-pathways-in-tumor-microenvironment-for-high-tp53-expressing-osteosarcoma-cells-through-single-cell-rna-sequencing
#20
JOURNAL ARTICLE
Kai Xiong, Yuqi Fang, Boyuan Qiu, Chaotao Chen, Nanchang Huang, Feiyuan Liang, Chuangming Huang, Tiantian Lu, Li Zheng, Jinmin Zhao, Bo Zhu
Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in unsatisfactory outcomes, particularly for metastatic cases. The tumor microenvironment (TME) has been recognized as a crucial determinant in OS progression. However, the intercellular dynamics between high TP53-expressing OS cells and neighboring cell types within the TME are yet to be thoroughly understood. In our study, we harnessed the single-cell RNA sequencing (scRNA-seq) technology in combination with the computational tool-Cellchat, aiming to elucidate the intercellular communication networks present within OS...
March 25, 2024: Medical Oncology
journal
journal
32014
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.