journal
https://read.qxmd.com/read/38851643/germline-aip-variants-in-sporadic-young-acromegaly-and-pituitary-gigantism-clinical-and-genetic-insights-from-a-han-chinese-cohort
#61
JOURNAL ARTICLE
Boni Xiang, Xintong Zhang, Wenjuan Liu, Bei Mao, Yao Zhao, Yongfei Wang, Wei Gong, Hongying Ye, Yiming Li, Zhaoyun Zhang, Yifei Yu, Min He
PURPOSE: Variants in the Aryl hydrocarbon receptor-interacting protein (AIP) gene have been identified in sporadic acromegaly and pituitary gigantism, especially in young patients, with a predisposition to aggressive clinical phenotype and poor treatment efficacy. The clinical characteristics of patients with sporadic acromegaly and pituitary gigantism as well as AIP variants in Han Chinese have been rarely reported. We aimed to identify AIP gene variants and analyze the clinical characteristics of patients with sporadic acromegaly and pituitary gigantism in Han Chinese...
June 8, 2024: Endocrine
https://read.qxmd.com/read/38850440/efficacy-and-safety-of-once-weekly-tirzepatide-for-weight-management-compared-to-placebo-an-updated-systematic-review-and-meta-analysis-including-the-latest-surmount-2-trial
#62
JOURNAL ARTICLE
Wenhui Qin, Jun Yang, Ying Ni, Chao Deng, Qinjuan Ruan, Jun Ruan, Peng Zhou, Kai Duan
AIM: Tirzepatide, a newly developed dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has received approval for treating type 2 diabetes (T2D) and is currently being studied for its potential in long-term weight control. We aim to explore the safety and efficacy of once-weekly subcutaneous tirzepatide for weight loss in T2D or obese patients. METHODS: A comprehensive search was performed on various databases including PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials...
June 8, 2024: Endocrine
https://read.qxmd.com/read/38850439/exploring-risk-factors-of-severe-pituitary-apoplexy-insights-from-a-multicenter-study-of-71-cases
#63
JOURNAL ARTICLE
Pablo Garcia-Feijoo, Carlos Perez Lopez, Igor Paredes, Alberto Acitores Cancela, Cristina Alvarez-Escola, Maria Calatayud, Alfonso Lagares, Maria Soledad Librizzi, Victor Rodriguez Berrocal, Marta Araujo-Castro
PURPOSE: To identify clinical and radiological factors associated with a higher risk of developing a severe pituitary apoplexy (PA). METHODS: Multicenter retrospective study of patients presenting with clinical PA in three Spanish tertiary hospitals of Madrid between 2008 and 2022. We classified PA as severe when presenting with an altered level of consciousness (Glasgow Coma Scale (GCS) < 15) or visual involvement. RESULTS: A total of 71 PA cases were identified, of whom 80...
June 8, 2024: Endocrine
https://read.qxmd.com/read/38849646/the-role-of-the-adrenalectomy-in-the-management-of-pheochromocytoma-the-experience-of-a-portuguese-referral-center
#64
JOURNAL ARTICLE
Inês Costa Carvalho, Miguel V B Machado, João P Morais, Filipa Carvalho, Elisabete Barbosa, José Barbosa
PURPOSE: Pheochromocytoma is a rare neuroendocrine tumor. Despite the low incidence, these tumors are of indisputable importance. This study aimed to analyze the management of pheochromocytoma in a referral center, with an emphasis on the minimally invasive adrenalectomy, which is the preferred therapeutic approach. METHODS: A retrospective analysis was performed on a cohort of patients diagnosed with pheochromocytoma who underwent adrenalectomy between January 2013 and December 2022...
June 8, 2024: Endocrine
https://read.qxmd.com/read/38849645/metabolic-score-and-its-components-are-associated-with-carotid-plaque-prevalence-in-young-adults
#65
JOURNAL ARTICLE
Jingwen Fan, Yongli Yang, Xiaocan Jia, Yuping Wang, Chenyu Zhao, Nana Wang, Suying Ding, Xuezhong Shi
PURPOSE: No study has comprehensively assessed the relationship of metabolic factors including insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia with the development of carotid plaque. Therefore, we constructed metabolic scores based on the above metabolic factors and examined its association with carotid plaque in young and older Chinese adults. METHODS: This study included 17,396 participants who underwent carotid ultrasound examinations, including 14,173 young adults (<65 years) and 3,223 older adults (≥65 years)...
June 7, 2024: Endocrine
https://read.qxmd.com/read/38849644/sglt2-inhibitors-may-reduce-non-small-cell-lung-cancer-and-not-increase-various-neoplasms-including-several-skin-cancers
#66
LETTER
Yu Xiao, Wanying Yang, Muyang Wang
No abstract text is available yet for this article.
June 7, 2024: Endocrine
https://read.qxmd.com/read/38849643/hematological-toxicities-with-lutathera%C3%A2-for-neuroendocrine-neoplasms-post-marketing-surveillance-data-from-the-us-fda
#67
LETTER
Udhayvir Singh Grewal, Anuj Thakre
No abstract text is available yet for this article.
June 7, 2024: Endocrine
https://read.qxmd.com/read/38844609/factors-associated-with-glycemia-risk-index-in-a-cohort-of-patients-with-type-1-diabetes-mellitus-and-latent-autoimmune-diabetes-in-adults-lada
#68
JOURNAL ARTICLE
Sandra Herranz-Antolín, Clara Cotón-Batres, María Covadonga López-Virgos, Verónica Esteban-Monge, Visitación Álvarez-de Frutos, Miguel Torralba
OBJECTIVE: To analyze the degree of control based on classical glucometric parameters and Glycemia Risk Index (GRI) in real-life conditions in a cohort of patients with type 1 Diabetes Mellitus (DM) and Latent Autoimmune Diabetes in Adults (LADA) and to assess the factors that are associated with GRI. PATIENTS AND METHODS: Cross-sectional study. 447 adult patients with type 1 DM and LADA users of Intermittent Continuous Glucose Monitoring (iCGM) with an adherence ≥ 70% were included...
June 6, 2024: Endocrine
https://read.qxmd.com/read/38844608/the-association-between-non-hdl-cholesterol-and-high-grade-pancreatic-neuroendocrine-neoplasms
#69
JOURNAL ARTICLE
Hao Zhou, Yong Zhu, Bin Qin, Yongkang Liu, Zhongqiu Wang, Chuangen Guo, Jianhua Wang, Xiao Chen
PURPOSE: High-density lipoprotein cholesterol (HDL-c) plays an important role in tumorigenesis in several endocrine-related cancers. Few studies have shown the effect of non-HDL-c in malignant tumors. The present study aimed to identify the association between non-HDL-c and high-grade pancreatic neuroendocrine neoplasms (PNENs). METHODS: A total of 197 PNEN patients who underwent surgery were analyzed retrospectively. Clinical and histopathological features, such as patients' age and sex, tumor location and size, tumor grade, the level of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and fasting plasma-glucose levels were obtained...
June 6, 2024: Endocrine
https://read.qxmd.com/read/38842765/evaluation-of-folliculogenesis-and-oxidative-stress-parameters-in-type-1-diabetes-mellitus-women-with-different-glycemic-profiles
#70
JOURNAL ARTICLE
A V Tiselko, E V Misharina, M I Yarmolinskaya, Y P Milyutina, I V Zalozniaia, A V Korenevsky
BACKGROUND: Despite enormous advances in diabetes treatment, women with type 1 diabetes mellitus (DM) still experience delayed menarche, menstrual irregularities, fewer pregnancies, and a higher rate of stillbirths compared to women without the disease. Due to the fact that type 1 DM occurs at a young age, the preservation of reproductive health is one of the most important goals of treatment. AIMS: The aim of this study was to evaluate the relationship between different glycemic profiles and changes in the pro-oxidant-antioxidant balance and ovarian follicular apparatus in reproductive-age patients with type 1 DM...
June 6, 2024: Endocrine
https://read.qxmd.com/read/38836992/dyslipidemia-and-angptl8-evaluation-in-young-females-with-type-1-diabetes-mellitus
#71
JOURNAL ARTICLE
Walaa Mohammedsaeed, Dalal Binjawhar
PURPOSE: ANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM). METHODS: A retrospective case-control study was performed on a group of 100 adolescent females, aged 13-17 years. This group consisted of individuals diagnosed with T1DM from the Diabetes and Endocrine Department at Medina's King Fahad Hospital in Saudi Arabia...
June 5, 2024: Endocrine
https://read.qxmd.com/read/38834859/the-impact-of-preoperative-calcitonin-screening-on-the-prognosis-of-patients-with-medullary-thyroid-cancer-a-retrospective-multicenter-cohort-study
#72
JOURNAL ARTICLE
Yingtong Hou, Yu Yang, Gang Chen, Jianyan Long, Yufei He, Dandan Xiong, Yuyan Pang, Qi Li, Guojie Dong, Siqi Qiao, Wenke Chen, Xuyang Li, Jiayuan Zhang, Tianyi Xu, Xinwen Chen, Fenghua Lai, Haixia Guan, Bo Lin, Yihao Liu
PURPOSE: There is still controversy in different guidelines regarding the necessity of routine preoperative calcitonin (Ctn) testing in medullary thyroid cancer (MTC). The level of preoperative Ctn may influence the extent of surgery. METHODS: This retrospective multicenter cohort study involved 149 MTC patients from 6 centers between 2013 to 2023. Clinical characteristics, surgical procedure and clinical outcomes were compared between Ctn-screened and Non-screened group...
June 4, 2024: Endocrine
https://read.qxmd.com/read/38833202/effects-of-sodium-intake-age-gender-blood-sampling-time-on-distribution-of-plasma-aldosterone-renin-activity-deoxycorticosterone-cortisol-cortisone-and-24%C3%A2-h-urinary-aldosterone-levels-in-normotensive-individuals-based-on-lc-ms-ms
#73
JOURNAL ARTICLE
Qi Zhang, Zheng Zhao, Weiyang Cheng, Yiling Zhang, Zhilong Li, Huiying Liu, Chunxia Xu, Kaijuan Wang
PURPOSE: This study aims to analyze the distribution of plasma aldosterone, renin activity, deoxycorticosterone (DOC), cortisol, cortisone, and 24 h urinary aldosterone (24 h-uAld) levels based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. MATERIALS AND METHODS: Plasma and 24 h urine were collected from 129 healthy volunteers in Northeast China. The effect of sodium intake, age, gender, blood sampling time on plasma aldosterone concentration (PAC), plasma renin activity (PRA), PAC to PRA ratio (ARR), DOC, cortisol, cortisone, cortisol to cortisone ratio, and 24 h-uAld were investigated by nonparametric test, multiple linear regression and Harris-Boyd's standard deviate test...
June 4, 2024: Endocrine
https://read.qxmd.com/read/38831236/diabetes-and-obesity-the-role-of-stress-in-the-development-of-cancer
#74
REVIEW
Angelo Avogaro
Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association. Managing diabetes and obesity is challenging as they both cause significant distress...
June 3, 2024: Endocrine
https://read.qxmd.com/read/38824220/cd147-mediates-s-protein-pseudovirus-of-sars-cov-2-infection-and-its-induction-of-spermatogonia-apoptosis
#75
JOURNAL ARTICLE
Pengyuan Dai, Chaoye Ma, Ting Jiang, Jianwu Shi, Sha Liu, Meihua Zheng, Yiwen Zhou, Xiaofeng Li, Yang Liu, Hao Chen
Male cases diagnosed COVID-19 with more complications and higher mortality compared with females, and the overall consequences of male sex hormones and semen parameters deterioration were observed in COVID-19 patients, whereas the involvement and mechanism for spermatogenic cell remains unclear. The study was aimed to investigate the infection mode of S protein (D614G) pseudovirus (pseu-S-D614G) to spermatogenic cells, as well as the influence on cell growth. Both mouse spermatogonia (GC-1 cell, immortalized spermatogonia) and spermatocyte (GC-2 cell, immortalized spermatocytes) were used to detect the infection of pseu-S-D614G of SARS-CoV-2, and further explored the effect of SARS-CoV-2-spike protein (S-protein) and SARS-CoV-2-spike protein (omicron) (O-protein) on GC-1 cell apoptosis and proliferation...
June 1, 2024: Endocrine
https://read.qxmd.com/read/38822895/psychological-impacts-of-lobectomy-and-total-thyroidectomy-in-ptc-measuring-1-to-4%C3%A2-cm-with-low-to-intermediate-risk-of-recurrence
#76
JOURNAL ARTICLE
Ziyang Ye, Lanlan Wang, Genpeng Li, Pan Zhang, Tao Wei, Jingqiang Zhu, Zhihui Li, Jianyong Lei, Juxiang Gou, Huairong Tang
PURPOSE: To investigate the implications of Lobectomy (LT) or total thyroidectomy (TT) on psychological distress and sleep quality in PTC patients with a low to intermediate risk of recurrence and tumors measuring 1 to 4 cm. METHODS: Patients who were admitted to our hospital between July 2021 and July 2022 were prospectively enrolled in this survey. Psychological distress and sleep quality were assessed at hospitalization, discharge, and 1, 3, and 6 months post-treatment using validated scales...
June 1, 2024: Endocrine
https://read.qxmd.com/read/38822184/alteration-in-gut-microbial-characteristics-of-patients-with-acromegaly
#77
JOURNAL ARTICLE
Afruz Babayeva, Ceren Ozkul, Meric Coskun, Arzu Uzun, Mehmet Muhittin Yalcin, Meltem Yalinay, Mujde Akturk, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Ilhan Yetkin, Alev Eroglu Altinova
PURPOSE: Studies on intestinal microbiota in acromegaly are scant. This study aimed to characterize the gut microbiome in patients with acromegaly. METHOD: Stool samples were collected from 11 patients newly diagnosed with acromegaly and 12 healthy controls matched for body mass index (BMI) and age after three days on a standard diet. Clinical and gut microbial composition assessments were performed for the two participant groups using 16S rRNA gene amplicon sequencing...
May 31, 2024: Endocrine
https://read.qxmd.com/read/38822183/continuous-glucose-monitoring-profile-in-covid-19-patients-with-and-without-diabetes-receiving-methylprednisolone
#78
JOURNAL ARTICLE
Xingxing He, Guangchen Duan, Jingyi Lu, Yaxin Wang, Jinghao Cai, Yiqing Tong, Wei Wu, Xiaojing Ma, Qiming Feng, Jian Zhou
PURPOSE: Methylprednisolone is widely used during the COVID-19 epidemic. We aimed to evaluate the glucose profile of COVID-19 patients with and without diabetes receiving methylprednisolone. METHODS: 36 patients with COVID-19 admitted to hospital were included: 17 with and 19 without diabetes. Methylprednisolone 40 mg was administered at about 9:00 a.m. Glucose levels were assessed by blinded intermittently scanned continuous glucose monitoring (isCGM) for an average of 6...
May 31, 2024: Endocrine
https://read.qxmd.com/read/38816664/adherence-to-the-dietary-approaches-to-stop-hypertension-diet-reduces-the-risk-of-diabetes-mellitus-a-systematic-review-and-dose-response-meta-analysis
#79
JOURNAL ARTICLE
Xiyan Quan, Xiaoming Shen, Chun Li, Yayuan Li, Tiangang Li, Baifan Chen
BACKGROUND: Despite several epidemiological studies reporting a significant association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and the risk of diabetes mellitus, the results remain controversial. In this systematic review and meta-analysis, we aimed to summarize the existing evidence from published observational studies and evaluate the dose-response relationship between adherence to the DASH diet and diabetes mellitus risk. METHODS: We performed a systematic search for relevant articles published up to September 2023 using electronic databases of PubMed, Embase, Scopus, and China National Knowledge Infrastructure (CNKI)...
May 30, 2024: Endocrine
https://read.qxmd.com/read/38814373/associations-of-four-surrogate-insulin-resistance-indexes-with-non-alcoholic-steatohepatitis-in-chinese-patients-with-obesity-a-cross-sectional-study
#80
JOURNAL ARTICLE
Jinfeng Xiao, Xinxin Zhang, Lina Chang, Hong Yu, Longhao Sun, Chonggui Zhu, Qing He
OBJECTIVES: This study was designed to evaluate the association of four surrogate indexes of IR with NASH in patients with obesity. METHODS: A total of 270 patients who underwent bariatric surgery, were included in this cross-sectional study. NASH was diagnosed based on liver biopsies. Binary logistics regression analyses were performed to assess the associations of four surrogate indexes of IR (HOMA-IR, Matsuda index, TyG, and TG/HDL-C) with NASH in patients with obesity...
May 30, 2024: Endocrine
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