journal
https://read.qxmd.com/read/38816664/adherence-to-the-dietary-approaches-to-stop-hypertension-diet-reduces-the-risk-of-diabetes-mellitus-a-systematic-review-and-dose-response-meta-analysis
#41
JOURNAL ARTICLE
Xiyan Quan, Xiaoming Shen, Chun Li, Yayuan Li, Tiangang Li, Baifan Chen
BACKGROUND: Despite several epidemiological studies reporting a significant association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and the risk of diabetes mellitus, the results remain controversial. In this systematic review and meta-analysis, we aimed to summarize the existing evidence from published observational studies and evaluate the dose-response relationship between adherence to the DASH diet and diabetes mellitus risk. METHODS: We performed a systematic search for relevant articles published up to September 2023 using electronic databases of PubMed, Embase, Scopus, and China National Knowledge Infrastructure (CNKI)...
May 30, 2024: Endocrine
https://read.qxmd.com/read/38814373/associations-of-four-surrogate-insulin-resistance-indexes-with-non-alcoholic-steatohepatitis-in-chinese-patients-with-obesity-a-cross-sectional-study
#42
JOURNAL ARTICLE
Jinfeng Xiao, Xinxin Zhang, Lina Chang, Hong Yu, Longhao Sun, Chonggui Zhu, Qing He
OBJECTIVES: This study was designed to evaluate the association of four surrogate indexes of IR with NASH in patients with obesity. METHODS: A total of 270 patients who underwent bariatric surgery, were included in this cross-sectional study. NASH was diagnosed based on liver biopsies. Binary logistics regression analyses were performed to assess the associations of four surrogate indexes of IR (HOMA-IR, Matsuda index, TyG, and TG/HDL-C) with NASH in patients with obesity...
May 30, 2024: Endocrine
https://read.qxmd.com/read/38814372/utility-of-time-in-tight-range-titr-in-evaluating-metabolic-control-in-pediatric-and-adult-patients-with-type-1-diabetes-in-treatment-with-advanced-hybrid-closed-loop-systems
#43
JOURNAL ARTICLE
Pilar Bahillo-Curieses, Pablo Fernández Velasco, Paloma Pérez-López, Ana María Vidueira Martínez, María de la O Nieto de la Marca, Gonzalo Díaz-Soto
PURPOSE: To analyze the time in tight range (TITR), and its relationship with other glucometric parameters in patients with type 1 diabetes (T1D) treated with advanced hybrid closed-loop (AHCL) systems. METHODS: A prospective observational study was conducted on pediatric and adult patients with T1D undergoing treatment with AHCL systems for at least 3 months. Clinical variables and glucometric parameters before and after AHCL initiation were collected. RESULTS: A total of 117 patients were evaluated...
May 30, 2024: Endocrine
https://read.qxmd.com/read/38809347/a-machine-learning-based-diagnosis-modeling-of-igg4-hashimoto-s-thyroiditis
#44
JOURNAL ARTICLE
Chenxu Zhao, Zhiming Sun, Yang Yu, Yiwei Lou, Liyuan Liu, Ge Li, Jumei Liu, Lei Chen, Sainan Zhu, Yu Huang, Yang Zhang, Ying Gao
PURPOSE: This study aims to develop a non-invasive diagnosis model using machine learning (ML) for identifying high-risk IgG4 Hashimoto's thyroiditis (HT) patients. METHODS: A retrospective cohort of 93 HT patients and a prospective cohort of 179 HT patients were collected. According to the immunohistochemical and pathological results, the patients were divided into IgG4 HT group and non-IgG4 HT group. Serum TgAb IgG4 and TPOAb IgG4 were detected by ELISAs. A logistic regression model, support vector machine (SVM) and random forest (RF) were used to establish a clinical diagnosis model for IgG4 HT...
May 29, 2024: Endocrine
https://read.qxmd.com/read/38809346/survival-benefit-of-postoperative-radioiodine-therapy-among-patients-with-intermediate-risk-differentiated-thyroid-carcinoma
#45
JOURNAL ARTICLE
Jinwen Wang, Yaqian Mao, Liantao Li, Jixing Liang, Huibin Huang, Wei Lin, Gang Chen, Junping Wen
BACKGROUND: The 2015 American Thyroid Association (ATA) guidelines proposed the use of the ATA Risk Stratification System and American Joint Committee on Cancer Tumor-Node-Metastasis (AJCC/TNM) Staging System for postoperative radioiodine decision-making. However, the management of patients with intermediate-risk differentiated thyroid carcinoma (DTC) is not well defined. In this study, we aimed to evaluate the therapeutic efficacy of radioactive iodine therapy (RAIT) among various subgroups of patients with intermediate-risk DTC after surgery...
May 29, 2024: Endocrine
https://read.qxmd.com/read/38809345/dxa-derived-lumbar-bone-strain-index-corrected-for-kyphosis-is-associated-with-vertebral-fractures-and-trabecular-bone-score-in-acromegaly
#46
JOURNAL ARTICLE
Simona Jaafar, Giacomo Cristofolini, Emanuela Morenghi, Luca Rinaudo, Maria Francesca Birtolo, Elisa Sala, Emanuele Ferrante, Roberta Mungari, Elisabetta Lavezzi, Lorenzo Leonardi, Pasquala Ragucci, Fabio M Ulivieri, Luca Balzarini, Giovanna Mantovani, Andrea G Lania, Gherardo Mazziotti
PURPOSE: The bone strain index (BSI) is a marker of bone deformation based on a finite element analysis inferred from dual X-ray absorptiometry (DXA) scans, that has been proposed as a predictor of fractures in osteoporosis (i.e., higher BSI indicates a lower bone's resistance to loads with consequent higher risk of fractures). We aimed to investigate the association between lumbar BSI and vertebral fractures (VFs) in acromegaly. METHODS: Twenty-three patients with acromegaly (13 males, mean age 58 years; three with active disease) were evaluated for morphometric VFs, trabecular bone score (TBS), bone mineral density (BMD) and BSI at lumbar spine, the latter being corrected for the kyphosis as measured by low-dose X-ray imaging system (EOS®-2D/3D)...
May 29, 2024: Endocrine
https://read.qxmd.com/read/38806892/single-cell-transcriptome-analysis-reveals-the-regulatory-functions-of-islet-exocrine-cells-after-short-time-obesogenic-diet
#47
JOURNAL ARTICLE
Qianqian Sun, Huiyu Tang, Huan Zhu, Yanyan Liu, Min Zhang, Chenghang Che, Bing Xiang, Shuang Wang
PURPOSE: This study aims to investigate the functions of exocrine islet cell subtypes in the early stage of obesity induced by high-fat diet (HFD), which is accompanied with deterioration of the systemic insulin response and islet subpopulation abnormalities. METHODS: In this study, we analyzed published islet single-cell RNA sequencing (scRNA-seq) datasets from the early stage induced by HFD feeding. Bioinformatics tools such as findMarkers, Cellchat, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and Gene Ontology (GO) terms were applied to identify the different functions of exocrine cell clusters...
May 28, 2024: Endocrine
https://read.qxmd.com/read/38806891/wnt-%C3%AE-catenin-signaling-is-a-therapeutic-target-in-anaplastic-thyroid-carcinoma
#48
JOURNAL ARTICLE
Diana Diaz, Kensey Bergdorf, Matthew A Loberg, Courtney J Phifer, George J Xu, Quanhu Sheng, Sheau-Chiann Chen, Jamal M Byrant, Megan L Tigue, Heather Hartmann, Sarah L Rohde, James L Netterville, Naira Baregamian, Jeremy A Goettel, Fei Ye, Ethan Lee, Vivian L Weiss
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy that has consistently shown Wnt/β-catenin (canonical) signaling activation in various study populations. There are currently no targetable treatments for BRAF-wildtype ATC and a lack of effective treatment for BRAFV600E ATC. Our aim is to identify whether Wnt inhibitors could be potential therapeutic agents for ATC patients with limited treatment options. METHODS: In this Institutional Review Board-approved study, we utilize a cohort of 32 ATCs and 20 non-neoplastic multinodular goiters (MNG)...
May 28, 2024: Endocrine
https://read.qxmd.com/read/38801599/small-rna-sequencing-reveals-snornas-and-pirna-019825-as-novel-players-in-diabetic-kidney-disease
#49
JOURNAL ARTICLE
L M 't Hart, J A de Klerk, G A Bouland, J H D Peerlings, M T Blom, S J Cramer, R Bijkerk, J W J Beulens, R C Slieker
INTRODUCTION: Micro- and macrovascular complications are common among persons with type 2 diabetes. Recently there has been growing interest to investigate the potential of circulating small non-coding RNAs (sncRNAs) as contributors to the development of diabetic complications. In this study we investigate to what extent circulating sncRNAs levels associate with prevalent diabetic kidney disease (DKD) in persons with type 2 diabetes. METHODS: Plasma sncRNAs levels were determined using small RNA-seq, allowing detection of miRNAs, snoRNAs, piRNAs, tRNA fragments, and various other sncRNA classes...
May 27, 2024: Endocrine
https://read.qxmd.com/read/38801598/value-of-radiofrequency-ablation-for-treating-locally-recurrent-thyroid-cancer-a-systematic-review-and-meta-analysis-for-2-year-follow-up
#50
JOURNAL ARTICLE
Zhen Yang, Mingbo Zhang, Lin Yan, Jing Xiao, Yingying Li, Xinyang Li, Yukun Luo
PURPOSE: To evaluate the safety and efficacy of radiofrequency ablation (RFA) in treating locoregional recurrent thyroid cancer (LRTC) after a 2-year follow-up time. METHODS: PubMed, Embase and Cochrane Library were searched from inception until 20 September 2022 to find studies reporting the safety and efficacy of RFA in LRTC patients after a 2-year follow-up. Two radiologists performed the data extraction and methodological quality assessment according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
May 27, 2024: Endocrine
https://read.qxmd.com/read/38801597/muscle-function-exercise-capacity-physical-activity-level-and-cardiovascular-disease-risk-factor-knowledge-in-patients-with-prolactinoma
#51
JOURNAL ARTICLE
Ayşegül Erkoç, İmdat Eroğlu, Tomris Erbas, Ebru Calik Kutukcu
OBJECTIVE: Prolactinoma can increase the risk of cardiovascular diseases (CVDs), such as arterial stiffness, atherosclerosis, dysrhythmia and heart failure. This study aimed to evaluate and compare muscle function, exercise capacity, physical activity (PA) level, CVD risk factor knowledge level, sleep quality, fatigue and quality of life between prolactinoma patients and healthy controls. METHODS: Nineteen female patients with prolactinomas and 19 healthy women were included in this study...
May 27, 2024: Endocrine
https://read.qxmd.com/read/38801596/primary-resistance-to-selpercatinib-in-a-patient-with-advanced-medullary-thyroid-cancer
#52
JOURNAL ARTICLE
Fabian Pitoia, Pierpaolo Trimboli, Erika Abelleira
Selpercatinib, a selective RET kinase inhibitor, has demonstrated remarkable efficacy in treating patients with advanced medullary (MTC) and differentiated thyroid cancer with RET alterations. Primary resistance to selpercatinib is a very uncommon situation, and its underlying mechanisms are poorly understood. We report the case of a 42-year-old female with advanced MTC harboring a somatic M918T RET mutation who exhibited a primary resistance to selpercatinib. Despite prompt treatment initiation after the diagnosis of progressive disease, the patient continued experiencing rapid spread of disease, characterized by the appearance of new metastatic lesions and increased tumor burden...
May 27, 2024: Endocrine
https://read.qxmd.com/read/38787511/quality-of-life-diabetes-related-stress-and-treatment-satisfaction-are-correlated-with-glycemia-risk-index-gri-time-in-range-and-hypoglycemia-hyperglycemia-components-in-type-1-diabetes
#53
JOURNAL ARTICLE
Gonzalo Díaz-Soto, Paloma Pérez-López, Pablo Férnandez-Velasco, Pilar Bahillo-Curieses, María de la O Nieto de la Marca, Rebeca Jimenez, Daniel de Luis
INTRODUCTION: To evaluate the relationship between the GRI -component of hypoglycemia (CHypo) and hyperglycemia (CHyper)- with diabetes quality of life (DQoL), diabetes-related stress (DDS), perception of hypoglycemia (Clarke Test), visual analogic scale (VAS) and diabetes-knowledge (DKQ2) in T1D. METHODS: Cross-sectional study in 92 patients with T1D under intensive insulin treatment (21.7% CSII) and flash glucose monitoring (isCGM). Clinical, metabolic and glycometric parameters and quality of life/satisfaction questionnaires were analyzed...
May 24, 2024: Endocrine
https://read.qxmd.com/read/38782863/correction-to-androgen-induced-upregulation-of-cftr-in-pancreatic-%C3%AE-cell-contributes-to-hyperinsulinemia-in-pcos-model
#54
Mengzhu Sun, Yong Wu, Chun Yuan, Jingya Lyu, Xinyi Zhao, Ye Chun Ruan, Jinghui Guo, Hui Chen, Wen Qing Huang
No abstract text is available yet for this article.
May 24, 2024: Endocrine
https://read.qxmd.com/read/38782862/association-between-the-triglyceride-glucose-index-and-thyroid-disorders-a-cross-sectional-survey-and-mendelian-randomization-analysis
#55
JOURNAL ARTICLE
Chenyu Zhang, Haoyu Wang, Yongze Li, Xichang Wang, Yutong Han, Xiaotong Gao, Yaxin Lai, Chuyuan Wang, Weiping Teng, Zhongyan Shan
BACKGROUND: Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders. METHODS: Eligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex...
May 23, 2024: Endocrine
https://read.qxmd.com/read/38782861/effects-of-metformin-on-the-glucose-regulation-lipid-levels-and-gut-microbiota-in-high-fat-diet-with-streptozotocin-induced-type-2-diabetes-mellitus-rats
#56
JOURNAL ARTICLE
Xuan Zhou, Jian Zhou, Qingfeng Ban, Mei Zhang, Bo Ban
OBJECTIVE: Metformin, an anti-diabetic drug, regulates blood glucose by affecting gut microbiotas. However, the potential mechanism underlying this effect remains unclear. This study aimed to evaluate the effect of metformin on glucose regulation, lipid levels, and the gut microbiota in rats with type 2 diabetes mellitus induced by a high-fat diet with streptozotocin. RESEARCH DESIGN METHODS: Thirty Wistar rats was using in this experiment. T2DM rats were administered 300 mg/kg metformin for 8 weeks...
May 23, 2024: Endocrine
https://read.qxmd.com/read/38775914/cardiac-magnetic-resonance-reveals-biventricular-impairment-in-cushing-s-syndrome-a-multicentre-case-control-study
#57
JOURNAL ARTICLE
Tiziana Feola, Alessia Cozzolino, Dario De Alcubierre, Riccardo Pofi, Nicola Galea, Carlo Catalano, Chiara Simeoli, Nicola Di Paola, Federica Campolo, Rosario Pivonello, Andrea M Isidori, Elisa Giannetta
PURPOSE: Cushing's syndrome (CS) is associated with severe cardiovascular (CV) morbidity and mortality. Cardiac magnetic resonance (CMR) is the non-invasive gold standard for assessing cardiac structure and function; however, few CMR studies explore cardiac remodeling in patients exposed to chronic glucocorticoid (GC) excess. We aimed to describe the CMR features directly attributable to previous GC exposure in patients with cured or treated endogenous CS. METHODS: This was a prospective, multicentre, case-control study enrolling consecutive patients with cured or treated CS and patients harboring non-functioning adrenal incidentalomas (NFAI), comparable in terms of sex, age, CV risk factors, and BMI...
May 22, 2024: Endocrine
https://read.qxmd.com/read/38772990/ten-years-real-life-experience-on-the-use-of-multikinase-inhibitors-in-patients-with-advanced-differentiated-thyroid-cancer
#58
JOURNAL ARTICLE
Fernando Jerkovich, Soledad Capalbo, Erika Abelleira, Fabián Pitoia
PURPOSE: To evaluate objective response rates (ORR), progression-free survival (PFS), and overall survival (OS) associated with tyrosine kinase inhibitors (TKIs) in patients with radioiodine refractory differentiated thyroid cancer (RR-DTC). Additionally, to compare: (i) ORR and PFS among patients treated with lenvatinib and sorafenib; (ii) ORR and PFS among patients receiving lenvatinib as first-line vs. second-line and; (iii) adverse effects (AEs) observed in patients treated with these medications...
May 21, 2024: Endocrine
https://read.qxmd.com/read/38772989/assessing-blood-sugar-measures-for-predicting-new-onset-diabetes-and-cardiovascular-disease-in-community-dwelling-adults
#59
JOURNAL ARTICLE
Jung-Hwan Kim, Yaeji Lee, Chung-Mo Nam, Yu-Jin Kwon, Ji-Won Lee
PURPOSE: Diabetes mellitus (DM) is a global health concern linked to various complications, including cardiovascular disease (CVD). However, long-term follow-up studies on the risk of DM and CVD using different blood glucose assessment methods in the general Korean population are lacking. This study aimed to assess the predictive abilities of fasting plasma glucose (FPG), 2-h oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) for new-onset DM and high CVD risk in a middle-aged and older Korean population...
May 21, 2024: Endocrine
https://read.qxmd.com/read/38771483/c-reactive-protein-to-albumin-ratio-and-risk-of-incident-metabolic-syndrome-in-community-dwelling-adults-longitudinal-findings-over-a-12-year-follow-up-period
#60
JOURNAL ARTICLE
Taekyeong Lim, Yong-Jae Lee
AIM: The C-reactive protein to albumin (CRP/Alb) ratio has emerged as a novel biomarker for various inflammatory diseases. This study aimed to evaluate the association between the CRP/Alb ratio and incident metabolic syndrome (MetS) with a large-sample, community-based Korean cohort over a 12-year follow-up period. MATERIALS AND METHODS: Among 10,030 participants, a total of 6205 participants aged 40-69 years without MetS were selected from the Korean Genome and Epidemiology Study (KoGES)...
May 21, 2024: Endocrine
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