journal
https://read.qxmd.com/read/39023839/thyroid-dysfunction-in-hashimoto-s-thyroiditis-a-pilot-study-on-the-putative-role-of-mir-29a-and-tgf%C3%AE-1
#1
JOURNAL ARTICLE
Maria Consiglia Trotta, Daniela Esposito, Raffaela Carotenuto, Rosa di Fraia, Lucia Digitale Selvaggio, Francesca Allosso, Marina Russo, Giacomo Accardo, Roberto Alfano, Michele D'Amico, Daniela Pasquali
PURPOSE: Hashimoto's thyroiditis (HT) is one of the most common causes of thyroid dysfunction in iodine sufficient worldwide areas, but its molecular mechanisms are not completely understood. To this regard, this study aimed to assess serum levels of miRNA-29a (miR-29a) and transforming growth factor beta 1 (TGFβ1) in HT patients with different patterns of thyroid function. METHODS: A total of 29 HT patients, with a median age of 52 years (21-68) were included...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39020240/17%C3%AE-hydroxylase-17-20-lyase-deficiency-clinical-features-and-genetic-insights-from-a-large-turkey-cohort
#2
JOURNAL ARTICLE
Zeynep Siklar, Emine Camtosun, Semih Bolu, Melek Yildiz, Aysehan Akinci, Firdevs Bas, İsmail Dündar, Asli Bestas, Edip Ünal, Pinar Kocaay, Tulay Guran, Gonul Buyukyilmaz, Aylin Kilinc Ugurlu, Buşra Gurpinar Tosun, Ihsan Turan, Erdal Kurnaz, Bilgin Yuksel, Doga Turkkahraman, Atilla Cayir, Gamze Celmeli, E Nazli Gonc, Beray Selver Eklioğlu, Semra Cetinkaya, Seniha Kiremitci Yilmaz, Mehmet Emre Atabek, Muammer Buyukinan, Emrullah Arslan, Eda Mengen, Esra Deniz Papatya Cakir, Murat Karaoglan, Nihal Hatipoglu, Zerrin Orbak, Ahmet Ucar, Nesibe Akyurek, Emine Demet Akbas, Emregül Isik, Sare Betul Kaygusuz, Zumrut Kocabey Sutcu, Gulcan Seymen, Merih Berberoglu
PURPOSE: 17α Hydroxylase/17,20 lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia, typically diagnosed in late adolescence with symptoms of pubertal delay and hypertension. This study aimed to determine the clinical and laboratory characteristics of 17OHD cases and gather data on disease management. METHODS: Data from 97 nationwide cases were analyzed using the CEDD-NET web system. Diagnostic, follow-up findings, and final heights of patients were evaluated...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39017835/assessment-of-potential-genetic-markers-for-diabetic-foot-ulcer-among-moscow-residents
#3
JOURNAL ARTICLE
Lev A Usakin, Nadezhda V Maksimova, Ekaterina D Pesheva, Ekaterina L Zaitseva, Alla Yu Tokmakova, Andrey A Panteleyev
PURPOSE: Diabetic foot ulcer (DFU) is one of the most severe complications of type 2 diabetes, which is manifested in chronic skin ulcers of lower extremities. DFU treatment remains complex and expensive despite the availability of well-established protocols. Early prediction of potential DFU development at the onset of type 2 diabetes can greatly improve the aftermath of this complication. METHODS: To assess potential genetic markers for DFU, a group of diabetic patients from Moscow region with and without DFU was genotyped for a number of SNPs previously reported to be associated with the DFU...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39017834/a-comprehensive-systematic-review-of-health-related-quality-of-life-measures-in-short-stature-paediatric-patients
#4
JOURNAL ARTICLE
Adekunle Adedeji, Stefanie Witt, Florian Innig, Julia Quitmann
This systematic review investigates Patient-reported Outcome Measures (PROMs) and Observed Reported Outcome Measures (ObsROMs) pertinent to assessing Health-Related Quality of Life (HRQoL) in short-stature paediatric patients, focusing on Achondroplasia (ACH), Growth Hormone Deficiency (GHD), Isolated Growth Hormone Deficiency (IGHD), and Small-for-Gestational-Age (SGA) diagnoses. Utilising rigorous selection criteria, 53 studies published from 1998 to 2023 were analysed, revealing a predominance of European-based research...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39017833/relation-between-blood-pressure-time-in-range-and-composite-cardiovascular-outcomes-in-patients-with-primary-aldosteronism-a-retrospective-case-study
#5
JOURNAL ARTICLE
Fangfang Yan, Huangdao Yu, Liping Lan, Ziqing Xu, Jinyang Zeng, Bingkun Huang, Changqin Liu, Xuejun Li, Mingzhu Lin
PURPOSE: To investigate the association between blood pressure (BP) time in range (TIR) and composite cardiovascular outcomes in patients with primary aldosteronism (PA). METHODS: Between January 2019 and December 2021, 47 patients with PA were recruited from the First Affiliated Hospital of Xiamen University. Twenty-four-hour ambulatory BP monitoring (ABPM) and cardiovascular outcomes were assessed in all patients during the first diagnosis of PA. RESULTS: The mean age of the patients was 48...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39017832/copeptin-in-obese-and-nonobese-pregnant-women
#6
LETTER
Federica Tonon, Barbara Toffoli, Tamara Stampalija, Stella Bernardi
No abstract text is available yet for this article.
July 17, 2024: Endocrine
https://read.qxmd.com/read/39014283/potentials-of-bone-marrow-cells-derived-from-na%C3%A3-ve-or-diabetic-mice-in-autoimmune-type-1-diabetes-immunomodulatory-anti-inflammatory-anti-hyperglycemic-and-antioxidative
#7
JOURNAL ARTICLE
Soha Gomaa, Mohamed Nassef, Amira Hafez
BACKGROUND: The scarcity of transplanted human islet tissue and the requirement for immunosuppressive drugs to prevent the rejection of allogeneic grafts have hindered the treatment of autoimmune type 1 diabetes mellitus (T1DM) through islet transplantation. However, there is hope in adoptively transferred bone marrow cells (BMCs) therapy, which has emerged as a propitious pathway for forthcoming medications. BMCs have the potential to significantly impact both replacement and regenerative therapies for a range of disorders, including diabetes mellitus, and have demonstrated anti-diabetic effects...
July 17, 2024: Endocrine
https://read.qxmd.com/read/39009923/treatment-and-management-of-medullary-thyroid-microcarcinoma-a-10-year-retrospective-study-from-a-single-center
#8
JOURNAL ARTICLE
Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Ruochuan Cheng
OBJECTIVE: To explore individualized treatment and management methods for medullary thyroid microcarcinoma (MTMC). METHODS: Clinical data of patients with medullary thyroid carcinoma with a diameter ≤1 cm admitted to the First Affiliated Hospital of Kunming Medical University from June 2013 to June 20× were collected. Combined with different treatment guidelines for medullary thyroid carcinoma, factors affecting lymph node metastasis and postoperative disease status were analyzed...
July 15, 2024: Endocrine
https://read.qxmd.com/read/39009922/comparison-of-four-confirmatory-tests-for-the-diagnosis-of-primary-aldosteronism-bayesian-analysis-in-the-absence-of-a-gold-standard
#9
JOURNAL ARTICLE
Hang Shen, Wenjin Luo, Jinbo Hu, Jun Yang, Ying Song, Xiangjun Chen, Yi Yang, Linqiang Ma, Qingfeng Cheng, Zhihong Wang, Qifu Li, Shumin Yang
BACKGROUND: Captopril challenge test (CCT), seated saline infusion test (SSIT), oral sodium loading test (OSLT) and fludrocortisone suppression test (FST) are widely used diagnostic tests for primary aldosteronism (PA). These tests differ in terms of safety and complexity. Whether the simpler tests (CCT and SSIT) are comparable in diagnostic performance to the more complex ones (FST and OSLT) is unclear. PURPOSE: To compare the diagnostic accuracy of the four tests...
July 15, 2024: Endocrine
https://read.qxmd.com/read/39009921/a-novel-nomogram-for-predicting-the-risk-of-persistent-hyperparathyroidism-after-kidney-transplantation
#10
JOURNAL ARTICLE
Changyu Ma, Congrong Shen, Haotian Tan, Ziyin Chen, Zhenshan Ding, Ying Zhao, Xiaofeng Zhou
PURPOSE: Persistent hyperparathyroidism (PTHPT) in kidney transplant recipients is associated with bone loss, graft dysfunction and cardiovascular mortality. There is no clear consensus on the management of PTHPT. Accurate risk prediction of the disease is needed to support individualized treatment decisions. We aim to develop a useful predictive model to provide early intervention for hyperparathyroidism in these patients. METHODS: We retrospectively analyzed 263 kidney transplantations in the urology department of China-Japan Friendship Hospital from January 2018 to December 2022...
July 15, 2024: Endocrine
https://read.qxmd.com/read/39008201/a-comparison-of-brown-fat-tissue-related-hormone-levels-in-metabolically-healthy-and-unhealthy-individuals-with-obesity
#11
JOURNAL ARTICLE
Hacer Hicran Mutlu, Saniye Koç Ada, Mehmet Uzunlulu, Hasan Hüseyin Mutlu, Mehmet Sargın, Aytekin Oğuz
PURPOSE: One of the key functions of brown adipose tissue is its positive impact on metabolism. This study aimed to examine the potential involvement of brown fat-related hormones in the development of metabolically healthy obesity. Specifically, we sought to compare the levels of NRG4, FGF21, and irisin between metabolically healthy and unhealthy individuals with obesity. METHODS: Patients with BMI ≥ 30 kg/m2 and aged between 20 and 50 years were included in the study...
July 15, 2024: Endocrine
https://read.qxmd.com/read/39008200/effective-strategies-for-pregnancy-and-lactation-associated-osteoporosis-teriparatide-use-in-focus
#12
REVIEW
Dalal S Ali, Aliya A Khan, Maria Luisa Brandi
INTRODUCTION: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition characterized by fragility fractures occurring during late pregnancy or lactation, primarily affecting the spine and causing significant morbidity and back pain. PLO can lead to mobility impairment and work incapacity, with recovery taking up to several years. Due to the lack of clinical trials, treatment strategies remain poorly defined, historically focusing on calcium supplements, vitamin D, and weaning from breastfeeding...
July 15, 2024: Endocrine
https://read.qxmd.com/read/39003661/oncological-features-of-sporadic-vs-hereditary-pediatric-medullary-thyroid-cancer
#13
JOURNAL ARTICLE
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
PURPOSE: No genomic data have been put forth that prove beyond a shadow of doubt that sporadic medullary thyroid cancer (MTC) occurs in infancy, childhood, and/or adolescence. METHODS: This was a retrospective comparative study of consecutive patients with MTC who had neck surgery at a tertiary center over a 30-year period. RESULTS: Included were 1252 patients with MTC (337 hereditary and 915 sporadic), of whom 107 (8.5%) were operated before the age of 18 yrs...
July 14, 2024: Endocrine
https://read.qxmd.com/read/39003660/clinicopathological-spectrum-management-and-outcome-of-ectopic-parathyroid-carcinoma-experience-with-24-cases
#14
JOURNAL ARTICLE
Teng Zhao, Jian Huang, Yuting Wang, Dongxue Zhang, Teng Zhang, Ruigang Lu, Hua Gu, Mulan Jin, Hong Shen, Xing Liu, Dalin Feng, Jiacheng Wang, Qian Wang, Bojun Wei
PURPOSE: Ectopic parathyroid carcinoma (EPC) is a rare clinical entity with multiple diagnostic pitfalls, making surgical cures challenging. We assessed the clinicopathological spectrum and outcome of EPCs. METHODS: In this retrospective cohort study, 24 EPCs were identified from 133 PC patients treated at a tertiary referral center. The relationship between clinicopathological findings and locations was analyzed. RESULTS: The locations of EPCs were predominantly intrathyroidal (62...
July 14, 2024: Endocrine
https://read.qxmd.com/read/39003436/remembering-dr-virginia-a-livolsi-july-29-1943-march-7-2024-the-lady-of-the-butterfly-gland
#15
LETTER
Zubair Baloch, Guido Fadda
No abstract text is available yet for this article.
July 13, 2024: Endocrine
https://read.qxmd.com/read/39001927/healthcare-costs-and-medical-utilization-patterns-associated-with-painful-and-severe-painful-diabetic-peripheral-neuropathy
#16
JOURNAL ARTICLE
Todd Bromberg, Nicolas C Gasquet, Christine N Ricker, Charlotte Wu
PURPOSE: Painful diabetic peripheral neuropathy (DPN) is a common complication in patients with diabetes. It is associated with a poor quality of life and high costs of care. This study investigated the impact of painful DPN on healthcare costs and resource utilization. METHODS: This was a retrospective analysis of administrative claims of adult patients with diabetes (type 1 or 2) from Optum's de-identified Clinformatics® Data Mart Database. Patients were assigned to four cohorts by presence of DPN and pain severity, based on diagnoses and prescription patterns in a one-year baseline...
July 13, 2024: Endocrine
https://read.qxmd.com/read/38987433/timing-of-the-repeat-thyroid-fine-needle-aspiration-biopsy-does-early-repeat-biopsy-change-the-rate-of-nondiagnostic-or-atypia-of-undetermined-significance-cytology-result
#17
JOURNAL ARTICLE
Fatma Dilek Dellal Kahramanca, Muhammet Sacikara, Aydan Kilicarslan, Berna Ogmen, Cevdet Aydin, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
PURPOSE: To determine whether early repeat fine needle aspiration biopsy (FNA) has an effect on adequate or atypia of undetermined significance (AUS) cytology rates in thyroid nodules with inadequate or AUS result in the first FNA. METHODS: Nodules of patients who underwent repeat biopsy due to insufficient or AUS cytology between 2019-2022 were included. Data of the patients and ultrasonographic, cytological and histopathological results of the nodules were recorded...
July 10, 2024: Endocrine
https://read.qxmd.com/read/38982023/evaluation-of-fragility-fracture-risk-using-deep-learning-based-on-ultrasound-radio-frequency-signal
#18
JOURNAL ARTICLE
Wenqiang Luo, Jionglin Wu, Zhiwei Chen, Peidong Guo, Qi Zhang, Baiying Lei, Zhong Chen, Shixun Li, Changchuan Li, Haoxian Liu, Teng Ma, Jiang Liu, Xiaoyi Chen, Yue Ding
BACKGROUND: It was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality, and economic burden associated with fragility fracture. The quantitative ultrasound (QUS) showed promise in assessing bone structure characteristics and determining the risk of fragility fracture. AIMS: To evaluate the performance of a multi-channel residual network (MResNet) based on ultrasonic radiofrequency (RF) signal to discriminate fragility fractures retrospectively in postmenopausal women, and compared it with the traditional parameter of QUS, speed of sound (SOS), and bone mineral density (BMD) acquired with dual X-ray absorptiometry (DXA)...
July 9, 2024: Endocrine
https://read.qxmd.com/read/38971945/diabetes-current-and-future-translatable-therapies
#19
REVIEW
Fabio Antonio Gonzalez-Sanchez, Triana Mayra Sanchez-Huerta, Alexandra Huerta-Gonzalez, Maricruz Sepulveda-Villegas, Julio Altamirano, Juan Pablo Aguilar-Aleman, Rebeca Garcia-Varela
Diabetes is one of the major diseases and concerns of public health systems that affects over 200 million patients worldwide. It is estimated that 90% of these patients suffer from diabetes type 2, while 10% present diabetes type 1. This type of diabetes and certain types of diabetes type 2, are characterized by dysregulation of blood glycemic levels due to the total or partial depletion of insulin-secreting pancreatic β-cells. Different approaches have been proposed for long-term treatment of insulin-dependent patients; amongst them, cell-based approaches have been the subject of basic and clinical research since they allow blood glucose level sensing and in situ insulin secretion...
July 6, 2024: Endocrine
https://read.qxmd.com/read/38970759/analyzing-the-correlation-between-low-proportion-of-hobnail-features-in-papillary-thyroid-carcinoma-and-clinical-aggressiveness-risk
#20
JOURNAL ARTICLE
Wen-Shun Liu, Yan-Ting Duan, Guo-Qing Ru, Wan-Yuan Chen, Yuan Chen, Tian Lv, Ju-Yong Liang, Guo-Wan Zheng, Jia-Jie Xu
PURPOSE: Hobnail features may enhance the clinical aggressiveness of papillary thyroid carcinoma (PTC). However, whether a low proportion (<30%) of these features contributes to increased PTC aggressiveness remains unclear. This study investigated whether PTC cases with a low proportion hobnail features (<30%) exhibit clinical invasiveness and pathological features of aggressiveness. METHODS: Pathological specimens from patients with postoperatively diagnosed PTC were retrospectively analyzed...
July 6, 2024: Endocrine
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