journal
https://read.qxmd.com/read/36940012/correction-assessment-of-the-reporting-quality-of-randomised-controlled-trials-for-vitamin-d-supplementation-in-autoimmune-thyroid-disorders-based-on-the-consort-statement
#1
Christos Vrysis, Eirini Beneki, Elias Zintzaras, Chrysoula Doxani
No abstract text is available yet for this article.
March 20, 2023: Endocrine
https://read.qxmd.com/read/36940011/development-and-validation-of-a-nomogram-to-estimate-future-risk-of-type-2-diabetes-mellitus-in-adults-with-metabolic-syndrome-prospective-cohort-study
#2
JOURNAL ARTICLE
Tongyue Yang, Jiao Wang, Lina Wu, Feng Guo, Fengjuan Huang, Yi Song, Na Jing, Mengxing Pan, Xiaoxu Ding, Zhe Cao, Shiyu Liu, Guijun Qin, Yanyan Zhao
OBJECTIVES: To develop and validate the 4-year risk of type 2 diabetes mellitus among adults with metabolic syndrome. DESIGN: Retrospective cohort study of a large multicenter cohort with broad validation. SETTINGS: The derivation cohort was from 32 sites in China and the geographic validation cohort was from Henan population-based cohort study. RESULTS: 568 (17.63) and 53 (18.67%) participants diagnosed diabetes during 4-year follow-up in the developing and validation cohort, separately...
March 20, 2023: Endocrine
https://read.qxmd.com/read/36933156/machine-learning-models-for-differential-diagnosis-of-cushing-s-disease-and-ectopic-acth-secretion-syndrome
#3
JOURNAL ARTICLE
Xiaohong Lyu, Dingyue Zhang, Hui Pan, Huijuan Zhu, Shi Chen, Lin Lu
BACKGROUND: Using machine learning (ML) to explore the noninvasive differential diagnosis of Cushing's disease (CD) and ectopic corticotropin (ACTH) secretion (EAS) model is the next hot research topic. This study was to develop and evaluate ML models for differentially diagnosing CD and EAS in ACTH-dependent Cushing's syndrome (CS). METHODS: Two hundred sixty-four CD and forty-seven EAS were randomly divided into training and validation and test datasets. We applied 8 ML algorithms to select the most suitable model...
March 18, 2023: Endocrine
https://read.qxmd.com/read/36930437/explore-the-diagnostic-performance-of-2020-chinese-thyroid-imaging-reporting-and-data-systems-by-comparing-with-the-2017-acr-tirads-guidelines-a-single-center-study
#4
JOURNAL ARTICLE
Miaomiao Cai, Libo Chen, Limin Shui, Xuan Lv, Hui Wang
OBJECTIVE: To compare the diagnostic efficacy of the Chinese Thyroid Imaging Reporting and Data Systems (C-TIRADS) with the well-accepted ACR-TIRADS guidelines in identifying benign from malignant thyroid nodules. METHODS: A total of 2064 nodules were collected from 1627 patients undergoing thyroid ultrasonography in our center between October 2019 and November 2021. Nodules were divided into two groups: "≥1 cm" and "<1 cm". Ultrasound features of each nodule were observed and recorded by two physicians with more than 15 years of experience and classified according to the ACR-TIRADS and C-TIRADS guidelines, respectively...
March 17, 2023: Endocrine
https://read.qxmd.com/read/36928602/inflammatory-biomarkers-predict-outcomes-of-patients-with-radioactive-iodine-refractory-thyroid-cancer-treated-with-sorafenib
#5
JOURNAL ARTICLE
Meihua Jin, Mijin Kim, Min Ji Jeon, Eui Young Kim, Dong Yeob Shin, Bo Hyun Kim, Won Bae Kim, Young Kee Shong, Dong Jun Lim, Won Gu Kim
BACKGROUND: The objective of this multicenter, retrospective cohort study was to evaluate the ability of inflammatory biomarkers representing the host immune system to predict outcomes in 70 patients with progressive radioactive iodine (RAI)-refractory thyroid cancer who were treated with sorafenib. METHOD: Patients were divided into low and high inflammatory biomarker groups based on median values. Progression-free survival (PFS) and overall survival (OS) were assessed based on the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)...
March 16, 2023: Endocrine
https://read.qxmd.com/read/36928601/false-positive-radioiodine-uptake-after-radioiodine-treatment-in-differentiated-thyroid-cancer
#6
REVIEW
Daniele Barbaro, Alfredo Campennì, Raffaella Forleo, Paola Lapi
BACKGROUND AND PURPOSE: False-positive radioiodine uptake can sometimes be observed with post-radioiodine treatment (RIT) whole body scanning. Radioiodine pitfall has often been reported as being caused by benign or inflammatory disease, or, in some cases, by tumor lesions. This paper reviews the possible causes of such false-positive imaging, and suggests possible reasons for suspecting these pitfalls. METHODS AND RESULTS: Online databases, including MEDLINE (via PubMed), Embase, ISI Web of Science, Google Scholar, and Scopus, were systematically examined, using different keyword combinations: "radioiodine false-positive imaging", "131 I false-positive imaging" and " RAI false-positive imaging"...
March 16, 2023: Endocrine
https://read.qxmd.com/read/36917416/the-addition-of-corticotropin-releasing-hormone-to-2-day-low-dose-dexamethasone-suppression-test-provides-additional-case-detection
#7
JOURNAL ARTICLE
Leen Wehbeh, Ula Abed Alwahab, Alexandra Mikhael, Georgiana Dobri, Divya Yogi-Morren, Laurence Kennedy, Amir H Hamrahian
ABSTARCT: PURPOSE: The diagnostic value of adding a Corticotropin-Releasing Hormone (CRH) Stimulation Test to the 2-day Low Dose Dexamethasone Suppression Test (Dex-CRH Test) has been debated in the literature. METHODS: We identified 65 patients with Cushing disease (CD) and 42 patients in whom a diagnosis of Cushing disease could not be confirmed (NCD) after a minimum follow-up of 14 months who underwent the Dex-CRH test. RESULTS: The female sex ratio, median (range) age, and BMI were similar between the two groups...
March 14, 2023: Endocrine
https://read.qxmd.com/read/36914829/contraception-in-women-with-diabetes-adequacy-of-medical-files-registration-and-prescription-a-cross-section-study
#8
JOURNAL ARTICLE
Caroline R Gerhardt, Geórgia T C Pulz, Fabíola Satler, Cristiane B Leitão
OBJECTIVE: To describe the adequacy of diabetes mellitus (DM) patient's files registry regarding contraception method (CM), factors associated with lack of registry, and if prescription is in accordance with World Health Organization (WHO) eligibility criteria. RESEARCH DESIGN AND METHODS: This cross-sectional study was developed in two phases: (1) electronic medical records of women with DM who attended the outpatient clinic of a university hospital were reviewed to identify women in reproductive age and to look for CM registration and (2) interviews regarding contraception use, comorbidities and chronic DM complications...
March 13, 2023: Endocrine
https://read.qxmd.com/read/36913171/serum-thyroglobulin-testing-after-thyroid-lobectomy-in-patients-with-1-4%C3%A2-cm-papillary-thyroid-carcinoma
#9
JOURNAL ARTICLE
Ahreum Jang, Meihua Jin, Chae A Kim, Min Ji Jeon, Yu-Mi Lee, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
BACKGROUND: The role of measuring serum thyroglobulin (Tg) levels in patients who have undergone lobectomy has not been proven. The goal of this research is to see if serum Tg levels can predict the recurrence of papillary thyroid carcinoma (PTC) after lobectomy. METHODS: The 463 patients with 1-4 cm PTC who underwent lobectomy between January 2005 and December 2012, were included in this retrospective cohort study. Postoperative serum Tg levels and neck ultrasound were evaluated every 6-12 months after lobectomy during a median 7...
March 13, 2023: Endocrine
https://read.qxmd.com/read/36905576/neutrophil-to-lymphocyte-ratio-as-an-independent-factor-for-worse-prognosis-in-radioiodine-refractory-thyroid-cancer-patients
#10
JOURNAL ARTICLE
Natália Treistman, Lara Bessa Campelo Pinheiro Cavalcante, Fabiola Gonzalez, Pollyanna Iemini Weyll Fernandes, Fernanda Accioly de Andrade, Paulo Alonso Garcis Alves-Junior, Rossana Corbo, Daniel Alves Bulzico, Fernanda Vaisman
PURPOSE: This study aimed to evaluate neutrophil to lymphocyte ratio (NLR) as a laboratory biomarker in radioactive iodine-refractory (RAIR) locally advanced and/or metastatic differentiated thyroid cancer (DTC) and determine its correlation with overall survival (OS). METHODS: We retrospectively included 172 patients with locally advanced and/or metastatic RAIR DTC admitted between 1993 and 2021 at INCA. Age at diagnosis, histology, presence of distant metastasis (DM), DM site, neutrophil-to- lymphocyte ratio (NLR), imaging studies such as PET/CT results, progression free survival (PFS) and overall survival (OS) data were analyzed...
March 11, 2023: Endocrine
https://read.qxmd.com/read/36905575/relationship-between-smoking-and-serum-levels-of-eye-muscle-and-orbital-connective-tissue-antibodies-in-patients-with-graves-ophthalmopathy
#11
JOURNAL ARTICLE
Hooshang Lahooti, Bernard Champion, Jack R Wall
Over the past three decades, several studies have quantified the risk of smoking in the development of ophthalmopathy in patients with Graves' hyperthyroidism, with an overall odds ratio of approximately 3.0. Smokers also have a greater risk of more advanced ophthalmopathy than non-smokers. We studied 30 patients with Graves' ophthalmopathy (GO) and 10 patients with upper eyelid signs as the only manifestation of ophthalmopathy, whose eye signs were assessed using the clinical activity score (CAS), NOSPECS classes and upper eyelid retraction (UER) score, half of whom were smokers and half of whom were non-smokers...
March 11, 2023: Endocrine
https://read.qxmd.com/read/36897499/clinical-characteristics-of-hypercalcemic-crises-in-a-tertiary-children-s-hospital
#12
JOURNAL ARTICLE
Xuhua Xia, Jie Cao, Chunli Long, Xin Chen, Jiajia Zheng
BACKGROUND: Hypercalcemic crisis is considered a critical and fatal endocrine condition. To date, few reports have focused on hypercalcemic crises in children. AIM: To explore the etiology and identify the clinical characteristics related to hypercalcemic crises in children. METHODS: We enrolled 101 children diagnosed with hypercalcemia between January 1, 2016 and December 31, 2021, admitted to the Children's Hospital of Chongqing Medical University...
March 10, 2023: Endocrine
https://read.qxmd.com/read/36882643/secondary-diabetes-mellitus-in-acromegaly
#13
REVIEW
Melpomeni Moustaki, Stavroula A Paschou, Paraskevi Xekouki, Kalliopi Kotsa, Melpomeni Peppa, Theodora Psaltopoulou, Sophia Kalantaridou, Andromachi Vryonidou
Secondary diabetes mellitus (DM) is a common complication of acromegaly, encountered in up to 55% of cases. Vice versa, the prevalence of acromegaly is markedly higher in cohorts of patients with type 2 DM (T2DM). The presence of secondary DM depends primarily on acromegaly status and is associated with increased cardiovascular morbidity, malignancy rate and overall mortality. The principal pathophysiologic mechanism is increased insulin resistance due to excessive lipolysis and altered fat distribution, reflected at the presence of intermuscular fat and attenuated, dysfunctional adipose tissue...
March 8, 2023: Endocrine
https://read.qxmd.com/read/36882642/low-plasma-glucose-results-in-non-diabetic-adults-referred-from-primary-care-are-not-associated-with-morbidity-mortality-or-underlying-endogenous-hypoglycemic-disorders
#14
JOURNAL ARTICLE
Kathryn Linton, Jonathan R Seckl, Fraser W Gibb
No abstract text is available yet for this article.
March 8, 2023: Endocrine
https://read.qxmd.com/read/36877453/autonomous-growth-hormone-secretion-due-to-mccune-albright-syndrome-in-paediatric-age-group-an-ominous-triad
#15
JOURNAL ARTICLE
Satyam Singh Jayant, Rama Walia, Rahul Gupta, Rimesh Pal, Shakun Chaudhary, Kanhaiya Agrawal, Ashu Rastogi, Anish Bhattacharya, Pinaki Dutta, Sanjay Kumar Bhadada, Anil Bhansali
PURPOSE: The current study aimed to report cases of McCune Albright syndrome (MAS) with growth hormone (GH) hyper secretion along with a systematic review of literature to elucidate challenges and intricacies in its diagnosis and management. METHODS: It was a single centre study carried out in individuals with MAS and autonomous GH secretion (AGHS). In addition, a systematic search of literature across three databases (PubMed, Scopus and EMBASE) was performed from inception until May 31, 2021 to identify cases of MAS with AGHS in the pediatric age group (<18 years)...
March 6, 2023: Endocrine
https://read.qxmd.com/read/36877452/diagnostic-tests-for-medullary-thyroid-carcinoma-an-umbrella-review
#16
REVIEW
Pierpaolo Trimboli, Caterina Mian, Arnoldo Piccardo, Giorgio Treglia
PURPOSE: To summarize the more robust evidence about the performance of tools useful for diagnosis of medullary thyroid carcinoma (MTC) such as calcitonin (Ctn) and other circulating markers, ultrasound (US), fine-needle aspiration (FNA), and other imaging procedures. METHODS: This systematic review of systematic reviews was carried out according to a predefined protocol. A search string was created. An electronical comprehensive search of literature was performed on December 2022...
March 6, 2023: Endocrine
https://read.qxmd.com/read/36867366/thyroid-dysfunction-after-immune-checkpoint-inhibitor-treatment-in-a-single-center-chinese-cohort-a-retrospective-study
#17
JOURNAL ARTICLE
Lingge Wu, Yan Xu, Xiang Wang, Xinqi Cheng, Yuelun Zhang, Yingyi Wang, Xinrong Fan, Haitao Zhao, He Liu, Xiaofeng Chai, Li Zhang, Mengzhao Wang, Naishi Li, Hui Pan, Xiaolan Lian
BACKGROUND: Thyroid dysfunction is a common adverse event after immune checkpoint inhibitor (ICI) therapy. The clinical manifestations of thyroid immune-related adverse events (irAEs) are variable and the underlying mechanisms remain unclear. PURPOSE: To identify the clinical and biochemical characteristics of Chinese patients with ICI-related thyroid dysfunction. METHODS: We retrospectively reviewed patients with carcinoma who received ICI therapy and underwent evaluation of thyroid function during hospitalization at Peking Union Medical College Hospital between January 1, 2017 and December 31, 2020...
March 3, 2023: Endocrine
https://read.qxmd.com/read/36857009/long-term-cardiometabolic-morbidity-in-young-adults-with-classic-21-hydroxylase-deficiency-congenital-adrenal-hyperplasia
#18
JOURNAL ARTICLE
Beatrice Righi, Salma R Ali, Jillian Bryce, Jeremy W Tomlinson, Walter Bonfig, Federico Baronio, Eduardo C Costa, Guilherme Guaragna-Filho, Guy T'Sjoen, Martine Cools, Renata Markosyan, Tania A S S Bachega, Mirela C Miranda, Violeta Iotova, Henrik Falhammar, Filippo Ceccato, Marianna R Stancampiano, Gianni Russo, Eleni Daniel, Richard J Auchus, Richard J Ross, S Faisal Ahmed
PURPOSE: To study the current practice for assessing comorbidity in adults with 21-hydroxylase CAH and to assess the prevalence of comorbidity in these adults. METHODS: A structured questionnaire was sent to 46 expert centres managing adults with CAH. Information collected included current therapy and surveillance practice with a particular focus on osteoporosis/osteopaenia, hyperlipidaemia, type 2 diabetes/hyperinsulinaemia, hypertension, CV disease, obesity. RESULTS: Of the 31 (67%) centres from 15 countries that completed the survey, 30 (97%) screened for hypertension by measuring blood pressure, 30 (97%) screened for obesity, 26 (84%) screened for abnormal glucose homoeostasis mainly by using Hb1Ac (73%), 25 (81%) screened for osteoporosis mainly by DXA (92%), 20 (65%) screened for hyperlipidaemia and 6 (19%) screened for additional CV disease...
March 1, 2023: Endocrine
https://read.qxmd.com/read/36857008/a-cross-sectional-analysis-of-the-association-between-testosterone-and-biopsy-proven-non-alcoholic-fatty-liver-disease-in-men-with-obesity
#19
JOURNAL ARTICLE
Carlien De Herdt, Christophe De Block, Sven Francque, An Verrijken, Kristof Van Dessel, Luc Van Gaal, Jolijn Van Cauwenberghe, Eveline Dirinck
PURPOSE: To study the association between testosterone and non-alcoholic fatty liver disease (NAFLD) since prior studies have reported inconsistent results. METHODS: A retrospective analysis was performed including obese men who underwent a liver biopsy and a metabolic and hepatological work-up. Free testosterone (CFT) was calculated by the Vermeulen equation. The association between total testosterone (total T) and CFT on the one hand and NAFLD and fibrosis on the other hand was investigated and corrected for biasing factors such as metabolic parameters...
March 1, 2023: Endocrine
https://read.qxmd.com/read/36854858/low-vitamin-d-levels-predict-outcomes-of-covid-19-in-patients-with-both-severe-and-non-severe-disease-at-hospitalization
#20
JOURNAL ARTICLE
Luigi di Filippo, Melin Uygur, Massimo Locatelli, Fabrizio Nannipieri, Stefano Frara, Andrea Giustina
PURPOSE: Low vitamin D in COVID-19 have been related to worse outcomes. However, most of the studies conducted so far were not-controlled and retrospective, including biases potentially influencing this association. We evaluated 25(OH)vitamin D levels of patients with both severe and non-severe disease at hospital-admission, and in a cohort of control subjects. Moreover, we evaluated sACE-2 levels to investigate the mechanisms underlying the association between vitamin D and COVID-19...
March 1, 2023: Endocrine
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