journal
https://read.qxmd.com/read/38635065/one-sip-of-water-with-lt-4-supplementation-a-key-to-euthyroidism-in-hashimoto-s-thyroiditis
#1
JOURNAL ARTICLE
Wolfgang J Schnedl, Simon Michaelis, Harald Mangge, Dietmar Enko
PURPOSE: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication. PATIENTS AND METHODS: We report on 35 HT patients with LT-4 therapy in this retrospective evaluation. In general, we recommend that a maximum of two sips of water, which would then amount to < 50 mL, be ingested at the same time as LT-4...
April 18, 2024: Endocrine
https://read.qxmd.com/read/38635064/neuroactive-steroids-in-the-neuroendocrine-control-of-food-intake-metabolism-and-reproduction
#2
REVIEW
Aleksandra Rasic-Markovic, Emilija Djuric, Daniel Skrijelj, Jelica Bjekic-Macut, Đurđica Ignjatovic, Nikola Sutulovic, Dragan Hrncic, Dusan Mladenovic, Aleksandra Marković, Saša Radenković, Lena Radić, Nebojsa Radunovic, Olivera Stanojlovic
Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent...
April 18, 2024: Endocrine
https://read.qxmd.com/read/38632164/the-health-related-quality-of-life-of-patients-with-type-1-and-type-2-diabetes-mellitus-a-meta-analysis
#3
JOURNAL ARTICLE
Cuma Fidan, İsmail Ağırbaş
PURPOSE: We need to know about the health-related quality of life (HRQoL) of patients with diabetes mellitus (DM) to assess their health outcomes. Quantitative studies have discussed whether patients with Type 1 DM (T1DM) have better HRQoL than those with Type 2 DM (T2DM) or vice versa. However, no meta-analyses have addressed the HRQoL of patients with T1DM and T2DM together. Therefore, the primary objective of this meta-analysis was to investigate the HRQoL of patients with T1DM and T2DM...
April 17, 2024: Endocrine
https://read.qxmd.com/read/38632163/new-insights-into-the-vitamin-d-pth-axis-in-endocrine-driven-metabolic-bone-diseases
#4
REVIEW
Luigi di Filippo, John P Bilezikian, Ernesto Canalis, Umberto Terenzi, Andrea Giustina
BACKGROUND: Endocrine regulation of bone metabolisms is the focus of the "Skeletal Endocrinology" series of meetings. AIMS: To report on the outcome of the discussion on the role of vitamin D/PTH axis in endocrine osteopathies held during the 10th Skeletal Endocrinology Meeting which took place in Stresa (Italy) in March 2023. OUTCOMES: Vitamin D/PTH axis has relevant influence on several outcomes in the general population and in patients affected by endocrinopathies such as hypoparathyroidism and secreting pituitary adenomas...
April 17, 2024: Endocrine
https://read.qxmd.com/read/38627329/hypertension-and-diabetes-but-not-leptin-and-adiponectin-mediate-the-relationship-between-body-fat-and-chronic-kidney-disease
#5
JOURNAL ARTICLE
Robin Lengton, Friedo W Dekker, Elisabeth F C van Rossum, Johan W de Fijter, Frits R Rosendaal, Ko Willems van Dijk, Ton J Rabelink, Saskia Le Cessie, Renée de Mutsert, Ellen K Hoogeveen
PURPOSE: Obesity may promote kidney damage through hemodynamic and hormonal effects. We investigated the association between body mass index (BMI), total body fat (TBF) and chronic kidney disease (CKD) and whether hypertension, diabetes, leptin and adiponectin mediated these associations. METHODS: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, 6671 participants (45-65 y) were included. We defined CKD as eGFR <60 ml/min/1...
April 16, 2024: Endocrine
https://read.qxmd.com/read/38625504/reappraising-the-role-of-thyroid-scintigraphy-in-the-era-of-tirads-a-clinically-oriented-viewpoint
#6
REVIEW
Pierpaolo Trimboli, Joerg Bojunga, Maurilio Deandrea, Francesco Frasca, Alessio Imperiale, Andrea Leoncini, Gaetano Paone, Fabian Pitoia, Mario Rotondi, Ramin Sadeghi, Lorenzo Scappaticcio, Giorgio Treglia, Arnoldo Piccardo
Thyroid nodules (TNs) are a common entity, with the majority being benign. Therefore, employing an accurate rule-out strategy in clinical practice is essential. In the thyroid field, the current era is significantly marked by the worldwide diffusion of ultrasound (US)-based malignancy risk stratification systems of TN, usually reported as Thyroid Imaging Reporting And Data System (TIRADS). With the advent of US (and later TIRADS), the role of thyroid scintigraphy (TS) in clinical practice has gradually diminished...
April 16, 2024: Endocrine
https://read.qxmd.com/read/38625503/neuroendocrine-modulation-by-metamizole-and-indomethacin-investigating-the-impact-on-neuronal-markers-and-gnrh-release
#7
JOURNAL ARTICLE
Erkan Maytalman, Dilara Nemutlu Samur
PURPOSE: Some evidence that non-steroidal anti-inflammatory drugs have neuroprotective effects indicates their potential for use in a new field. However, their effects on hormone secretion have yet to be adequately discovered. Therefore, we aimed to evaluate the effects of metamizole and indomethacin on neuronal markers as well as the GnRH expression in the GT1-7 cell line. METHODS: The effects of these drugs on proliferation were evaluated by MTT analysis. The effect of 10-50-250 µM concentrations of the drugs also on the expression of neuronal factors and markers, including NGF, nestin and βIII Tubulin, and additionally GnRH, was determined by the RT-qPCR method...
April 16, 2024: Endocrine
https://read.qxmd.com/read/38622435/predictive-value-of-postprandial-c-peptide-for-utilizing-multiple-daily-injection-therapy-in-type-2-diabetes
#8
JOURNAL ARTICLE
Wei Liu, Ying Gao, Rui Zhang, Siqian Gong, Xiangqing Wang, Yanai Wang, Xiaoling Cai, Xiuying Zhang, Xiaoqi Xie, Xueyao Han, Linong Ji
PURPOSE: Multiple daily injection (MDI) insulin therapy is an effective method of glycemic control and appropriate assignment to MDI therapy could minimize the risks of hypoglycemia and weight gain. The aim of the present study was to identify factors associated with indication for MDI therapy in type 2 diabetes (T2DM). METHODS: We recruited 360 participants with T2DM that were admitted to the Endocrinology Department of Peking University People's Hospital between August 2017 and July 2018...
April 15, 2024: Endocrine
https://read.qxmd.com/read/38622434/interventions-to-improve-symptomatology-in-patients-with-hypothyroidism-and-persistent-symptoms-a-systematic-review
#9
JOURNAL ARTICLE
Jessica Hidalgo, Eddy P Lincango, Sandra Cordova-Madera, Kim Ruiz-Arellanos, Camila Wenczenovicz, Oscar Ponce, Neri Álvarez-Villalobos, Arbaaz Rao, Naykky M Singh Ospina, Spyridoula Maraka, Gonzalo J Acosta, Juan P Brito
BACKGROUND: Levothyroxine (LT4) monotherapy is the standard treatment for hypothyroidism; however, 10-15% of patients have persistent hypothyroid symptoms despite normalizing thyroid hormone levels with LT4. This study aims to summarize the best available evidence on interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms. METHODS: A systematic search was conducted in March 2022 for randomized controlled trials and observational studies on interventions for adult patients with persistent hypothyroid symptoms despite biochemical euthyroidism on thyroid hormone replacement...
April 15, 2024: Endocrine
https://read.qxmd.com/read/38622433/the-survival-after-thyroidectomy-versus-lobectomy-in-multifocal-papillary-thyroid-microcarcinoma-patients
#10
JOURNAL ARTICLE
Xiang Ai, Kongyong Zhang, Juan Xu, Hualin Xiao, Lingfan Li, Peng Sun, Junyan Li
BACKGROUND: The extent of thyroid surgery for multifocal papillary thyroid microcarcinoma (PTMC) remains controversial. Studies on the optimal surgical approach for a multifocal PTMC are scarce. This study aimed to compare the effectiveness of thyroidectomy and lobectomy for the treatment of multifocal PTMC. METHODS: A population-based retrospective cohort of patients with multifocal PTMC was analyzed using the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2017, and divided into two groups (thyroidectomy, lobectomy) based on the surgical approach...
April 15, 2024: Endocrine
https://read.qxmd.com/read/38613640/the-effect-of-coping-strategies-on-health-related-quality-of-life-in-acromegaly-patients
#11
JOURNAL ARTICLE
Lisa Schock, Witold X Chmielewski, Sonja Siegel, Mario Detomas, Timo Deutschbein, Sabrina Giese, Jürgen Honegger, Nicole Unger, Ilonka Kreitschmann-Andermahr
PURPOSE: Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive coping styles are associated with poor HRQoL in a number of diseases and patients with pituitary adenomas in general exhibit less effective coping styles than healthy controls. This study aimed to assess coping strategies in acromegaly patients in order to explore leverage points for the improvement of HRQoL. METHODS: In this cross-sectional study, we administered self-report surveys for coping strategies and HRQoL (Short Form SF-36, Freiburg questionnaire on coping with illness, FKV-LIS) in patients with acromegaly...
April 13, 2024: Endocrine
https://read.qxmd.com/read/38602617/development-and-internal-validation-of-a-clinical-score-to-predict-neonatal-hypoglycaemia-in-women-with-gestational-diabetes
#12
JOURNAL ARTICLE
Bruna Silva, Catarina A Pereira, Catarina Cidade-Rodrigues, Catarina Chaves, Anabela Melo, Vânia Gomes, Vânia Benido Silva, Alexandra Araújo, Cláudia Machado, Ana Saavedra, Odete Figueiredo, Mariana Martinho, Maria Céu Almeida, Ana Morgado, Margarida Almeida, Filipe M Cunha
INTRODUCTION: Gestational diabetes (GD) is a risk factor for neonatal hypoglycaemia (NH), but other factors can increase this risk. OBJECTIVES: To create a score to predict NH in women with GD. METHODS: Retrospective study of women with GD with a live singleton birth between 2012 and 2017 from the Portuguese GD registry. Pregnancies with and without NH were compared. A logistic regression was used to study NH predictors. Variables independently associated with NH were used to score derivation...
April 11, 2024: Endocrine
https://read.qxmd.com/read/38600392/risk-factors-for-tumor-enlargement-in-low-risk-papillary-thyroid-microcarcinoma-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
Nengwen Luo, Xinlong Shi, Yu Xia, Luying Gao, Xiaoyi Li, Yuxin Jiang
PURPOSE: The current management guidelines for low-risk papillary thyroid microcarcinoma (PTMC) do not specify how to screen for growing tumors. We sought to explore the possible risk factors for tumor enlargement in patients with low-risk PTMC under active surveillance (AS). METHODS: We searched the PubMed and Embase databases for high quality studies up to January 10th, 2024. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the included studies, and Review Manager 5...
April 10, 2024: Endocrine
https://read.qxmd.com/read/38598064/psychological-impacts-of-thermal-ablation-and-conventional-thyroidectomy-in-btn-patients-a-prospective-observational-study
#14
JOURNAL ARTICLE
Pan Zhang, Lanlan Wang, Genpeng Li, Tao Wei, Jingqiang Zhu, Jianyong Lei, Zhihui Li
BACKGROUND: Thermal ablation and conventional thyroidectomy are effective therapeutic methods for treating benign thyroid nodules (BTNs), but the psychological impacts of these methods in BTN patients are largely unknown. MATERIALS AND METHODS: This survey study prospectively enrolled patients who were admitted to our hospital between July 2021 and July 2022. The four validated scales were applied to quantify psychological distress and sleep quality at five points (the day admitted to the hospital, the day discharged from the hospital, and 1, 3, and 6 months after treatment)...
April 10, 2024: Endocrine
https://read.qxmd.com/read/38592637/epidemiological-analysis-to-identify-predictors-of-x-linked-hypophosphatemia-xlh-diagnosis-in-an-italian-pediatric-population-the-epix-project
#15
JOURNAL ARTICLE
Salvatore Crisafulli, Ylenia Ingrasciotta, Giacomo Vitturi, Andrea Fontana, Luca L'Abbate, Ylenia Alessi, Francesco Ferraù, Luigi Cantarutti, Debora Lazzerini, Salvatore Cannavò, Gianluca Trifirò
PURPOSE: X-linked hypophosphatemia (XLH) is a rare multi-systemic disease characterized by low plasma phosphate levels. The aim of this study was to investigate the annual XLH prevalence and internally evaluate predictive algorithms' application performance for the early diagnosis of XLH. METHODS: The PediaNet database, containing data on more than 400,000 children aged up to 14 years, was used to identify a cohort of XLH patients, which were matched with up to 10 controls by date of birth and gender...
April 9, 2024: Endocrine
https://read.qxmd.com/read/38587785/landscape-of-congenital-adrenal-hyperplasia-cases-in-adult-endocrinology-clinics-of-t%C3%A3-rkiye-a-nation-wide-multicentre-study
#16
JOURNAL ARTICLE
Melek Eda Ertorer, Inan Anaforoglu, Nusret Yilmaz, Gamze Akkus, Seda Turgut, Kursad Unluhizarci, Ozlem Soyluk Selcukbiricik, Fatma Avci Merdin, Ersen Karakilic, Esma Pehlivan, Goknur Yorulmaz, Ozen Oz Gul, Rifat Emral, Medine Nur Kebapci, Fettah Acubucu, Dilek Tuzun, Suheyla Gorar, Emek Topuz, Gulay Simsek Bagir, Selin Dincer Genc, Kezban Demir, Gonca Tamer, Guzin Yaylali, Tulay Omma, Sevde Nur Firat, Gonul Koc, Emre Sedar Saygili, Banu Sarer Yurekli
BACKGROUND AND AIMS: Congenital adrenal hyperplasia (CAH) is a group of disorders that affect the production of steroids in the adrenal gland and are inherited in an autosomal recessive pattern. The clinical and biochemical manifestations of the disorder are diverse, ranging from varying degrees of anomalies of the external genitalia to life-threatening adrenal insufficiency. This multicenter study aimed to determine the demographics, biochemical, clinical, and genetic characteristics besides the current status of adult patients with CAH nationwide...
April 8, 2024: Endocrine
https://read.qxmd.com/read/38581593/adrenal-tumors-in-patients-with-neuroendocrine-neoplasms
#17
JOURNAL ARTICLE
Henrik Falhammar, Adam Stenman, C Christofer Juhlin, Anna Kistner
PURPOSE: To study the prevalence of primary adrenal tumors and adrenal metastases in patients with neuroendocrine neoplasms (NENs) and describe these in detail. NENs can be further divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC). METHODS: A review of medical files was conducted for all patients who underwent a 68 Gallium-DOTATOC-PET/CT during 2010-2023 or adrenalectomy during 1999-2023 at the Karolinska University Hospital. RESULTS: In total, 68 Gallium-DOTATOC-PET/CT was performed on 1750 individuals with NEN, among whom 12 (0...
April 6, 2024: Endocrine
https://read.qxmd.com/read/38580894/lncrna-gas8-as1-dinucleotide-genetic-variant-n-713a-g-n-714t-c-is-associated-with-early-stage-disease-lymph-node-and-distant-metastasis-in-differentiated-thyroid-cancer
#18
JOURNAL ARTICLE
Avaniyapuram Kannan Murugan, Hindi Al-Hindi, Ali S Alzahrani
PURPOSE: Long noncoding RNAs (lncRNAs) play an essential role in the epigenetic regulation of various key genes involved in vital cellular functions. A somatic dinucleotide mutation in the lncRNA GAS8-AS1 was reported in Chinese papillary thyroid cancer. However, GAS8-AS1 dinucleotide alteration and its impact have never been explored in differentiated thyroid cancers and other populations. METHODS: We extracted genomic DNA from 265 DTCs and 97 normal healthy subjects, PCR amplified and Sanger sequenced to examine the GAS8-AS1 dinucleotide alteration...
April 5, 2024: Endocrine
https://read.qxmd.com/read/38580893/an-unusual-brain-lesion-in-a-patient-with-laron-syndrome
#19
LETTER
Liora Kornreich, Zvi Laron
No abstract text is available yet for this article.
April 5, 2024: Endocrine
https://read.qxmd.com/read/38578401/long-term-use-of-clomiphene-in-male-macroprolactinomas-with-persistent-hypogonadism
#20
JOURNAL ARTICLE
Matheo A M Stumpf, Stefano A Galliano, Cristina B F Bueno, Andrea Glezer
BACKGROUND: Men with macroprolactinoma can present persistent hypogonadism despite normoprolactinemia achieved with clinical and/or neurosurgical treatment. Usually, testosterone replacement therapy is indicated. Nevertheless, although off-label, clomiphene citrate (CC), a selective estrogen receptor modulator, has also been used, mainly when fertility is an issue. The aim of this study is to evaluate the effectiveness of CC in recovering the gonadal axis in men with macroprolactinoma, with or without hyperprolactinemia, and evaluate its safety as a long-term therapy...
April 5, 2024: Endocrine
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