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Magdalena Szopa, Tomasz Klupa, Maria Kapusta, Bartlomiej Matejko, Damian Ucieklak, Wojciech Glodzik, Barbara Zapala, Cyrus Maurice Sani, Jerzy Hohendorff, Maciej T Malecki, Jan Skupien
PURPOSE: To investigate the utility of biomarkers of maturity-onset diabetes of the young (MODY), high-sensitivity C-reactive protein (hsCRP), and 1,5-anhydroglucitol (1,5-AG) in conjunction with other clinical and laboratory features to improve diagnostic accuracy and provide a diagnostic algorithm for HNF1A MODY. METHODS: We examined 77 patients with HNF1A MODY, 88 with GCK MODY mutations, 99 with type 1 diabetes, and 92 with type 2 diabetes. In addition to 1,5-AG and hsCRP, we considered body mass index (BMI), fasting glucose, and fasting serum C-peptide as potential biomarkers...
February 18, 2019: Endocrine
Xiaohong Liu, Xin Zeng, Xuanming Chen, Ruixi Luo, Linzhao Li, Chengshi Wang, Jingping Liu, Jingqiu Cheng, Yanrong Lu, Younan Chen
PURPOSE: It is demonstrated that unsaturated fatty acids can counteract saturated fatty acids-induced lipotoxicity, but the molecular mechanisms are unclear. In this study, we investigated the protective effects of monounsaturated oleic acid (OA) against saturated palmitic acid (PA)-induced cytotoxicity in rat β cells as well as islets, and mechanistically focused on its regulation on endoplasmic reticulum (ER) stress. METHODS: Rat insulinoma cell line INS-1E cells and primary islets were treated with PA with or without OA for 24 h to determine the cell viability, apoptosis, and ER stress...
February 18, 2019: Endocrine
Deng-Ke Teng, He-Qun Li, Guo-Qing Sui, Yuan-Qiang Lin, Qiang Luo, Ping Fu, Jia-Rui Du, Chun-Xiang Jin, Hui Wang
PURPOSE: To assess the safety and efficacy of microwave ablation (MWA) for primary papillary thyroid microcarcinoma (PTMC) with a large sample of 185 patients. METHODS: A total of 185 patients underwent MWA for 206 primary PTMC nodules. They received ultrasound follow-up at 1, 3, 6, and 12 months after MWA and every 6 months thereafter. Nodule volumes were calculated at each follow-up and compared with those before MWA. Additionally, the volume reduction rate (VRR) of the nodules was calculated...
February 15, 2019: Endocrine
Nusrath Fathima, Parimala Narne, Mohammed Ishaq
PURPOSE: Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population. METHODS: A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method...
February 15, 2019: Endocrine
Parin Rattananon, Sakditad Saowapa, Chutintorn Sriphrapradang
No abstract text is available yet for this article.
February 15, 2019: Endocrine
Silvia Cantara, Eugenio Bertelli, Rossella Occhini, Marì Regoli, Lucia Brilli, Furio Pacini, Maria Grazia Castagna, Paolo Toti
PURPOSE: Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive form of thyroid cancer (TC) characterized by an aggressive behavior and poor prognosis, resulting in patients' death within a year. Standard treatments, such as chemo and radiotherapy, as well as tyrosine kinase inhibitors, are ineffective for ATC treatment. Cancer immunotherapy is one of the most promising research area in oncology. The PD-1/PD-L1 axis is of particular interest, in light of promising data showing a restoration of host immunity against tumors, with the prospect of long-lasting remissions...
February 14, 2019: Endocrine
Azusa Harada, Emiko Nomura, Kumiko Nishimura, Mitsuru Ito, Hiroshi Yoshida, Akira Miyauchi, Mitsushige Nishikawa, Ichiro Shiojima, Nagaoki Toyoda
PURPOSE: The serum free triiodothyronine (FT3 )/free thyroxine (FT4 ) ratio in patients with huge goitrous Hashimoto's thyroiditis (HG-HT) is relatively high. We investigated the cause of high FT3 /FT4 ratios. METHODS: We measured the serum FT3 , FT4 , and thyrotropin (TSH) levels of seven patients with HG-HT who had undergone a total thyroidectomy. Eleven patients with papillary thyroid carcinoma served as controls. The activities and mRNA levels of type 1 and type 2 iodothyronine deiodinases (D1 and D2, respectively) were measured in the thyroid tissues of HG-HT and perinodular thyroid tissues of papillary thyroid carcinoma...
February 8, 2019: Endocrine
Leonardo G B Ferreira, Jessika P Prevatto, Hercules R Freitas, Ricardo A M Reis, Patrícia M R Silva, Marco A Martins, Robson X Faria, Vinicius F Carvalho
INTRODUCTION: Glucocorticoid release by adrenals has been described as significant to survive sepsis. The activation of transient receptor potential vanilloid type 1 (TRPV1) inhibited ACTH-induced glucocorticoid release by adrenal glands in vitro. OBJECTIVE: The aim of this study was to investigate if capsaicin, an activator of TRPV1, would prevent LPS-induced glucocorticoid production by adrenals. METHODS: Male Swiss-Webster mice were treated with capsaicin intraperitoneally (0...
February 7, 2019: Endocrine
Yorihiro Iwasaki, Akihiro Hamasaki
No abstract text is available yet for this article.
February 4, 2019: Endocrine
Abdullah M Al Alawi, Anna Nordenström, Henrik Falhammar
PURPOSE: 3β-hydroxysteroid dehydrogenase type 2 deficiency (3βHSD2D) is a very rare variant of congenital adrenal hyperplasia (CAH) causing less than 0.5% of all CAH. The aim was to review the literature. METHODS: PubMed was searched for relevant articles. RESULTS: 3βHSD2D is caused by HSD3B2 gene mutations and characterized by impaired steroid synthesis in the gonads and the adrenal glands and subsequent increased dehydroepiandrosterone (DHEA) concentrations...
February 4, 2019: Endocrine
Elisa Pignatti, Eleonora Vighi, Elisa Magnani, Elda Kara, Luca Roncati, Antonino Maiorana, Daniele Santi, Bruno Madeo, Katia Cioni, Cesare Carani, Vincenzo Rochira, Manuela Simoni, Giulia Brigante
PURPOSE: Dysregulation of microRNA expression has been involved in the development and progression of follicular thyroid carcinoma (FTC). The aim of this work was to study the expression of miRNA146a in FTC and the association with clinicopathological features of the disease. METHODS: Thirty-eight patients affected by FTC were included in the study. Twenty patients carrying follicular thyroid adenoma (FA) were also enroled as the benign counterpart of FTC. Total RNA including miRNA146a was extracted from formalin-fixed paraffin-embedded (FFPE) pairs of affected/unaffected tissue and its expression was assessed by real-time PCR...
January 30, 2019: Endocrine
Daniele Santi, Sara De Vincentis, Sara Scaltriti, Vincenzo Rochira
OBJECTIVE: Klinefelter Syndrome (KS) is classically described as characterized by hyperestrogenism, although solid evidence is lacking. This study aims to test the hypothesis that men with KS have higher serum estradiol than normal controls. DESIGN: Meta-analysis of all studies extracted by MEDLINE from 1942 to 31 January 2018. All studies reporting serum estradiol measurement were considered, among them only case-control studies were included in the meta-analysis...
January 30, 2019: Endocrine
Michael T Caton, Fiona Malone
No abstract text is available yet for this article.
January 28, 2019: Endocrine
Simiao Tian
No abstract text is available yet for this article.
January 28, 2019: Endocrine
Bin Xu, Ed Reznik, R Michael Tuttle, Jeffrey Knauf, James A Fagin, Nora Katabi, Snjezana Dogan, Nathaniel Aleynick, Venkatraman Seshan, Sumit Middha, Danny Enepekides, Gian Piero Casadei, Erica Solaroli, Giovanni Tallini, Ronald Ghossein, Ian Ganly
PURPOSE: In 2016, non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NI-EFVPTC) was renamed as noninvasive thyroid follicular neoplasm with papillary-like nuclear features (NIFTP). However, as the study cohort did not mention tumors with oncocytic features, such lesions are still labeled by some as FVPTC. It is therefore crucial to evaluate the outcome and molecular profile of oncocytic NI-EFVPTC. METHODS: A multi-institutional clinico-pathologic review was conducted to select 61 patients having oncocytic NI-EFVPTC...
January 28, 2019: Endocrine
Pedro Souteiro, Patrícia Gouveia, Gonçalo Ferreira, Sandra Belo, Cláudia Costa, Davide Carvalho, Hugo Duarte, Inês Lucena Sampaio
OBJECTIVE: Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68 Ga-DOTANOC PET/CT and 18 F-FDG PET/CT performance and to explore the correlations between tumoral markers and functional imaging. METHODS: This a retrospective cross-sectional study including 13 patients with MTC and high calcitonin/CEA levels that underwent both 68 Ga-DOTANOC PET/CT and 18 F-FDG PET/CT...
January 25, 2019: Endocrine
Marie Helene Schernthaner-Reiter, Christina Siess, Alois Gessl, Christian Scheuba, Stefan Wolfsberger, Philipp Riss, Engelbert Knosp, Anton Luger, Greisa Vila
The original version of this article unfortunately published with traditional Springer copyright instead of open access under Springer compact agreement.
January 24, 2019: Endocrine
Atieh Mirzababaei, Kurosh Djafarian, Hadis Mozafari, Sakineh Shab-Bidar
PURPOSE: This meta-analysis aimed to assess the association of different categories of weight and metabolic status with risk of heart diseases including myocardial infarction (MI), cardiovascular diseases (CVDs), and heart failure (HF). METHODS: Data from relevant studies were identified systematically by searching PubMed and Scopus search engines up to 29 May 2018. Prospective studies were included in the analyses with metabolically healthy normal weight (MHNW) as the reference...
January 22, 2019: Endocrine
Valentina Maggisano, Marilena Celano, Saverio Massimo Lepore, Marialuisa Sponziello, Francesca Rosignolo, Valeria Pecce, Antonella Verrienti, Federica Baldan, Catia Mio, Lorenzo Allegri, Marianna Maranghi, Rosa Falcone, Giuseppe Damante, Diego Russo, Stefania Bulotta
PURPOSE: Mutations in TERT promoter have been detected in the more aggressive papillary thyroid cancers (PTCs). To elucidate the role of TERT as an eligible molecular target in these tumors, the expression of hTERT was analyzed in a series of PTCs and the effects of both pharmacological and RNA-interference-induced hTERT silencing were investigated in two human PTC cell lines (K1 and BCPAP). METHODS: The expression levels of hTERT mRNA and protein were evaluated by real-time PCR and western blot assays, respectively...
January 19, 2019: Endocrine
Luying Gao, Xuehua Xi, Yuxin Jiang, Xiao Yang, Ying Wang, Shenling Zhu, Xingjian Lai, Xiaoyan Zhang, Ruina Zhao, Bo Zhang
PURPOSE: To compare the value of Thyroid Imaging Reporting and Data Systems proposed by Kwak (KWAK-TIRADS) and ACR (ACR TI-RADS) and 2015 American Thyroid Association (ATA) guidelines in the diagnosis of surgically resected thyroid nodules. METHODS: From January 2015 to December 2015, 2544 thyroid nodules in 1758 patients who underwent thyroidectomy at our center were included. The KWAK-TIRADS category, ACR TI-RADS and ultrasound (US) pattern based on ATA guidelines were assigned to each thyroid nodule...
January 18, 2019: Endocrine
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