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Pathophysiology: the Official Journal of the International Society for Pathophysiology

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https://read.qxmd.com/read/30765120/experimental-obesity-and-diabetes-reduce-male-fertility-potential-involvement-of-hypothalamic-kiss-1-pituitary-nitric-oxide-serum-vaspin-and-visfatin
#1
Mahmoud R Abdel-Fadeil, Eman S H Abd Allah, Heba M Iraqy, Dalia A Elgamal, Mohammed A Abdel-Ghani
Reproductive dysfunction is a common consequence of both obesity and diabetes. This study investigated the impact of obesity and diabetes, alone or combined, on physiological reproductive parameters in male rats. Twenty-four male Wistar Albino rats were divided into four groups: Control; obese non-diabetic; diabetic; and obese diabetic. Obesity was provoked by consumption of a high-fat diet (HFD) consisting of 40% energy from fat for 90 days. Diabetes was induced by an intraperitoneal injection of streptozotocin at a dose of 40 mg/kg/day for three consecutive days...
February 5, 2019: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30616995/dietary-macronutrients-modulate-hypertrophy-and-contractility-of-the-detrusor-in-an-experimental-model-of-bladder-obstruction
#2
Temitope G Adedeji, Adesoji A Fasanmade, Emiola O Olapade-Olaopa
OBJECTIVES: To investigate the effects of various diets on structure and function of the bladder in both normal and obstructed bladders of male Wistar rats. METHODS: Sham-operated rats and rats with experimentally-induced bladder outlet obstruction (BOO) were fed with standard rats' feed (control), High-carbohydrate (HCD), High-fat (HFD) and High-protein (HPD) diets. Feeding was continued for 4 weeks after BOO surgery. Bladder weight, detrusor contractility, Rho-Kinase (ROK) and Myosin Light Chain Kinase (MLCK) expressions were determined using standard methods...
December 28, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30551914/aphrodisiac-effect-of-hunteria-umbellata-seed-extract-modulation-of-nitric-oxide-level-and-arginase-activity-in-vivo
#3
Ganiyu Oboh, Adeniyi A Adebayo, Ayokunle O Ademosun, Oluwaseun A Abegunde
Hunteria umbellata has been reported useful in managing the male sexual related disorder, but there is a dearth of information on its possible mechanism of action. Hence, this study was designed to investigate the effect of H. umbellata on some sexual behavior parameters in male rats, in order to ascertain its acclaimed aphrodisiac property. Twenty-four male rats were divided into four groups (n = 6). The extract (50 and 100 mg/kg body weight/day) and sildenafil citrate (5 mg/kg body weight) were administered orally by gavages for 28 days...
December 5, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30551913/%C3%AE-eta-sitosterol-enhances-motor-coordination-attenuates-memory-loss-and-demyelination-in-a-vanadium-induced-model-of-experimental-neurotoxicity
#4
Olamide Elizabeth Adebiyi, Funsho Olakitike Olayemi, James Olukayode Olopade, Ning-Hua Tan
Environmental discharge of vanadium causes cognitive and behavioral impairments in humans and animals via production of reactive oxygen species leading to lipid peroxidation and alteration in antioxidant defence system. The current study was carried out to investigate the cognitive-enhancing ability of β-sitosterol in vanadium-induced neurotoxicity. Forty eight mice were randomly assigned into 4 groups (A-D) with the following treatments: group A; distilled water, B; α-tocopherol + sodium metavanadate (NaO3 V), C; β-sitosterol + NaO3 V and D; only NaO3 V...
December 5, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30528337/short-and-long-term-roles-of-phosphatidylinositol-4-5-bisphosphate-pip-2-on-cav3-1-and-cav3-2-t-type-calcium-channel-current
#5
Yangong Liu, Tomohiro Iwano, Fangfang Ma, Pu Wang, Yan Wang, Mingqi Zheng, Gang Liu, Katsushige Ono
T-type calcium (Ca2+ ) channels play important physiological functions in excitable cells including cardiomyocyte. Phosphatidylinositol-4,5-bisphosphate (PIP2 ) has recently been reported to modulate various ion channels' function. However the actions of PIP2 on the T-type Ca2+ channel remain unclear. To elucidate possible effects of PIP2 on the T-type Ca2+ channel, we applied patch clamp method to investigate recombinant CaV 3.1- and CaV 3.2-T-type Ca2+ channels expressed in mammalian cell lines with PIP2 in acute- and long-term potentiation...
December 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30528338/no-association-between-the-abdominal-aorta-diameter-and-cervicocephalic-atherosclerosis-potential-non-atherosclerotic-origins-of-abdominal-aorta-aneurysms
#6
Oscar H Del Brutto, Robertino M Mera, Aldo F Costa, Gautam Matcha, Pablo R Castillo
The atherosclerotic origin of abdominal aorta (AA) aneurysms is controversial. Using the Atahualpa Project Cohort, we aimed to assess the relationship between the AA diameter and two surrogates of cervicocephalic atherosclerosis, including the carotid intima-media thickness (cIMT) and the presence of carotid siphon calcifications (CSC). Atahualpa residents aged ≥60 years undergoing ultrasound examinations of the abdominal aorta and the carotid arteries (to calculate the AA diameter and the cIMT), and head CT (to assess CSC severity) were included...
November 30, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30528174/role-of-oxidative-stress-angiogenesis-and-chemo-attractant-cytokines-in-the-pathogenesis-of-ischaemic-protection-induced-by-remote-ischaemic-conditioning-study-of-a-human-model-of-ischaemia-reperfusion-induced-vascular-injury
#7
Ken Dewitte, Marc Claeys, Emeline Van Craenenbroeck, Koen Monsieurs, Hein Heidbuchel, Vicky Hoymans, Tibor Stoop
AIMS: We explored the effect of remote ischaemic conditioning (RIC) on endothelial function and on circulating mediators. METHODS AND RESULTS: In 20 healthy male volunteers (mean age 31 ± 10 years), flow-mediated dilation (FMD) was measured before and after 20 min of arm ischaemia, followed by reperfusion. Remote ischaemic conditioning (RIC) was performed by applying 3 cycles of 5 min of ischaemia of the leg at the onset of index arm ischaemia. Each volunteer underwent the IR-induced vascular injury protocol with and without RIC in a crossover study design...
November 30, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30017743/resveratrol-prevents-high-fat-diet-induced-obesity-and-oxidative-stress-in-rabbits
#8
A Jimoh, Y Tanko, A Ahmed, A Mohammed, J O Ayo
The rapid epidemiological progression of obesity worldwide has been associated with increased consumption of diets, rich in fat and sugar. Mediterranean diets rich in resveratrol are associated with reduced risk of obesity and oxidative stress. The aim of the experiment was to investigate the protective effect of resveratrol on high fat diet (HFD) induced obesity and oxidative stress changes in rabbits. Thirty rabbits divided into six groups of five animals each were used for the experiment: Group 1 = control (C), Group 2 = high fat diet (HFD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = HFD + R200 and group 6 = HFD + R400...
December 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/29685587/the-pathophysiology-of-myocardial-infarction-induced-heart-failure
#9
REVIEW
Daniele Gabriel-Costa
Heart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to HF...
December 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/29673924/food-additives-food-and-the-concept-of-food-addiction-is-stimulation-of-the-brain-reward-circuit-by-food-sufficient-to-trigger-addiction
#10
REVIEW
A Y Onaolapo, O J Onaolapo
In the last few years, the concept of 'food addiction' has continued to gain popularity, with human and animal studies demonstrating the differential effects of foods that are high in fat, sugar or protein on appetite, satiety, eating behaviour and the development of food addiction. However, a number of studies have disputed the occurrence of food addiction in humans. Questions have also arisen regarding the possible impacts that food additives may have on the development of food addiction or eating disorders...
December 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30528175/hydrogen-sulfide-therapeutic-or-injurious-in-ischemic-stroke
#11
REVIEW
Priya Gopalakrishnan, B Shrestha, A M Kaskas, J Green, J S Alexander, C B Pattillo
Hydrogen sulfide (H2 S) has been identified as a vasodilatory, neuromodulatory, and anti-inflammatory gasotransmitter with antioxidant properties. Studies focused in cardiac tissue suggest H2 S functions as a protective agent; however in the central nervous system (CNS) the effects of H2 S during states of stress or injury, such as stroke, remain controversial. Currently, the application of H2 S donors and modulators in stroke depends on the type of H2 S donor and the timing of the therapy.
November 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30401578/hepatotoxic-effects-of-euphol-rich-fractions-from-euphorbia-bivonae-relevance-to-cytotoxic-and-anti-tumor-activities
#12
Khaled Athmouni, Abdelfattah El Feki, Habib Ayadi
These studies were designed to evaluate the preliminary oral toxicity profile of the crude ethanolic aerial part extract of E. bivonae in the Male albino Wistar rats and its active chemical constituents. The 24-h LD50 was determined using probit analysis method. The single dose LD50 was found to be 2568.64 mg/kg bw when administrated orally in mice. Additionally, the Wistar rats were used to evaluate the subchronic toxicity of E. bivonae ethanolic extract. The serum biomarkers, lipid peroxidation and antioxidants status in liver and histopathological analysis were investigated in normal and treated groups...
November 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30413288/jobelyn%C3%A2-ameliorates-neurological-deficits-in-rats-with-ischemic-stroke-through-inhibition-of-release-of-pro-inflammatory-cytokines-and-nf-%C3%AE%C2%BAb-signaling-pathway
#13
Solomon Umukoro, Ejiroghene E Oghwere, Benneth Ben-Azu, Olatunde Owoeye, Abayomi M Ajayi, Osarume Omorogbe, Olajuwon Okubena
The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control received normal saline while groups 3-5 were given JB (25, 50 and 100 mg/kg, p.o) daily for 28 days. Then, rats in groups 2-5 were subjected to BCCAO for 30 min and reperfusion afterwards...
October 28, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30391101/tetracarpidium-conophorum-m%C3%A3-ll-arg-modulates-sexual-behaviour-and-biochemical-parameters-relevant-to-sexual-function-in-male-wistar-rats
#14
Ayodeji Augustine Olabiyi, Ganiyu Oboh, Azeez Olakunle Ishola, Philip Adeyemi Adeniyi, Aline Augusti Boligon
Walnut (Tetracarpidium conophorum Müll. Arg) has been reported to be an essential ingredient in folklore medicine for sexual enhancement with little scientific validation. Hence, this study investigated the effects of walnut supplemented diet on sexual behaviour and biochemical parameters relevant to erection in male Wistar rats. Forty animals used in this study were divided into five groups (n = 8); Group 1 - normal control rats fed with basal diet, Group II - rats fed diet supplemented with 10% processed walnut, Group III - rats fed diet supplemented with 10% raw walnut, Group IV - rats fed diet supplemented with 20% processed walnut and Group V - rats fed diet supplemented with 20% raw walnut...
October 28, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30309759/coconut-oil-protects-against-light-induced-retina-degeneration-in-male-wistar-rats
#15
Bamidele Victor Owoyele, Opeyemi Gideon Ayilara
The retinoprotective effect of Cocos nucifera oil (CNO) was investigated. Twenty male Wistar rats weighing 140 g and 180 g were randomly divided into four groups comprising of five animals each. The control group received distilled water. Retinal degeneration was induced in the remaining three groups by exposing the animals to 5,000 lux of bright white light for two hours. Prior to the light exposure, the light model group (LMG) received distilled water for 14 days, low Cocos nucifera oil (LCNO) group received 5 ml/kg of CNO for 14 days, and the high Cocos nucifera oil (HCNO) group received 10 ml/kg of CNO for 14 days...
October 5, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30293777/interventricular-vessel-of-the-heart-and-myocardial-infarction-induced-heart-failure
#16
Pekka J Kuusela
No abstract text is available yet for this article.
September 22, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30244824/does-loss-of-hormonal-receptors-influence-the-pathophysiological-characteristics-of-the-her-2-breast-cancer-phenotype
#17
Rabab Ahmed Ahmed Mohammed, Moustafa EzEldien M Radwan, Bashayer Marzoog Alrufayi, Linah Abdulsamad Qari Abdulaziz
BACKGROUND: Some breast carcinomas (BC) of the HER-2 type respond poorly to endocrine therapy, indicating that hormonal receptor (HR) status possibly impacts the biological criteria of this tumor class. The aim of this study was to compare the clinicopathological characteristics of HR-positive and HR-negative tumors occurring in HER-2 and non-HER-2 BC. METHODS: Tissue microarray sections from 336 primary invasive BC specimens were stained immunohistochemically with antibodies against HER-2, ER, and PR...
September 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30224102/expression-of-thioredoxin-and-glutaredoxin-in-experimental-hepatocellular-carcinoma-relevance-for-prognostic-and-diagnostic-evaluation
#18
Nabil M Abdel-Hamid, Tarek K Mahmoud, Shimaa A Abass, Mamdouh M El-Shishtawy
Hepatocellular carcinoma (HCC), represents more than 85% of liver cancers. The diagnosis of HCC may be delayed due to the absence of early, sensitive and specific biomarkers. This study was conducted to investigate whether the expression of thioredoxin (Trx) and glutaredoxin (Grx) is helpful for HCC diagnosis in an experimental model. Twenty male albino rats were equally divided into two groups (HCC and control). Hepatocarcinogenesis was performed by single intraperitoneal (i.p) injection of 200 mg/kg of diethylnitrosamine (DENA)...
September 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30473323/can-crude-alkaloids-extract-of-rhazya-stricta-induce-apoptosis-in-pancreatic-cancer-in-vitro-study
#19
Nehad Abdulgader Shaer
Cancer is a complicateddisease that reveals genetic variability even among the cells within the same tumor. Pancreatic cancer is the 12th cause of cancer deaths over the world. As a result of the incomplete recovery and the many side effects of current clinical treatment approaches, Herbal diet therapy as a single or adjuvant therapy show high significant output in cancer treatment. Our study focused on the role of the crude alkaloid extract of Rhazya stricter (R. stricta) on pancreatic cancer cells using MTT assay...
September 8, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/30193790/the-relationship-between-the-neck-circumference-and-the-carotid-intima-media-thickness-in-amerindians-potential-links-to-health-risks
#20
Oscar H Del Brutto, Robertino M Mera, Juan A Nader, Mauricio Zambrano, Pablo R Castillo, Gautam Matcha, Leslie V Simon
The carotid intima media thickness (cIMT) is a predictor of cardiovascular events. The neck circumference (NC) has been investigated as a risk factor for increased cIMT with contradictory results. This study assessed the relationship between NC and cIMT in Atahualpa residents aged ≥40 years who had sonographic examination of carotid arteries (n = 590). We also discussed on potential pathogenetic mechanisms underlying this association. Participants belonged to the Native Ecuadorian (Amerindians) ethnic group...
September 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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