Nadine Abdallah, Angela Dispenzieri, Eli Muchtar, Francis K Buadi, Prashant Kapoor, Martha Q Lacy, Yi L Hwa, Amie Fonder, Miriam A Hobbs, Suzanne R Hayman, Nelson Leung, David Dingli, Ronald S Go, Yi Lin, Wilson I Gonsalves, Moritz Binder, Taxiarchis Kourelis, Rahma Warsame, Robert A Kyle, S Vincent Rajkumar, Morie A Gertz, Shaji K Kumar
INTRODUCTION: The current treatment paradigm of AL amyloidosis lacks effective fibril-directed therapies. Doxycycline has been shown to have anti-fibril properties in preclinical models. In 2012, we reported that posttransplant prophylaxis with doxycycline was associated with improved survival compared to penicillin in patients with haematologic response. We provide here updated results after long-term follow up. METHODS: We included 553 patients who underwent transplant between July 24th , 1996, and June 24th , 2014...
December 19, 2022: Amyloid: the International Journal of Experimental and Clinical Investigation