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Acta Dermatovenerologica Croatica: ADC

Ivan Dobrić
Everything included in this overview is a list of facts without analyses, which makes this a purely factual overview. The circumstances of the preparation for the foundation of the Croatian Dermatovenereological Society - the Croatian Medical Association (hereafter CDS-CMA) and the journal Acta Dermatovenerologica Croatica (hereafter ADC) Geopolitical changes in former Yugoslavia following 1990 and the Homeland War (1991-1995) led to new circumstances in almost all areas of social activity and the need for a restructuring and further development of professional physicians associations in our Homeland...
December 2018: Acta Dermatovenerologica Croatica: ADC
Luca Roncati
Dear Editor, Immune-checkpoint blockade is a type of passive immunotherapy aimed at enhancing preexisting anti-tumor responses of the organism, blocking self-tolerance molecular interactions between T-lymphocytes and neoplastic cells (1,2). Despite a significant increase in progression-free survival, a large proportion of patients affected by metastatic melanoma do not show durable responses even after appropriate diagnostic categorization and shared therapeutic choices (3-9). Therefore, predictive biomarkers of clinical response are urgently needed, and predictive immunohistochemistry (IHC) meets these requirements...
December 2018: Acta Dermatovenerologica Croatica: ADC
Antonella Tammaro, Francesca Magri, Flavia Pigliacelli, Enza Gelormini, Romana Parisella Francesca, Camilla Chello, Severino Persechino
Dear Editor, Nickel is a ubiquitous allergen and an important cause of allergic contact dermatitis (ACD). Sensitized patients generally develop a localized eruption after cutaneous exposure to nickel, characterized by erythema, vesicles, eczematous plaques, and itching. Nickel is frequently found in several everyday objects. It is used in numerous industrial and consumer products, including stainless steel, magnets, metal plating, coinage, and special alloys, and is therefore almost impossible to completely avoid in daily life (1)...
December 2018: Acta Dermatovenerologica Croatica: ADC
Suzana Ljubojević Hadžavdić, Maja Kovačević, Mihael Skerlev, Šime Zekan
Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3)...
December 2018: Acta Dermatovenerologica Croatica: ADC
Flávio Mileo Bacelar Guerreiro, Celso Tavares Sodré, Lorena Brandão Pavan, Paulo Feijó Barroso, Daniele Carvalho Quintella, Tullia Cuzzi, Marcia Ramos-E-Silva
Strongyloidiasis is a parasitic infestation caused by the helminth Strongyloides stercoralis. It is essentially gastrointestinal and in general asymptomatic but can sometimes present with skin signs. Immunocompromised patients can develop the disseminated form of the disease due to the parasite's opportunistic behavior, as in cases of coinfection by the human T-lymphotropic type 1 virus (HTLV-1). This article presents a case of a patient infected with HTLV-I and Strongyloides stercoralis who developed the disseminated form...
December 2018: Acta Dermatovenerologica Croatica: ADC
Marija V'lckova-Laskoska, Margareta Balabanova-Stefanova, Irina Arsovska-Bezhoska, Nina Caca-Biljanovska, Dimitri Laskoski
Necrolytic migratory erythema is considered an obligatory cutaneous paraneoplastic sign associated with glucagonoma. Glucagonoma syndrome is defined by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema. Although necrolytic migratory erythema is a specific finding in glucagonoma syndrome, it may occur in other settings, unassociated with an alpha-cell pancreatic tumor (pseudoglucagonoma syndrome). The rarity of glucagonoma imposes a challenge, with most patients being diagnosed after a long period of treatment for their skin rash...
December 2018: Acta Dermatovenerologica Croatica: ADC
Anes Yang, Minhee Kim, Philip Craig, Dedee F Murrell
A 49-year-old man with recalcitrant mechanobullous epidermolysis bullosa acquisita (EBA) with significant esophageal involvement was treated with rituximab. EBA is a chronic autoimmune subepidermal bullous disease. It is characterized by skin fragility and scarring caused by circulating and tissue bound antibodies to type VII collagen. EBA is often unresponsive or poorly responsive to conventional immunosuppressive therapies such as corticosteroids, methotrexate, and cyclosporine. The burden of long-term use of immunosuppressants also limits their use in the treatment of chronic autoimmune diseases such as EBA...
December 2018: Acta Dermatovenerologica Croatica: ADC
Gustavo Moreira Amorim, Celso Sodré, Eduardo Mastrangelo Marinho Falcão, Renata Fernandes Timbó, Tullia Cuzzi, Marcia Ramos-E-Silva
Glomeruloid hemangiomas were first described by Chan in 1990 as a cutaneous marker of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal proteinemia, and Skin changes). POEMS syndrome is a multisystem disease with a significant cutaneous involvement. Among its manifestations, hemangiomas are common, observed in up to one third of the patients, and, although specific, the glomeruloid subtype is very rare. The vascular endothelium growth factor (VEGF) is an angiogenic stimulation factor, which also induces increased systemic vascular permeability...
December 2018: Acta Dermatovenerologica Croatica: ADC
Tatjana Vilibić-Čavlek, Branko Kolarić, Jasmina Pavlić, Mirjana Lana Kosanović-Ličina, Tatjana Nemeth-Blažić
HIV and sexually-transmitted diseases (STDs) represent a significant public health problem worldwide. We analyzed the seroprevalence and risk factors for HIV, hepatitis B and syphilis in populations with high-risk behaviors in Croatia. During a three-year period, a total of 443 men who have sex with men (MSM) / bisexual persons, sex workers (SW) / clients of SW, persons with multiple sexual partners, and persons with a history of STD were tested for the presence of HIV, hepatitis B virus (HBV), and Treponema pallidum (syphilis) antibodies within the framework of second generation HIV surveillance...
December 2018: Acta Dermatovenerologica Croatica: ADC
Abbas Darjani, Reza Nafezi, Hassan Moladoust, Hojat Eftekhari, Kaveh Gharaei Nejad, Rana Rafiei, Narges Alizadeh, Seyyede Zeinab Azimi
Psoriasis is a recurrent chronic inflammatory skin disease with various mild to severe clinical manifestations. The relationship between severity of the skin lesions and nail involvement has always been underestimated. Aim of the study was to evaluate the severity of skin involvement in psoriatic patients with and without nail manifestations. In this analytic cross-sectional study, patients with psoriasis referred to Razi University Hospital of Rasht from November 2015 to March 2016 were enrolled. Demographical features (i...
December 2018: Acta Dermatovenerologica Croatica: ADC
Pernille Lindsø Andersen, Mattias Arvid Simon Henning, Gregor B E Jemec, Maiken Cavling Arendrup, Ditte Marie Saunte
Proximal subungual onychomycosis (PSO) is a rare subtype of onychomycosis with a clinical presentation characterized by proximal leukonychia in the lunular area of the nail. PSO is associated with immunosuppression and regarded a sign of Human Immunodeficiency Virus (HIV) infection when caused by Trichophyton (T.) rubrum. We present two cases of PSO caused by T. rubrum developed during treatment with TNF-α inhibitors combined with methotrexate (MTX).
December 2018: Acta Dermatovenerologica Croatica: ADC
Jelena Meštrović-Štefekov, Gaby Novak-Bilić, Matea Kuna, Nives Pap, Liborija Lugović-Mihić
Atopic dermatitis (AD) is a frequent dermatosis with a growing incidence and multifactorial and complex pathogenic mechanisms that are still being investigated. Although the connection between AD and psychological stress has been known for a long time, there is a lack of reliable and objective indicators for the characterization of this association. Psychological stress triggers complex immune pathways. Therefore, acute stress quickly triggers a high release of cortisol and adrenalin or noradrenalin which then stimulates the immune system, primarily T-helper type 1 (Th1 cells) to produce pro-inflammatory cytokines, resulting in a cellular immune response and inflammation...
December 2018: Acta Dermatovenerologica Croatica: ADC
Iben Marie Miller, Ole Ahlehoff, Gabrielle Vinding, Helene Rytgaard, Ulla Brasch Mogensen, Hans Christian Ring, Christina Ellervik, Gregor B E Jemec
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease with inflammatory mechanisms overlapping those of psoriasis, and both diseases have been associated with cardiovascular risk factors i.e. smoking and metabolic syndrome. Two studies have recently linked psoriasis with Atrial Fibrillation (AF). AF is the most frequently occurring cardiac arrhythmia in the general population and is typically accompanied by increased heart rate. Both AF and heart rate are linked with inflammation. The aim of the study was to investigate a potential association between HS and increased heart rate as well as AF...
December 2018: Acta Dermatovenerologica Croatica: ADC
Aslı Bilgic-Teme, Ismail Cem Temel, Aslı Bostancı-Toptas, Murat Turhan, Selen Bozkurt, Soner Uzun
Pemphigus vulgaris (PV) frequently affects the mucous membranes of the ear, nose, and throat (ENT). Since ENT examination is not a routinely performed procedure, the exact involvement of PV remains unrecognized. The available severity scoring systems (Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS)) for PV do not include a full ENT examination. This study was designed to evaluate the real extent of PV in ENT areas and to find out the specific scores which indicate the need for ENT examination...
December 2018: Acta Dermatovenerologica Croatica: ADC
Suzana Ljubojević Hadžavdić, Sandra Marinović Kulišić, Dragana Ljubojević Grgec, Ana Poljanac, Brankica Ilić
Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1)...
October 2018: Acta Dermatovenerologica Croatica: ADC
Yaru Wang, Baoqi Yang, Guizhi Zhou, Furen Zhang
Dear Editor, Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic autoimmune blistering skin disease characterized by subepidermal blisters, neutrophilic microabscesses, and granular IgA deposition within the dermal papillae. DH is classified as a cutaneous manifestation of coeliac disease, a type of gluten-sensitive enteropathy (1). The treatment of DH includes dapsone and a gluten-free diet (GFD). Other therapies should be considered in patients who are unable to tolerate dapsone, including sulfapyridine and glucocorticoids...
October 2018: Acta Dermatovenerologica Croatica: ADC
Maria Rotaru, Sanda Marchian, Gyula Laszlo Fekete, Gabriela Mariana Mariana Iancu
Dear Editor, Eczema is an inflammatory dermatitis mediated by cellular immunity, with an etiology in which environmental, immunological, and genetic factors are involved. Skin inflammation through proinflammatory cytokines creates a favorable environment for microbial antigens and optimal conditions for infection (1). In case of underlying immunosuppression, inflammatory features of dermatitis and superimposed infections are more severe. The presence of minor trauma of the skin in the form of fissures can favor both easier inoculation of some bacterial germs, leading to a dermatitis superinfection, and/or the transcutaneous inoculation of atypical mycobacteria, with a possibility of developing localized types of tuberculous lymphadenitis (TLA)...
October 2018: Acta Dermatovenerologica Croatica: ADC
Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Roberto Arenas Guzman
Dear Editor, A 29-year-old woman presented with abscesses on her buttock and leg attributed to flea bites inflicted 5 days earlier on return to Spain after 2 months in Guinea-Bissau. Ciprofloxacin was ineffective after 7 days, and she was referred for dermatologic evaluation. Examination revealed 4 round, indurated, erythematous-violet furunculoid lesions with a 1.5-2 mm central orifice draining serous material. She reported seeing larvae exiting a lesion, and we extracted several more (Figure 1). Parasitology identified Dermatobia (D...
October 2018: Acta Dermatovenerologica Croatica: ADC
Anamaria Balić, Lucija Bartolić, Ivana Ilić, Jaka Radoš
Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsies were performed during a 14-year period with no change in histopathological or immunophenotypical characteristics. Lymphomatoid papulosis (LP) is a chronic, recurrent, self-healing papulonodular skin eruption with the histopathologic features of a cutaneous T-cell lymphoma but an often benign and indolent clinical course (1). It is designated as a primary, cutaneous, CD30+ lymphoproliferative disorder...
October 2018: Acta Dermatovenerologica Croatica: ADC
Suzana Ljubojević Hadžavdić, Lucija Bartolić, Mirna Bradamante
Dear Editor,Eosinophilic annular erythema (EAE) is a rare figurate dermatitis of unknown etiology with prominent tissue eosinophilia. A 59-year-old male patient presented with a one-month history of itchy, polycyclic, annular, and partially serpiginous lesions involving the back, the gluteal region, and the extremities (Figure 1, a, b). There was no medical history of drug intake. High potency local steroids and antihistamines were prescribed, but without adequate therapeutic results. Extensive laboratory work-up including serological infectious disease testing was performed and was within normal ranges...
October 2018: Acta Dermatovenerologica Croatica: ADC
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