Samantha J Westrop, Ashley Thomas, Alun Williams, Fiona Johnson, Hui Liao, Kirsty Edlin, Karen Burgess, Olive Kearins, Rebecca Maclean
In response to the COVID-19 pandemic, a temporary change in policy was implemented in 2020. Breast screening services in England were advised to change from timed appointments to an open invitation for invitees to contact the service and arrange an appointment. This change to invitation methodology had potential benefits and risks including impacting inequalities in uptake. Qualitative data were collected by online questionnaire from 23 service providers and routinely collected quantitative uptake data were analysed to investigate the impact of open invitations on the National Programme in the South of England...
December 17, 2023: Journal of Medical Screening
Johannes D M Otten, André L M Verbeek, Mireille J M Broeders
OBJECTIVE: Early detection through mammographic screening and various treatment modalities of cancer may have changed life expectancy and cause-specific mortality of breast cancer patients. We aimed to determine the long-term cause of death patterns in screening-detected patients and clinically diagnosed patients in the Netherlands compared with the general population. METHODS: Using data from the Netherlands Cancer Registry and Statistics Netherlands of around 26,000 women, aged 50-75 at diagnosis and surgically treated for invasive breast cancer in 2004-2008, we compared patients with screening-detected and clinically diagnosed cancer for major causes of death until 2020...
December 2023: Journal of Medical Screening
Glenn E Palomaki, Geralyn M Lambert-Messerlian, Donna Fullerton, Madhuri Hegde, Stéphanie Conotte, Matthew L Saidel, Jacques C Jani
OBJECTIVE: A rolling circle amplification (RCA) based commercial methodology using cell-free (cf)DNA to screen for common trisomies became available in 2018. Relevant publications documented high detection but with a higher than expected 1% false positive rate. Preliminary evidence suggested assay variability was an issue. A multi-center collaboration was created to explore this further and examine whether subsequent manufacturer changes were effective. METHODS: Three academic (four devices) and two commercial (two devices) laboratories provided run date, chromosome 21, 18, and 13 run-specific standard deviations, number of samples run, and reagent lot identifications...
December 2023: Journal of Medical Screening
Heather Bittner Fagan, Claudine Jurkovitz, Zugui Zhang, L Anna Thompson, Freda Patterson, Martha A Zazzarino, Ronald E Myers
INTRODUCTION: Lung cancer screening rates are very low despite a level B recommendation from the United States Preventive Services Task Force since 2013 and clear evidence that lung cancer screening reduces mortality. The Center for Medicare and Medicaid Services requires shared decision-making (SDM) for lung cancer screening reimbursement. The objective of this study was to determine the effect of an SDM intervention on lung cancer screening in primary care. METHODS: The study design was a single-arm clinical trial design...
November 21, 2023: Journal of Medical Screening
Wilber Deck, James A Hanley
INTRODUCTION: Screening trials and meta-analyses emphasize the ratio of cancer death rates in screening and control arms. However, this measure is diluted by the inclusion of deaths from cancers that only became detectable after the end of active screening. METHODS: We review traditional analysis of cancer screening trials and show that ratio estimates are inevitably biased to the null, because follow-up (FU) must continue beyond the end of the screening period and thus includes cases only becoming detectable after screening ends...
November 21, 2023: Journal of Medical Screening
Zohar Levi, Naim Abu-Frecha, Doron Comanesther, Tania Backenstein, Arnon D Cohen, Sapir Eizenstein, Anath Flugelman, Orly Weinstein
OBJECTIVES: Israel is regarded as a country with a developed economy and a moderate income inequality index. In this population-based study, we aimed to measure the inequalities in colorectal cancer screening within Clalit Health, an organization with universal insurance, before and during the coronavirus disease 2019 pandemic. SETTING: Retrospective analysis within Clalit Health Services, Israel. METHODS: We evaluated the rate of being up to date with screening (having a colonoscopy within 10 years or a fecal occult blood test within 1 year) and the colonoscopy completion rate (having a colonoscopy within 6 months of a positive fecal occult blood test) among subjects aged 50-75 in 2019-2021...
November 14, 2023: Journal of Medical Screening
Jo Waller, Frances Waite, Laura Marlow
OBJECTIVES: Human papillomavirus (HPV) primary testing for cervical screening is being implemented around the world. We explored HPV awareness, and knowledge about primary screening in Great Britain (England, Scotland and Wales), where it has been in place for several years, ahead of extended screening intervals being implemented in England. SETTING/METHODS: Women aged 18-70 ( n  = 1995) were recruited by YouGov from their online panel in August 2022...
October 24, 2023: Journal of Medical Screening
Michael R Gieske, Jessica Kerns, Gary M Schmitt, Goetz Kloecker, Irfan A Budhani, Joseph Nolan, Valerie A Williams, Deema Alkapalan, Katelyn Ferguson, Ryan Yadav, Royce F Calhoun
BACKGROUND: The lung cancer screening program at St Elizabeth Healthcare (Kentucky, USA) began in 2013. Over 33,000 low-dose computed tomography lung cancer screens have been performed. From 2015 through 2021, 2595 lung cancers were diagnosed systemwide. A Screening Program with Impactful Results from Early Detection, reviews that experience; 342 (13.2%) were diagnosed by screening and 2253 (86.8%) were non-screened. As a secondary objective, the non-screened cohort was queried to determine how many additional individuals could have been screened, identifying barriers and failures to meet eligibility...
October 19, 2023: Journal of Medical Screening
Kieran Jd Steer, Zhuolu Sun, Daniel C Sadowski, Jean H E Yong, Andrew Coldman, Nicole Nemecek, Huiming Yang
OBJECTIVE: To estimate the impact on clinical outcomes and healthcare resource use from recommending that patients with 1-2 low-risk adenomas (LRAs) return to routine fecal immunochemical test (FIT) screening instead of surveillance colonoscopy, from a Canadian provincial healthcare system perspective. METHODS: The OncoSim-Colorectal microsimulation model simulated average-risk individuals eligible for FIT-based colorectal cancer (CRC) screening in Alberta, Canada...
September 20, 2023: Journal of Medical Screening
Jonas E Thy, Marthe Larsen, Einar Vigeland, Henrik Koch, Tone Hovda, Solveig Hofvind
OBJECTIVE: Irregular attendance in breast cancer screening has been associated with higher breast cancer mortality compared to regular attendance. Early performance measures of a screening program following regular versus irregular screening attendance have been less studied. We aimed to investigate early performance measures following regular versus irregular screening attendance. METHODS: We used information from 3,302,396 screening examinations from the Cancer Registry of Norway...
September 11, 2023: Journal of Medical Screening
Angela Chiereghin, Lorena Squillace, Lorenzo Pizzi, Carmen Bazzani, Lorenzo Roti, Francesca Mezzetti
OBJECTIVE: The first level of a colorectal cancer (CRC) screening process was systematically analysed using the Healthcare Failure Mode and Effects Analysis (HFMEA) approach by a multidisciplinary team aiming to improve the programme quality. SETTING: The study was conducted at the Local Health Authority of Bologna, Northern Italy. METHODS: Seven brainstorming sessions were conducted and all the activities performed were recorded on a FMEA worksheet consisting of individual records reporting the specific phases of the analysed process along with associated activities, possible failure modes, their causes and effects, the obtained risk priority numbers (RPNs) and the control measures to plan...
September 7, 2023: Journal of Medical Screening
Amanda F Petrik, Eric S Johnson, Matthew Slaughter, Michael C Leo, Jamie Thompson, Rajasekhara R Mummadi, Ricardo Jimenez, Syed Akmal Hussain, Gloria Coronado
OBJECTIVES: Fecal immunochemical testing (FIT) is an effective screening tool for colorectal cancer. If an FIT is abnormal, a follow-up colonoscopy is necessary to remove polyps or find cancers. We sought to develop a usable risk prediction model to identify patients unlikely to complete a colonoscopy following an abnormal FIT test. METHODS: We recalibrated and then redeveloped a prediction model in federally qualified health centers (FQHCs), using a retrospective cohort of patients aged 50-75 with an abnormal FIT test and clinical data...
September 4, 2023: Journal of Medical Screening
Daniel B Kopans, Richard E Sharpe, Peter R Eby
Debates about breast cancer screening have continued in part because the Surveillance, Epidemiology, and End Results database, which began in 1974, has never included the method of detection so that it has been impossible to determine the role that early detection has played in the major decline in deaths from breast cancer that we have seen in the US since 1990. Method of detection should be added to the Surveillance, Epidemiology, and End Results database as soon as possible.
August 25, 2023: Journal of Medical Screening
Robert Old
No abstract text is available yet for this article.
August 24, 2023: Journal of Medical Screening
Hannah Scobie, Kathryn A Robb, Sara Macdonald, Stephen Harrow, Frank Sullivan
OBJECTIVES: Pre-trial focus groups of the Early detection of Cancer of the Lung Scotland (ECLS) trial indicated that those at high risk of lung cancer are more likely to engage with community-based recruitment methods. The current study aimed to understand if general practitioner (GP) and community-based recruitment might attract different groups of people, and to quantitatively explore the demographic and psychosocial differences between people responding to GP or community-based recruitment...
August 1, 2023: Journal of Medical Screening
Gavin Rc Clark, Thomas Godfrey, Calum Purdie, Judith Strachan, Francis A Carey, Callum G Fraser, Robert Jc Steele
OBJECTIVE: To compare interval cancer proportions (ICP) in the faecal immunochemical test (FIT)-based Scottish Bowel Screening Programme (SBoSP) with the former guaiac faecal occult blood test (gFOBT)-based SBoSP and investigate associations between interval cancer (IC) and faecal haemoglobin concentration (f-Hb) threshold, sex, age, deprivation, site, and stage. METHODS: The ICP data from first year of the FIT-based SBoSP and the penultimate year of the gFOBT-based SBoSP were compared in a prospective cohort design...
July 19, 2023: Journal of Medical Screening
Susan Yuill, Sam Egger, Megan A Smith, Louiza Velentzis, Marion Saville, Erich V Kliewer, Deborah Bateson, Karen Canfell
OBJECTIVE: Equitable elimination of cervical cancer in Australia within the next decade will require high National Cervical Screening Program (NCSP) participation by all subgroups of women. The aim of this study was to examine the participation of immigrants compared to Australian-born women. METHODS: Participation in the NCSP (≥1cytology test) over a 3-year (2010-2012) and 5-year (2008-2012) period, by place of birth and time since immigration was examined using individually linked data of 67,350 New South Wales (NSW) women aged ≥45 enrolled in the 45 and Up Study...
July 19, 2023: Journal of Medical Screening
Hanna Heyman, Johannes Blom, Deborah Saraste
OBJECTIVE: To evaluate participation and participation patterns in a population-based screening programme for colorectal cancer (CRC) using the faecal immunochemical test (FIT). METHODS: All individuals invited to three consecutive screening rounds in the population-based CRC screening between October 2015 and December 2020 in the Stockholm-Gotland Region, Sweden were included. Patterns of participation were assessed. RESULTS: The study included 26 541 individuals which resulted in 79 623 screening events...
July 18, 2023: Journal of Medical Screening
Hanna Ribbing Wilén, Johannes Blom
OBJECTIVE: To evaluate interval cancer (IC) after two screening rounds of the Swedish population-based screening program of Stockholm-Gotland applying gender-specific cut-off levels in the fecal immunochemical test (FIT). METHODS: All 60- to 69-year-olds invited to screening 2015-2019 were included. The cut-off level for a positive test was 40 µg/g in women and 80 µg/g in men. Screening-detected colorectal cancers (SD CRCs) and ICs were verified in the Swedish Colorectal Cancer Register, and the follow-up time was two years from invitation...
July 16, 2023: Journal of Medical Screening
Yajun Chen, Rui Zhong, Xueqin Guo, Shiping Chen, Yan Wang, Jiufeng Li, Lichan Huang, Yi Li, Xiaoling Wang, Liting Wu, Mubao Huang, Xiaoyan Huang, Junbin Fang, Zhongjie Chu, Jun Sun, Zhiyu Peng, Yan Sun
OBJECTIVES: As one of the most common hereditary diseases, thalassemia affects a large number of people in China. The aim of this study was to investigate the feasibility of a method based on next-generation sequencing (NGS) for screening of thalassemia carriers among high school students in the Shaoguan area. MATERIALS AND METHODS: The NGS-based method was performed using 25,910 high school students recruited from 38 schools. The screening yield was systematically analyzed...
July 12, 2023: Journal of Medical Screening
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