Yajun Chen, Rui Zhong, Xueqin Guo, Shiping Chen, Yan Wang, Jiufeng Li, Lichan Huang, Yi Li, Xiaoling Wang, Liting Wu, Mubao Huang, Xiaoyan Huang, Junbin Fang, Zhongjie Chu, Jun Sun, Zhiyu Peng, Yan Sun
OBJECTIVES: As one of the most common hereditary diseases, thalassemia affects a large number of people in China. The aim of this study was to investigate the feasibility of a method based on next-generation sequencing (NGS) for screening of thalassemia carriers among high school students in the Shaoguan area. MATERIALS AND METHODS: The NGS-based method was performed using 25,910 high school students recruited from 38 schools. The screening yield was systematically analyzed...
July 12, 2023: Journal of Medical Screening