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Matrix Biology: Journal of the International Society for Matrix Biology

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https://read.qxmd.com/read/30776427/collagen-fiber-structure-guides-3d-motility-of-cytotoxic-t-lymphocytes
#1
Hawley C Pruitt, Daniel Lewis, Mark Ciccaglione, Sydney Connor, Quinton Smith, John W Hickey, Jonathan P Schneck, Sharon Gerecht
Lymphocyte motility is governed by a complex array of mechanisms, and highly dependent on external microenvironmental cues. Tertiary lymphoid sites in particular have unique physical structure such as collagen fiber alignment, due to matrix deposition and remodeling. Three dimensional studies of human lymphocytes in such environments are lacking. We hypothesized that aligned collagenous environment modulates CD8+ T cells motility. We encapsulated activated CD8+ T cells in collagen hydrogels of distinct fiber alignment, a characteristic of tumor microenvironments...
February 15, 2019: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30738849/limb-and-tendon-specific-adamtsl2-deletion-identifies-a-role-for-adamtsl2-in-tendon-growth-in-a-mouse-model-for-geleophysic-dysplasia
#2
Dirk Hubmacher, Nandaraj Taye, Zerina Balic, Stetson Thacker, Sheila M Adams, David E Birk, Ronen Schweitzer, Suneel S Apte
Geleophysic dysplasia is a rare, frequently lethal condition characterized by severe short stature with progressive joint contractures, cardiac, pulmonary, and skin anomalies. Geleophysic dysplasia results from dominant fibrillin-1 (FBN1) or recessive ADAMTSL2 mutations, suggesting a functional link between ADAMTSL2 and fibrillin microfibrils. Mice lacking ADAMTSL2 die at birth, which has precluded analysis of postnatal limb development and mechanisms underlying the skeletal anomalies of geleophysic dysplasia...
February 7, 2019: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30716392/denervation-induced-skeletal-muscle-fibrosis-is-mediated-by-ctgf-ccn2-independently-of-tgf-%C3%AE
#3
Daniela L Rebolledo, David González, Jennifer Faundez-Contreras, Osvaldo Contreras, Carlos P Vio, Joanne E Murphy-Ullrich, Kenneth E Lipson, Enrique Brandan
Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that replaces functional tissue, and it is a feature of several myopathies and neuropathies. Knowledge of the biology and regulation of pro-fibrotic factors is critical for the development of new therapeutic strategies. Upon unilateral sciatic nerve transection, we observed accumulation of ECM proteins such as collagen and fibronectin in the denervated hindlimb, together with increased levels of the profibrotic factors transforming growth factor type β (TGF-β) and connective tissue growth factor (CTGF/CCN2)...
February 1, 2019: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30641137/nuclear-softening-is-essential-for-protease-independent-migration
#4
Alakesh Das, Amlan Barai, Melissa Monteiro, Sandeep Kumar, Shamik Sen
During amoeboidal migration, cancer cells migrate in a protease-independent manner by squeezing through pre-existing gaps in the extracellular matrix (ECM). However, the extent to which cells alter their physical properties in order to sustain this mode of migration remains unclear. Here, we address this question by documenting biophysical changes in the properties of highly invasive MDA-MB-231 and HT-1080 cells upon inhibition of pericellular proteolysis. Remarkably, treatment with the broad spectrum MMP inhibitor GM6001 not only induces cell rounding and loss of actomyosin contractility, but also induces nuclear softening via increased phosphorylation of the nuclear membrane protein lamin A/C...
January 11, 2019: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30633963/an-integrated-assay-to-probe-endothelial-glycocalyx-blood-cell-interactions-under-flow-in-mechanically-and-biochemically-well-defined-environments
#5
Heather S Davies, Natalia S Baranova, Nouha El Amri, Liliane Coche-Guerente, Claude Verdier, Lionel Bureau, Ralf P Richter, Delphine Débarre
Cell-cell and cell-glycocalyx interactions under flow are important for the behaviour of circulating cells in blood and lymphatic vessels. However, such interactions are not well understood due in part to a lack of tools to study them in defined environments. Here, we develop a versatile in vitro platform for the study of cell-glycocalyx interactions in well-defined physical and chemical settings under flow. Our approach is demonstrated with the interaction between hyaluronan (HA, a key component of the endothelial glycocalyx) and its cell receptor CD44...
January 8, 2019: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30528862/decorin-counteracts-disease-progression-in-mice-with-recessive-dystrophic-epidermolysis-bullosa
#6
Francesca Cianfarani, Emanuela De Domenico, Alexander Nyström, Simona Mastroeni, Damiano Abeni, Enke Baldini, Salvatore Ulisse, Paolo Uva, Leena Bruckner-Tuderman, Giovanna Zambruno, Daniele Castiglia, Teresa Odorisio
Loss-of-function mutations in the gene encoding type VII collagen underlie recessive dystrophic epidermolysis bullosa (RDEB), a disease characterized by skin and mucosal blistering, impaired wound healing, and diffuse dermal inflammation and fibrosis. Transforming growth factor-β signaling plays a crucial role in determining RDEB fibrotic microenvironment that leads to the development of disabling secondary disease manifestations, including hand and foot deformities. Experimental findings indicate that expression levels of decorin, a small leucine-rich proteoglycan and an endogenous TGF-β inhibitor, can modulate RDEB disease phenotype by contrasting dermal fibroblast fibrotic behavior...
December 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30502484/cartilage-oligomeric-matrix-protein-initiates-cancer-stem-cells-through-activation-of-jagged1-notch3-signaling
#7
Konstantinos S Papadakos, Michael Bartoschek, Carmen Rodriguez, Chrysostomi Gialeli, Shao-Bo Jin, Urban Lendahl, Kristian Pietras, Anna M Blom
Cancer stem cell populations are important for the initiation, progression and metastasis of tumors. The mechanisms governing cancer stem cell control are only partially understood, but activation of the Notch3 pathway plays a crucial role in the maintenance of breast cancer stem cells. Expression of Cartilage Oligomeric Matrix Protein (COMP) in breast cancer cells is correlated with poor survival and higher recurrence rates in patients. In this study, we provide in vivo and in vitro evidence that COMP expression increases the proportion of cancer stem cells in breast cancer...
November 28, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30466509/constitutional-absence-of-epithelial-integrin-%C3%AE-3-impacts-the-composition-of-the-cellular-microenvironment-of-ilneb-keratinocytes
#8
Yinghong He, Kerstin Thriene, Melanie Boerries, Ingrid Hausser, Claus-Werner Franzke, Hauke Busch, Joern Dengjel, Cristina Has
Integrin α3β1, a major epidermal adhesion receptor is critical for organization of the basement membrane during development and wound healing. Integrin α3 deficiency leads to interstitial lung disease, nephrotic syndrome and epidermolysis bullosa (ILNEB), an autosomal recessive multiorgan disease characterized by basement membrane abnormalities in skin, lung and kidney. The pathogenetic chains from ITGA3 mutation to tissue abnormalities are still unclear. Although integrin α3 was reported to regulate multiple extracellular proteins, the composition of the extracellular compartment of integrin α3-negative keratinocytes has not been resolved so far...
December 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29981372/a-scar-like-lesion-is-apparent-in-basement-membrane-after-wound-repair-in-vivo
#9
William Ramos-Lewis, Kimberly S LaFever, Andrea Page-McCaw
Basement membrane is a highly conserved sheet-like extracellular matrix in animals, underlying simple and complex epithelia, and wrapping around tissues like muscles and nerves. Like the tissues they support, basement membranes become damaged by environmental insults. Although it is clear that basement membranes are repaired after damage, virtually nothing is known about this process. For example, it is not known how repaired basement membranes compare to undamaged ones, whether basement membrane components are necessary for epithelial wound closure, or whether there is a hierarchy of assembly that repairing basement membranes follow, similar to the hierarchy of assembly of embryonic basement membranes...
December 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30463024/mutations-in-plod3-encoding-lysyl-hydroxylase-3-cause-a-complex-connective-tissue-disorder-including-recessive-dystrophic-epidermolysis-bullosa-like-blistering-phenotype-with-abnormal-anchoring-fibrils-and-type-vii-collagen-deficiency
#10
Hassan Vahidnezhad, Leila Youssefian, Amir Hossein Saeidian, Andrew Touati, Sara Pajouhanfar, Taghi Baghdadi, Azam Ahmadi Shadmehri, Cecilia Giunta, Marius Kraenzlin, Delfien Syx, Fransiska Malfait, Cristina Has, Su M Lwin, Razieh Karamzadeh, Lu Liu, Alyson Guy, Mohammad Hamid, Ariana Kariminejad, Sirous Zeinali, John A McGrath, Jouni Uitto
Epidermolysis bullosa (EB), the paradigm of heritable skin fragility disorders, is associated with mutations in as many as 20 distinct genes. One of the clinical variants, recessive dystrophic EB (RDEB), demonstrates sub-lamina densa blistering accompanied by alterations in anchoring fibrils due to mutations in COL7A1. In this study, we characterized a patient with widespread connective tissue abnormalities including skin blistering similar to that in RDEB. Whole exome sequencing, combined with genome-wide homozygosity mapping, identified a homozygous missense mutation in PLOD3 encoding lysyl hydroxylase 3 (LH3)...
November 18, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30439444/calcium-activated-nucleotidase-1-cant1-is-critical-for-glycosaminoglycan-biosynthesis-in-cartilage-and-endochondral-ossification
#11
Chiara Paganini, Luca Monti, Rossella Costantini, Roberta Besio, Silvia Lecci, Marco Biggiogera, Kun Tian, Jean-Marc Schwartz, Céline Huber, Valérie Cormier-Daire, Beth G Gibson, Katarzyna A Pirog, Antonella Forlino, Antonio Rossi
Desbuquois dysplasia type 1 (DBQD1) is a chondrodysplasia caused by mutations in CANT1 gene encoding an ER/Golgi calcium activated nucleotidase 1 that hydrolyses UDP. Here, using Cant1 knock-in and knock-out mice recapitulating DBQD1 phenotype, we report that CANT1 plays a crucial role in cartilage proteoglycan synthesis and in endochondral ossification. Specifically, the glycosaminoglycan synthesis was decreased in chondrocytes from Cant1 knock-out mice and their hydrodynamic size was reduced, whilst the sulfation was increased and the overall proteoglycan secretion was delayed...
November 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30412725/rigidity-controls-human-desmoplastic-matrix-anisotropy-to-enable-pancreatic-cancer-cell-spread-via-extracellular-signal-regulated-kinase-2
#12
R Malik, T Luong, X Cao, B Han, N Shah, J Franco-Barraza, L Han, V B Shenoy, P I Lelkes, E Cukierman
It is predicted that pancreatic ductal adenocarcinoma (PDAC) will become the second most lethal cancer in the US by 2030. PDAC includes a fibrous-like stroma, desmoplasia, encompassing most of the tumor mass, which is produced by cancer-associated fibroblasts (CAFs) and includes their cell-derived extracellular matrices (CDMs). Since elimination of desmoplasia has proven detrimental to patients, CDM reprogramming, as opposed to stromal ablation, is therapeutically desirable. Hence, efforts are being made to harness desmoplasia's anti-tumor functions...
November 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29649546/pulmonary-immunity-and-extracellular-matrix-interactions
#13
REVIEW
David N O'Dwyer, Stephen J Gurczynski, Bethany B Moore
The lung harbors a complex immune system composed of both innate and adaptive immune cells. Recognition of infection and injury by receptors on lung innate immune cells is crucial for generation of antigen-specific responses by adaptive immune cells. The extracellular matrix of the lung, comprising the interstitium and basement membrane, plays a key role in the regulation of these immune systems. The matrix consists of several hundred assembled proteins that interact to form a bioactive scaffold. This template, modified by enzymes, acts to facilitate cell function and differentiation and changes dynamically with age and lung disease...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29559389/matrix-remodeling-in-chronic-lung-diseases
#14
REVIEW
Bon-Hee Gu, Matthew C Madison, David Corry, Farrah Kheradmand
Multicellular organisms synthesize and renew components of their subcellular and scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the lung, ECMs maintain tensile strength, elasticity, and dictate the specialized function of multiple cell lineages. These functions are critical in lung homeostatic processes including cellular migration and proliferation during morphogenesis or in response to repair. Alterations in lung ECMs that expose cells to new cryptic fragments, generated in response to endogenous proteinases or exogenous toxins, are associated with the development of several common respiratory diseases...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29524630/extracellular-matrix-in-lung-development-homeostasis-and-disease
#15
REVIEW
Yong Zhou, Jeffrey C Horowitz, Alexandra Naba, Namasivayam Ambalavanan, Kamran Atabai, Jenna Balestrini, Peter B Bitterman, Richard A Corley, Bi-Sen Ding, Adam J Engler, Kirk C Hansen, James S Hagood, Farrah Kheradmand, Qing S Lin, Enid Neptune, Laura Niklason, Luis A Ortiz, William C Parks, Daniel J Tschumperlin, Eric S White, Harold A Chapman, Victor J Thannickal
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29331337/elastin-in-lung-development-and-disease-pathogenesis
#16
REVIEW
Robert P Mecham
Elastin is expressed in most tissues that require elastic recoil. The protein first appeared coincident with the closed circulatory system, and was critical for the evolutionary success of the vertebrate lineage. Elastin is expressed by multiple cell types in the lung, including mesothelial cells in the pleura, smooth muscle cells in airways and blood vessels, endothelial cells, and interstitial fibroblasts. This highly crosslinked protein associates with fibrillin-containing microfibrils to form the elastic fiber, which is the physiological structure that functions in the extracellular matrix...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/29274939/matrix-biomechanics-and-dynamics-in-pulmonary-fibrosis
#17
REVIEW
Andrew J Haak, Qi Tan, Daniel J Tschumperlin
The composition and mechanical properties of the extracellular matrix are dramatically altered during the development and progression of pulmonary fibrosis. Recent evidence indicates that these changes in matrix composition and mechanics are not only end-results of fibrotic remodeling, but active participants in driving disease progression. These insights have stimulated interest in identifying the components and physical aspects of the matrix that contribute to cell activation and disease initiation and progression...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30394292/effects-of-mutations-in-the-post-translational-modification-sites-on-the-trafficking-of-hyaluronan-synthase-2-has2
#18
R M Melero-Fernandez de Mera, U T Arasu, R Kärnä, S Oikari, K Rilla, D Vigetti, A Passi, P Heldin, M I Tammi, A J Deen
Vesicular trafficking of hyaluronan synthases (HAS1-3) from endoplasmic reticulum (ER) through Golgi to plasma membrane (PM), and either back to endosomes and lysosomes, or out into extracellular vesicles, is important for their activities. We studied how post-translational modifications affect the trafficking of HAS2 by mutagenesis of the sites of ubiquitination (K190R), phosphorylation (T110A) and O-GlcNAcylation (S221A), using Dendra2- and EGFP-HAS2 transfected into COS1 cells. Confocal microscopy showed HAS2 wild type (wt) and its K190R and S221A mutants in ER, Golgi and extracellular vesicles, while the T110A mutant remained mostly in the ER...
October 27, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30408617/integrin-binding-site-within-the-gc1q-domain-orchestrates-emilin-1-induced-lymphangiogenesis
#19
Alessandra Capuano, Eliana Pivetta, Francesca Baldissera, Giulia Bosisio, Bruna Wassermann, Francesco Bucciotti, Alfonso Colombatti, Patrizia Sabatelli, Roberto Doliana, Paola Spessotto
Lymphatic vessels (LVs) play a pivotal role in the control of tissue homeostasis and also have emerged as important regulators of immunity, inflammation and tumor metastasis. EMILIN-1 is the first ECM protein identified as a structural modulator of the growth and maintenance of LV; accordingly, Emilin1-/- mice display lymphatic morphological alterations leading to functional defects as mild lymphedema, leakage and compromised lymph drainage. Many EMILIN-1 functions are exerted by the binding of its gC1q domain with the E933 residue of α4 and α9β1 integrins...
October 26, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/30367951/regulation-of-extracellular-matrix-degradation-and-metastatic-spread-by-iqgap1-through-endothelin-1-receptor-signalling-in-ovarian-cancer
#20
Lidia Chellini, Valentina Caprara, Francesca Spadaro, Rosanna Sestito, Anna Bagnato, Laura Rosanò
The invasive phenotype of serous ovarian cancer (SOC) cells is linked to the formation of actin-based protrusions, invadopodia, operating extracellular matrix (ECM) degradation and metastatic spread. Growth factor receptors might cause engagement of integrin-related proteins, like the polarity protein IQ-domain GTPase-activating protein 1 (IQGAP1), to F-actin core needed for invadopodia functions. Here, we investigated whether IQGAP1 forms a signalosome with endothelin-1 (ET-1)/β-arrestin1 (β-arr1) network, as signal-integrating module for adhesion components, cytoskeletal remodelling and ECM degradation...
October 25, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
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