journal
https://read.qxmd.com/read/38607250/molecular-pathology-of-small-cell-lung-cancer-overview-from-studies-on-neuroendocrine-differentiation-regulated-by-ascl1-and-notch-signaling
#41
REVIEW
Takaaki Ito
Pulmonary neuroendocrine (NE) cells are rare airway epithelial cells. The balance between Achaete-scute complex homolog 1 (ASCL1) and hairy and enhancer of split 1, one of the target molecules of the Notch signaling pathway, is crucial for NE differentiation. Small cell lung cancer (SCLC) is a highly aggressive lung tumor, characterized by rapid cell proliferation, a high metastatic potential, and the acquisition of resistance to treatment. The subtypes of SCLC are defined by the expression status of NE cell-lineage transcription factors, such as ASCL1, which roles are supported by SRY-box 2, insulinoma-associated protein 1, NK2 homeobox 1, and wingless-related integration site signaling...
May 2024: Pathology International
https://read.qxmd.com/read/38477638/evaluation-of-pancreatic-cancer-specimens-for-comprehensive-genomic-profiling
#42
JOURNAL ARTICLE
Kota Washimi, Yukihiko Hiroshima, Shinya Sato, Makoto Ueno, Satoshi Kobayashi, Naoto Yamamoto, Chie Hasegawa, Emi Yoshioka, Kyoko Ono, Yoichiro Okubo, Tomoyuki Yokose, Yohei Miyagi
Inadequate specimen quality or quantity hinders comprehensive genomic profiling in identifying actionable mutations and guiding treatment strategies. We investigated the optimal conditions for pancreatic cancer specimen selection for comprehensive genomic profiling. We retrospectively analyzed 213 pancreatic cancer cases ordered for comprehensive genomic profiling and compared results from pancreatic biopsy, liver biopsy of pancreatic cancer metastases, pancreatectomy, liquid, and nonliver metastatic organ specimens...
May 2024: Pathology International
https://read.qxmd.com/read/38656745/clinicopathological-importance-of-bcl-2-and-p53-in-postmenopausal-triple-negative-breast-carcinoma-and-association-with-age
#43
JOURNAL ARTICLE
Kei Ito, Naoko Honma, Hideaki Ogata, Akimitsu Yamada, Mika Miyashita, Tomio Arai, Eiichi Sasaki, Kazutoshi Shibuya, Tetuo Mikami, Masataka Sawaki
Appropriate biomarkers are required to predict the clinical outcome of triple-negative breast cancer (TNBC). In this study, we focused on the clinical importance of two representative tumor-associated proteins, Bcl-2 and p53. Bcl-2 expression is usually related to estrogen receptor expression and a favorable outcome in breast cancer. TNBC has been reported to show a high frequency of p53 positivity suggesting TP53 mutations. The expressions of Bcl-2 and p53 were immunohistochemically examined in TNBC involving two age groups of postmenopausal women (≥75 y/o, n = 75; 55-64 y/o, n = 47), who underwent surgery without neoadjuvant therapy...
April 24, 2024: Pathology International
https://read.qxmd.com/read/38656535/composite-alk-negative-anaplastic-large-cell-lymphoma-and-follicular-lymphoma-involving-jejunum-and-mesenteric-lymph-nodes
#44
LETTER
Qiongzhi Yang, Tianming Zhang, Na Fang, Wenjia Sun
No abstract text is available yet for this article.
April 24, 2024: Pathology International
https://read.qxmd.com/read/38651939/retinal-gliosis-with-osseous-metaplasia-in-an-infant
#45
LETTER
Daichi Morii, Takahiro Matsui, Taisuke Mori, Yasushi Yatabe, Eiichi Morii
No abstract text is available yet for this article.
April 23, 2024: Pathology International
https://read.qxmd.com/read/38651922/the-first-lichen-planus-case-coexisting-bronchiolitis-obliterans-without-malignant-tumors
#46
LETTER
Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Natsumi Watanabe, Xintao Wang, Naoko Fukuhara, Rina Harigane, Koshi Saito, Kentaro Kazama, Ryuki Yamada, Riko Sato, Hikaru Tomita, Mami Rikimaru, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Toshiyuki Yamamoto, Yuko Hashimoto, Akira Hebisawa, Yoko Shibata
No abstract text is available yet for this article.
April 23, 2024: Pathology International
https://read.qxmd.com/read/38634742/predominant-cd8-cell-infiltration-and-low-accumulation-of-regulatory-t-cells-in-immune-checkpoint-inhibitor-induced-tubulointerstitial-nephritis
#47
JOURNAL ARTICLE
Kenta Tominaga, Etsuko Toda, Kazuhiro Takeuchi, Shoichiro Takakuma, Emi Sakamoto, Hideaki Kuno, Yusuke Kajimoto, Yasuhiro Terasaki, Shinobu Kunugi, Akiko Mii, Yukinao Sakai, Mika Terasaki, Akira Shimizu
Immune checkpoint inhibitors (ICIs) can provide survival benefits to cancer patients; however, they sometimes result in the development of renal immune-related adverse events (irAEs). Tubulointerstitial nephritis (TIN) is the most representative pathological feature of renal irAEs. However, the clinicopathological entity and underlying pathogenesis of ICI-induced TIN are unclear. Therefore, we compared the clinical and histological features of this condition with those of non-ICI drug-induced TIN. Age and C-reactive protein levels were significantly higher in ICI-induced TIN, but there were no significant differences in renal function...
April 18, 2024: Pathology International
https://read.qxmd.com/read/38578156/co-occurrence-of-epstein-barr-virus-positive-nodal-t-nk-cell-lymphoma-and-nodal-t-follicular-helper-cell-lymphoma-of-different-clonal-origins-an-autopsy-case-report
#48
Daisuke Hoshi, Nami Migita, Shin Ishizawa, Yasuharu Sato, Koichi Yamamura, Etsuko Kiyokawa
Nodal T-follicular helper cell lymphoma (TFHL) is a subset of T-cell lymphoma and frequently co-occurs with Epstein-Barr virus (EBV)-positive B-cell lymphoma but not with T/NK-cell lymphoma. Recently, a new entity with a worse prognosis, called EBV-positive nodal T/NK-cell lymphoma (NTNKL) has been established. Here, we report an autopsy case of synchronous multiple lymphomas, including TFHL and NTNKL. The patient was a 78-year-old female admitted with pneumonia. Although pneumonic symptoms were improved, fever, pancytopenia, and disseminated intravascular coagulation emerged, implicating lymphoma...
April 5, 2024: Pathology International
https://read.qxmd.com/read/38563592/polymorphic-lymphoproliferative-disorder-arising-in-a-rheumatoid-arthritis-patient-presenting-as-fibrin-associated-large-b-cell-lymphoma-like-lesions-in-aortic-and-mitral-valves
#49
Hideaki Tsujii, Ryuko Nakayama, Sohei Funakoshi, Shuhei Tsuji, Hironori Haga, Kazuo Ono
We herein report a case of methotrexate-associated lymphoproliferative disorder (MTX-LPD) showing fibrin-associated large B-cell lymphoma-like heart valve lesions, and Epstein-Barr virus (EBV)-positive mucocutaneous ulcer-like cutaneous and oral mucosal lesions. MTX-LPD is a critical complication that can occur in RA patients who are treated with MTX. EBV also plays a defining or important role in LPDs. Among the sites of MTX-LPD, 40-50% occur in extranodal sites, including the gastrointestinal tract, skin, liver, lung, and kidney...
April 2, 2024: Pathology International
https://read.qxmd.com/read/38563588/low-grade-carcinoma-with-acinic-cell-carcinoma-like-features-of-the-parotid-gland-with-crtc3-iqgap1-fusion
#50
LETTER
Masami Iwamoto, Taisuke Mori, Eijitsu Ryo, Shoko Handa, Yuuki Nishimura, Masato Nagaoka, Masayuki Shimoda
No abstract text is available yet for this article.
April 2, 2024: Pathology International
https://read.qxmd.com/read/38558427/multi-unifocality-muf-in-contrast-to-multifocality-in-thyroid-lesions-relation-to-lymphocytic-thyroiditis
#51
JOURNAL ARTICLE
Mehtap Derya Aydemirli, Hans Morreau
Whereas multifocality typically concerns papillary thyroid carcinoma (PTC) without specification of intrathyroidal metastatic or independent nature of tumor foci, the designation of the latter as Multi-UniFocal (MUF) may be relevant for select cases. A case series involving multifocal thyroid lesions with divergent histopathological morphology and/or molecular profile, with molecular evaluation of multiple individual tumor foci per patient based on a next-generation sequencing approach, was retrospectively reviewed...
April 1, 2024: Pathology International
https://read.qxmd.com/read/38488752/carcinoma-showing-thymus-like-elements-castle-with-amyloid-deposition-in-the-parotid-gland
#52
Mei Hamada, Yu Miyama, Satoko Matsumura, Yukako Shintani-Domoto, Makoto Urano, Masanori Yasuda
Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63-year-old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an approximately 28 × 23 mm mass lesion in the left parotid gland, and squamous cell carcinoma was suspected on biopsy...
April 2024: Pathology International
https://read.qxmd.com/read/38482965/molecular-pathological-approach-to-cancer-epigenomics-and-its-clinical-application
#53
REVIEW
Yae Kanai
Careful microscopic observation of histopathological specimens, accumulation of large numbers of high-quality tissue specimens, and analysis of molecular pathology in relation to morphological features are considered to yield realistic data on the nature of multistage carcinogenesis. Since the morphological hallmark of cancer is disruption of the normal histological structure maintained through cell-cell adhesiveness and cellular polarity, attempts have been made to investigate abnormalities of the cadherin-catenin cell adhesion system in human cancer cells...
April 2024: Pathology International
https://read.qxmd.com/read/38456605/papillary-renal-neoplasm-with-reverse-polarity-is-biologically-and-clinically-distinct-from-eosinophilic-papillary-renal-cell-carcinoma
#54
JOURNAL ARTICLE
Vincent Francis Castillo, Kiril Trpkov, Theodorus Van der Kwast, Fabio Rotondo, Malek Hamdani, Rola Saleeb
Papillary renal neoplasm with reverse polarity (PRNRP) is a recently described indolent entity with distinct features and its recognition from other oncocytic/eosinophilic papillary renal cell carcinoma (ePRCC) has important prognostic implications. ABCC2, a renal drug transporter, is overexpressed in aggressive PRCCs. In this study, we compared the clinicopathological parameters and the biological ABCC2 expression between PRNRP and ePRCC. PRNRP (n = 8) and ePRCC (n = 21) cases were selected from resection specimens and corresponding clinicopathological data were collected...
April 2024: Pathology International
https://read.qxmd.com/read/38353379/yin-yang-1-facilitates-the-activation-inflammation-and-extracellular-matrix-deposition-of-hepatic-stellate-cells-in-hepatic-fibrosis
#55
JOURNAL ARTICLE
Xiao Fu, Xin Luo, Ping Xiao, Ninghong Guo
Chronic hepatic diseases often involve fibrosis as a pivotal factor in their progression. This study investigates the regulatory mechanisms of Yin Yang 1 (YY1) in hepatic fibrosis. Our data reveal that YY1 binds to the prolyl hydroxylase domain 1 (PHD1) promoter. Rats treated with carbon tetrachloride (CCl4 ) display heightened fibrosis in liver tissues, accompanied by increased levels of YY1, PHD1, and the fibrosis marker alpha-smooth muscle actin (α-SMA). Elevated levels of YY1, PHD1, and α-SMA are observed in the liver tissues of CCl4 -treated rats, primary hepatic stellate cells (HSCs) isolated from fibrotic liver tissues, and transforming growth factor beta-1 (TGF-β1)-induced HSCs...
April 2024: Pathology International
https://read.qxmd.com/read/38546010/cystic-primary-squamous-cell-carcinoma-of-the-thyroid
#56
LETTER
Sakurako Harada-Kagitani, Yusuke Kouchi, Yoshiki Shinomiya, Takuto Hiramoto, Tomoyuki Arai, Toyoyuki Hanazawa, Kiyotaka Onodera, Kaito Nakama, Takanori Aihara, Masayuki Ota, Jun-Ichiro Ikeda, Takashi Kishimoto
No abstract text is available yet for this article.
March 28, 2024: Pathology International
https://read.qxmd.com/read/38501371/glycoprotein-nonmetastatic-melanoma-protein-b-impacts-the-malignant-potential-of-bladder-cancer-cells-through-its-hem-immunoreceptor-tyrosine-based-activation-motif
#57
JOURNAL ARTICLE
Tomokazu Kimura, Yukari Okita, Yoshiyuki Nagumo, Jas Min Chin, Muhammad Ali Fikry, Masanobu Shiga, Shuya Kandori, Takashi Kawahara, Hiroyuki Suzuki, Hiroyuki Nishiyama, Mitsuyasu Kato
Bladder cancer is one of the most common cancers among men worldwide. Although multiple genomic mutations and epigenetic alterations have been identified, an efficacious molecularly targeted therapy has yet to be established. Therefore, a novel approach is anticipated. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that is highly expressed in various cancers. In this study, we evaluated bladder cancer patient samples and found that GPNMB protein abundance is associated with high-grade tumors, and both univariate and multivariate analyses showed that GPNMB is a prognostic factor...
March 19, 2024: Pathology International
https://read.qxmd.com/read/38506350/abstracts-of-presentation-by-the-winners-of-the-japanese-society-of-pathology-japan-pathology-award-in-2024-in-program-order
#58
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Pathology International
https://read.qxmd.com/read/38421215/late-relapsing-testicle-cancer-identified-with-isochromosome-12p-i12p-fluorescence-in-situ-hybridization-fish-analysis
#59
LETTER
Teruki Isobe, Noriyasu Kawai, Maria Aoki, Toshiharu Morikawa, Masakazu Gonda, Nami Tomiyama, Takashi Nagai, Keitaro Iida, Toshiki Etani, Taku Naiki, Toyonori Tsuzuki, Takahiro Yasui
No abstract text is available yet for this article.
February 29, 2024: Pathology International
https://read.qxmd.com/read/38411359/jmjd2a-mediates-transcriptional-activation-of-sfrp4-and-regulates-oxidative-stress-and-mitochondrial-dysfunction-in-heart-failure
#60
JOURNAL ARTICLE
Mingming Ren, Xiaoqiang Ye, Chun Ouyang, Qing'en Da, Weiwei Xue, Piji Chen
The importance of mitochondrial dysfunction and oxidative stress has been indicated in the progression of heart failure (HF). The molecular mechanisms, however, remain to be fully elucidated. This study aimed to explore the role and underlying mechanism of secreted frizzled-related protein 4 (SFRP4) in these two events in HF. Mice with HF were developed using transverse aortic constriction, and hematoxylin-eosin staining, MASSON staining, and Terminal deoxynucleotidyl transferase (TdT)-mediated 2'-Deoxyuridine 5'- Triphosphate nick end labeling (TUNEL assays) were conducted to detect morphological damage in the myocardial tissues of mice...
February 27, 2024: Pathology International
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