journal
https://read.qxmd.com/read/38224248/decoding-the-dna-methylome-of-central-nervous-system-tumors-an-emerging-modality-for-integrated-diagnosis
#21
REVIEW
Kaishi Satomi, Koichi Ichimura, Junji Shibahara
The definitive diagnosis and classification of individual cancers are crucial for patient care and cancer research. To achieve a robust diagnosis of central nervous system (CNS) tumors, a genotype-phenotype integrated diagnostic approach was introduced in recent versions of the World Health Organization classification, followed by the incorporation of a genome-wide DNA methylome-based classification. Microarray-based platforms are widely used to obtain DNA methylome data, and the German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]) has a webtool for a DNA methylation-based classifier (DKFZ classifier)...
February 2024: Pathology International
https://read.qxmd.com/read/38131501/colostomy-site-carcinoma-with-primitive-phenotype-in-a-rectal-cancer-patient-after-achieving-pathological-complete-response-with-neoadjuvant-chemoradiotherapy
#22
Takayuki Kodama, Maki Kanzawa, Hiroshi Hasegawa, Shuichi Tsukamoto, Mari Nishio, Manabu Shigeoka, Yu-Ichiro Koma, Tomoo Itoh, Hiroshi Yokozaki
Herein, we report a rare case of a carcinoma with primitive phenotype (enteroblastic and/or hepatoid differentiation) occurring at a colostomy site. The patient was an elderly male who underwent neoadjuvant chemoradiotherapy for rectal cancer, followed by abdominoperineal resection. A biopsy specimen for the rectal carcinoma before neoadjuvant chemoradiotherapy was conventional tubular adenocarcinoma. Moreover, a pathological complete response was confirmed in the proctectomy specimen. However, a colostomy-site tumor appeared 6 months after the proctectomy, and it was resected 1 year after the initial proctectomy...
January 2024: Pathology International
https://read.qxmd.com/read/38149499/is-the-endomyocardial-biopsy-in-giant-cell-myocarditis-of-some-help-for-the-rapid-indication-for-heart-transplantation
#23
LETTER
Andrea Marzullo, Gabriella Serio, Gerardo Cazzato, Marialessandra Capuzzolo, Carla Nardelli, Cecilia Salzillo
No abstract text is available yet for this article.
December 27, 2023: Pathology International
https://read.qxmd.com/read/38116903/what-is-the-role-of-membrane-located-epithelial-cell-transforming-sequence-2-at-the-interphase-of-lung-adenocarcinoma-cells
#24
LETTER
Yoshihiko Murata, Ai Yoshida, Yuko Minami, Zeinab Kosibaty, Daisuke Matsubara, Masayuki Noguchi
No abstract text is available yet for this article.
December 20, 2023: Pathology International
https://read.qxmd.com/read/38116849/the-first-autopsy-case-of-epstein-barr-virus-positive-marginal-zone-lymphoma-that-deteriorated-after-covid-19-vaccination
#25
Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki
This is the first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma (EBV + MZL) with an other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) (methotrexate [MTX]-associated LPD) that deteriorated after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case had a unique immunophenotype. A 71-year-old female patient with rheumatoid arthritis receiving MTX presented with fatigue 1 week after the SARS-CoV-2 vaccination. She was hospitalized due to hepatorenal dysfunction and pancytopenia...
December 20, 2023: Pathology International
https://read.qxmd.com/read/38088470/epidemiological-study-of-the-subtype-frequency-of-systemic-amyloidosis-listed-in-the-annual-of-the-pathological-autopsy-cases-in-japan
#26
JOURNAL ARTICLE
Aina Yamaguchi, Masayoshi Tasaki, Mitsuharu Ueda, Yukio Ando, Hironobu Naiki
Clinical presentation of systemic amyloidosis differs among subtypes, and accurate subtype classification is important for choosing the treatment. Amyloid transthyretin (ATTR) amyloidosis was the predominant among the recently consulted amyloidosis cases in Japan. To reveal the latest subtype frequency of systemic amyloidosis among autopsy cases in Japan. We analyzed systemic amyloidosis cases autopsied from January 2017 to December 2018, that were listed in the Annuals of the Pathological Autopsy Cases in Japan, Volumes 60 and 61...
December 13, 2023: Pathology International
https://read.qxmd.com/read/38050833/csf3r-asxl1-and-setbp1-mutated-chronic-neutrophilic-leukemia-with-monoclonal-gammopathy-of-undetermined-significance-in-a-patient-who-developed-severe-ascites-due-to-sinusoidal-neutrophilic-infiltration
#27
LETTER
Naonori Harada, Daiki Mukai, Yuto Izuta, Ikumi Shibano, Yusuke Kizawa, Hiroshi Shiragami, Nobuhiko Ohnishi, Naoki Hosaka, Atsuko Mugitani
No abstract text is available yet for this article.
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050808/characterization-of-colorectal-cancer-by-hierarchical-clustering-analyses-of-five-immune-cell-markers
#28
JOURNAL ARTICLE
Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair-proficient (pMMR) CRC were categorized into four groups with survival differences (p = 0.0084): CD4Low , CD4High , MΦHigh , and CD8Low ...
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050802/prevalence-and-diagnostic-significance-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-japan-a-multi-institutional-study
#29
JOURNAL ARTICLE
Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu
This multi-institutional study investigated non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) frequency and its diagnostic significance in Japan. We reviewed 4008 thyroid nodules resected in six institutions before NIFTP was proposed. Overall, 26 cases diagnosed as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) and 145 cases of follicular thyroid adenoma (FTA) were included. Of these nodules, 80.8% and 31.0%, respectively, were NIFTPs. In five institutions, NIFTPs were more commonly found in FTA than in PTC nodules...
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050798/the-enigmatic-occurrence-of-pacinian-corpuscles-in-the-prostate-gland-report-of-a-case-with-pericorpuscular-and-intracorpuscular-growth-of-prostatic-acinar-adenocarcinoma
#30
LETTER
João Lobo, Paula Lopes, Rui Henrique, Ângelo Rodrigues
No abstract text is available yet for this article.
December 5, 2023: Pathology International
https://read.qxmd.com/read/38130238/acknowledgment
#31
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2023: Pathology International
https://read.qxmd.com/read/38038152/the-cap-your-resource-for-artificial-intelligence-information
#32
LETTER
Emily E Volk
Artificial intelligence (AI) has become increasingly studied and implemented in some pathology departments; but how might AI models help change medicine? While technology leaders are calling for a pause on developing AI systems until there is greater confidence "that their effects will be positive and their risks will be manageable," (Pause Giant AI Experiments: An Open Letter. March 22, 2023. https://futureoflife.org/open-letter/pause-giant-ai-experiments/) could breakthrough innovations in AI make medicine and physicians better? (There's One Hard Question My Fellow Doctors and I Will Need to Answer Soon...
December 1, 2023: Pathology International
https://read.qxmd.com/read/38038140/distribution-of-proteinase-k-resistant-anti-%C3%AE-synuclein-immunoreactive-axons-in-the-cardiac-plexus-is-unbiased-to-the-left-ventricular-anterior-wall
#33
JOURNAL ARTICLE
Nei Fukasawa, Miku Maeda, Yoshifumi Sugiyama, Takahiro Fukuda, Masayuki Shimoda
Lewy body disease (LBD) is characterized by the appearance of Lewy neurites and Lewy bodies, which are predominantly composed of α-synuclein. Notably, the cardiac plexus (CP) is one of the main targets of LBD research. Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any part of the CP. Thus, we aimed to clarify the emergence and/or propagation of LBP in the CP. In this study, 263 consecutive autopsy cases of patients aged ≥50 years were included, with one region per case selected from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically stained with anti-α-synuclein antibodies to assess LBP...
December 1, 2023: Pathology International
https://read.qxmd.com/read/37975422/epithelioid-granulomas-with-proliferating-t-lymphocytes-in-bone-marrow-in-a-patient-with-infectious-mononucleosis-modified-by-secondary-hemophagocytic-lymphohistiocytosis
#34
LETTER
Haruo Ohtani, Yoshihiro Sato, Isho Izumi, Keisuke Kato, Masahiro Tsuchida
No abstract text is available yet for this article.
November 17, 2023: Pathology International
https://read.qxmd.com/read/37975408/mechanisms-underlying-retardation-of-aging-by-dietary-energy-restriction
#35
REVIEW
Isao Shimokawa
Moderate restriction of dietary energy intake, referred to here as dietary restriction (DR), delays aging and extends lifespan in experimental animals compared with a diet of ad libitum feeding (AL) control animals. Basic knowledge of the mechanisms underlying the effects of DR could be applicable to extending the healthspan in humans. This review highlights the importance of forkhead box O (FoxO) transcription factors downstream of the growth hormone-insulin-like growth factor 1 signaling in the effects of DR...
November 17, 2023: Pathology International
https://read.qxmd.com/read/37933792/influence-of-formalin-fixation-duration-on-rna-quality-and-quantity-from-formalin-fixed-paraffin-embedded-hepatocellular-carcinoma-tissues
#36
JOURNAL ARTICLE
Kenji Amemiya, Yosuke Hirotsu, Yuki Nagakubo, Hitoshi Mochizuki, Toshio Oyama, Masao Omata
Analyzing RNA samples from formalin-fixed paraffin-embedded (FFPE) tissues is essential for precision medicine. We investigated RNA quantity and quality from FFPE tumor tissues fixed in formalin for various times and compared sequencing metrics from next-generation sequencing (NGS). Hepatocellular carcinoma (HCC) tissues were fixed in 10% neutral buffered formalin (1-240 h) and FFPE blocks were prepared. Total RNA was extracted, and the quantity and quality were assessed using the NanoDrop, Qubit and Bioanalyzer...
November 7, 2023: Pathology International
https://read.qxmd.com/read/37975419/abstracts-of-a-presentation-by-the-winners-of-the-japanese-society-of-pathology-pathology-research-award-in-2023-in-program-order
#37
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 2023: Pathology International
https://read.qxmd.com/read/37608749/pten-loss-in-intraductal-carcinoma-of-the-prostate-has-low-incidence-in-japanese-patients
#38
JOURNAL ARTICLE
Takanori Ito, Taishi Takahara, Natsuki Taniguchi, Yuki Yamamoto, Akira Satou, Akiko Ohashi, Emiko Takahashi, Naoto Sassa, Toyonori Tsuzuki
Clinical and genomic features of prostate cancer (PCa) vary considerably between Asian and Western populations. PTEN loss is the most frequent abnormality in intraductal carcinoma of the prostate (IDC-P) in Western populations. However, its prevalence and significance in Asian populations have not yet been well studied. In the present study, we evaluated PTEN expression in IDC-P in a Japanese population and its association with ERG expression. This study included 45 and 59 patients with PCa with and without IDC-P, respectively, who underwent radical prostatectomy...
November 2023: Pathology International
https://read.qxmd.com/read/37888146/large-cell-neuroendocrine-carcinoma-with-discohesive-growth-pattern-of-the-sigmoid-colon-resembling-undifferentiated-carcinoma
#39
LETTER
Rin Yamada, Osamu Nakahara, Hiroshi Takamori, Yoshihiro Komohara, Minako Fujiwara
No abstract text is available yet for this article.
October 27, 2023: Pathology International
https://read.qxmd.com/read/37830504/donepezil-attenuates-inflammation-and-apoptosis-in-ulcerative-colitis-via-regulating-lrp1-ampk-nf-%C3%AE%C2%BAb-signaling
#40
JOURNAL ARTICLE
Angqing Li, Junyi Zhang, Ke Chen, Jian Wang, Aman Xu, Zhengguang Wang
This article focuses on the specific effects and mechanisms of donepezil (DNPZ) hydrochloride on inflammation and apoptosis in ulcerative colitis (UC). In vivo and in vitro models of UC were established using dextran sodium sulfate (DSS)-induced mice and NCM460 cells, respectively. Following oral administration of DNPZ, body weight, disease activity index (DAI) scores and colon lengths of mice were recorded. Histopathological damage was detected employing hematoxylin and eosin (H&E) staining. Inflammatory factors were tested using enzyme-linked immunosorbent assay and quantitative reverse transcription polymerase chain reaction, respectively...
October 13, 2023: Pathology International
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