journal
https://read.qxmd.com/read/38353379/yin-yang-1-facilitates-the-activation-inflammation-and-extracellular-matrix-deposition-of-hepatic-stellate-cells-in-hepatic-fibrosis
#1
JOURNAL ARTICLE
Xiao Fu, Xin Luo, Ping Xiao, Ninghong Guo
Chronic hepatic diseases often involve fibrosis as a pivotal factor in their progression. This study investigates the regulatory mechanisms of Yin Yang 1 (YY1) in hepatic fibrosis. Our data reveal that YY1 binds to the prolyl hydroxylase domain 1 (PHD1) promoter. Rats treated with carbon tetrachloride (CCl4 ) display heightened fibrosis in liver tissues, accompanied by increased levels of YY1, PHD1, and the fibrosis marker alpha-smooth muscle actin (α-SMA). Elevated levels of YY1, PHD1, and α-SMA are observed in the liver tissues of CCl4 -treated rats, primary hepatic stellate cells (HSCs) isolated from fibrotic liver tissues, and transforming growth factor beta-1 (TGF-β1)-induced HSCs...
February 14, 2024: Pathology International
https://read.qxmd.com/read/38328872/investigation-of-cancer-induced-myocardial-damage-in-autopsy-cases-a-comparison-of-cases-with-and-without-chemotherapy
#2
LETTER
Hitoshi Ohmori, Rina Fujiwara-Tani, Shota Nukaga, Ryoichi Nishida, Kiyomu Fujii, Shiori Mori, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Shingo Kishi, Yi Luo, Hiroki Kuniyasu
No abstract text is available yet for this article.
February 8, 2024: Pathology International
https://read.qxmd.com/read/38319011/molecular-pathological-demonstration-of-an-unusual-angiosarcoma-like-dedifferentiation-pattern-in-hepatocellular-carcinoma
#3
LETTER
Keigo Murakami, Taito Itoh, Yasunobu Okamura, Kengo Kinoshita, Hideki Ota, Michiaki Unno, Takashi Kamei, Toru Furukawa
No abstract text is available yet for this article.
February 6, 2024: Pathology International
https://read.qxmd.com/read/38289139/identification-of-uromodulin-deposition-in-the-stroma-of-perinephric-fibromyxoid-nephrogenic-adenoma-by-mass-spectrometry
#4
JOURNAL ARTICLE
Kaori Yoshimura, Yukinobu Ito, Mina Suzuki, Masafumi Horie, Takumi Nishiuchi, Yukako Shintani-Domoto, Kazuyoshi Shigehara, Hiroko Oshima, Masanobu Oshima, Akiteru Goto, Takayuki Nojima, Tsuzuki Toyonori, Atsushi Mizokami, Hiroko Ikeda, Daichi Maeda
Nephrogenic adenoma (NA) is an epithelial lesion that usually occurs in the mucosa of the urinary tract. Rare cases of deep infiltrative or perinephric lesions have also been reported. Recently, NA with characteristic fibromyxoid stroma (fibromyxoid NA) has been proposed as a distinct variant. Although shedding of distal renal tubular cells due to urinary tract rupture has been postulated as the cause of NA in general, the mechanism underlying extraurinary presentation of NA and fibromyxoid stromal change in fibromyxoid NA remains unknown...
January 30, 2024: Pathology International
https://read.qxmd.com/read/38289121/microrna-196a-5p-facilitates-the-onset-and-progression-via-targeting-itm2b-in-esophageal-squamous-cell-carcinoma
#5
JOURNAL ARTICLE
Dubiao Xian, Shubo Yang, Yunzhong Liu, Qingfeng Liu, Ding Huang, Yuechang Wu
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumor cells, garnering widespread attention. Here, we discovered that miR-196a-5p was significantly upregulated in both ESCC tissues and cells, which was correlated with an unfavorable prognosis. Series functional in vitro investigations have confirmed that silencing miR-196a-5p obviously restrained the ESCC cells malignant phenotypes and promoted apoptosis...
January 30, 2024: Pathology International
https://read.qxmd.com/read/38258897/pseudoimmunofluorescent-immunohistochemistry-image-analysis-of-phosphorylated-signaling-proteins-in-human-esophageal-squamous-cell-carcinoma-tissue
#6
JOURNAL ARTICLE
Mari Nishio, Shuichi Tsukamoto, Takayuki Kodama, Manabu Shigeoka, Yu-Ichiro Koma, Hiroshi Yokozaki
Immunohistochemistry is primarily employed to visualize the localization of specific molecules in tissue samples. However, there is an increasing need for software-assisted quantitative assessment. In the present study, we performed inverted blue channel-based pseudoimmunofluorescence image analysis using original immunohistochemistry images. In human esophageal squamous cell carcinoma tissues, various humoral factors promote the phosphorylation of signaling proteins, including protein kinase B (Akt) and/or extracellular signal-regulated kinase 1/2 (ERK1/2), leading to tumor progression...
January 23, 2024: Pathology International
https://read.qxmd.com/read/38251871/alteration-of-small-intestinal-occludin-and-zo-1-expession-in-liver-cirrhosis
#7
LETTER
Theodoros Voulgaris, Dina Tiniakos, Dimitrios Karagiannakis, Despoina Myoteri, Despoina Karandrea, Spilios Manolakopoulos, George Papatheodoridis, Jiannis Vlachogiannakos
No abstract text is available yet for this article.
January 22, 2024: Pathology International
https://read.qxmd.com/read/38240458/erianin-inhibits-tumor-growth-by-promoting-ferroptosis-and-inhibiting-invasion-in-hepatocellular-carcinoma-through-the-jak2-stat3-slc7a11-pathway
#8
JOURNAL ARTICLE
Liyan Chen, Rongrong Sun, Kun Fang
Iron has been found to be involved in the tumor cell proliferation process, which can lead to the increased sensitivity of cancer cells to ferroptosis. Since erianin is associated with oxidative stress in hepatocellular carcinoma (HCC), we hypothesized that the therapeutic effect and mechanism of erianin on HCC is related to ferroptosis. HCC cells were stimulated with increase of erianin concentrations for 24 h, and the survival rates of Huh-7 and HepG2 cells gradually decreased. After intervention with different doses of erianin, cell proliferation, clone number, and invasion were prominently decreased, apoptosis ratio was increased...
January 19, 2024: Pathology International
https://read.qxmd.com/read/38240415/enterocolic-granulomatous-phlebitis-associated-with-epidermal-growth-factor-containing-fibulin-like-extracellular-matrix-protein-1-deposition-and-focal-amyloid-properties-a-case-report
#9
Shojiro Ichimata, Akane Aikawa, Naonori Sugishita, Nagaaki Katoh, Fuyuki Kametani, Hibiki Tagawa, Yusuke Handa, Masahide Yazaki, Yoshiki Sekijima, Takashi Ehara, Naoki Nishida, Shin Ishizawa
A woman in her 60s with rheumatoid arthritis was admitted with fever and abdominal pain. Laparoscopic examination with the differential diagnosis of peritoneal neoplasm and infection revealed granulomatous phlebitis in the resected greater omentum. Amorphous eosinophilic deposits observed in the resected tissue exhibited focal, weak positivity for Congo red but were strongly positive for thioflavin S, confirming their focal amyloid properties. Marked degeneration of elastic fibers was also evident. Electron microscopy revealed deposits around the affected elastic fibers...
January 19, 2024: Pathology International
https://read.qxmd.com/read/38226479/impact-of-the-quality-of-resected-thyroid-cancer-tissue-sample-on-next-generation-sequencing-testing
#10
JOURNAL ARTICLE
Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka
Activating rearranged during transfection (RET) proto-oncogene alterations can be identified using next-generation sequencing (NGS) of tumor DNA/RNA. We assessed factors associated with NGS (Oncomine Dx Target Test [ODxTT]) success for resected thyroid cancer (TC) specimens, including sample age, processing conditions, and DNA/RNA quality. TC samples were from three Japanese hospitals, with sample age <1-<10 years, fixative 10%/15% neutralized buffered formalin (NBF), and fixation time ≤48 h/>48 h-≤72 h...
January 16, 2024: Pathology International
https://read.qxmd.com/read/38224248/decoding-the-dna-methylome-of-central-nervous-system-tumors-an-emerging-modality-for-integrated-diagnosis
#11
REVIEW
Kaishi Satomi, Koichi Ichimura, Junji Shibahara
The definitive diagnosis and classification of individual cancers are crucial for patient care and cancer research. To achieve a robust diagnosis of central nervous system (CNS) tumors, a genotype-phenotype integrated diagnostic approach was introduced in recent versions of the World Health Organization classification, followed by the incorporation of a genome-wide DNA methylome-based classification. Microarray-based platforms are widely used to obtain DNA methylome data, and the German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]) has a webtool for a DNA methylation-based classifier (DKFZ classifier)...
January 15, 2024: Pathology International
https://read.qxmd.com/read/38197542/her2-staining-of-breast-cancer-is-reduced-under-the-current-protocol-of-ventana-pathway-anti-her-2-neu-4b5
#12
LETTER
Yoshiya Horimoto, Hiroko Onagi, Junichiro Watanabe, Takuo Hayashi
No abstract text is available yet for this article.
January 10, 2024: Pathology International
https://read.qxmd.com/read/38149499/is-the-endomyocardial-biopsy-in-giant-cell-myocarditis-of-some-help-for-the-rapid-indication-for-heart-transplantation
#13
LETTER
Andrea Marzullo, Gabriella Serio, Gerardo Cazzato, Marialessandra Capuzzolo, Carla Nardelli, Cecilia Salzillo
No abstract text is available yet for this article.
December 27, 2023: Pathology International
https://read.qxmd.com/read/38116903/what-is-the-role-of-membrane-located-epithelial-cell-transforming-sequence-2-at-the-interphase-of-lung-adenocarcinoma-cells
#14
LETTER
Yoshihiko Murata, Ai Yoshida, Yuko Minami, Zeinab Kosibaty, Daisuke Matsubara, Masayuki Noguchi
No abstract text is available yet for this article.
December 20, 2023: Pathology International
https://read.qxmd.com/read/38116849/the-first-autopsy-case-of-epstein-barr-virus-positive-marginal-zone-lymphoma-that-deteriorated-after-covid-19-vaccination
#15
Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki
This is the first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma (EBV + MZL) with an other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) (methotrexate [MTX]-associated LPD) that deteriorated after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case had a unique immunophenotype. A 71-year-old female patient with rheumatoid arthritis receiving MTX presented with fatigue 1 week after the SARS-CoV-2 vaccination. She was hospitalized due to hepatorenal dysfunction and pancytopenia...
December 20, 2023: Pathology International
https://read.qxmd.com/read/38088470/epidemiological-study-of-the-subtype-frequency-of-systemic-amyloidosis-listed-in-the-annual-of-the-pathological-autopsy-cases-in-japan
#16
JOURNAL ARTICLE
Aina Yamaguchi, Masayoshi Tasaki, Mitsuharu Ueda, Yukio Ando, Hironobu Naiki
Clinical presentation of systemic amyloidosis differs among subtypes, and accurate subtype classification is important for choosing the treatment. Amyloid transthyretin (ATTR) amyloidosis was the predominant among the recently consulted amyloidosis cases in Japan. To reveal the latest subtype frequency of systemic amyloidosis among autopsy cases in Japan. We analyzed systemic amyloidosis cases autopsied from January 2017 to December 2018, that were listed in the Annuals of the Pathological Autopsy Cases in Japan, Volumes 60 and 61...
December 13, 2023: Pathology International
https://read.qxmd.com/read/38050833/csf3r-asxl1-and-setbp1-mutated-chronic-neutrophilic-leukemia-with-monoclonal-gammopathy-of-undetermined-significance-in-a-patient-who-developed-severe-ascites-due-to-sinusoidal-neutrophilic-infiltration
#17
LETTER
Naonori Harada, Daiki Mukai, Yuto Izuta, Ikumi Shibano, Yusuke Kizawa, Hiroshi Shiragami, Nobuhiko Ohnishi, Naoki Hosaka, Atsuko Mugitani
No abstract text is available yet for this article.
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050808/characterization-of-colorectal-cancer-by-hierarchical-clustering-analyses-of-five-immune-cell-markers
#18
JOURNAL ARTICLE
Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair-proficient (pMMR) CRC were categorized into four groups with survival differences (p = 0.0084): CD4Low , CD4High , MΦHigh , and CD8Low ...
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050802/prevalence-and-diagnostic-significance-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-japan-a-multi-institutional-study
#19
JOURNAL ARTICLE
Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu
This multi-institutional study investigated non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) frequency and its diagnostic significance in Japan. We reviewed 4008 thyroid nodules resected in six institutions before NIFTP was proposed. Overall, 26 cases diagnosed as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) and 145 cases of follicular thyroid adenoma (FTA) were included. Of these nodules, 80.8% and 31.0%, respectively, were NIFTPs. In five institutions, NIFTPs were more commonly found in FTA than in PTC nodules...
December 5, 2023: Pathology International
https://read.qxmd.com/read/38050798/the-enigmatic-occurrence-of-pacinian-corpuscles-in-the-prostate-gland-report-of-a-case-with-pericorpuscular-and-intracorpuscular-growth-of-prostatic-acinar-adenocarcinoma
#20
LETTER
João Lobo, Paula Lopes, Rui Henrique, Ângelo Rodrigues
No abstract text is available yet for this article.
December 5, 2023: Pathology International
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