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Pathology International

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https://read.qxmd.com/read/30990957/a-b-iosafety-algorithm-for-the-protection-of-pathology-staff-during-intraoperative-examinations-of-pulmonary-lesions
#1
Tomoko Sugiyama, Takuma Tajiri, Hirotaka Fujita, Shinichiro Hiraiwa, Suguru Toguchi, Nozomi Nomura, Tomohisa Machida, Atsushi Suga, Yusuke Nakamura, Tomoki Nakagawa, Shyunsuke Yamada, Masayuki Iwazaki, Naoya Nakamura
We aimed to propose a biosafety algorithmfor the protection of pathology staff during intraoperative examinations of pulmonary lesions when working with cytological imprints and/or frozen sections for the intraoperative diagnosis of pulmonary lesions. We examined 148 pulmonary surgical tissues obtained intraoperatively for imprint cytology (IC) and for frozen sectioning and compared the diagnoses against the final pathological diagnoses. We analyzed concordance and non-concordance rates and then used the data to produce a biosafety algorithm...
April 16, 2019: Pathology International
https://read.qxmd.com/read/30990953/prediction-of-steroid-demand-in-the-treatment-of-patients-with-ulcerative-colitis-by-immunohistochemical-analysis-of-the-mucosal-microenvironment-and-immune-checkpoint-role-of-macrophages-and-regulatory-markers-in-disease-severity
#2
Shingo Tsuda, Joaquim Carreras, YaraY Kikuti, Hirohiko Nakae, Makiko Dekiden-Monma, Jin Imai, Kota Tsuruya, Jun Nakamura, Yoko Tsukune, Tetsufumi Uchida, Masashi Matsushima, Giovanna Roncador, Takayoshi Suzuki, Naoya Nakamura, Tetsuya Mine
We aimed to characterize the mucosal immune microenvironment and immune checkpoint of Ulcerative colitis (UC) by immunohistochemistry with correlation to prognosis: requirement of second-line steroid-therapy within the 2-years after diagnosis (SR). A series of 72 cases included 56 UC, 43 non-SR (with first-line treatment 5-ASA) and 13 SR, 11 infectious colitis and 5 normal colonic biopsies. Normal mucosa was characterized by low infiltrates but high BTLA and TNFRSF14. Compared to normal, UC had increased pan-immune-markers of CD3, CD8, FOXP3, PD-1, CD68, CD16, CD163, PTX3 and CD11C but had decreased BTLA (P < 0...
April 16, 2019: Pathology International
https://read.qxmd.com/read/30983082/fat-forming-variant-of-solitary-fibrous-tumor-of-the-pleura-mimicking-spindle-cell-lipoma
#3
LETTER
Maiko Takeda, Kensuke Kojima, Yoshihiko Taniguchi, Hyung-Eun Yoon, Akihide Matsumura, Chiho Ohbayashi, Takahiko Kasai
No abstract text is available yet for this article.
April 14, 2019: Pathology International
https://read.qxmd.com/read/30977946/fibrin-associated-diffuse-large-b-cell-lymphoma-arising-in-a-mature-cystic-teratoma-a-case-report
#4
LETTER
Kenji Yorita, Yu Tanaka, Koki Hirano, Miki Mizobuchi, Kei Kohno, Shigeo Nakamura, Hiroshi Sakaeda
No abstract text is available yet for this article.
April 12, 2019: Pathology International
https://read.qxmd.com/read/30957322/atypical-pseudoangiomatous-stromal-hyperplasia-showing-rapid-growth-of-the-breast-report-of-a-case
#5
Yuri Noda, Ayaka Nishimae, Yuka Sawai, Hideo Inaji, Masaru Yamasaki
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion manifesting as myofibroblastic proliferation and anastomosing slit-like spaces. Atypical PASH is an extremely rare lesion characterized by cytological alteration of myofibroblast, presenting as myofibroblastic sarcoma arising from PASH. To our knowledge, only one other case has been reported since the first report of Rosen. We present a case of atypical PASH. A 39-year-old female presented with a round, elastic hard, painless mass in the left breast...
April 7, 2019: Pathology International
https://read.qxmd.com/read/30957299/rapid-and-extensive-intrahepatic-metastatic-recurrence-of-hepatocellular-carcinoma-with-very-small-portal-vein-tumor-thrombus-after-surgery-and-sustained-virological-response-of-hcv-with-direct-acting-antivirals
#6
Soo Ki Kim, Soo Ryang Kim, Susumu Imoto, Naomi Shida, Yumi Fujii, Takako Fujii, Masahiro Kido, Hisoka Kinoshita, Yu-Ichiro Koma, Yoshitake Hayashi, Toshiyuki Matsuoka, Masatoshi Kudo
No abstract text is available yet for this article.
April 7, 2019: Pathology International
https://read.qxmd.com/read/30900377/overexpression-of-cd-133-and-bcl-2-in-non-small-cell-lung-cancer-with-neuroendocrine-differentiation-after-transformation-in-alk-rearrangement-positive-adenocarcinoma
#7
Kiyoko Koyama, Naoko Katsurada, Naoe Jimbo, Motoko Tachihara, Daisuke Tamura, Kyosuke Nakata, Tatsuya Nagano, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Tomoo Itoh, Yoshihiro Nishimura
Transformation to small cell lung cancer is one phenomenon of acquired resistance to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in ALK rearrangement-positive non-small cell lung cancer (NSCLC). Few case reports have focused on other types of histological transformation. We report a case of transformation of ALK rearrangement-positive adenocarcinoma to NSCLC with neuroendocrine differentiation during alectinib therapy. A 36-year-old woman presented with a tumor in the left lower lobe and bone metastases...
March 22, 2019: Pathology International
https://read.qxmd.com/read/30864171/pulmonary-carcinosarcoma-characterized-by-small-round-cells-with-neuroendocrine-myogenic-and-chondrogenic-differentiation-an-extremely-rare-case
#8
Harumi Nakamura, Motohiro Tamiya, Yukinaga Sato, Koji Tsuta, Jiro Okami, Shin-Ichi Nakatsuka
Carcinosarcoma is a clonal tumor developed through sarcomatoid changes in a carcinoma via the epithelial-mesenchymal transition (EMT). Here, we present an extremely rare case of pulmonary carcinosarcoma characterized by components suggesting pluripotency, namely neuroendocrine, myogenic, and chondrogenic differentiation, based on immunohistochemical analysis. A 42-year-old Japanese man was admitted to our hospital. Analysis of tumor tissue after right upper lobe lobectomy revealed a transition between carcinomatous and sarcomatous components...
March 12, 2019: Pathology International
https://read.qxmd.com/read/30843648/renal-medullary-carcinoma-in-a-young-mixed-race-man-in-japan
#9
Akane Toriyama, Hiroshi Izumi, Shigeki Tomita, Yoji Nagashima, Yoshihiko Ueda, Yusuke Aoki, Akira Tsujimura, Takashi Yao, Okio Hino
Renal medullary carcinoma (RMC) is a rare and aggressive cancer associated with the sickle cell trait. The diagnosis of RMC depends on recognition of its histologic features and immunohistochemical deficiency of INI1, but correct diagnosis is sometimes difficult, especially if a patient's information on race, past, and family medical history is unclear. At present, this is the first report on RMC in Japan.
March 7, 2019: Pathology International
https://read.qxmd.com/read/30843305/decalcification-can-cause-the-failure-of-braf-molecular-analyses-and-anti-brafv600e-ve1-immunohistochemistry
#10
Amélie Bourhis, Glen Le Flahec, Arnaud Uguen
BRAF mutation detection is worthwhile for the management of patients with some advanced cancers. The tumor samples are sometimes difficult to analyze using DNA-based molecular methods because of poor tumor DNA quality or quantity. Anti-BRAFV600E VE1 immunohistochemistry (IHC) has been proposed as a valuable ancillary tool to analyze some "molecularly challenging" tumor samples. In this technical study, we focused on its application in the field of decalcified tumor samples. We selected four patients with known BRAFV600E-mutated cancer (3 metastatic melanomas and 1 hairy cell leukemia) and paired non-decalcified/decalcified tumor samples...
March 7, 2019: Pathology International
https://read.qxmd.com/read/30830714/appearance-of-large-scavenger-receptor-a-positive-cells-in-peripheral-blood-a-potential-risk-factor-for-severe-exacerbation-of-chronic-obstructive-pulmonary-disease
#11
Iwao Emura, Hiroyuki Usuda, Kazuhiro Satou
Fresh peripheral blood (PB) samples from 432 outpatients with stable chronic obstructive pulmonary disease (COPD) were examined. Patients were classified into Group A (large SRA+ cells were undetected) and Group B (large SRA+ cells were detected) and followed-up for 1 year. Patients were further subdivided according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Cox proportional hazard model had shown that Gold, Group, home oxygen therapy (HOT), and treatment were significant predictors of severe exacerbation...
March 4, 2019: Pathology International
https://read.qxmd.com/read/30811774/interobserver-and-intraobserver-variation-in-the-morphological-evaluation-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-asian-practice
#12
Zhiyan Liu, Andrey Bychkov, Chan Kwon Jung, Mitsuyoshi Hirokawa, Shaofeng Sui, SoonWon Hong, Chiung-Ru Lai, Deepali Jain, Sule Canberk, Kennichi Kakudo
To evaluate the current diagnostic criteria in reporting nuclear features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), nine Asian pathologists with expertise in thyroid reviewed virtual slides of 30 noninvasive follicular patterned thyroid lesions according to the nuclear scoring system originally proposed by an international expert and a more detailed scoring system proposed by the Asian Working Group. The interobserver agreement for nuclear grading score was generally moderate (kappa value = 0...
February 27, 2019: Pathology International
https://read.qxmd.com/read/30811750/mixed-pleomorphic-lobular-and-apocrine-carcinoma-of-the-breast-a-case-report-suggesting-pathogenesis
#13
Akiko Ishii, Takuma Oishi, Yuko Kakuda, Haruna Yasui, Takuya Kawata, Koji Muramatsu, Kaoru Takahashi, Takashi Sugino
Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E-cadherin expression and high-grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is presented. Histologically, the tumor showed two distinct carcinoma components: one was a typical apocrine carcinoma, and the other was a pleomorphic invasive lobular carcinoma. The former showed complete membranous expression of E-cadherin, whereas the latter aberrantly expressed it not on the cell membrane, but in the cytoplasm...
February 27, 2019: Pathology International
https://read.qxmd.com/read/30811747/targeted-next-generation-sequencing-of-pancreatic-solid-pseudopapillary-neoplasms-show-mutations-in-wnt-signaling-pathway-genes
#14
Jayson Wang, Gareth Gerrard, Ben Poskitt, Kay Dawson, Pritesh Trivedi, Letizia Foroni, Mona El-Bahrawy
Solid pseudopapillary neoplasms of the pancreas are rare neoplasms that have been shown to harbor recurrent somatic pathogenic variants in the beta-catenin gene, CTNNB1. Here, we used targeted next generation sequencing to analyze these tumors for other associated mutations. Six cases of solid pseudopapillary neoplasms were studied. DNA extracted from formalin-fixed paraffin embedded tissue blocks was analyzed using the Ion Torrent platform, with the 50-gene Ampliseq Cancer Hotspot Panel v2 (CHPv2), with further variant validation performed by Sanger sequencing...
February 27, 2019: Pathology International
https://read.qxmd.com/read/30791193/immunohistochemical-examination-using-the-pericyte-marker-myosin-1b-in-a-perivascular-myoid-tumor-of-soft-tissue-with-definitive-pericytic-differentiation
#15
LETTER
Shiori Meguro, Sayomi Matsushima, Yasunori Enomoto, Hideya Kawasaki, Isao Kosugi, Takashi Tsuchida, Satoshi Baba, Hidekazu Fukamizu, Yu Yamato, Toshihide Iwashita
No abstract text is available yet for this article.
February 21, 2019: Pathology International
https://read.qxmd.com/read/30779453/a-case-of-spheroid-type-localized-lactoferrin-amyloidosis-in-the-bronchus
#16
Shojiro Ichimata, Daiju Aoyagi, Tsuneaki Yoshinaga, Nagaaki Katoh, Fuyuki Kametani, Masahide Yazaki, Takeshi Uehara, Satoshi Shiozawa
We report a case of localized bronchial lactoferrin amyloidosis. A 47-year-old man presented with a complaint of persistent dry cough for two months. Chest computed-tomography revealed a calcification shadow of the right main bronchus; hence, a biopsy was performed, showing layered spheroid-type eosinophilic deposits in the bronchial wall. These deposits were positive for Congo red staining, exhibiting apple-green birefringence under polarized light. In addition, an electron microscopic examination demonstrated that this layered structure was formed by very thin cord-like amyloid deposits...
February 19, 2019: Pathology International
https://read.qxmd.com/read/30775828/primary-non-gestational-uterine-choriocarcinoma-mimicking-leiomyoma
#17
Rikiya Sano, Takuya Moriya, Soichiro Suzuki, Wataru Saito, Koichiro Shimoya, Mitsuru Shiota
Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non-gestational in origin. However, primary non-gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non-gestational uterine choriocarcinoma. This 46-year-old woman had no history of pregnancy. She was referred to our hospital for treatment of the myoma delivery...
February 18, 2019: Pathology International
https://read.qxmd.com/read/30775827/a-case-of-lung-adenocarcinoma-complicated-by-pulmonary-talcosis-occurring-in-a-patient-employed-in-the-confectionery-industry
#18
Kazuhiro Kobayashi, Naoki Watanabe, Teruaki Oka, Hiroyuki Tomita, Natsuko Suzui, Yasunori Oumi, Akira Hara, Tatsuhiko Miyazaki
A 73-year-old Japanese man, who worked at a confectionery company for more than 20 years, was diagnosed with a 28 mm nodular lesion in the superior lobe of the right lung by whole-body computed tomography examination. A biopsy revealed the presence of adenocarcinoma. With a diagnosis of a primary lung cancer, a right upper lobectomy was performed. A nodular lesion, 25 × 23 mm in size, was observed in the upper right lobe lung field, and was diagnosed histopathologically as a papillary adenocarcinoma...
February 18, 2019: Pathology International
https://read.qxmd.com/read/30758118/invasive-papillary-carcinoma-of-the-breast-with-an-unusual-immunophenotype
#19
LETTER
Norie Abe, Hirofumi Matsumoto, Tokiwa Motonari, Norihiro Nakada, Hisamitsu Zaha, Puay Hoon Tan, Naoki Yoshimi
No abstract text is available yet for this article.
February 13, 2019: Pathology International
https://read.qxmd.com/read/30758105/anxa10-induction-by-interaction-with-tumor-associated-macrophages-promotes-the-growth-of-esophageal-squamous-cell-carcinoma
#20
Himiko Kodaira, Yu-Ichiro Koma, Masayoshi Hosono, Nobuhide Higashino, Kazuki Suemune, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki
Tumor-associated macrophages (TAMs) have important roles in the growth, angiogenesis and progression of various tumors. Although we have demonstrated the association of an increased number of infiltrating CD204+ TAMs with poor prognosis in esophageal squamous cell carcinomas (ESCCs), the roles of TAMs in ESCC remain unclear. Here, to study the effects of TAMs on the tumor microenvironment of ESCCs, we established a co-culture assay using a human ESCC cell line and TAM-like peripheral blood monocyte-derived macrophages and performed a cDNA microarray analysis between monocultured and co-cultured ESCC cell lines...
February 13, 2019: Pathology International
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