Tao Li, Yongxian Jiang, Zhenyu Zhang, Sisi Zhang, Wei Wu, Daqin Liao, Yanfang Chen, Chengmin Yang, Xuewen Xu, Jin Liu
To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group...
August 2012: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology