Yaolei Zhang, Xin Guo, Ting Li, Yaxing Feng, Wei Li, Xiaoyan Zhu, Rui Gu, Longfu Zhou
Renal ischaemia reperfusion injury (IRI), characterized by excessive cell apoptosis and inflammation, remains a clinical challenge. Mitochondrial membrane potential is related to apoptosis and inflammation of IRI. Previous studies have indicated that uncoupling protein 2 (UCP2) and its receptors play an important role in inflammation, apoptosis and injuries, especially in oxidative stress injury. However, the underlying mechanisms of UCP2 in IRI are still not fully understood. In the present study, male C57 mice were randomly divided into three groups:sham, IR, and UCP2-/- +IR...
December 4, 2019: Molecular Membrane Biology