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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2024: Journal of Gastroenterology
#22
LETTER
Yu Huang, Hong Lu
No abstract text is available yet for this article.
February 14, 2024: Journal of Gastroenterology
#23
EDITORIAL
Tadashi Namisaki, Shinya Sato, Hitoshi Yoshiji
No abstract text is available yet for this article.
February 8, 2024: Journal of Gastroenterology
#24
JOURNAL ARTICLE
Takehisa Watanabe, Sanae Hayashi, Yan Zhaoyu, Hiroki Inada, Katsuya Nagaoka, Masakuni Tateyama, Yasuhito Tanaka
BACKGROUND: Currently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a functional cure (defined as sustained HBsAg loss). We report the discovery of a novel, 4-pyridone compound, SAG-524, a potent and orally bioavailable small molecule inhibitor of HBV replication. METHODS: The antiviral characteristics and selectivity of SAG-524 and its derivative compound against HBV were evaluated in HBV-infection assays and HBV-infected chimeric urokinase-type plasminogen activator/severe combined immunodeficiency mice with humanized livers (PXB mice), alone or in combination with entecavir...
February 5, 2024: Journal of Gastroenterology
#25
JOURNAL ARTICLE
Yuta Matsubara, Hiroki Kiyohara, Yohei Mikami, Kosaku Nanki, Ho Namkoong, Shotaro Chubachi, Hiromu Tanaka, Shuhei Azekawa, Shinya Sugimoto, Yusuke Yoshimatsu, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Toshiro Sato, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Koichi Fukunaga, Takanori Kanai
BACKGROUND: Research on whether gastrointestinal symptoms correlate with the severity of Coronavirus Disease 2019 (COVID-19) has been inconclusive. This study aimed to clarify any associations between gastrointestinal symptoms and the prognosis of COVID-19. METHODS: We collected data from the Japanese nationwide registry for COVID-19 to conduct a retrospective cohort study. Data from 3498 Japanese COVID-19 patients, diagnosed at 74 facilities between February 2020 and August 2022, were analyzed in this study...
January 25, 2024: Journal of Gastroenterology
#26
JOURNAL ARTICLE
Isabel Cornejo-Pareja, Mohamed Reda Amiar, Luís Ocaña-Wilhelmi, Rocío Soler-Humanes, Isabel Arranz-Salas, Lourdes Garrido-Sánchez, Carolina Gutiérrez-Repiso, Francisco Jose Tinahones
BACKGROUND/AIM: Alterations in gut microbiota are associated with the pathogenesis of metabolic diseases, including metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate gut microbiota composition and functionality in patients with morbid obesity with different degrees of MAFLD, as assessed by biopsy. SUBJECTS/METHODS: 110 patients with morbid obesity were evaluated by biopsy obtained during bariatric surgery for MAFLD. Stool samples were collected prior to surgery for microbiota analysis...
January 24, 2024: Journal of Gastroenterology
#27
JOURNAL ARTICLE
Ayumi Kashiro, Michimoto Kobayashi, Takanori Oh, Mitsuko Miyamoto, Jun Atsumi, Kengo Nagashima, Keiko Takeuchi, Satoshi Nara, Susumu Hijioka, Chigusa Morizane, Shojiro Kikuchi, Shingo Kato, Ken Kato, Hiroki Ochiai, Daisuke Obata, Yuya Shizume, Hiroshi Konishi, Yumiko Nomura, Kotone Matsuyama, Cassie Xie, Christin Wong, Ying Huang, Giman Jung, Sudhir Srivastava, Hiromu Kutsumi, Kazufumi Honda
BACKGROUND: We have previously reported apolipoprotein A2-isoforms (apoA2-is) as candidate plasma biomarkers for early-stage pancreatic cancer. The aim of this study was the clinical development of apoA2-is. METHODS: We established a new enzyme-linked immunosorbent sandwich assay for apoA2-is under the Japanese medical device Quality Management System requirements and performed in vitro diagnostic tests with prespecified end points using 2732 plasma samples. The clinical equivalence and significance of apoA2-is were compared with CA19-9...
January 23, 2024: Journal of Gastroenterology
#28
JOURNAL ARTICLE
Shiko Kuribayashi, Fumihiko Nakamura, Sei-Ichiro Motegi, Kenichiro Hara, Hiroko Hosaka, Akiko Sekiguchi, Mai Ishikawa, Yukie Endo, Tomonari Harada, Hidemi Sorimachi, Masaru Obokata, Mitsuo Uchida, Koichi Yamaguchi, Toshio Uraoka
BACKGROUNDS: Patients with systemic sclerosis (SSc) often have esophageal motility abnormalities and weak esophago-gastric junction (EGJ) barrier function, which causes proton pump inhibitor (PPI)-refractory reflux esophagitis (RE). The aims of this study were to clarify the current management of RE and prevalence and risk factors of medication-refractory RE in patients with SSc in Japan. METHODS: A total of 188 consecutive patients with SSc who underwent both esophageal high-resolution manometry (HRM) and esophagogastroduodenoscopy (EGD) were reviewed...
January 22, 2024: Journal of Gastroenterology
#29
JOURNAL ARTICLE
Haruka Komatsu, Hiromu Morikubo, Yoko Kimura, Chihiro Moue, Hiromi Yonezawa, Minoru Matsuura, Jun Miyoshi, Tadakazu Hisamatsu
BACKGROUND: Endoscopic improvement (EI; a Mayo endoscopic subscore of 0 or 1) is considered a therapeutic target in ulcerative colitis (UC) treatment. The potential to estimate EI non-invasively is an advantage of intestinal ultrasound (IUS). In a previous study, we developed a new sonographic parameter, the submucosa index (SMI), calculated as the ratio of the submucosal thickness to bowel wall thickness (BWT), and reported that combining BWT and SMI results in a practical and promising criterion for estimating EI without color Doppler assessment...
January 21, 2024: Journal of Gastroenterology
#30
JOURNAL ARTICLE
Shohei Abe, Atsuhiro Masuda, Tomonori Matsumoto, Jun Inoue, Hirochika Toyama, Arata Sakai, Takashi Kobayashi, Takeshi Tanaka, Masahiro Tsujimae, Kohei Yamakawa, Masanori Gonda, Shigeto Masuda, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Yoshiyuki Harada, Mika Miki, Yosuke Irie, Noriko Juri, Testuhisa Ko, Yusuke Yokotani, Yuki Oka, Shogo Ota, Maki Kanzawa, Tomoo Itoh, Toshio Imai, Takumi Fukumoto, Eiji Hara, Yuzo Kodama
BACKGROUND: Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, the significance of tumor-resident microbiome remains unclear. We aimed to elucidate the impact of intratumoral bacteria on the pathophysiology and prognosis of human PDAC. METHODS: The presence of intratumoral bacteria was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) and in situ hybridization (ISH) targeting 16S rRNA...
January 20, 2024: Journal of Gastroenterology
#31
JOURNAL ARTICLE
Makoto Naganuma, Naohiro Nakamura, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Taku Kobayashi, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Tomohisa Takagi, Teppei Omori, Toshiyuki Tahara, Tadakazu Hisamatsu
BACKGROUND: Hospitalization for ulcerative colitis (UC) is potentially life-threatening. Severe disease in the Japanese criteria which modifies the Truelove-Witts' criteria might encompass more fulminant cases than the definition for acute severe UC. However, few studies have investigated the predictive factors for clinical remission (CR) after medical treatments for severe hospitalized patients by Japanese criteria. METHODS: Medical treatment selection, CR rates, and factors contributing to CR on day 14 were assessed in severe patients by Japanese criteria...
April 2024: Journal of Gastroenterology
#32
REVIEW
Qi-Yue Tong, Min-Jiao Pang, Xiao-Hai Hu, Xuan-Zhang Huang, Jing-Xu Sun, Xin-Yu Wang, Joseph Burclaff, Jason C Mills, Zhen-Ning Wang, Zhi-Feng Miao
Most gastric cancers arise in the setting of chronic inflammation which alters gland organization, such that acid-pumping parietal cells are lost, and remaining cells undergo metaplastic change in differentiation patterns. From a basic science perspective, recent progress has been made in understanding how atrophy and initial pyloric metaplasia occur. However, pathologists and cancer biologists have long been focused on the development of intestinal metaplasia patterns in this setting. Arguably, much less progress has been made in understanding the mechanisms that lead to the intestinalization seen in chronic atrophic gastritis and pyloric metaplasia...
April 2024: Journal of Gastroenterology
#33
JOURNAL ARTICLE
Juan Wang, Haoye Zhang, Limin Chen, Kangkang Fu, Yu Yan, Zhenguo Liu
BACKGROUND: Liver fibrosis can progress to cirrhosis and hepatic carcinoma without treatment. CircDCBLD2 was found to be downregulated in liver fibrosis. However, the precise underlying mechanism requires further investigation. METHODS: qRT-PCR, Western blot, and immunohistochemistry assays were used to detect the related molecule levels. HE, Masson's trichrome, and Sirius Red staining were used to assess the pathological changes in mice's liver tissues. Flow cytometric analysis and commercial kit were used to assess the levels of lipid reactive oxygen species (ROS), malonaldehyde (MDA), glutathione (GSH), and iron...
March 2024: Journal of Gastroenterology
#34
MULTICENTER STUDY
Kazuhito Sasaki, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Hideyuki Ishida, Keiichiro Ishibashi, Yoshiko Mori, Satoki Shichijo, Yasuhiro Tani, Yoji Takeuchi, Akiko Chino, Misato Takao, Kenji Fujiyoshi, Takaaki Matsubara, Yasuyuki Miyakura, Fumitaka Taniguchi, Tatsuro Yamaguchi, Kohji Tanakaya, Naohiro Tomita, Yoichi Ajioka
BACKGROUND: Patients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the clinical course of FAP with these gastric lesions has not yet been fully clarified. The present study aimed to clarify the changes in the incidence risk of developing gastric adenoma or gastric cancer during the lifespan of patients with FAP. METHODS: Four hundred forty-three patients with data regarding gastric adenoma and gastric cancer retrospectively registered in a nationwide Japanese multicenter study were enrolled...
March 2024: Journal of Gastroenterology
#35
REVIEW
Tom Leech, Madusha Peiris
Gastro-oesophageal reflux disease (GORD) is a chronic condition characterised by visceral pain in the distal oesophagus. The current first-line treatment for GORD is proton pump inhibitors (PPIs), however, PPIs are ineffective in a large cohort of patients and long-term use may have adverse effects. Emerging evidence suggests that nerve fibre number and location are likely to play interrelated roles in nociception in the oesophagus of GORD patients. Simultaneously, alterations in cells of the oesophageal mucosa, namely epithelial cells, mast cells, dendritic cells, and T lymphocytes, have been a focus of GORD research for several years...
March 2024: Journal of Gastroenterology
#36
JOURNAL ARTICLE
Takumi Kawaguchi, Atsushi Kawaguchi, Ryuki Hashida, Dan Nakano, Tsubasa Tsutsumi, Machiko Kawaguchi, Shunji Koya, Keisuke Hirota, Manabu Tomita, Jin Tsuchihashi, Hayato Narao, Hiroo Matsuse, Koji Hiraoka, Keisuke Ejima, Shingo Iwami, Sachiyo Yoshio
BACKGROUND: Exercise, particularly resistance exercise, is beneficial for sarcopenia in patients with liver cirrhosis. However, the effects of exercise on events remain unclear. We aimed to examine the effects of exercise on serious events in patients with liver cirrhosis using a meta-analysis of randomized controlled trials (RCTs). METHODS: A literature search was conducted in 2022. Eleven RCTs were selected for the meta-analysis (exercise group, n = 232; control group, n = 193)...
March 2024: Journal of Gastroenterology
#37
LETTER
Tomoki Sakakida, Takeshi Ishikawa, Yoshito Itoh
No abstract text is available yet for this article.
February 2024: Journal of Gastroenterology
#38
LETTER
Chikamasa Ichita, Tadahiro Goto, Sayuri Shimizu
No abstract text is available yet for this article.
February 2024: Journal of Gastroenterology
#39
JOURNAL ARTICLE
Chihiro Takeuchi, Junichi Sato, Nobutake Yamamichi, Natsuko Kageyama-Yahara, Akiko Sasaki, Takemi Akahane, Rika Aoki, Shigemi Nakajima, Masayoshi Ito, Mitsue Yamamichi, Yu-Yu Liu, Nobuyuki Sakuma, Yu Takahashi, Yoshiki Sakaguchi, Yosuke Tsuji, Kouhei Sakurai, Shuta Tomida, Keiko Niimi, Toshikazu Ushijima, Mitsuhiro Fujishiro
BACKGROUND: Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene expression profiles, activated signaling pathways, and their underlying mechanisms. METHODS: A comprehensive gene expression analysis was conducted using biopsy specimens from AIG, Helicobacter pylori-associated gastritis (HPG), and non-inflammatory normal stomachs...
February 2024: Journal of Gastroenterology
#40
JOURNAL ARTICLE
Jun Omori, Mitsuru Kaise, Naoyoshi Nagata, Tomonori Aoki, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Sho Suzuki, Toshiaki Narasaka, Junnosuke Hayasaka, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Takuto Hikichi, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kiyonori Kobayashi, Tamotsu Matsuhashi, Yuga Komaki, Kuniko Miki, Kazuhiro Watanabe, Katsuhiko Iwakiri
BACKGROUND: Current evidence on the surgical rate, indication, procedure, risk factors, mortality, and postoperative rebleeding for acute lower gastrointestinal bleeding (ALGIB) is limited. METHODS: We constructed a retrospective cohort of 10,342 patients admitted for acute hematochezia at 49 hospitals (CODE BLUE J-Study) and evaluated clinical data on the surgeries performed. RESULTS: Surgery was performed in 1.3% (136/10342) of the cohort with high rates of colonoscopy (87...
January 2024: Journal of Gastroenterology
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