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Journal of Gastroenterology

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https://read.qxmd.com/read/31093771/dose-response-relationship-between-cigarette-smoking-and-risk-of-ulcerative-colitis-a-nationwide-population-based-study
#1
Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
BACKGROUND: Former cigarette smokers are at risk of developing ulcerative colitis (UC). However, the impact of smoking behavior on the occurrence of UC according to the amount smoked remains elusive. We aimed to determine the relationship between smoking behavior and the risk of UC development. METHODS: We conducted a retrospective population-based cohort study using the National Health Insurance Service database in South Korea. From January 2009 to December 2012, 23,235,771 individuals over 18 years of age who underwent a national health examination were enrolled and followed until 2016...
May 15, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31055660/impact-of-the-charlson-comorbidity-index-on-the-treatment-strategy-and-survival-in-elderly-patients-after-non-curative-endoscopic-submucosal-dissection-for-esophageal-squamous-cell-carcinoma-a-multicenter-retrospective-study
#2
Keiichiro Nakajo, Seiichiro Abe, Ichiro Oda, Ryu Ishihara, Masaki Tanaka, Toshiyuki Yoshio, Chikatoshi Katada, Tomonori Yano
BACKGROUND: In elderly patients with superficial esophageal squamous cell carcinoma (ESCC), the optimal treatment strategy after non-curative endoscopic submucosal dissection (ESD) remains unclear. We aimed to evaluate the validity of additional treatments after non-curative ESD and post-ESD survival predictors in elderly patients with ESCC. METHODS: Elderly patients (age > 75 years) treated with ESD for ESCC between January 2010 and July 2014 at six tertiary referral hospitals in Japan were retrospectively investigated and stratified according to lymph node metastasis risk, based on histological findings (high-risk factors: positive lymphovascular invasion, submucosal invasion, and positive/indeterminate vertical margin) and post-ESD treatment strategy: group A (287 patients; low risk), group B (41 patients; high risk, without additional treatment), and group C (32 patients; high risk, with additional treatment)...
May 4, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31049715/epitope-peptides-of-helicobacter-pylori-caga-antibodies-from-sera-by-whole-peptide-mapping
#3
Shamshul Ansari, Junko Akada, Yuichi Matsuo, Seiji Shiota, Yoko Kudo, Tadayoshi Okimoto, Kazunari Murakami, Yoshio Yamaoka
BACKGROUND: Helicobacter pylori CagA has been found to be immuno-dominant protein and utilized for the diagnosis of the infection with cagA-positive strains. It is important to characterize the peptide epitopes capable of detecting serum anti-CagA antibodies to understand CagA immunogenicity. METHODS: Sera from 171 Japanese patients were subjected for the epitope mapping study. Eighty seven peptides were designed from the CagA consensus sequence and were used for ELISA protocol to test the serum samples...
May 2, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31041545/withdrawal-of-thiopurines-in-crohn-s-disease-treated-with-scheduled-adalimumab-maintenance-a-prospective-randomised-clinical-trial-diamond2
#4
Tadakazu Hisamatsu, Shingo Kato, Reiko Kunisaki, Minoru Matsuura, Masakazu Nagahori, Satoshi Motoya, Motohiro Esaki, Norimasa Fukata, Satoko Inoue, Takeshi Sugaya, Hirotake Sakuraba, Fumihito Hirai, Kenji Watanabe, Takanori Kanai, Makoto Naganuma, Hiroshi Nakase, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Masanori Nojima, Takayuki Matsumoto
BACKGROUND: The risk:benefit ratio of concomitant use of thiopurines with scheduled adalimumab (ADA) maintenance therapy for Crohn's disease is controversial. The aim of this study is to identify the influence of withdrawal of thiopurines in patients in remission with combination therapy in an open-label, randomised, controlled trial (DIAMOND2; UMIN000009596). METHODS: Patients in corticosteroid-free clinical remission (CFCR) for ≥ 6 months with ADA (40 mg, s...
April 30, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31037450/integrated-analysis-of-circrnas-and-mrnas-expression-profile-revealed-the-involvement-of-hsa_circ_0007919-in-the-pathogenesis-of-ulcerative-colitis
#5
Tingting Wang, Ning Chen, Weixia Ren, Fangfang Liu, Fangfang Gao, Lei Ye, Ying Han, Yujun Zhang, Yulan Liu
BACKGROUND: Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown. METHODS: Microarrays were used to detect the differentially expressed genes, and quantitative real-time PCR was used to identify the changes in UC...
April 29, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31037449/efficacy-and-safety-of-hangeshashinto-for-treatment-of-gerd-refractory-to-proton-pump-inhibitors-usual-dose-proton-pump-inhibitors-plus-hangeshashinto-versus-double-dose-proton-pump-inhibitors-randomized-multicenter-open-label-exploratory-study
#6
Toshihisa Takeuchi, Hitoshi Hongo, Tsuguhiro Kimura, Yuichi Kojima, Satoshi Harada, Kazuhiro Ota, Nozomi Takeuchi, Takao Noguchi, Takuya Inoue, Mitsuyuki Murano, Kazuhide Higuchi
BACKGROUND: Proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) leads to a clinical decline in the quality of life (QOL). Therefore, new treatment options are needed. We performed a multicenter, randomized, parallel-group exploratory trial to determine the efficacy of hangeshashinto (HST) in patients with PPI-refractory GERD. METHODS: We enrolled 78 patients with PPI-refractory GERD for standard PPI regimens for at least 4 weeks and randomly assigned patients to receive either a combination of usual dose of rabeprazole (10 mg/day) + HST (7...
April 29, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31037448/is-the-new-potent-acid-inhibitory-drug-vonoprazan-effective-for-healing-idiopathic-peptic-ulcers-a-multicenter-observational-study-in-akita-prefecture-japan
#7
Kae Sugawara, Shigeto Koizumi, Yohei Horikawa, Nobuya Mimori, Tsuyotoshi Tsuji, Hajime Ishii, Shusei Fujimori, Kengo Onochi, Hiroyuki Watanabe, Katsunori Iijima
BACKGROUND: The incidence of peptic ulcers unrelated to H. pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs), termed idiopathic peptic ulcers (IPUs), has increased worldwide. We recently reported that IPUs were refractory to proton pump inhibitor (PPI) treatment. Vonoprazan, which was recently developed in Japan, has shown a more potent acid-inhibitory effect than ordinary PPIs. In the present study, we compared the healing rates among peptic ulcers of different etiologies following treatment with vonoprazan...
April 29, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31032528/the-relationship-between-the-pd-l1-expression-of-surgically-resected-and-fine-needle-aspiration-specimens-for-patients-with-pancreatic-cancer
#8
Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Akinobu Takaki, Masahiro Takahara, Noriyuki Tanaka, Hironari Kato, Shigeru Horiguchi, Ryuichi Yoshida, Yuzo Umeda, Soichiro Fushimi, Takahito Yagi, Akihiro Matsukawa, Hiroyuki Okada
BACKGROUND: Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens for patients with pancreatic cancer. METHODS: Of 121 patients who underwent endoscopic ultrasound-guided (EUS)-FNA before surgery for pancreatic cancer in an academic center, the 94 (78%) with adequate FNA specimens for a histological evaluation were retrospectively analyzed...
April 29, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31011797/polyethylene-glycol-3350-plus-electrolytes-for-chronic-constipation-a-2-week-randomized-double-blind-placebo-controlled-study-with-a-52-week-open-label-extension
#9
Atsushi Nakajima, Kazuhiko Shinbo, Akira Oota, Yoshikazu Kinoshita
BACKGROUND: Although polyethylene glycol 3350 plus electrolytes (PEG3350 + E) is the most widely used osmotic laxative in Europe, prospective data on its long-term (over 6 months) safety and efficacy are not available to date. METHODS: Japanese patients with chronic constipation were randomized to receive PEG3350 + E or placebo for 2 weeks orally. Following this, the patients received PEG3350 + E in the 52-week extension study. The starting dose was 13...
April 22, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/31025187/management-of-elderly-ulcerative-colitis-in-japan
#10
REVIEW
Masaaki Higashiyama, Akira Sugita, Kazutaka Koganei, Kenji Wanatabe, Yoko Yokoyama, Motoi Uchino, Masakazu Nagahori, Makoto Naganuma, Shigeki Bamba, Shingo Kato, Ken Takeuchi, Teppei Omori, Tomohisa Takagi, Satohiro Matsumoto, Mitsuo Nagasaka, Shintaro Sagami, Kazuya Kitamura, Takehiko Katsurada, Ken Sugimoto, Noritaka Takatsu, Masayuki Saruta, Toshiyuki Sakurai, Kazuhiro Watanabe, Shiro Nakamura, Yasuo Suzuki, Ryota Hokari
Japan has the largest aging society, where many elderly people have intractable diseases including ulcerative colitis (UC). Along with the increasing total number of UC patients, the number of elderly UC patients has also been increasing and will continue to do so in the future. Although the clinical features and natural history of UC in the elderly have many similarities with UC in the non-elderly population, age-specific concerns including comorbidities, immunological dysfunction, and polypharmacy make the diagnosis and management of elderly UC challenging compared to UC in non-elderly patients...
April 20, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30941514/bone-morphogenetic-protein-4-provides-cancer-supportive-phenotypes-to-liver-fibroblasts-in-patients-with-hepatocellular-carcinoma
#11
Yohei Mano, Sachiyo Yoshio, Hirotaka Shoji, Shimagaki Tomonari, Yoshihiko Aoki, Nobuyoshi Aoyanagi, Toru Okamoto, Yoshiharu Matsuura, Yosuke Osawa, Kiminori Kimura, Kyohei Yugawa, Huanlin Wang, Yoshinao Oda, Tomoharu Yoshizumi, Yoshihiko Maehara, Tatsuya Kanto
BACKGROUND: Cancer-associated fibroblasts (CAFs) are essential constituents of cancer-supportive microenvironments. The high incidence of hepatocellular carcinoma (HCC) in advanced fibrosis patients implies that fibroblasts have a promoting effect on HCC development. We aimed to explore the regulators of phenotypes and function of CAFs in the liver. METHODS: We established primary cancer-associated fibroblasts (CAFs) and non-cancerous liver fibroblasts (NFs) from 15 patients who underwent HCC resection...
April 2, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30937625/relationship-between-esophageal-motility-abnormalities-and-skin-or-lung-involvements-in-patients-with-systemic-sclerosis
#12
Shiko Kuribayashi, Sei-Ichiro Motegi, Kenichiro Hara, Yasuyuki Shimoyama, Hiroko Hosaka, Akiko Sekiguchi, Kouichi Yamaguchi, Osamu Kawamura, Takeshi Hisada, Osamu Ishikawa, Motoyasu Kusano, Toshio Uraoka
BACKGROUND: Esophageal motility abnormalities (EMAs) and interstitial lung diseases (ILDs) are often seen in patients with systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) could be associated with ILDs, but it is not fully understood if ILDs are caused by GERD or SSc itself. METHODS: A total of 109 patients with SSc who underwent high-resolution manometry were enrolled. Esophageal motility was diagnosed with the Chicago classification v3.0. The severity of skin thickness was evaluated by the modified Rodnan total skin thickness score (mRSS)...
April 1, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30927083/time-trends-in-the-incidence-of-esophageal-adenocarcinoma-gastric-adenocarcinoma-and-superficial-esophagogastric-junction-adenocarcinoma
#13
Kenshi Matsuno, Ryu Ishihara, Masayasu Ohmori, Hiroyoshi Iwagami, Satoki Shichijyo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Takashi Matsunaga, Toshitaka Morishima, Isao Miyashiro
BACKGROUND: In Japan, the incidence of esophageal adenocarcinoma (EAC) and esophagogastric junction (EGJ) adenocarcinoma is expected to increase and that of gastric adenocarcinoma (GAC) is expected to decrease due to Westernization of the diet and the decreasing prevalence of Helicobacter pylori infection. However, few reports about these trends have included the latest data, and no reports about the time trend in the incidence of EGJ adenocarcinoma have focused on the etiologies (gastric cardia adenocarcinoma or EAC, including Barrett's adenocarcinoma)...
March 29, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30923916/genetic-variants-in-rpa1-associated-with-the-response-to-oxaliplatin-based-chemotherapy-in-colorectal-cancer
#14
Shuwei Li, Kaili Xu, Dongying Gu, Lei He, Lisheng Xie, Zhengxin Chen, Zhimin Fan, Lingjun Zhu, Mulong Du, Haiyan Chu, Zhengdong Zhang, Yuan Wu, Min Ni, Meilin Wang
BACKGROUND: Oxaliplatin (L-OHP) is a commonly used first-line chemotherapy for colorectal cancer. Genetic variants in nucleotide excision repair (NER) pathway genes may alter genomic integrity and the efficacy of oxaliplatin-based chemotherapy in colorectal cancer. METHODS: We investigated the association between genetic variants in 19 NER pathway genes and the disease control rate (DCR) and progression-free survival (PFS) among 166 colorectal cancer patients who received oxaliplatin-based chemotherapy...
March 28, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30923915/a-new-era-for-understanding-genetic-evolution-of-multistep-carcinogenesis
#15
EDITORIAL
Shu Shimada, Shinji Tanaka
Cancer development is a multistep process involving genetic and cellular alterations, and recent advances in next-generation sequencing have elucidated mutation landscapes of premalignant lesions as well as early- and late-stage tumors. In this issue of Journal of Gastroenterology, Kim and colleagues contributed to the better understanding of genetic events in putative precursors of hepatocellular carcinoma (HCC). Precancerous tissues are divided into canonical and non-canonical types, which share common driver mutations with cancerous lesions or not, and potential gatekeeper gene(s) for clonal selection play a critical role in driving precursors to cancers not only in HCC, but also in esophageal, gastric, colorectal, and pancreatic cancers...
March 28, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30919071/systematic-review-with-network-meta-analysis-indirect-comparison-of-the-efficacy-of-vonoprazan-and-proton-pump-inhibitors-for-maintenance-treatment-of-gastroesophageal-reflux-disease
#16
Hiroto Miwa, Ataru Igarashi, Lida Teng, Akihito Uda, Hisato Deguchi, Toshiro Tango
BACKGROUND: Long-term maintenance treatment of gastroesophageal reflux disease (GERD) is important to prevent relapse. Proton-pump inhibitors (PPIs) are used for both treatment and maintenance therapy of GERD. Recently, a potassium-competitive acid blocker vonoprazan was launched in Japan. We evaluated the comparative efficacy of vonoprazan and other PPIs for GERD maintenance. METHODS: A systematic literature search was performed using MEDLINE and Cochrane Central Register of Controlled Trials...
March 27, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30915535/is-the-grade-of-ballooned-hepatocytes-a-significant-risk-factor-for-rapid-progression-of-hepatic-fibrosis-in-patients-with-nafld
#17
LETTER
Yoshio Sumida, Masashi Yoneda, Takeshi Okanoue
No abstract text is available yet for this article.
March 26, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30915534/response-to-the-letter-by-sumida-et-al-regarding-our-manuscript-evaluation-of-ballooned-hepatocytes-as-a-risk-factor-for-future-progression-of-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#18
LETTER
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
No abstract text is available yet for this article.
March 26, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30903385/initial-and-re-treatment-effectiveness-of-glecaprevir-and-pibrentasvir-for-japanese-patients-with-chronic-hepatitis-c-virus-genotype-1-2-3-infections
#19
Hitomi Sezaki, Fumitaka Suzuki, Tetsuya Hosaka, Shunichirou Fujiyama, Yusuke Kawamura, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
BACKGROUND: Glecaprevir and pibrentasvir (GLE/PIB) are potent antiviral agents for hepatitis C virus (HCV) pan-genotypic infections; however, their clinical effectiveness and safety remain limited in the real-world. This study aimed to evaluate viral responses and the safety of GLE/PIB for patients with chronic HCV-1/2/3 infections during both initial- (Arm A) and re-treatment (Arm B) with all-oral direct-acting antiviral agents (DAAs). METHODS: This prospective-observational cohort study included Japanese patients with chronic HCV-1/2/3 infections (n = 271: 183 in Arm A and 83 in Arm B), who had started receiving GLE/PIB...
March 22, 2019: Journal of Gastroenterology
https://read.qxmd.com/read/30868245/integrated-analysis-of-8-week-glecaprevir-pibrentasvir-in-japanese-and-overseas-patients-without-cirrhosis-and-with-hepatitis-c-virus-genotype-1-or-2-infection
#20
Atsushi Naganuma, Kazuaki Chayama, Kazuo Notsumata, Edward Gane, Graham R Foster, David Wyles, Paul Kwo, Eric Crown, Abhi Bhagat, Federico J Mensa, Tetsuya Otani, Lois Larsen, Margaret Burroughs, Hiromitsu Kumada
BACKGROUND: Chronic hepatitis C virus (HCV) infection with genotypes (GT) 1 and 2 accounts for over 50% of HCV infections globally, including over 97% of all HCV infections in Japan. Here, we report an integrated analysis of efficacy and safety of 8-week treatment with the all-oral, fixed-dose combination of the direct acting antivirals (DAA), glecaprevir and pibrentasvir (G/P), in DAA-naïve Japanese and overseas patients without cirrhosis and with HCV GT1 or GT2 infection. METHODS: Data from 899 DAA-naïve patients without cirrhosis and with HCV GT1 or GT2 infection treated with G/P (300/120 mg) for 8 weeks in the six Phase 2 or 3 overseas or Japan-only clinical trials were included...
March 13, 2019: Journal of Gastroenterology
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