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LETTER
Reply to "Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis".
Akihito Yokote, Noriyuki Imazu, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuta Fuyuno, Yuichi Matsuno, Tomohiko Moriyama, Kohta Miyawaki, Koichi Akashi, Takanari Kitazono, Takehiro Torisu
No abstract text is available yet for this article.
November 27, 2023: Journal of Gastroenterology
#2
JOURNAL ARTICLE
Tomoki Sakakida, Takeshi Ishikawa, Toshifumi Doi, Ryuichi Morita, Seita Kataoka, Hayato Miyake, Kanji Yamaguchi, Michihisa Moriguchi, Yoshio Sogame, Hiroaki Yasuda, Masahiro Iwasaku, Hideyuki Konishi, Koichi Takayama, Yoshito Itoh
BACKGROUND: Microsatellite instability high (MSI-H) and tumor mutational burden high (TMB-high) pancreatic cancer are rare, and information is lacking. Based on the C-CAT database, we analyzed the clinical and genomic characteristics of patients with these subtypes. METHODS: We retrospectively reviewed data on 2206 patients with unresectable pancreatic adenocarcinoma enrolled in C-CAT between July 2019 and January 2022. The clinical features, proportion of genomic variants classified as oncogenic/pathogenic in C-CAT, overall response rate (ORR), disease control rate (DCR), and time to treatment failure (TTF) of chemotherapy as first-line treatment were evaluated...
November 25, 2023: Journal of Gastroenterology
#3
JOURNAL ARTICLE
Jun Omori, Mitsuru Kaise, Naoyoshi Nagata, Tomonori Aoki, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Sho Suzuki, Toshiaki Narasaka, Junnosuke Hayasaka, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Takuto Hikichi, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kiyonori Kobayashi, Tamotsu Matsuhashi, Yuga Komaki, Kuniko Miki, Kazuhiro Watanabe, Katsuhiko Iwakiri
BACKGROUND: Current evidence on the surgical rate, indication, procedure, risk factors, mortality, and postoperative rebleeding for acute lower gastrointestinal bleeding (ALGIB) is limited. METHODS: We constructed a retrospective cohort of 10,342 patients admitted for acute hematochezia at 49 hospitals (CODE BLUE J-Study) and evaluated clinical data on the surgeries performed. RESULTS: Surgery was performed in 1.3% (136/10342) of the cohort with high rates of colonoscopy (87...
November 25, 2023: Journal of Gastroenterology
#4
LETTER
Shaopeng Sun, Bin Lv
The protective effect of indigo on intestinal epithelial cells remains unclear. Yokote Akihito et al. preliminarily investigated the anti-ferroptosis effect of indigo in inflammatory bowel disease. Here, we further discuss and evaluate the role of indigo based on the results.
November 23, 2023: Journal of Gastroenterology
#5
JOURNAL ARTICLE
Tomoyuki Kawaguchi, Koichi Okamoto, Shota Fujimoto, Masahiro Bando, Hironori Wada, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma, Katsuhisa Horimoto, Tetsuji Takayama
BACKGROUND: Although the serrated-neoplasia pathway reportedly accounts for 15-30% of colorectal cancer (CRC), no studies on chemoprevention of sessile serrated lesions (SSLs) have been reported. We searched for effective compounds comprehensively from a large series of compounds by employing Connectivity Map (CMAP) analysis of SSL-specific gene expression profiles coupled with in vitro screening using SSL patient-derived organoids (PDOs), and validated their efficacy using a xenograft mouse model of SSL...
November 22, 2023: Journal of Gastroenterology
#6
EDITORIAL
Katsunori Iijima, Kenta Watanabe, Yosuke Shimodaira
No abstract text is available yet for this article.
November 16, 2023: Journal of Gastroenterology
#7
JOURNAL ARTICLE
Chihiro Takeuchi, Junichi Sato, Nobutake Yamamichi, Natsuko Kageyama-Yahara, Akiko Sasaki, Takemi Akahane, Rika Aoki, Shigemi Nakajima, Masayoshi Ito, Mitsue Yamamichi, Yu-Yu Liu, Nobuyuki Sakuma, Yu Takahashi, Yoshiki Sakaguchi, Yosuke Tsuji, Kouhei Sakurai, Shuta Tomida, Keiko Niimi, Toshikazu Ushijima, Mitsuhiro Fujishiro
BACKGROUND: Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene expression profiles, activated signaling pathways, and their underlying mechanisms. METHODS: A comprehensive gene expression analysis was conducted using biopsy specimens from AIG, Helicobacter pylori-associated gastritis (HPG), and non-inflammatory normal stomachs...
November 14, 2023: Journal of Gastroenterology
#8
JOURNAL ARTICLE
Yuki Kojima, Mamoru Tanaka, Makiko Sasaki, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka
BACKGROUND: Photodynamic therapy (PDT) is an effective tumor treatment that involves the administration of a photosensitizer to generate cytotoxic 1 O2 [reactive oxygen species (ROS)] from molecular oxygen that is produced from energy absorption following tumor irradiation at specific wavelengths. Ferroptosis is induced by the disruption of the glutathione peroxidase 4 (GPX4) antioxidant system, leading to lipid peroxidation. We hypothesized that talaporfin sodium-photodynamic therapy (TS-PDT)-generated ROS would lead to ferroptosis via accumulation of lipid peroxidation...
November 10, 2023: Journal of Gastroenterology
#9
JOURNAL ARTICLE
Zhao Yang, Mengran Shi, Youfeng Liang, Fuhan Zhang, Cong Li, Yinying Lu, Taian Yin, Zhaohai Wang, Yongchao Li, Mingxuan Hao, Rui Guo, Hao Yang, Guanglin Lei, Fang Sun, Yu Zhang, Zhuoya Deng, Yuying Tian, Linxiang Yu, Changqing Bai, Lei Wang, Chuanxing Wan, Haifeng Wang, Penghui Yang
BACKGROUND: Three-dimensional (3D) chromatin architecture frequently altered in cancer. However, its changes during the pathogenesis of hepatocellular carcinoma (HCC) remained elusive. METHODS: Hi-C and RNA-seq were applied to study the 3D chromatin landscapes and gene expression of HCC and ANHT. Hi-C Pro was used to generate genome-wide raw interaction matrices, which were normalized via iterative correction (ICE). Moreover, the chromosomes were divided into different compartments according to the first principal component (E1)...
November 5, 2023: Journal of Gastroenterology
#10
JOURNAL ARTICLE
Jia-Feng Wu, Steven Shinn-Forng Peng, Chi-San Tai, Wen-Hsi Lin, Yung-Ming Jeng, Wen-Ming Hsu, Huey-Ling Chen, Yen-Hsuan Ni, Mei-Hwei Chang
BACKGROUND: We investigated the utilities of the liver-to-psoas apparent diffusion coefficient ratios (LTPAR) yielded by diffusion-weighted magnetic resonance imaging (DWMRI) and the age-adjusted serum matrix metalloproteinase-7 (MMP-7) for the diagnosis of biliary atresia (BA) in cholestatic infants. METHODS: In total, 170 cholestatic infants were recruited, of whom 50 (29.41%) were diagnosed with BA after cholestatic workups. The LTPAR and MMP7 levels were assessed...
October 30, 2023: Journal of Gastroenterology
#11
JOURNAL ARTICLE
Satoshi Kotani, Kotaro Shibagaki, Noriyuki Hirahara, Nobuaki Hasegawa, Ryo Tanabe, Yuri Ebisutani, Saya Nonomura, Kenichi Kishimoto, Yasuhide Kodama, Yusuke Takahashi, Masatoshi Kataoka, Akihiko Oka, Nobuhiko Fukuba, Yoshiyuki Mishima, Naoki Oshima, Kousaku Kawashima, Norihisa Ishimura, Asuka Araki, Kyuichi Kadota, Ayako Itawaki, Makoto Nagasaki, Yoichi Miyaoka, Hideyuki Onuma, Shunji Ishihara
BACKGROUND: The incidence of gastric neoplasms in Helicobacter pylori (Hp)-naïve patients has recently increased due to a remarkable decrease in the Hp-infected population in Japan. We investigated the clinicopathologic differences between Hp-infected gastric neoplasms (HpIGNs) and Hp-naïve gastric neoplasms (HpNGNs) that have not been fully elucidated so far. METHODS: This retrospective multicenter study investigated 966 consecutive patients with 1131 gastric dysplasia or cancers who underwent endoscopic or surgical treatment for the recent decade...
October 19, 2023: Journal of Gastroenterology
#12
JOURNAL ARTICLE
Takashi Kobayashi, Michihiro Iwaki, Asako Nogami, Nobuyoshi Kawamura, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Satoru Saito, Atsushi Nakajima
BACKGROUND: The prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with liver fibrosis. We aimed to investigate whether liver stiffness measurement (LSM) and changes in LSM (ΔLSM) on magnetic resonance elastography (MRE) can predict clinical events in patients with MASLD. METHODS: We included 405 patients with MASLD who underwent at least two MREs. The patients were divided into five groups corresponding to fibrosis stages (0-4) based on initial LSM and classified as progressors (ΔLSM ≥ 19%) or non-progressors (ΔLSM < 19%) based on the difference between the first and last LSM...
October 16, 2023: Journal of Gastroenterology
#13
JOURNAL ARTICLE
Hanxiao Wang, You Li, Xiting Pu, Xueying Liang, Ruqi Tang, Xiong Ma
BACKGROUND: Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease. Previous genome-wide meta-analysis has identified the association between variants in TMEM163 with PBC. Here we aimed to evaluate the association between variants near the reported risk loci of TMEM163 at 2q21.3 and prognosis of PBC patients. METHODS: We performed a retrospective analysis of 347 PBC patients treated with ursodeoxycholic acid (UDCA) for at least 1 year. We collected clinical data at diagnosis and 1 year after UDCA treatment...
October 16, 2023: Journal of Gastroenterology
#14
JOURNAL ARTICLE
Tatsunori Hanai, Kayoko Nishimura, Shinji Unome, Takao Miwa, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
BACKGROUND: Physical activity can reduce the risk of morbidity and mortality in patients with chronic liver disease (CLD), whereas physical inactivity adversely affects clinical outcomes. Since data on physical activity in CLD are scarce, we conducted a questionnaire survey to assess the physical activity patterns and determinants in patients with CLD. METHODS: We surveyed 437 patients from outpatient clinics at Gifu University Hospital about their physical activity patterns and determinants in 2022 using a validated questionnaire...
October 16, 2023: Journal of Gastroenterology
#15
JOURNAL ARTICLE
Fumitaka Suzuki, Tetsuya Hosaka, Yoshiyuki Suzuki, Hitomi Sezaki, Norio Akuta, Shunichiro Fujiyama, Yusuke Kawamura, Satoshi Saitoh, Yasuji Arase, Mariko Kobayashi, Hiromitsu Kumada
BACKGROUND: We determined the long-term clinical outcome and the durability of treatment cessation after HBsAg seroclearance following nucleos(t)ide analog (NA) therapy in patients with chronic hepatitis B (CHB). METHODS: We analyzed virological relapse (VR), HBsAg reversion, clinical relapse, and changes in HBsAg and HBcrAg levels by iTACT assay after treatment cessation of 90 CHB patients who achieved HBsAg seroclearance by NA treatment. RESULTS: Median age of patients at treatment cessation was 57 years...
October 14, 2023: Journal of Gastroenterology
#16
JOURNAL ARTICLE
Makoto Naganuma, Taku Kobayashi, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Takayuki Abe, Tadakazu Hisamatsu
BACKGROUND: This multicenter observational cohort study aimed to evaluate the utilization and short-term efficacy of advanced therapy (AT) in hospitalized patients with acute severe ulcerative colitis (ASUC). METHODS: In total, 221 patients with ASUC were enrolled between August 2020 and July 2021. The primary endpoint was clinical remission (CR, defined as a patient-reported outcome score < 2 with no blood in the stool) rate on Day 7 and 14 in hospitalized patients who received corticosteroids (CS) and AT...
October 13, 2023: Journal of Gastroenterology
#17
JOURNAL ARTICLE
Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Akio Ido, Hidekatsu Kuroda, Daiki Miki, Masayuki Kurosaki, Yoichi Hiasa, Ryotaro Sakamori, Norifumi Kawada, Taro Yamashita, Goki Suda, Hiroshi Yatsuhashi, Hitoshi Yoshiji, Naoya Kato, Taro Takami, Kazuhiko Nakao, Kentaro Matsuura, Yasuhiro Asahina, Yoshito Itoh, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Yoshiyuki Ueno, Norio Akuta, Masanori Miyazaki, Yasutoshi Nozaki, Masayuki Kabayama, Satoshi Sobue, Akihiro Moriuchi, Tomokatsu Miyaki, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara
BACKGROUND: The prognosis of cirrhosis is clearly stratified by liver function. Although direct-acting antiviral (DAA) has recently been used to eliminate hepatitis C virus (HCV), it is not clear whether liver function stratifies the prognosis of decompensated cirrhotic patients treated with DAA. METHODS: A total of 206 HCV-associated decompensated cirrhotic patients who started DAA from February 2019 to December 2021 at 31 Japanese hospitals were prospectively registered...
October 13, 2023: Journal of Gastroenterology
#18
JOURNAL ARTICLE
Haruki Uojima, Kadzuki Nakabayashi, Kazumi Yamasaki, Masaya Sugiyama, Norihiro Ishii, Ken Shirabe, Takuya Kyoutou, Koji Ueda, Yoichi Takahama, Nobuharu Tamaki, Masayuki Kurosaki, Hisashi Hidaka, Chika Kusano, Keisuke Amano, Takumi Kawaguchi, Akinobu Taketomi, Satoru Joshita, Takeji Umemura, Miyako Murakawa, Yasuhiro Asahina, Takanori Suzuki, Kentaro Matsuura, Takashi Nishimura, Hiroko Iijima, Kazumasa Sakamoto, Kiyoaki Ito, Sohji Nishina, Keisuke Hino, Hidenori Toyoda, Hiroshi Yatsuhashi, Masayoshi Kage, Masashi Mizokami
BACKGROUND: This study aimed to evaluate the quantitative measurement of Mac-2 binding protein glycosylation isomer (M2BPGi) levels using the new chemiluminescent enzyme immunoassay. METHODS: The data of a total of 347 patients with hepatitis C virus (HCV) infection and 150 health volunteers from 13 locations in Japan were evaluated. The quantitative system for measuring M2BPGi-Qt levels was based on a new chemiluminescent enzyme immunoassay. We evaluated the reproducibility and quantitation range in quantitative M2BPGi-Qt measurement...
October 8, 2023: Journal of Gastroenterology
#19
JOURNAL ARTICLE
Ying-Ying Han, Lin Zhou, Yun-Lian Hu, Xiang-Wu Ding, Hui Long, Fei Liu, Ming Xu, Zhen-Yu Zhang, Shuang-Ling Li, Qiu-Yan Wang, Cheng-Xia Su, Yan Chen, Jie Chen, Ya Lin, Pei-Yuan Li
BACKGROUND: The application of vonoprazan significantly improved the eradication rate of Helicobacter pylori (H. pylori). This study aimed to compare efficacy and safety of the 10-day vonoprazan-amoxicillin (VA) and 14-day rabeprazole-amoxicillin (RA) dual therapy, and to provide a more efficient, safer, and convenient dual regimen for H. pylori infection. METHODS: This was a prospective, open-label, multi-center, randomized controlled study of treatment-naive patients with H...
October 1, 2023: Journal of Gastroenterology
#20
Shin Fukudo, Toshikatsu Okumura, Masahiko Inamori, Yusuke Okuyama, Motoyori Kanazawa, Takeshi Kamiya, Ken Sato, Akiko Shiotani, Yuji Naito, Yoshiko Fujikawa, Ryota Hokari, Tatsuhiro Masaoka, Kazuma Fujimoto, Hiroshi Kaneko, Akira Torii, Kei Matsueda, Hiroto Miwa, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike
No abstract text is available yet for this article.
September 26, 2023: Journal of Gastroenterology
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