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Journals Pakistan Journal of Pharmaceut...

Pakistan Journal of Pharmaceutical Sciences

https://read.qxmd.com/read/38124413/assessment-of-neuropharmacological-consequences-induced-by-dexamethasone-administration-in-rats-model-of-neurodegenerative-diseases
#21
JOURNAL ARTICLE
Muhammad Farhan, Samia Khan, Ayesha Ahmed Soomro, Shoaib Ahmed, Anila Bibi, Syeda Rabab Zehra, Maria Arshad, Fatima Riaz, Sadia Rehman, Saher Asif
Stress is a well-known and frequently used term among present generation. It has been referred to the response of body to any challenge for a change. It is a natural process and our body is designed to cope with it. However, if stress becomes chronic, it can lead to mental health problems. Stress due to the prolonged administration of glucocorticoid is enabled to produce impressive alterations in rats model shoeing depressive like behavior. In this investigation; purpose was to study the impact of episodic treatment of dexamethasone with respect to behavioral changes in rats...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124412/the-effect-of-ritonavir-on-the-pharmacokinetics-of-clonidine-in-vivo-and-in-vitro
#22
JOURNAL ARTICLE
Peng Wang, Xiaoxia Hu
This project aims to explore the repercussions of ritonavir on both the drug kinetics of clonidine in rats and clonidine metabolism in liver micro somes. Eighteen healthy male laboratory rats were haphazardly placed into groups: Group A, the control, Group B, got 20mg/kg ritonavir and Group C, got 180 mg/kg ritonavir. Ritonavir was administered to the rats by oral gavage and 30 minutes later, clonidine at 0.25mg/kg was administered for once. Moreover, rat and human liver micro somes, along with recombinant human CYP2D6*1, were used to study the inhibition effect of ritonavir on clonidine in vitro...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124411/formulation-of-aloe-vera-based-curcumin-topical-gel-and-its-in-vitro-evaluation
#23
JOURNAL ARTICLE
Maira Shuja, Imtiaz Majeed, Tehseen Riaz, Muhammad Ahsan Waqar, Naila Tabassam, Tooba Mehboob, Abeeha Imtiaz
Curcumin is a polyphenolic compound obtained from the rhizome of plant. Curcuma longa possesses antioxidant, anti-inflammatory and wound-healing properties. The current study was designed to formulate an Aloe vera-based curcumin topical gel. To enhance curcumin's solubility, it was first complexed with β-cyclodextrin, given its hydrophobic nature. While Carbopol, carboxy methyl cellulose and guar gum were used in various concentrations as gelling agents for preparation of the formulations. The effect of propylene glycol as a permeation enhancer was also observed...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124410/astragaloside-iv-reduces-lung-injury-in-lethal-sepsis-via-promoting-treg-cells-expansion-and-inhibiting-inflammatory-responses
#24
JOURNAL ARTICLE
Haihao Yang, Na Yin, Qianlan Gu, Zhao Wu, Ying Xu, Jie Gao, Dongdong Qin, Chunping Wan
Sepsis is a systemic inflammatory response syndrome caused by an infection progressing to sepsis-associated organ failure (such as lung injury). Our previous review revealed that Astragaloside IV (ASI-IV), one of the primary bioactive ingredients in Astragalus membranaceus (Fisch) Bge (Huang-Qi), had been shown to exert anti-inflammatory and immunomodulatory effects. Nevertheless, it is still unclear whether ASI-IV could attenuate septic lung injury via activating regulatory T-cells (Tregs). This study was designed to evaluate the therapeutic potential of ASI-IV on sepsis-induced lung injury and to further explore its underlying mechanism...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124409/phytochemical-analysis-and-antihyperglycemic-activity-of-carissa-grandiflora-leaves-extract-on-streptozotocin-induced-diabetic-mice
#25
JOURNAL ARTICLE
Imran Waheed, Sayyeda Saba, Khurram Aamir, - Maria, Madiha Javaid, Hira Ijaz, Farooq Saleem, Sulaman Yaqub
Diabetes mellitus (DM), a prevalent metabolic condition that impairs glucose metabolism, causes morbidity and hospitalization. Thus, there is need to establish novel therapeutics against DM. The current study examined the phytochemical analysis and antidiabetic effects of Carissa grandiflora leave extracts (CGLE) on streptozotocin (STZ)-induced DM in mice. CGLE (n-hexane, chloroform, ethanol) was extracted and phytochemically examined for primary and secondary metabolites. Fourier transformed infrared spectroscopy (FTIR) detected functional groups, while 2,2-diphenyl-1-picrylhydrazyl (DPPH) test assessed antioxidant capacity...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124408/efficacy-and-safety-of-dapagliflozin-for-treating-heart-failure-in-china-a-meta-analysis
#26
JOURNAL ARTICLE
Wanshi Wu, Shang Yao, Qing Xu, Hui Cheng, Qing Jiang
This study assesses the efficacy and safety of dapagliflozin in Chinese patients with heart failure through a systematic review of randomized controlled trials from PubMed and the China National Knowledge Infrastructure databases. Focusing on 977 patients across eight trials, the meta-analysis used Review Manager 5.4.1 for data analysis. Key findings include a significant reduction in N-terminal pro-B-type natriuretic peptide levels (standardized mean difference: -2.88, 95% CI: -4.31 to -1.44, p<0.001) and an increase in left ventricular ejection fraction (weighted mean difference: 5...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008967/formulation-design-and-evaluation-of-epalrestat-mouth-dissolving-tablets-comprising-superdisintegrant-from-natural-sources-manufactured-by-direct-compression-method-and-stability-studies-of-optimized-formulation
#27
JOURNAL ARTICLE
Awaji Y Safhi, Sajid Ali, Meshal Alshamrani, Mohammad Intakhab Alam, Fahad Y Sabei, Ahmad Salawi
Among the oral route, mouth dissolving tablets (MDTs) offer a benefit for drugs with slow dissolution and having low oral bioavailability. Epalrestat is one of the best effective diabetic neuropathy medication used for treating nerve pain. The problem associated with this drug is high first pass metabolism and low solubility in acidic media as well in basic media leads to short half-life, delayed dissolution and side effects. Therefore, the goal of the current work is to developed an epalrestat MDTs tablet that will provide quick drug dissolution and a quick onset of action for the treatment of nerve pain...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008966/the-protective-effect-of-taurine-on-cyclophosphamide-induced-testicular-toxicity-in-rats
#28
JOURNAL ARTICLE
Muhammed Cemil Busı, Semra Yigitaslan, Zuhal Kaltus, Nusin Harmancı, Ezgi Eroglu, Orhan Ozatık, Coskun Kaya
This study aimed to evaluate the protective effect of taurine (TAU) with regard to antioxidant, anti inflammatory and antiapoptotic pathways on cyclophosphamide (CP)-induced testicular toxicity in rats. Forty Sprague-Dawley male rats were used in this experimental study. The CP group animals received a single dose of 200mg/kg CP on Day 8 intraperitoneally (i.p). The other groups were treated with TAU (75, 150 and 300mg/kg) orally for 14 days prior to and following a single i.p injection of CP. Morphometrical analysis and histological examination of testicular tissue were performed...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008965/exploring-the-potential-of-natural-polymers-from-plants-as-tablet-binder-and-accessing-their-release-profiles-a-comparative-analysis
#29
JOURNAL ARTICLE
Rabia Manzar, Shazma Massey, Laiba Arshad, Irva Waqar
A tablet is a compact dosage form that includes both the active pharmaceutical ingredient (API) and various excipients, where a binder acts as an excipient, imparting cohesive quality in the powdered material. The present study aimed to extract polysaccharides from plant samples; Plantago ovata seeds, Plantago ovata husk, Lallemantia royleana, Ocimum basilicum and Acacia nilotica and to investigate their efficacy as tablet excipients. The wet granulation method was adopted for tablet formulation. Three different formulations (3%, 5% and 7%) were prepared by varying the binder concentration (hemicellulose extracted from plant samples)...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008964/combination-therapy-of-methotrexate-and-iguratimod-for-female-patients-with-moderate-to-severe-active-rheumatoid-arthritis-and-its-impact-on-ovarian-function
#30
JOURNAL ARTICLE
Zhang Jingzhou, Zhou Xiong, Kong Qing Xin
Rheumatoid arthritis is systemic inflammatory disease, presenting as symmetrical polyarthritis, mainly affecting hands and feet. Female patients with rheumatoid arthritis have also decreased fertility and premature ovarian failure. Methotrexate is used in treatment of rheumatoid arthritis. However, single treatment of Methotrexate is not ideal and often needs to be combined with other drugs like Iguratimod for intensive treatment of refractory rheumatoid arthritis. We aim to explore efficacy of combined use of MTX and IGU for female patients with rheumatoid arthritis and its impact on ovarian reserve function...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008963/biopolymer-based-film-loaded-with-cholecalciferol-a-novel-technique-to-enhance-nutritional-supplement-absorbance
#31
JOURNAL ARTICLE
Yasir Mehmood, Hira Shahid, Mohsan Sohail, Umar Farooq, Shabbir Ahmed, Sherjeel Adnan, Muhammad Azam Tahir, Rashid Mahmood, Anjum Khursheed, Momina Nadeem
In terms of delivery systems for active compounds, orally disintegrating films are a great option. The initial stage in creating an oral disintegrating film is selecting a film-forming polymer. The basic polymers combination Microcrystalline Cellulose (MCC), which is co-processed with Carboxymethylcellulose Sodium (CMC) and hydroxypropylmethyl cellulose were used to create an oral disintegrating film that contains cholecalciferol (Vitamin D3), a fat-soluble vitamin that aids in the body's absorption of calcium and phosphorus...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008962/in-vivo-evaluation-of-the-traditional-uses-of-salvia-veneris-hedge-and-development-of-a-topical-formulation-for-localized-pain-and-inflammation
#32
JOURNAL ARTICLE
Goksu Oduncuoglu, Emmanuel Mshelia Halilu
Salvia veneris is endemic to Cyprus and used for pain relief and infectious diseases by local people. This study aimed to evaluate folkloric uses of Salvia veneris and develop a topical formulation for analgesic and anti-inflammatory effects as an alternative to NSAIDs. The analgesic activity of Salvia veneris ethanol extract was studied using an acetic acid-induced writhing test in mice and formalin-induced paw licking in rats. For anti-inflammatory activity, the formalin-induced paw edema model was used. Five topical formulations were prepared by varying the concentrations of ingredients and evaluated...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008961/development-and-characterization-of-letrozole-encapsulated-polymeric-beads-for-sustained-release
#33
JOURNAL ARTICLE
Muhammad Abu Sufian, Syed Atif Raza, Humayun Riaz, Waqas Ahmad, Zia Mohy Uddin Khan, Hammad Yousuf, Muhammad Affan, Ayesha Ghafoor, Adeel Masood Butt, Muhammad Umar Farooq, Wajeeha Akram
The study aimed to prepare and characterize biodegradable sustained-release beads of letrozole (LTZ) for treating cancerous disease. The ionotropic gelation method was used for the preparation and calcium chloride (CaCl2 ) was used as a gelating agent, while chitosan (CTS) and sodium alginate (NaAlg) as biodegradable polymeric matrices in the blend hydrogel beads. The beads were characterized for their size, surface morphology, drug entrapment efficiency, drug-polymer interaction and crystallinity using different analytic techniques, including optical microscopy, Scanning Electron Microscopy (SEM), UV-spectroscopy, Fourier-transform Infrared Spectroscopy (FTIR), Thermo gravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and X-ray Diffraction Analysis (XRD) respectively...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008960/evaluation-of-hypoglycemic-and-antioxidant-effects-of-brickellia-eupatorioides-citrus-limettioides-and-gochnatia-hypoleuca
#34
JOURNAL ARTICLE
Silvia Guadalupe Trevino-Moreno, Diana Patricia Moreno-Peña, Ezequiel Viveros-Valdez, María Julia Verde-Star, Catalina Rivas-Morales, Paula Cordero-Perez
Diabetes is a chronic metabolic condition with a rapidly increasing prevalence. It comes with a rise in the generation of free radicals, potentially leading to additional health issues. Further studies and creative approaches are required to address this. Natural products are potential new antidiabetic drugs that are worth exploring. The aim of the present study is to assess the antihyperglycemic and antioxidant effects of ethanolic extracts of Brickellia eupatorioides, Citrus limettioides and Gochnatia hypoleuca...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008959/memory-and-cognition-enhancing-effects-of-combination-of-melissa-officinalis-and-panax-ginseng
#35
JOURNAL ARTICLE
Hira Afshan, Humera Khatoon, Aisha Aziz, Mariam Arefa, Sheikh Abdul Khaliq, Nausheen Alam
Melissa officinalis and Panax ginseng extracts were investigated to determine combinatorial effects on cognitive behaviors' of albino-rats. The study was prospective-experimental; lasted from June-2022 to March-2023. Learning and memory measurements were done by animal-models. Data analyzed by 22nd version of SPSS. In Passive-avoidance-test both doses of Melissa officinalis and Panax ginseng (100/100mg/kg and 200/200mg/kg) showed significant differences in number of acquisition-trial between groups (p<0...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008958/a-validated-method-for-the-determination-of-quetiapine-fumarate-tablets-in-human-plasma-by-uplc-ms-ms-and-its-application-to-a-pharmacokinetic-study-in-healthy-chinese-subjects
#36
JOURNAL ARTICLE
Kaiwei Luo, Haiming Zhao, Huina Zhang, Lihong Huang, Jie Lin, Qunan Cheng, Wenjuan Yang, Weiyong Lu, Pingping Sun, Tingting Lou
A rapid, highly specific and sensitive UPLC-MS/MS method was developed for the determination of Quetiapine Fumarate, a therapeutic drug for various psychiatric disorders, in human plasma. The samples were pretreated using a protein precipitation method, followed by chromatographic separation using a column (Kinetex C18, 2.6µm 50*2.1mm) equipped with an ESI source and MRM mode mass spectrometer. In the validation results of the method, the analyte quetiapine showed a peak at approximately 1.0 minute and exhibited good linearity within the concentration from 2...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008957/synergistic-effect-of-moringa-oleifera-and-allium-sativum-on-bmi-and-lipid-profile-a-randomized-controlled-trial
#37
JOURNAL ARTICLE
Amna Sarfraz, Muhammad Imran Hussain, Ramisha Ibtisam, Annum Maha, Saher Asghar, Khizra Zubair, Khurram Sarfraz
We investigate the synergistic effect of Moringa oleifera and Allium sativum on hyperlipidemic patients. It was a randomized controlled trial. The sample size of this study was 60 patients who were divided into four equal groups (n=15) through a random sampling technique. Pre assessment of all participants was conducted at the start of the research. The control group (group A) received atorvastatin 10mg QD as well as placebo capsules. The treatment group 1 (group B) received atorvastatin 10mg QD as well as Moringa oleifera 2g (capsule 1g BID)...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008956/formulation-of-aspirin-nanoparticles-using-solvent-evaporation-method-and-in-vivo-evaluation-of-its-antithrombotic-effect
#38
JOURNAL ARTICLE
Lara Alhajj, Collins Ovenseri Airemwen, Leyla Beba Pozharani
Nanotechnology offers several advantages in the treatment of chronic diseases through site-specific and target-oriented drug delivery. The purpose of this study was to formulate aspirin nanoparticles using the solvent evaporation method and evaluate the physicochemical properties of nanoparticles using X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and zeta sizer. In vitro dissolution studies, release kinetics, antioxidant and in vivo antithrombotic studies were also done...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38008955/development-and-characterization-of-polyamidoamine-based-doxorubicin-loaded-polymeric-nanocarriers-and-in-vitro-evaluation-on-liver-cancer-cell-lines
#39
JOURNAL ARTICLE
Nadia Mazhar, Zeeshan Danish, Hamid Saeed
In order to achieve the benefits of targeted drug delivery, this study intended to encapsulate doxorubicin in a linear polyamidoamine and its PEGylated co-polymer. The drug was loaded by using the emulsion solvent evaporation method. By adjusting the doxorubicin to polymer ratios to 1:10, 1:20 and 1:30, three formulations of each polymer/copolymer were prepared. The drug release profile was investigated using phosphate buffered saline. In vitro cytotoxicity investigation was executed on liver cancer cell line (Hep G2 cell lines) by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay...
September 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37869932/chemical-characterization-nematicidal-and-antioxidant-activities-of-thymus-linearis-benth
#40
JOURNAL ARTICLE
Rubeena Saleem, Aisha Sana, Yusra Ghani, Faiza Mushtaq, Rubina Abid, Jan Alam, Marium Tariq, Shahnaz Dawar, Razia Sultana, Shaheen Faizi
Thymus linearis and its essential oil (EO) are used to cure a range of diseases in traditional medicine. GC-MS analysis of Thymus linearis EO revealed the presence of sixty-four components. Thymol (50.62%), carvacrol (13.23 %), carvacrol acetate (7.72%), -bisabolene (5.47%) and o-cymene (5.47%) are the only five basic constituents in the oil which accounts for 82.07% of oil. When compared to other compounds, the EO and its primary components thymol and carvacrol had the largest proportion of mortality in Meloidogyne javanica...
September 2023: Pakistan Journal of Pharmaceutical Sciences
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