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Veterinary Dermatology

Rebecca Huhmann, Ralf S Mueller
BACKGROUND: Topical application of polyunsaturated fatty acids (PUFAs) has shown satisfactory results in dogs and humans with allergic skin diseases. Urea and glycolic acid act as keratolytics and moisturizers. Culicoides hypersensitivity is the most common equine hypersensitivity disorder and only limited treatment options exist. OBJECTIVES: To evaluate the effect of a cream containing topical PUFAs, humectants and emollients on clinical signs of equine Culicoides hypersensitivity...
February 6, 2019: Veterinary Dermatology
Karen A Moriello
BACKGROUND: Dermatophytosis is a superficial fungal skin disease of animals. A key part of treatment is cleaning and disinfection of the environment to prevent false-positive results due to fomite carriage. Furthermore, there is a perception in the lay literature that decontamination of homes is difficult or impossible. CLINICAL SUMMARY: Data from a 10 year period identified 70 foster family homes where Microsporum canis infected cats had lived for varying periods of time...
February 6, 2019: Veterinary Dermatology
Jessika Daniel, Camila N Barra, Lidia H Pulz, Silvia Regina Kleeb, José Guilherme Xavier, José Luiz Catão-Dias, Adriana T Nishiya, Heidge Fukumasu, Ricardo F Strefezzi
BACKGROUND: Mast cell tumours (MCTs) constitute almost 25% of cutaneous neoplasms in dogs. Their biological behaviour is predicted using histopathological grading which is based on several subjective criteria that are vulnerable to intra- and interobserver variability. To improve the prediction of the biological behaviour, several complementary markers have been studied. The integrity of the extracellular matrix (ECM) may play a protective role against tumoral progression, and favour cellular proliferation, angiogenesis, invasion and metastases when altered...
January 28, 2019: Veterinary Dermatology
Joseph A Bernstein, Kathy Tater, Rodrigo C Bicalho, Mark Rishniw
BACKGROUND: The availability of direct-to-consumer medical testing for human and veterinary health conditions has increased in recent years. For allergies, several companies market proprietary hair and saliva tests directly to pet owners. These tests have not been validated and there is limited regulatory oversight for such tests in veterinary medicine. HYPOTHESIS/OBJECTIVES: To examine the accuracy and reproducibility of a commercial direct-to-consumer hair and saliva allergen test...
January 24, 2019: Veterinary Dermatology
Chie Tamamoto-Mochizuki, Judy S Paps, Thierry Olivry
BACKGROUND: Once the signs of canine atopic dermatitis (AD) are controlled, the proactive application of topical glucocorticoids can delay disease flares. OBJECTIVES: We wished to determine if the proactive administration of the anti-IL-31 lokivetmab would prevent or delay flares of canine AD. ANIMALS: We tested this strategy in four Maltese-beagle atopic dogs before enrolling 21 dogs with spontaneous AD. METHODS AND MATERIALS: In our acute AD model, house dust mite (HDM)-sensitized dogs were injected once with lokivetmab...
January 23, 2019: Veterinary Dermatology
Stefano Ciccarelli, Antonio Di Bello, Carmela Valastro, Chiara Leo, Diana Lenoci, Elisa Rana, Delia Franchini
BACKGROUND: Renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare inherited cancer syndrome observed predominantly in the German shepherd dog breed, known to be associated with dominant autosomal transmission of mutation H255R of the encoding folliculin gene (FLCN). The syndrome usually features bilateral, multifocal kidney tumours and skin nodules, consisting of dense collagen fibres, with previous reports showing a poor prognosis. Although historically nodular dermatofibrosis (ND) has been considered a paraneoplastic syndrome associated with renal cystadenocarcinoma; this hypothesis has been questioned...
January 23, 2019: Veterinary Dermatology
Megan Boyd, Domenico Santoro, Dunbar Gram
BACKGROUND: The value of susceptibility tests for the selection of topical otological antimicrobial agents is unclear. Laboratories test antibiotic concentrations substantially lower than concentrations supplied in topical formulations. Additionally, microbiological consensus statements are not available for topical antimicrobials. HYPOTHESIS/OBJECTIVES: The primary aim of this study was to measure the minimum inhibitory and bactericidal concentrations of enrofloxacin, gentamicin, marbofloxacin, neomycin, orbifloxacin, polymyxin B and silver sulfadiazine from concentrations available in otological formulations (COF) to 1:59,000 dilution...
January 23, 2019: Veterinary Dermatology
Debbie J Gow, Hilary Jackson, Peter Forsythe, Adam G Gow, Richard J Mellanby, David A Hume, Tim Nuttall
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease of dogs. Macrophage migration inhibitory factor (MIF) initiates pro-inflammatory cytokine release in human AD and serum concentrations are correlated with disease severity. HYPOTHESIS: Canine serum MIF concentrations are increased in dogs with AD and correlate with clinical lesion and pruritus scores. ANIMALS: Client owned dogs (n = 49) diagnosed with AD and 17 healthy, unaffected control dogs were used for the study...
January 23, 2019: Veterinary Dermatology
Takafumi Osumi, Takashi Shimada, Masahiro Sakaguchi, Hajime Tsujimoto
BACKGROUND: Gastrointestinal microbiome modulation is reported to be an effective therapy to reduce the clinical signs of canine atopic dermatitis (cAD). The killed strain of Enterococcus faecalis FK-23 has been shown to reduce allergic responses in mice and people. HYPOTHESIS/OBJECTIVE: The aim of this multicentre, double-blinded, placebo-controlled study was to evaluate the safety and efficacy of an orally administered heat-killed E. faecalis FK-23 preparation (FK-23p) for the control of cAD...
January 20, 2019: Veterinary Dermatology
Maritta S E von Silva-Tarouca, Georg Wolf, Ralf S Mueller
BACKGROUND: Otitis externa is a common presenting complaint in practice. Ear infections by Pseudomonas aeruginosa are particularly problematic due to the organism's high level of resistance and ability to damage the tympanum. Treatment should be based on susceptibility testing although minimum inhibitory concentrations (MICs) are not available for all treatment options. Silver sulfadiazine has been used in cases of recurrent P. aeruginosa otitis, although a MIC for silver sulfadiazine as a single agent has not been established...
January 20, 2019: Veterinary Dermatology
Chiara Noli, Irina Matricoti, Carlo Schievano
BACKGROUND: Oclacitinib is a Janus-kinase inhibitor that decreases interleukin-31-induced pruritus in cats. At 0.4-0.6 mg/kg/day orally, it decreased pruritus and skin lesions in <50% of allergic cats. HYPOTHESIS/OBJECTIVES: To evaluate efficacy and safety of oclacitinib in feline nonflea nonfood-induced hypersensitivity dermatitis (NFNFIHD). ANIMALS: Forty cats with NFNFIHD. METHODS AND MATERIALS: Cats were randomly assigned to receive oclacitinib (group A, 20 cats, 0...
January 17, 2019: Veterinary Dermatology
Danielle Cobiella, Linda Archer, Mary Bohannon, Domenico Santoro
BACKGROUND: Atopic dermatitis is associated with skin barrier defects. In people, noninvasive techniques are used to quantify the skin barrier functionality. In dogs, transepidermal water loss (TEWL), stratum corneum hydration and pH have been used to assess skin barrier function. However, few studies have determined their repeatability. OBJECTIVE: To assess the repeatability of measurements of skin hydration, TEWL, pH, skin absorbance and erythema in healthy and atopic dogs...
January 15, 2019: Veterinary Dermatology
Lynette K Cole, Päivi J Rajala-Schultz, Gwendolen Lorch, Joshua B Daniels
BACKGROUND: Primary secretory otitis media (PSOM) in the cavalier King Charles spaniel (CKCS) is similar to otitis media with effusion (OME) in humans. A proposed aetiology of OME is inflammation of the middle ear mucosa, usually due to bacterial infection, leading to auditory tube dysfunction. HYPOTHESIS/OBJECTIVES: Our objective was to characterize the microbiological and cytological findings of otic exudates from the external ear canal (EEC) (n = 68) and middle ear (ME) (n = 69) from 41 CKCSs with PSOM...
January 15, 2019: Veterinary Dermatology
Fábio P Sellera, Miriam R Fernandes, Caetano P Sabino, Laura M de Freitas, Luciano C B A da Silva, Fabio C Pogliani, Martha S Ribeiro, Michael R Hamblin, Nilton Lincopan
BACKGROUND: Carbapenem-resistant bacterial infections are a critical problem in veterinary medicine with limited treatment options. OBJECTIVE: To describe effective probiotic and photodynamic therapy of a dog with gut colonization and ear infection caused by a hospital-associated lineage of carbapenemase (VIM-2)-producing Pseudomonas aeruginosa. ANIMALS: A 5-year-old Lhasa apso dog presented with otitis externa. METHODS AND MATERIALS: Unilateral otitis externa caused by carbapenem-resistant P...
January 3, 2019: Veterinary Dermatology
Enrique Yarto Jaramillo, Rufino Osorio Marquez, Josué Rangel Díaz, Camilo Romero Núñez, Laura Miranda Contreras, Rafael Heredia Cardenas
BACKGROUND: Ectoparasitism of ornamental birds, including captive species kept in zoos, represents a serious health problem. Up to 13 different species of lice have been reported to affect peacocks worldwide and heavy infestation may cause anaemia. Because of this, alternatives to the prevailing treatments have been sought including use of isoxazolines. This class of drugs has been used successfully in poultry without adverse effects on health or production. OBJECTIVE: To evaluate the effect of afoxolaner on the peacock louse (Goniodes pavonis)...
December 17, 2018: Veterinary Dermatology
Thierry Olivry
No abstract text is available yet for this article.
December 17, 2018: Veterinary Dermatology
Wei Yee Chan, Manouchehr Khazandi, Elizabeth E Hickey, Stephen W Page, Darren J Trott, Peter B Hill
BACKGROUND: An antibiotic adjuvant is a chemical substance used to modify or augment the effectiveness of primary antimicrobial agents against drug-resistant micro-organisms. Its use provides an alternative approach to address the global issue of antimicrobial resistance and enhance antimicrobial stewardship. HYPOTHESIS/OBJECTIVES: To determine the antimicrobial activity of a panel of potential antimicrobial adjuvants against common pathogens associated with canine otitis externa (OE)...
December 13, 2018: Veterinary Dermatology
Diana Di Mattia, Alessandra Fondati, Moira Monaco, Mario Pasquetti, Andrea Peano
BACKGROUND: The fungal culture toothbrush method is a common method for obtaining material for fungal cultures to diagnose dermatophytosis. The optimal technique for inoculation onto the agar surface has not been studied. HYPOTHESIS/OBJECTIVES: To compare two inoculation techniques; the first involved pressing the toothbrush onto the plate surface (Procedure A) and the second involved pressing the toothbrush onto the agar, as well as transferring hairs and scales entrapped in the bristles...
December 10, 2018: Veterinary Dermatology
Kristina Meichner, Matti Kiupel, Tanit Kasantikul, Pauline Rakich, Frane Banovic
BACKGROUND: Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus. HYPOTHESIS/OBJECTIVE: To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. ANIMAL: A 4-year-old, spayed female cross-bred dog presented with severely pruritic, erythematous to pigmented macules and papules involving the ventral abdomen, interdigital skin, perivulval area and both pinnae; the pruritus had been unresponsive to treatment with antihistamines, prednisone and ciclosporin...
November 26, 2018: Veterinary Dermatology
Megan Boyd, Domenico Santoro, William F Craft, Pamela E Ginn, April L Childress, James F X Wellehan, Heather Stockdale Walden
BACKGROUND: Cercopithifilaria bainae is a tick-vectored filarioid nematode associated with erythematous dermatitis in dogs. It has not been reported previously in the United States. HYPOTHESIS/OBJECTIVE: To describe clinical, histological and parasitological diagnosis and treatment of C. bainae in a dog. ANIMALS: An 11-month-old golden retriever/standard poodle mixed breed dog from Florida (USA). METHODS AND MATERIALS: The dog had no travel history within or outside the United States, was presented with a one month history of annular erythematous plaques on the head and ulcers on the medial canthi...
November 25, 2018: Veterinary Dermatology
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