journal
Journals Indian Journal of Hematology &...

Indian Journal of Hematology & Blood Transfusion

https://read.qxmd.com/read/37304493/splenic-lymphomas-a-tertiary-care-center-experience-and-review-of-literature
#1
JOURNAL ARTICLE
Surabhi Jain, Prashant Ramteke, Ajay Gogia, Trisha Mandal, Mukul Aggarwal, Jasmita Dass, Mehar Chand Sharma, Manoranjan Mahapatra, Raja Parmanik, Sameer Bakhshi, Atul Sharma, Saumyaranjan Mallick
Primary splenic lymphomas are rare with the majority of lymphomas in spleen being secondary to an extra-splenic lymphoma. We aimed to analyze the epidemiological profile of the splenic lymphoma and review the literature. This was a retrospective study including all splenectomies and splenic biopsies from 2015 to September 2021. All the cases were retrieved from Department of Pathology. Detailed histopathological, clinical and demographic evaluation was done. All the lymphomas were classified according to WHO 2016 classification...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304492/comparison-of-point-of-care-pt-inr-by-hand-held-device-with-conventional-pt-inr-testing-in-anti-phospholipid-antibody-syndrome-patients-on-oral-anticoagulation
#2
JOURNAL ARTICLE
Arvind Ganapati, John Mathew, Bijesh Yadav, Jayakanthan Kabeerdoss, Mahasampath Gowri, Rutvi Gautam Dave, Roy Thankachen, Sukesh C Nair
Evidence on agreement of point-of-care (POC) INR testing with laboratory testing in APS patients on oral anticoagulation (OAC), is scarce. This study assessed agreement of paired PT INR testing by a POC device vs. conventional platform-based laboratory test, in APS patients on OAC using a pre-determined definition of agreement. Simultaneous paired PT INR estimation in 92 APS patients was carried out, during October 2020-September 2021. POC INR was performed on capillary blood (pin prick) using the qLabs® PT-INR hand-held device, while laboratory INR estimation was performed using citrated blood (venepuncture) on STA-R Max Analyzer® using STA-NeoPTimal thromboplastin reagent®...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304491/efficacy-and-safety-analysis-of-vrd-pdce-in-treatment-native-patients-with-multiple-extramedullary-plasmacytomas-or-plasma-cell-leukemia
#3
JOURNAL ARTICLE
Weiwei Zhao, Liyan Chen, Lianjie Wang, Wei Wang
The prognosis of multiple extramedullary plasmacytomas (MEP) and plasma cell leukemia (PCL) is extremely poor, with the median overall survival (OS) of only 8 months with standard chemotherapy. Innovative treatment approaches incorporating various strategies are required to improve outcome. From November 2019 to September 2021, a total of 12 newly diagnosed MEP or PCL patients were enrolled in our department. An intensive chemotherapy treatment as VRD-PDCE consisted of bortezomib, lenalidomide, dexamethasone plus cisplatin, pegylated liposomal doxorubicin, cyclophosphamide and etoposide was first proposed...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304490/blood-donation-screening-of-transfusion-transmissible-viral-infection-using-two-different-nucleic-acid-testing-nat-platforms-a-single-tertiary-care-oncology-centre-experience
#4
JOURNAL ARTICLE
Amardeep Pathak, Devasis Panda, Manushri Sharma, Narender Tejwani, Anurag Mehta
Nucleic acid testing (NAT) is used to screen transfusiontransmittable infections (TTIs) in donated blood samples and provide an additional layer of blood safety. In this study, we describe our experience in screening viral TTIs using two formats of NAT: cobas® MPX2 polymerase chain reaction- based minipool NAT (PCR MP-NAT) and Procleix Utrio Plus transcription-mediated amplificationbased individual donor-NAT (TMA ID-NAT). Data routinely collected as a part of blood bank operations were retrospectively analysed over a period of 70 months for TTIs...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304489/clinico-hematological-profile-in-hemoglobin-se-disease-a-case-series-from-a-tertiary-care-centre
#5
JOURNAL ARTICLE
Tista Basu, Mou Das, Moumita Sengupta, Mamata Guha Mallik Sinha
Hemoglobin SE (HbSE) disease are rare globally and there is paucity of literature regarding this condition. Cases reported in the Indian scenario so far have been limited to the tribal populations. This case series aims to highlight the rarity of this double heterozygous state and to raise awareness of its community prevalence beyond the tribal population. This is a case series over a 5-year observation period with six cases of double heterozygosity for HbS and HbE in our tertiary care centre. Four cases were in the 8-15 years' age group and 2 cases of 24-25 years' age group reported for initial evaluation due to easy fatigability and weakness: Two cases were siblings with history of consanguineous marriages in the family...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304488/efficacy-and-safety-of-biosimilar-romiplostim-versus-innovator-romiplostim-in-patients-with-chronic-immune-thrombocytopenia
#6
JOURNAL ARTICLE
S Chandrakala, Manoj Toshniwal, Mitesh Halvawala, Namita Padwal, Neeraj Sidharthan, Pankaj Malhotra, B Prashantha, Riya Ballikar, Sandip Shah, Shashikant Apte, T Kasi Viswanathan, Vijay Ramanan, Akhilesh Sharma, Dattatray Pawar, Roshan Pawar, Vinayaka Shahavi
Romiplostim is a Food and Drug Administration (FDA)-approved therapy for immune thrombocytopenia (ITP). Biosimilar is a biological product that has no clinical meaningful difference from an existing FDA-approved reference product. It has a potential of lowering health-care-related cost. Biosimilar of romiplostim can be made available to patients with ITP at a low cost and can be beneficial in providing the best therapy. Thus, the efficacy and safety of biosimilar romiplostim (ENZ110) was compared with innovator romiplostim (Nplate) with respect to platelet response in patients with chronic ITP...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304487/does-the-inclusion-of-cd34-%C3%A2-b-cell-progenitors-hematogones-in-stem-cell-enumeration-of-apheresis-product-using-ishage-protocol-affect-the-final-harvest-dose-adequacy-and-the-outcome-of-transplantation-a-single-institution-experience-from-southern-india
#7
JOURNAL ARTICLE
Naadia Fatima Nadeem, Prabhu Manivannan, Smita Kayal, Abhishekh Gowda
PURPOSE: Hematogones have similar antigenic and light scatter properties when compared to CD34+ hematopoietic stem cells (HSC) but they form a separate cluster with dimmer CD45 expression. These should be excluded while enumerating HSC, as their inclusion can overestimate and hence affect the final dose of HSC. However, their exact impact on the outcome of HSC transplant (HSCT) is not entirely known and hence this study was undertaken to address these issues, if any. METHODS: This was a retrospective study in which patients undergoing HSCT were included, and flow cytometric enumeration was done on the apheresis product using single platform ISHAGE protocol...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304486/the-usability-of-platelet-mass-index-thresholds-to-assess-the-repeated-platelet-transfusion-requirements-in-neonates
#8
JOURNAL ARTICLE
Asli Okbay Gunes, Suleyman Geter, Mehmet Emin Avlanmis
To evaluate the usability of platelet mass index (PMI) thresholds to assess the repeated platelet transfusion requirements in neonates who have received transfusion within the previous six days. This is a retrospective cross-sectional study conducted with neonates who received prophylactic platelet transfusion. The PMI was calculated as platelet count (× 1000/mm3) × mean platelet volume (MPV) (fL). Platelet transfusions were divided into two groups as first (Group 1) and repeated transfusions (Group 2)...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304485/high-gli-1-expression-is-a-reliable-indicator-of-bad-prognosis-in-newly-diagnosed-acute-leukemia-patients
#9
JOURNAL ARTICLE
Reham S El Zaiat, Reem Nabil, Khaled A Khalifa, Aliaa A El Feshawy
PURPOSE: To explore the expression and prognostic significance of Hedgehog signaling transcription factor GLI-1 in newly diagnosed acute myeloid leukemia (AML) patients. METHODS: Clinical specimens were obtained from 46 recently diagnosed AML patients. Real-time qPCR was used to measure the GLI-1 mRNA expression in bone marrow mononuclear cells.Also, the relationship between GLI-1 mRNA levels and clinical variables and prognostic variables was assessed. RESULTS: GLI-1 was overexpressed in the bone marrow samples of our patients...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304484/a-patient-with-acute-erythroid-leukaemia-with-granular-leukaemic-cells-mimicking-megakaryoblast
#10
JOURNAL ARTICLE
Zhaoliang Wang, Jiaquan Guo, Jinlin Liu
No abstract text is available yet for this article.
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304483/bendamustine-rituximab-in-young-cll-relevance-in-the-era-of-small-molecule-inhibitors
#11
JOURNAL ARTICLE
Sukrita Bhattacharjee, Shouriyo Ghosh, Maitreyee Bhattacharyya
PURPOSE: Chemo-immunotherapies like Fludarabine-Cyclophosphamide-Rituximab (FCR) are used for treatment of chronic lymphocytic leukemia (CLL) in young and fit patients while Bendamustine-Rituximab (BR) is used in older patients. In a resource constrained setting, managing toxicities of FCR chemotherapy is challenging and this study explores the use of upfront BR treatment in young CLL patients (age < 65). METHODS: Data of 61 CLL patients treated with the BR regimen between 2016 and 2020 was analysed...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304482/profile-and-predictors-of-infection-following-anti-thymocyte-globulin-or-anti-lymphocyte-globulin-with-cyclosporine-in-aplastic-anemia
#12
JOURNAL ARTICLE
Sharon Anbumalar Lionel, Sushil Selvarajan, Anu Korula, Uday Kulkarni, Anup Devasia, Fouzia N Abubacker, Aby Abraham, Vikram Mathews, Kavitha M Lakshmi, Biju George
Immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and Cyclosporine (CSA) in aplastic anaemia (AA) results in improvement of blood counts between 3 and 6 months for the majority of patients. Infection is the most lethal complication in aplastic anemia and may arise due to several factors. We performed this study to determine the prevalence and predictors of specific infection types before and after IST. Six hundred and seventy-seven (546 adults; 434 males) transplant ineligible patients received ATG and CSA between 1995 and 2017...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304481/transfusion-management-in-a-bleeding-patient-with-rare-h-deficient-blood-group-variant
#13
JOURNAL ARTICLE
Suvro Sankha Datta
No abstract text is available yet for this article.
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304480/correction-to-efects-of-ages-srage-and-hmgb1-on-clinical-outcomes-in-multiple-myeloma
#14
Ayfer Geduk, Berrin Oztas, Baldan Huri Eryılmaz, Esra Terzi Demirsoy, Meral U Menguc, Serkan Unal, Sinan Mersin, Merve Gokcen Polat, Kemal Aygun, Emel Merve Yenihayat, Hayrunnisa Albayrak, Hasim Atakan Erol, Sibel Balcı, Ozgur Mehtap, Pinar Tarkun, Abdullah Hacihanefioglu
[This corrects the article DOI: 10.1007/s12288-022-01574-6.].
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304479/role-of-extracorporeal-membrane-oxygenation-ecmo-and-stem-cell-transplant-in-the-management-of-acute-myeloid-leukaemia-with-pulmonary-involvement
#15
JOURNAL ARTICLE
Shilpa Prabhu, Richard Dillon, Iara Maria Sequeiros, Caroline Besley FrcPath, David Ian Marks
No abstract text is available yet for this article.
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304478/evaluation-of-a-new-method-of-leukocyte-extractions-from-the-leukoreduction-filter
#16
JOURNAL ARTICLE
Zahra Abbasi Malati, Ali Akbar Pourfathollah, Rasul Dabbaghi, Sahar Balagholi, Mohammad Reza Javan
This study's purpose was to optimize the leukocyte extraction protocol and evaluate the efficacy of this new protocol. 12BioR blood filters were collected from Tehran Blood Transfusion Center. A twosyringe system and Multi-step rinsing were designed for cell extraction. The final purpose of this optimization was: (1) removed the residual RBCs, (2) reversed the leukocyte trapping process, and (3) remove the microparticles to obtain the high yield of target cells. Finally, Extracted cells were evaluated by Automated Cell count; Samples smear differential cell count, Trypan blue, and Annexin-PI staining...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304477/infections-associated-hemophagocytosis-secondary-hlh-mimics-in-children
#17
JOURNAL ARTICLE
Bhavika Rishi, Aroonima Misra, Ravneet Kaur, Varsha Mishra, Sonal Jain, Amitabh Singh
Infection-associated hemophagocytosis is a diagnostic challenge. The varied presentation makes timely diagnosis difficult. We report two cases with unusual presentation of well-established secondary triggers for hemophagocytic lymphohistiocytosis.
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304476/body-iron-store-and-its-association-with-risk-of-first-episode-of-spontaneous-lower-extremity-deep-vein-thrombosis-%C3%A2-pulmonary-embolism-a-case-control-study
#18
JOURNAL ARTICLE
Ritwik Dey, Kolar Vishwanath Vinod, Prashant Shankarrao Adole
BACKGROUND AND OBJECTIVES: The association between body iron stores and risk of deep vein thrombosis/ pulmonary embolism (DVT/ PE) has not been studied among Indian subjects. This study aimed to evaluate the same and also study the association between iron stores and recanalization of affected veins at week-12. METHODS: This Case-Control with follow-up study enrolled 85 consecutive adult (≥ 18 years) cases presenting with first episode of spontaneous, proximal lower extremity DVT/ PE and 170 age (± 3 years) and sex matched adult controls without DVT/ PE...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304475/second-allogeneic-hematopoietic-stem-cell-transplantation-for-hemophagocytic-syndrome-with-engraftment-failure
#19
JOURNAL ARTICLE
Fan Jiang, Zhouyang Liu, Zikuan Guo, Juan Xiao, Nanhai Wu, Shifen Fan, Yan Yue, Jiao Chen, Yuan Sun
This study aims to assess the efficacy of second allogeneic hemopoietic stem cell transplantation (allo-HSCT) for treating hemophagocytic syndrome with first engraftment failure. Among a total of 35 patients who underwent allo-HSCT between June 2015 and July 2021 for HLH, 10 patients who underwent a second HSCT following graft rejection were retrospectively analyzed. Various factors, such as the treatment course and outcome, the remission status, donor selection, and the conditioning regimen of patients before second allo-HSCT, were scrutinized for transplant-related complications and transplant-related mortality, as well as transplant outcomes...
July 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37304474/adenopathy-in-multiple-myeloma-an-enigma-unravelled-by-fdg-pet
#20
JOURNAL ARTICLE
Ashish Mohite, Sayak Choudhury, Nilendu Purandare, Tushar Agrawal, Tanuja Shet, Archi Agrawal, Sneha Shah, Ameya Puranik, Venkatesh Rangarajan
No abstract text is available yet for this article.
July 2023: Indian Journal of Hematology & Blood Transfusion
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