Xuzhao Zhou, Yan He, Tao Xu, Zhaofa Wu, Wei Guo, Xi Xu, Yuntao Liu, Yi Zhang, Huiping Shang, Libin Huang, Zhimo Yao, Zewen Li, Lingya Su, Zhihui Li, Tao Feng, Shaomin Zhang, Olivia Monteiro, Rodrigo A Cunha, Zhi-Li Huang, Kang Zhang, Yulong Li, Xiaohong Cai, Jia Qu, Jiang-Fan Chen
Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical underpinning has hampered its therapeutic development. Here, we demonstrate that light flickering triggered an immediate and sustained increase (up to 3 h after flickering) in extracellular adenosine levels in the primary visual cortex (V1) and other brain regions, as a function of light frequency and intensity, with maximal effects observed at 40 Hz frequency and 4000 lux...
February 8, 2024: Cell Research