journal
https://read.qxmd.com/read/38374214/cytolytic-too-granzyme-b-expressing-human-ilc2s-mediate-tumor-rejection
#1
JOURNAL ARTICLE
Hergen Spits, Jenny Mjösberg
No abstract text is available yet for this article.
February 19, 2024: Cell Research
https://read.qxmd.com/read/38351128/car-toner-an-ai-driven-approach-for-car-tonic-signaling-prediction-and-optimization
#2
LETTER
Shizhen Qiu, Jian Chen, Tao Wu, Li Li, Gang Wang, Haitao Wu, Xianmin Song, Xuesong Liu, Haopeng Wang
No abstract text is available yet for this article.
February 14, 2024: Cell Research
https://read.qxmd.com/read/38337022/base-editing-effectively-prevents-early-onset-severe-cardiomyopathy-in-mybpc3-mutant-mice
#3
LETTER
Shuo Wu, Ping Yang, Zilong Geng, Yige Li, Zhizhao Guo, Yingmei Lou, Shasha Zhang, Junhao Xiong, Huan Hu, Xiaoling Guo, William T Pu, Yan Zhang, Dan Zhu, Bing Zhang
No abstract text is available yet for this article.
February 9, 2024: Cell Research
https://read.qxmd.com/read/38332200/convenient-synthesis-and-delivery-of-a-megabase-scale-designer-accessory-chromosome-empower-biosynthetic-capacity
#4
JOURNAL ARTICLE
Yuan Ma, Shuxin Su, Zongheng Fu, Chu Zhou, Bin Qiao, Yi Wu, Ying-Jin Yuan
Synthetic biology confers new functions to hosts by introducing exogenous genetic elements, yet rebuilding complex traits that are based on large-scale genetic information remains challenging. Here, we developed a CRISPR/Cas9-mediated haploidization method that bypasses the natural process of meiosis. Based on the programmed haploidization in yeast, we further developed an easy-to-use method designated HAnDy (Haploidization-based DNA Assembly and Delivery in yeast) that enables efficient assembly and delivery of large DNA, with no need for any fussy in vitro manipulations...
February 8, 2024: Cell Research
https://read.qxmd.com/read/38332199/40-hz-light-flickering-promotes-sleep-through-cortical-adenosine-signaling
#5
JOURNAL ARTICLE
Xuzhao Zhou, Yan He, Tao Xu, Zhaofa Wu, Wei Guo, Xi Xu, Yuntao Liu, Yi Zhang, Huiping Shang, Libin Huang, Zhimo Yao, Zewen Li, Lingya Su, Zhihui Li, Tao Feng, Shaomin Zhang, Olivia Monteiro, Rodrigo A Cunha, Zhi-Li Huang, Kang Zhang, Yulong Li, Xiaohong Cai, Jia Qu, Jiang-Fan Chen
Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical underpinning has hampered its therapeutic development. Here, we demonstrate that light flickering triggered an immediate and sustained increase (up to 3 h after flickering) in extracellular adenosine levels in the primary visual cortex (V1) and other brain regions, as a function of light frequency and intensity, with maximal effects observed at 40 Hz frequency and 4000 lux...
February 8, 2024: Cell Research
https://read.qxmd.com/read/38326479/sensing-the-toxic-aluminum-cations-in-acidic-soils
#6
JOURNAL ARTICLE
Peter R Ryan, Jianli Yang
No abstract text is available yet for this article.
February 7, 2024: Cell Research
https://read.qxmd.com/read/38326478/b-cell-reactive-triad-of-b-cells-follicular-helper-and-regulatory-t-cells-at-homeostasis
#7
JOURNAL ARTICLE
Yihan Lin, Zurong Wan, Bo Liu, Jiacheng Yao, Tianqi Li, Fang Yang, Jianhua Sui, Yongshan Zhao, Wanli Liu, Xuyu Zhou, Jianbin Wang, Hai Qi
Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive B cells are ignorant because of physical segregation from their cognate autoantigen. Unexpectedly, we find that follicular B cell-derived autoantigen, including cell surface molecules such as FcγRIIB, is a class of homeostatic autoantigen that can induce spontaneous germinal centers (GCs) and B cell-reactive autoantibodies in non-autoimmune animals with intact T and B cell repertoires...
February 7, 2024: Cell Research
https://read.qxmd.com/read/38302740/mfsd7c-functions-as-a-transporter-of-choline-at-the-blood-brain-barrier
#8
JOURNAL ARTICLE
Xuan Thi Anh Nguyen, Thanh Nha Uyen Le, Toan Q Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C P Leong, Dat T Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Qianhui Huang, Ling Fam, Lo Ngah Leong, Isabelle Bonne, Angela Lee, Jorge L Granadillo, Catherine Gooch, Dejie Yu, Hua Huang, Tuck Wah Soong, Matthew Wook Chang, Markus R Wenk, Jerzy Adamski, Amaury Cazenave-Gassiot, Long N Nguyen
Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler syndrome. Here, we used Mfsd7c knockout (Mfsd7c-/- ) mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood-brain barrier (BBB). We performed comprehensive metabolomics analysis and detected differential changes of metabolites in the brains and livers of Mfsd7c-/- embryos. Particularly, we found that choline-related metabolites were altered in the brains but not in the livers of Mfsd7c-/- embryos...
February 2, 2024: Cell Research
https://read.qxmd.com/read/38287118/structural-and-functional-characterization-of-the-endogenous-agonist-for-orphan-receptor-gpr3
#9
LETTER
Geng Chen, Nico Staffen, Zhangsong Wu, Xinyu Xu, Jinheng Pan, Asuka Inoue, Tingyi Shi, Peter Gmeiner, Yang Du, Jun Xu
No abstract text is available yet for this article.
January 30, 2024: Cell Research
https://read.qxmd.com/read/38287117/identification-of-oleic-acid-as-an-endogenous-ligand-of-gpr3%C3%A2-corrections
#10
JOURNAL ARTICLE
Yangjie Xiong, Zhenmei Xu, Xinzhi Li, Yuqin Wang, Jing Zhao, Na Wang, Yaning Duan, Ruixue Xia, Zhengbin Han, Yu Qian, Jiale Liang, Anqi Zhang, Changyou Guo, Asuka Inoue, Yu Xia, Zheng Chen, Yuanzheng He
Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, its endogenous ligand remains elusive. Here, by combining structural approach (including cryo-electron microscopy), mass spectrometry analysis, and functional studies, we identify oleic acid (OA) as an endogenous ligand of GPR3. Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane, enabling fatty acids to readily engage the receptor...
January 29, 2024: Cell Research
https://read.qxmd.com/read/38267638/the-roles-and-regulatory-mechanisms-of-tgf-%C3%AE-and-bmp-signaling-in-bone-and-cartilage-development-homeostasis-and-disease
#11
REVIEW
Mengrui Wu, Shali Wu, Wei Chen, Yi-Ping Li
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis. TGF-βs and BMPs transduce signals through SMAD-dependent and -independent pathways; specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique biological readouts. BMPs promote osteogenesis, osteoclastogenesis, and chondrogenesis at all differentiation stages, while TGF-βs play different roles in a stage-dependent manner...
January 24, 2024: Cell Research
https://read.qxmd.com/read/38263279/author-correction-crispr-cas12a-has-both-cis-and-trans-cleavage-activities-on-single-stranded-dna
#12
Shi-Yuan Li, Qiu-Xiang Cheng, Jia-Kun Liu, Xiao-Qun Nie, Guo-Ping Zhao, Jin Wang
No abstract text is available yet for this article.
January 23, 2024: Cell Research
https://read.qxmd.com/read/38263278/the-hidden-face-of-glud1-at-inhibitory-synapses
#13
JOURNAL ARTICLE
Masayuki Itoh, Michisuke Yuzaki
No abstract text is available yet for this article.
January 23, 2024: Cell Research
https://read.qxmd.com/read/38253655/publisher-correction-the-new-horizon-of-plant-auxin-signaling-via-cell-surface-co-receptors
#14
Jen Sheen
No abstract text is available yet for this article.
January 22, 2024: Cell Research
https://read.qxmd.com/read/38253654/cchfv-entry-via-ldlr-keeps-it-ticking
#15
JOURNAL ARTICLE
Ahmed K Oraby, David J Marchant
No abstract text is available yet for this article.
January 22, 2024: Cell Research
https://read.qxmd.com/read/38242944/packaging-monoamine-neurotransmitters
#16
JOURNAL ARTICLE
Ravi Yadav, Cornelius Gati
No abstract text is available yet for this article.
January 19, 2024: Cell Research
https://read.qxmd.com/read/38242943/decoding-t-cell-state-specific-regulomes-in-cancer
#17
JOURNAL ARTICLE
Giulia Escobar, Ana C Anderson
No abstract text is available yet for this article.
January 19, 2024: Cell Research
https://read.qxmd.com/read/38228880/a-dual-purpose-fusion-complex-in-autophagy
#18
JOURNAL ARTICLE
Yan Zhen, Harald Stenmark
No abstract text is available yet for this article.
January 16, 2024: Cell Research
https://read.qxmd.com/read/38212509/a-perfect-storm-sleep-loss-causes-systemic-inflammation-and-death
#19
JOURNAL ARTICLE
Andrew D Nguyen, Paula Carvalho Costa, David M Raizen
No abstract text is available yet for this article.
January 11, 2024: Cell Research
https://read.qxmd.com/read/38200278/the-lrr-receptor-like-kinase-alr1-is-a-plant-aluminum-ion-sensor
#20
JOURNAL ARTICLE
Zhong Jie Ding, Chen Xu, Jing Ying Yan, Yu Xuan Wang, Meng Qi Cui, Jun Jie Yuan, Ya Nan Wang, Gui Xin Li, Jian Xiang Wu, Yun Rong Wu, Ji Ming Xu, Chun Xiao Li, Yuan Zhi Shi, Chuan Zao Mao, Jiang Tao Guo, Jian Min Zhou, Moussa Benhamed, Nicholas P Harberd, Shao Jian Zheng
Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling pathways are mostly unknown. Aluminum (Al) ions are highly phytotoxic, and cause severe crop yield loss and forest decline on acidic soils which represent ∼30% of land areas worldwide. Here we found an Arabidopsis mutant hypersensitive to Al. The gene encoding a leucine-rich-repeat receptor-like kinase, was named Al Resistance1 (ALR1). Al ions binding to ALR1 cytoplasmic domain recruits BAK1 co-receptor kinase and promotes ALR1-dependent phosphorylation of the NADPH oxidase RbohD, thereby enhancing reactive oxygen species (ROS) generation...
January 10, 2024: Cell Research
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