Leila Zahedi Mohammadi, Masoomeh Shams-Ghahfarokhi, Zahra Salehi, Mehdi Razzaghi-Abyaneh
Terbinafine resistance has become epidemic as an emerging problem in treatment of dermatohpytosis. This could be attributed in part to a point mutation in the squalene epoxidase (SQLE) gene. In this study, point mutations in the SQLE gene were studied in T. rubrum and T. mentagrophytes/T. interdigitale species complex as two main causative agents of dermatophytosis. Antifungal susceptibility of clinical isolates of T. rubrum (n = 27) and T. mentagrophytes/T. interdigitale (n = 56) was assessed using the M38-3rd edition CLSI method...
June 16, 2024: Journal de Mycologie Médicale
Marc Sautour, Adrien Guilloteau, Stéphane Valot, Louise Basmaciyan, Eloise Bailly, Nathalie Sixt, Jennifer Tetu, Ingrid Lafon, Denis Caillot, Frédéric Dalle
BACKGROUND: Patients with hematological malignancies are at a high risk of developing invasive fungal infections (IFI) because they undergo several cycles of treatment leading to episodes of neutropenia. In addition, they alternate between hospital stays and periods spent at home. Thus, when an IFI is diagnosed during their hospital stays, it is highly challenging to identify the origin of the fungal contamination. The objective of this study was to analyze at home fungal exposure of 20 patients with leukemia by taking air and water samples in their living residence...
June 8, 2024: Journal de Mycologie Médicale
Abin M Abraham, Mary John, Vikas Loomba, Navjot Singh, Lydia Solomon, Sunil Sam Varghese
MATERIALS AND METHODS: Patients diagnosed with COVID-19 associated mucormycosis were followed up for 6 months to study the clinical profile, readmissions, long-term treatment outcome and the mortality rate. RESULTS: Among 37 patients with COVID-19 associated mucormycosis, the mortality rate was 33.3 %, 42.9% and 100 % among patients with mild, moderate and severe COVID-19 infection. One month after discharge, among the 20 patients who survived, 10 (50 %) patients had worsening symptoms and required readmission...
June 4, 2024: Journal de Mycologie Médicale
J Guitard, A P Bellanger, J Dorin, S Cassaing, A Capitaine, F Gabriel, M Nicolas, N Coron, P Penn, M Moniot, D Quinio, S Ranque, M Sasso, P Lepape, E Dannaoui, S Brun, C Lacroix, M Cornu, A Debourgogne, M F Durieux, G Laurent, V Bru, N Bourgeois, K Brunet, T Chouaki, A Huguenin, L Hasseine, D Maubon, J P Gangneux, N Desbois-Nogard, S Houze, F Dalle, M E Bougnoux, A Alanio, D Costa, F Botterel, C Hennequin
Due to large outbreaks observed worldwide, Candida auris has emerged as a major threat to healthcare facilities. To prevent these phenomena, a systematic screening should be performed in patients transferred from regions where the pathogen is highly endemic. In this study, we recorded and analyzed French mycologists' current knowledge and practice regarding C. auris screening and diagnosis. Thirty-six centers answered an online questionnaire. Only 11 (30.6 %) participants were aware of any systematic screening for C...
June 4, 2024: Journal de Mycologie Médicale
Priscila Guerino Vilela Alves, Ralciane de Paula Menezes, Nagela Bernadelli Sousa Silva, Gabriel de Oliveira Faria, Meliza Arantes de Souza Bessa, Lúcio Borges de Araújo, Paula Augusta Dias Fogaça Aguiar, Mário Paulo Amante Penatti, Reginaldo Dos Santos Pedroso, Denise von Dolinger de Brito Röder
Fungal infections in neonatal intensive care units (NICU) are mainly related to Candida species, with high mortality rates. They are predominantly of endogenous origin, however, cross-infection transmitted by healthcare professionals' hands has occurred. The aim of this study was to identify Candida species isolated from the hands of healthcare professionals in a NICU before and after hygiene with 70% ethanol-based gel and evaluate virulence factors DNase, phospholipase, proteinase, hemolysin, biofilm biomass production, and metabolic activity...
May 9, 2024: Journal de Mycologie Médicale
Hamed Fakhim, Shirin Irani, Zeynab Yassin, Hamid Badali, Elahe Nasri, Yasser Nasoori, Seyedhadi Samimiardestani, Saleh Mohebbi, Mojtaba Mohammadi Ardehali, Pegah Alizadeh Pahlavan, Mohammadreza Firouzifar, Ardavan Tajdini, Samira Ahadi, Afsane Vaezi
OBJECTIVES: The present study aimed to assess the features, clinical characteristics, and species diversity among patients admitted to referral Hospitals for SARS-CoV-2 pneumonia and mucormycosis in Tehran, Iran, and the relationship between seasonal and species diversity was considered. METHODS: Confirmed COVID-19 patients with a positive reverse-transcriptase real-time (rRT-PCR) test for SARS-CoV2 were primarily included based on clinically suspected mucormycosis infection and confirmed by histopathology and mycology examination of biopsy specimens...
April 30, 2024: Journal de Mycologie Médicale
Eliane Devillers, Emeline Scherer, Jean-Chistophe Navellou, Frédéric Grenouillet, Laurence Millon, Anne-Pauline Bellanger
Several lateral flow assays (LFA) capable of detecting Aspergillus fumigatus in serum and broncho-alveolar lavage fluid (BALF) within the hour, thereby potentially accelerating the screening process, are now commercially available. We prospectively compared three LFA targeting A. fumigatus on BALF collected from non-surgical intensive care patients between June 2022 and February 2023. The three LFA tested were Sõna Aspergillus galactomannan LFA (Immy), Fungadia Aspergillus antigen (Gadia), and AspLFD (OLM Diagnostics)...
April 30, 2024: Journal de Mycologie Médicale
Akila Fathallah, Hamed Chouaieb, Moadh Ben Saief, Samar Ismaïl, Moncef Ben Said, David W Denning
With increasing concern about the negative health impact of fungal disease, there is a need to survey what is and is not known about the epidemiology of these infections in Tunisia. We have estimated the incidence and prevalence of the most serious fungal diseases in Tunisia for the first time. Using published literature from Tunisia, or if absent other countries, we have estimated the burden of life-threatening fungal infections and those causing significant morbidity, using deterministic modeling, based on populations at greatest risk...
April 5, 2024: Journal de Mycologie Médicale
Sara Norozipor, Mehdi Bamorovat, Seyyed Amin Ayatollahi Mosavi, Ehsan Salarkia, Sanaz Hadizadeh, Fatemeh Sharifi, Ali Karamoozian, Mehdi Ranjbar, Setareh Agha Kuchak Afshari
INTRODUCTION: Since the drug resistance in Candida species is becoming a serious clinical challenge, novel alternative therapeutic options, particularly herbal medicine, have attracted increasing interest. This study aimed to pinpoint the potential antifungal activity of crocin (Cro), the efficacy of the niosomal formulation of Cro (NCro), and the synergistic activity of both formulations in combination with fluconazole (FLC) against susceptible and resistant C. albicans isolates. MATERIAL AND METHODS: NCro was formulated using the heating method...
April 3, 2024: Journal de Mycologie Médicale
Lida Politi, Georgia Vrioni, Sofia Hatzianastasiou, Malvina Lada, Maria Martsoukou, Nikolaos V Sipsas, Maria Chini, Vasiliki Baka, Eleni Kafkoula, Aikaterini Masgala, Maria Pirounaki, Christos Michailidis, Georgios Chrysos, Olympia Zarkotou, Vasiliki Mamali, Vasileios Papastamopoulos, Georgios Saroglou, Spyros Pournaras, Joseph Meletiadis, Ioannis Karakasiliotis, Stefanos Karachalios, Stavroula Smilakou, Vasiliki Skandami, Maria Orfanidou, Athina Argyropoulou, Athanassios Tsakris, Flora Kontopidou
BACKGROUND: Candida auris was sporadically detected in Greece until 2019. Thereupon, there has been an increase in isolations among inpatients of healthcare facilities. AIM: We aim to report active surveillance data on MALDI-TOF confirmed Candida auris cases and outbreaks, from November 2019 to September 2021. METHODS: A retrospective study on hospital-based Candida auris data, over a 23-month period was conducted, involving 11 hospitals within Attica region...
March 26, 2024: Journal de Mycologie Médicale
Katarzyna Góralska, Małgorzata Szybka, Filip Franciszek Karuga, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska-Lasota
The increasing prevalence of fungal strains showing acquired resistance and multidrug resistance is an increasing therapeutic problem, especially in patients with a severely weakened immune system and undergoing chemotherapy. What is also extremely disturbing is the similarity of the resistance mechanisms of fungal cells and other eukaryotic cells, including human cells, which may contribute to the development of cross-resistance in fungi in response to substances used in e.g. anticancer treatment. An example of such a drug is methotrexate, which is pumped out of eukaryotic cells by ABC transmembrane transporters - in fungi, used to remove azoles from fungal cells...
March 15, 2024: Journal de Mycologie Médicale
Yamara V Sousa, Marie G Santiago, Bianca M de Souza, Kelly M Keller, Camila S F Oliveira, Leonel Mendoza, Raquel V R Vilela, Gisele A C Goulart
Diagnosis and management of fungal infections are challenging in both animals and humans, especially in immunologically weakened hosts. Due to its broad spectrum and safety profile when compared to other antifungals, itraconazole (ITZ) has been widely used in the treatment and prophylaxis of fungal infections, both in human and veterinary medicine. The dose and duration of management depend on factors such as the type of fungal pathogen, the site of infection, sensitivity to ITZ, chronic stages of the disease, the health status of the hosts, pharmacological interactions with other medications and the therapeutic protocol used...
March 11, 2024: Journal de Mycologie Médicale
Adama Zida, Thierry K Guiguemdé, Marcel P Sawadogo, Chanolle Tchekounou, Ibrahim Sangaré, Sanata Bamba
Histoplasmosis is a mycosis due to a dimorphic fungus Histoplasma capsulatum. This study aimed at providing an overview of histoplasmosis epidemiological, clinical, diagnostic, and therapeutic aspects from the last 30 years. This review was carried out using a systematic literature search on histoplasmosis from 1992 to 2021. We describe the clinical features, diagnostic methods and treatment. Empirical searches were conducted via the databases PubMed, Google Scholar and Science Direct. Between 1992 and 2021, 190 manuscripts were published and reported 212 cases of histoplasmosis...
March 11, 2024: Journal de Mycologie Médicale
Simone Merkel, Bruna Pippi, Paula Reginatto, Angélica R Joaquim, Gabriella R M Machado, Daiane Heidrich, Marina E Furasté, Jonnathan A Silva, Estela J S Konzen, Maria Lúcia Scroferneker, Saulo F Andrade, Alexandre M Fuentefria, Régis A Zanette
Malassezia pachydermatis is often reported as the causative agent of dermatitis in dogs. This study aims to evaluate the in vitro and in vivo antifungal activity of azoles and terbinafine (TRB), alone and in combination with the 8-hydroxyquinoline derivatives (8-HQs) clioquinol (CQL), 8-hydroxyquinoline-5-(n-4-chlorophenyl)sulfonamide (PH151), and 8-hydroxyquinoline-5-(n-4-methoxyphenyl)sulfonamide (PH153), against 16 M. pachydermatis isolates. Susceptibility to the drugs was evaluated by in vitro broth microdilution and time-kill assays...
March 11, 2024: Journal de Mycologie Médicale
Florian Bélik, Corentin Deckers, Mehdi Khourssaji, Te-Din Huang, Olivier Denis, Isabel Montesinos
PURPOSE: Antifungal susceptibility testing (AFST) is essential to ensure appropriate antifungal therapy in candidaemia. This study compared two commercial colorimetric broth microdilution tests: Sensititre YeastOne (SYO; Thermo Scientific) and Micronaut-AM EUCAST AFST (M-AM; Bruker) for the AFST of Candida spp. MATERIAL AND METHODS: A total of 74 yeast strains, including C. albicans (n = 40) and non-albicans Candida species (NACS) (n = 34), were obtained from blood cultures of patients admitted to a tertiary care hospital in Belgium from 2017 to 2022...
March 2024: Journal de Mycologie Médicale
Cristel Rodríguez-Vargas, Ana Alastruey-Izquierdo, David W Denning, Ana Belén Araúz
Data published on Panamanian fungal disease are scarce, mostly case reports. To date, there is no paper that compiles the burden of fungal disease Here we estimate for the first time the incidence and prevalence of fungal diseases in Panama. Data on fungal disease were obtained from different search engines: PubMed, Google Scholar, Scielo and Lilacs. For population and at risk diseases, we used statistics from worldometer, UNAIDS, and WHO. Incidence, prevalence, and absolute numbers were calculated based on the population at risk...
March 2024: Journal de Mycologie Médicale
Aakash Mahesan, Abin Sheref Mohammed, Gautam Kamila, Prashant Jauhari, Biswaroop Chakrabarty, Sumanta Das, Prasenjit Das, Vaishali Suri, Sudesh Gourav, Immaculata Xess, Atin Kumar, Sheffali Gulati
A 3-year-old boy presented with acute headache, vomiting and right focal clonic seizures without history of fever, joint pain or altered sensorium. Neuroimaging showed multifocal contrast enhancing lesions with significant perilesional edema. CECT chest and abdomen showed multiple variable sized nodules in the lungs and hypodense lesion in liver with mesenteric lymphadenopathy. There was persistent eosinophilia with maximum upto 35 %. Liver biopsy and brain biopsy revealed Cladophialophora bantiana. He was treated with IV liposomal amphotericin and voriconazole for 6 weeks with repeat neuroimaging showing more than 50 % resolution of the intracranial lesions...
February 24, 2024: Journal de Mycologie Médicale
Bárbara da Costa, Bruna Pippi, Magda Chaves, Giovanna Agostineto, Alexandre Meneghello Fuentefria
INTRODUCTION: The cases of dermatophytosis are increasing and they are associated with a higher number of therapeutic failures leading the doctor to prescribe combinations of antifungals as therapy. The objective was to evaluate the interaction of terbinafine and ciclopirox, the most commonly antifungals used in the clinic, in dermatophyte isolates. METHODOLOGY: The minimum inhibitory concentrations (MIC) of ciclopirox and terbinafine were determined by the broth microdilution method according CLSI and the checkerboard assay was used to evaluate the interaction between the antifungal agents...
February 10, 2024: Journal de Mycologie Médicale
Gilles Nevez, Gaelle Guillerm, Jean-Philippe Talarmin, Dorothée Quinio, Xavier Iriart, Pierre-Luc Lissillour, Schéhérazade Rezig, Marie-Sarah Fangous, Marion Ranty, Laetitia Bodenes, Cécile Aubron, Marie-Anne Couturier, Solène Le Gal
Hormographiella aspergillata is a basidiomycete exceptionally involved in invasive fungal infections (IFI). We report a case of H. aspergillata pulmonary infection in a 30-year-old female in a context of pancytopenia and relapsed of acute myeloid leukemia (AML). She presented with fever, thoracic pain, left pleural effusion and pneumonia, diagnosed on chest X-ray and CT-scan. Direct examination of a bronchoalveolar lavage (BAL) specimen performed on day (d) 10 was negative, while the culture was positive on d30...
February 4, 2024: Journal de Mycologie Médicale
Zeynep Cansu Caliskan, Gizem Karahan, Neslihan Koray, Yasin Gokcinar, Dolunay Gülmez, Sevtap Arikan-Akdagli, Serhat Unal, Omrum Uzun
Antifungal prophylaxis with a mold-effective agent has led to a substantial decrease in invasive infections caused by Aspergillus spp. in the management of patients with acute myeloid leukemia undergoing induction chemotherapy. However, difficult-to-treat infections caused by other molds, such as Fusarium, Lomentospora, and Scedosporium species may still complicate the neutropenic period. Here, we present a case of a 23-year-old woman with acute myeloid leukemia who developed a breakthrough invasive fungal rhinosinusitis caused by Fusarium proliferatum/annulatum on posaconazole prophylaxis...
January 27, 2024: Journal de Mycologie Médicale
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