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Revista Iberoamericana de Micología

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https://read.qxmd.com/read/30765275/antifungal-susceptibility-of-saccharomyces-cerevisiae-and-therapy-in-a-murine-model-of-disseminated-infection
#1
Alba Pérez-Cantero, Pamela Thomson, Katihuska Paredes, Josep Guarro, Javier Capilla
BACKGROUND: The incidence of systemic infections by Saccharomyces cerevisiae has increased in recent years, especially among immunocompromised patients. Amphotericin B, voriconazole or echinocandins have been used with favorable outcome against systemic infections by this fungus. However, clinical experience is limited and no in vivo studies have been conducted. AIMS: We evaluated the in vitro activity of nine antifungal compounds against S.cerevisiae and the in vivo efficacy of those three antifungals showing the highest in vitro activity by using a murine model of systemic infection...
February 11, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30745018/simvastatin-and-other-inhibitors-of-the-enzyme-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-of-ustilago-maydis-um-hmgr-affect-the-viability-of-the-fungus-its-synthesis-of-sterols-and-mating
#2
Blanca Rosales-Acosta, Aarón Mendieta, Clara Zúñiga, Joaquín Tamariz, César Hernández Rodríguez, José Antonio Ibarra-García, Lourdes Villa-Tanaca
BACKGROUND: The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgr) catalyzes the synthesis of mevalonate, a key compound for the synthesis of cholesterol in humans and ergosterol in fungi. Since the Hmgr enzymes of Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida glabrata are similar to the Hmgr enzymes of mammals, fungal Hmgr enzymes have been proposed as a model for studying antifungal agents. AIMS: To examine the correlation between inhibiting Um-Hmgr enzyme and the viability, sterols synthesis and mating in Ustilago maydis...
February 7, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30704831/false-positive-results-in-the-galactomannan-platelia%C3%A2-aspergillus-assay-with-generic-piperacillin-tazobactam
#3
LETTER
Edgar Ortiz-Brizuela, Andrea Rangel-Cordero, Alfredo Ponce-de-León, Juan Sierra-Madero
No abstract text is available yet for this article.
January 28, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30691952/activity-of-antifungal-agents-alone-and-in-combination-against-echinocandin-susceptible-and-resistant-candida-parapsilosis-strains
#4
Francieli Chassot, Tarcieli Pozzebon Venturini, Fernanda Baldissera Piasentin, Janio Morais Santurio, Terezinha Inez Estivalet Svidzinski, Sydney Hartz Alves
BACKGROUND: Candida parapsilosis may acquire resistance to echinocandins, a fact that prompts the search for new therapeutic options. AIMS: The present study aimed to evaluate the in vitro activity of antifungal agents, alone and in combination, against four groups of C. parapsilosis strains: (1) echinocandin-susceptible (ES) clinical isolates (MIC ≤ 2μg/ml), (2) anidulafungin-resistant strains (MIC ≥ 8μg/ml), (3) caspofungin-resistant strains (MIC ≥ 8μg/ml), and (4) micafungin-resistant strains (MIC ≥ 8μg/ml)...
January 25, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30691951/dermatophytosis-caused-by-nannizzia-nana-in-two-siblings
#5
Alexandro Bonifaz, Berenice Córdoba-García, Tania Simancas-Llanos, Marco A Hernández, Erick Martínez-Herrera, Andrés Tirado-Sánchez
BACKGROUND: Nannizzia nana is a zoophilic dermatophyte that affects animals like pigs, boars and, exceptionally, humans, in whom it causes tinea capitis, as well as tinea corporis and onychomycosis. CASE REPORT: Case 1. A previously healthy 8 year-old boy presented to our clinic with a 1-month evolution dermatosis that affected scalp, developing a pseudoalopecic tumor lesion with abundant seropurulent material. The patient had worked in a pig farm. Case 2. A previously healthy 6 year-old girl, sister of the aforementioned child, presented to our clinic with a dermatosis characterized by multiple erythematous-scaly plaques that affected her face, trunk and arms...
January 25, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30686747/anti-candidaalbicans-germ-tube-antibodies-reduce-in-vitro-growth-and-biofilm-formation-of-c-albicans
#6
Giulia Carrano, Simona Paulone, Lucía Lainz, María-Jesús Sevilla, Elisabetta Blasi, María-Dolores Moragues
BACKGROUND: Invasive candidiasis by Candida albicans is associated with high morbidity and mortality, due in part to the late implementation of an appropriate antifungal therapy hindered by the lack of an early diagnosis. AIMS: We aimed to evaluate the in vitro antifungal activity of the antibodies against C. albicans germ tubes (CAGTA) raised in a rabbit model of candidemia. METHODS: We measured the effect of CAGTA activity by colorimetric XTT and crystal violet assays, and colony forming units count, both on C...
January 24, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30686746/-uncommon-mycoses
#7
Lourdes Viñuela, Marta Domínguez-Gil, Mónica de Frutos, Luis López-Urrutia, Carmen Ramos, José María Eiros
BACKGROUND: Fungal infections should be suspected in severe wounds that have been contaminated with organic material or soil, even when the patient is immunocompetent. The aim of this article is to contribute to a better understanding and knowledge of the antifungal sensitivity and epidemiology of some rare pathogens that may trigger severe infections. CASE REPORT: Four different moulds were isolated from the wounds of an immunocompetent woman who was involved in a road accident: Lichtheimia corymbifera, Scedosporium boydii, Fusarium solani and Purpureocillium lilacinum...
January 24, 2019: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30503225/-obstructive-tracheobronchitis-due-to-aspergillus-fumigatus-in-an-immunocompetent-patient
#8
Alberto Romero-Palacios, Oliva Mera Gallardo, Patricia Jiménez Aguilar, José Javier Borrallo Torrejón, Carmen Maza Ortega, Manuel A Rodriguez-Iglesias
BACKGROUND: Aspergillus tracheobronchitis (ATB) is an uncommon type of invasive pulmonary aspergillosis in which fungal involvement is limited to the tracheobronchial tree. While the more severe forms, such as pseudomembranous and ulcerative ATB, occur almost exclusively in immunocompromised patients, the milder obstructive form may occur in patients without immune deficiency. CASE REPORT: The case of a 32 year-old man with no previous history of illness, who was evaluated for recurrent right lower lobe pneumonia, is presented...
November 29, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30477963/-pharmacological-profile-of-isavuconazole
#9
José Ramón Azanza Perea, Belén Sádaba Díaz de Rada
Isavuconazole is a new azole, structurally related to fluconazole and voriconazole, that presents a very high oral absorption with no first-pass effect which is not interfered by the presence of food, gastric pH modifications, or mucositis. Its distribution volume is very high, probably also to cerebrospinal fluid, in spite of the fact that it circulates highly bound to plasma proteins. It is extensively metabolized through the CYP3A4 isoenzyme. Due to this reason, it is recommended to avoid co-administration with strong CYP3A4 inducers...
November 23, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30471896/-the-treatment-of-mucormycosis-zygomycosis-in-the-21st-century
#10
Isabel Ruiz Camps, Miguel Salavert Lletí
Infections due to zygomycetes, caused by mucorales and entomophthorales, are characterized by angioinvasion and invasion of neighboring organs or structures. Mucorales most commonly cause rhinocerebral, pulmonary, cutaneous or disseminated infection and its spread is favored by several diseases (such as diabetes or chronic kidney disease) and risk factors (neutropenia, immunosuppression, iron overload). They have a high mortality rate, and the key to success in their treatment are early diagnosis, prompt administration of antifungal treatment, and extensive surgical debridement...
November 21, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30471895/-microbiological-diagnosis-of-invasive-mycosis
#11
Julio García, Javier Pemán
The prognosis of invasive fungal infections (IFI) depends on the speed of diagnosis and treatment. Conventional diagnostic methods are of low sensitivity, laborious and too slow, leading to the need for new, faster, and more efficient diagnostic strategies. There are several techniques for diagnosing a candidemia that are faster than the conventional blood culture (BC). Once yeast growth in BC is detected, species identification can be speeded up by mass spectrometry (30minutes), commercialised molecular techniques (60-80minutes) or fluorescent in situ hybridization (90minutes)...
November 21, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30467000/-invasive-aspergillosis-in-solid-organ-transplantation
#12
José Tiago Silva, Julián Torre-Cisneros, José María Aguado
Solid organ transplant (SOT) recipients have a high risk for developing invasive fungal infections (IFI). Treatment is difficult due to the interaction between the antifungal and immunosuppressant drugs, as well as the risk of hepatotoxicity and kidney failure associated with voriconazole and amphotericinB, respectively. Isavuconazole is a new antifungal triazole agent with excellent oral bioavailability, predictable and linear pharmacokinetics, good tolerance and low adverse effects. It has been approved for the treatment of invasive aspergillosis and mucormycosis...
November 19, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30466999/-epidemiology-of-invasive-mycoses-a-landscape-in-continuous-change
#13
Guillermo Quindós
The landscape of invasive mycoses is in a continuous evolution with important implications for their diagnosis and treatment. The overall burden remains high, particularly in neonates and the elderly, patients admitted to intensive care units, using prostheses, catheters or other intravenous devices, those receiving different immunosuppressant treatments or antineoplastic chemotherapy, or transplant recipients. In addition, opportunistic mycoses can be associated with HIV infection. Many fungal infections are acquired by inhalation, direct contact or ingestion, but fungi can also enter into the bloodstream through needles or catheters...
November 19, 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30554674/-invasive-aspergillosis-in-critically-ill-patients
#14
Paula Ramírez, José Garnacho-Montero
Critically ill patients without severe immunosuppression make up a population in which invasive aspergillosis (IA) has been identified as an emergent pathology. Chronic treatment with corticosteroids, chronic obstructive pulmonary disease, and liver cirrhosis are repeatedly identified risk factors. However, due to the non-specificity of the symptoms and signs in the critical patient, and the relative low diagnostic capacity of the complementary tests, the diagnosis of the IA is a challenge for the specialist in critical care medicine...
October 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30554673/-invasive-aspergillosis-in-the-patient-with-oncohematologic-disease
#15
Carlos Solano, Lourdes Vázquez
Invasive aspergillosis is the most common invasive fungal infection in patients with acute hematological malignancies or treated with hematopoietic stem cell transplantation due to the marked alteration of the physiological mechanisms of antifungal immunity that takes place in these situations. For this reason, antifungal prophylaxis has a relevant role in these patients. The introduction of new antifungal agents has motivated the updating of recommendations for prophylaxis and treatment in different guidelines...
October 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30455108/-current-therapeutic-options-in-invasive-mycosis-and-potential-therapeutic-role-of-isavuconazole
#16
Carolina Garcia-Vidal
The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections: invasive candidiasis, aspergillosis, mucormicosis, infections caused by other filamentous fungi and those caused by dimorphic fungi.
October 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30343837/t2-magnetic-resonance-for-the-diagnosis-of-deep-seated-invasive-candidiasis-in-a-liver-recipient-without-candidemia
#17
Jesus Fortún, Francesca Gioia, Patricia Muñoz, Javier Graus, Elia Gómez-García de la Pedrosa, Pilar Martín-Dávila, Ana Saiz, Antonio Vena, Santiago Moreno
BACKGROUND: T2 magnetic resonance imaging (T2MR) is a new method for the diagnosis of invasive candidiasis, although most studies have analyzed its role in patients with candidemia or not infection. CASE REPORT: We present the case of a patient with arteritis and thrombosis of the hepatic graft resulted from an undocumented fungal infection in the explanted liver.T2MR in serum was a suitable diagnostic tool for the diagnosis of the deep-seated invasive candidiasis in the absence of candidemia or the isolation of the yeast in culture...
July 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30343836/evaluation-of-the-vitek-ms%C3%A2-system-in-the-identification-of-candida-isolates-from-bloodstream-infections
#18
Carlos Ruiz de Alegría Puig, Jesús Agüero-Balbín, Carlos Fernández-Mazarrasa, Luis Martínez-Martínez
BACKGROUND: Matrix-assisted laser desorption-time of flight mass spectrometry (MALDI-TOF-MS) represents a revolution in the identification of microorganisms of clinical interest. Many studies have confirmed the accuracy and fastness of this tool with routine strains. AIMS: To identify clinical isolates of Candida from patients diagnosed with candidemia. METHODS: Vitek-MS™ system was used with a collection of 298 blood isolates of the genus Candida represented by 9 different species...
July 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30274955/-clinical-features-and-outcome-in-patients-with-mucormycosis-in-a-tertiary-hospital-2012-2016
#19
Marc Xipell, Ricardo Arturo Losno, Carolina Garcia-Vidal, Montserrat Rovira, Izaskun Alejo-Cancho, Jorge Puig de la Bellacasa, Miriam López, Celia Cardozo, Marta Bodro, Josep Mensa, Alex Soriano
BACKGROUND: The most common presentation of mucormycosis in the past was the nasosinusal involvement in patients with diabetic ketoacidosis. However, in the last few years, new groups of patients with risk of mucormycosis have emerged. AIMS AND METHODS: Retrospective analysis of the characteristics, treatment and evolution of patients with mucormycosis in a tertiary hospital in the years 2012-2016. RESULTS: Of the 12 patients included in the study, 7 had a haematological disease as a predisposing factor, most of them (6 patients) related to transplantation of haematopoietic progenitors...
July 2018: Revista Iberoamericana de Micología
https://read.qxmd.com/read/30274954/-first-report-of-a-case-of-fungal-keratitis-due-to-curvularia-hominis-in-spain
#20
Ana Miqueleiz Zapatero, Cristina Hernando, Josefa Barba, Buenaventura Buendía
BACKGROUND: Dematiaceous fungal genus Curvularia is a causal agent of keratitis, onychomycosis, and skin infections. In 2014, using DNA sequencing techniques, five new species, including Curvularia hominis, were described. In this article, a report is presented on the first clinical case of C.hominis infection in Spain. It concerns a corneal ulcer caused by this recently described species. CASE REPORT: A 46 year-old male patient with a corneal ulcer in his left eye went to the Emergency Department...
July 2018: Revista Iberoamericana de Micología
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