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Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti

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https://read.qxmd.com/read/30894002/stereotactic-body-radiotherapy-current-indications
#1
P Burkoň, M Slavik, T Kazda, P Pospíšil, T Prochazka, M Vrzal, P Šlampa
BACKGROUND: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses of radiation to a small number of fractions using specially equipped linear accelerators, modern immobilization devices, and imaging methods, which are considered special, advanced techniques in modern day radiotherapy. SBRT is a very well tolerated, non-invasive, short-term treatment that does not require hospitalization or any complicated preparation. Compared to standard radiotherapy techniques, SBRT allows, due to its precision, significantly higher doses to be applied to the target with less damage to surrounding healthy tissues...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764633/effective-immunotherapy-of-glioblastoma-in-an-adolescent-with-constitutional-mismatch-repair-deficiency-syndrome
#2
Z Pavelka, K Zitterbart, H Nosková, V Bajčiová, O Slabý, J Štěrba
BACKGROUND: Individuals with constitutional mismatch repair-deficiency syndrome (CMMR-D) are characterised by early occurrence of colon cancer, haematological malignancies, and brain tumors (malignant gliomas, high-grade gliomas) in childhood, adolescence, and early adulthood. High mutational tumor burden is typical of glioblastoma in CMMR-D patients and could be a reason why this type of glioblastoma responds well to immunotherapies, including those that employ checkpoint inhibitors...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764632/development-of-resistant-gvhd-in-a-patient-treated-with-nivolumab-for-hodgkins-lymphoma-relapse-after-allogeneic-unrelated-transplantation
#3
K Steinerová, P Jindra, D Lysák, M Karas
BACKGROUND: Allogeneic hematopoietic stem cell transplantation is one of the therapeutic options for patients with relapsed or refractory classic Hodgkins lymphoma (cHL). In the case of dis-ease relapse after transplant, other treatment options are still limited (for example donor lymphocyte infusion, and chemother-apy with brentuximab, bendamustine, or other agents) with uncertain outcomes in terms of patient tolerance and long-term dis-ease remission. One way to achieve remission is administration of the PD-1 inhibitor nivolumab, a PD-1 checkpoint inhibitor...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764631/effect-of-tumor-size-and-p16-status-on-treatment-outcomes-achievement-of-complete-remission-in-prospectively-followed-patients-with-oropharyngeal-tumors
#4
M Slavik, T Kazda, I Selingerová, J Šána, P Ahmad, D Gurín, M Hermanová, T Novotný, R Červená, R Dymáčková, P Burkoň, O Slabý, P Šlampa
BACKGROUND: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764630/high-dose-rate-brachyther-apy-in-the-treatment-of-early-stages-of-penile-carcinoma
#5
D Pohanková, I Sirák, L Kašaová, J Grepl, P Paluska, M Louda, L Holub, J Špaček, P Prošvic, J Petera
BACKGROUND: Interstitial low dose rate brachyther-apy is established organ spar-ing treatment of T1- T2 penile carcinoma. Experience with high-dose rate brachyther-apy is limited in this indication. MATERIALS AND METHODS: Twenty-six patients with early penile carcinoma were treated by high-dose rate brachyther-apy at dose 18 × 3 Gy per fraction twice daily between 2002- 2018 at the Department of Oncology and Radiother-apy, University Hospital in Hradec Kralove...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764629/epidemiology-of-plasma-cell-leukemia-in-the-czech-republic
#6
M Zapletalova, D Krejci, J Jarkovský, J Muzik, L L Pour Dusek
BACKGROUND: Plasma cell leukemia (PCL) is a rare but most aggressive form of monoclonal gammopathies. PCL is characterized by the presence of clonal plasma cells in peripheral blood. There are two forms of PCL - primary which presents de novo in patients with no evidence of previous multiple myeloma and secondary which is a leukemic transformation of relapsed or refractory dis-ease in patients with previously recognized multiple myeloma. MATERIALS AND METHODS: This is the first study to provide information on PCL epidemiology in the Czech population us-ing The Czech National Cancer Registry (CNCR) as the basic source of data for the population-based evaluation of PCL epidemiology...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764628/plasma-cell-leukemia-%C3%A2-the-forgotten-dis%C3%A2-ease
#7
M Žárska, D Vrábel, R Bezdekova, M Štork, M Jarošová, Z Adam, M Krejčí, L Pour, S Ševčíková
BACKGROUND: Plasma cell leukemia (PCL) is a rare dis-ease and possibly the most aggressive form of monoclonal gammopathy. It is classified into two forms -  primary PCL that occurs without a previously identifiable multiple myeloma stage, and secondary PCL that develops from previously dia-gnosed multiple myeloma. These two forms have different cytogenetic and molecular profiles, but both forms have an aggressive clinical course. Combinations of different therapeutic approaches includ-ing autologous stem cell transplantation and currently proteasome inhibitors and immunomodulatory drugs are used to treat PCL...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764627/malignant-tumors-of-the-penis-dia-gnostics-and-therapy
#8
B Mrinakova, M Ondrušová, M Švantnerová, D Ondruš
BACKGROUND: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). The geographical distribution of malignant cancer of the penis is reported. A higher incidence is observed in less developed parts of the world, particularly in South America, Southeast Asia, and some areas of Africa (> 2.0/100,000). In Slovakia, there has been a recent increase in incidence (1...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764626/is-there-a-benefit-of-her2-positive-breast-cancer-subtype-determination-in-clinical-practice
#9
I Kolářová, J Vaňásek, K Odrážka, L Dušek, Z Šinkorová, A Hlávka, J Štuk, J Stejskal, D Dvořáková, L Sákra, J Mergancová, Z Vilasová
BACKGROUND: Breast cancer (BC) with increased expression of human epidermal growth factor receptor 2 with tyrosine kinase activity (HER2+) is a clinically and bio-logically heterogeneous dis-ease. In terms of gene expression, there are four major molecular subtypes - Luminal A, Luminal B, HER2-enriched (HER2-E), and Basal-like. The most common subtype is HER2-E (50- 60%). In hormone-dependent (HR+) HER2-positive tumors, the subgroup HER2-E represents 40- 50% of cases; others are luminal A and B subtypes...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545227/influence-of-gastrointestinal-flora-in-the-treatment-of-cancer-with-immune-checkpoint-inhibitors
#10
L Mendoza
The author declares he has no potential conflicts of interest concerning drugs, pro-ducts, or services used in the study. The Editorial Board declares that the manu-script met the ICMJE recommendation for biomedical papers. Submitted: 4. 10. 2018 Accepted: 14. 10. 2018.
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545226/animal-type-melanoma-a-mini-review-concern-ing-one-of-the-rarest-variants-of-human-melanoma
#11
L Roncati, F Piscioli
The authors declare they have no potential conflicts of interest concerning drugs, pro-ducts, or services used in the study. The Editorial Board declares that the manu-script met the ICMJE recommendation for biomedical papers. Submitted: 17. 6. 2017 Accepted: 1. 11. 2018.
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545225/dia-gnostic-challenges-and-extraordinary-treatment-response-in-rare-malignant-pecoma-tumor-of-the-kidney
#12
S Huľová, Z Sycova-Mila, D Macák, P Janega, M Chovanec, J Mardiak, M Mego
BACKGROUND: Epithelioid angiomyolipoma (EAML) of the kidney, in contrast to classic benign renal angiomyolipoma, is a rare mesenchymal neoplasm with malignant potential. Represent-ing a member of the perivascular epithelioid cells (PEComa) tumor family aris-ing from the perivascular epithelioid cells, its accurate dia-gnosis and therapeutic approach remains challenging. METHODS: We report a case of a patient with malignant EAML, initially treated as renal cell carcinoma (RCC) at our institution...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545224/use-of-the-metal-deletion-technique-for-radiotherapy-planning-in-patients-with-cardiac-implantable-devices
#13
A Odlozilikova, A Kurzyukova, M Sepsi, D Pospisil, P Slampa
BACKGROUND: The number of cancer patients with cardiac implantable electronic devices receiving radiotherapy is increasing. Irradiation of such patients can cause malfunctions in pacemakers and implantable cardioverter-defibrillators. In this respect, it is necessary to make a proper irradiation plan for such cancer patients to minimize the dose received by both cardiac devices and pacing leads. However, planning computed tomography (CT) scans have metal artifacts that degrade the image quality and make it difficult to create a qualitative radiation plan...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545223/down-regulation-of-tsga10-aurkc-oip5-and-akap4-genes-by-lactobacillus-rhamnosus-gg-and-lactobacillus-crispatus-sj-3c-us-supernatants-in-hela-cell-line
#14
Z Nouri, N Neyazi, Modarressi, F Karami, A Abedin-Do, Z Taherian-Esfahani, S Ghafouri-Fard, E Motevaseli
BACKGROUND: Cancer testis antigens (CTAs) are considered cancer bio-markers due to their highly specific expression pattern in human malignancies and near absence from normal somatic tissues. Their specific expression has made them potential targets for early dia-gnosis, assessment of patients prognosis and treatment of cancer in recent years. Lactobacilli are a group of probio-tics with anti-cancer, immunomodulatory and other beneficial features. These bacteria have been shown to alter expression of several cancer-related genes...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545222/infiltration-of-prostate-cancer-by-cd204-and-cd3-cells-correlates-with-erg-expression-and-tmprss2-erg-gene-fusion
#15
A Burdova, P Rulisek, J Bouchal, M Král, V Student, Z Kolar
BACKGROUND: The aim of the study was to detect CD204 + and CD3 + cells in the infiltrate of benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostatic cancer in prostate specimens after radical prostatectomy. Another goal was to determine correlation of the intensity of the infiltration with ERG oncoprotein expression as well as with the presence of activat-ing translocation TMPRSS2-ERG. MATERIALS AND METHODS: To confirm the translocation, we used fluorescence in situ hybridization...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30545221/long-non-cod-ing-rna-signature-in-cervical-cancer
#16
M Taheri, S Ghafouri-Fard
BACKGROUND: Cervical cancer as a common urogenital cancer among women has caused significant health problems. Efforts have been made to identify its pathogenic process in order to find targeted ther-apies. Long non-cod-ing ribonucleic acids (lncRNAs) have been shown to regulate several cancer-related pathways and genes that contribute to pathogenesis of human malignancies, includ-ing cervical cancer. In the present review, we searched PubMed, Google scholar, Web of Science and Scopus databases for key words "cervical cancer" or "cervical neoplasm" and "long non-cod-ing RNA" or "lncRNA" (up to December 2017)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30541326/afatinib-in-the-treatment-of-advanced-non-small-cell-lung-cancer-with-rare-egfr-in-exon-18-t179x-mutation-a-case-report
#17
Čoupková Helena, Vyzula Rostislav
INTRODUCTION: Exon 18-T719X EGFR mutation in non-small cell lung cancer is rare, only 1-5% of all EGFR mutations. The efficacy of EGFR tyrosin kinase inhibitors in tumours with uncommon mutations is still unclear and the prediction of response of such tumours to therapy remains unexplored. CASE: A 71-year-old woman with no previous smoking history with disseminated lung adenocarcinoma with exon 18-T719X EGFR mutation was treated with afatinib. A partial response was achieved in 2 months, progression-free survival was 19 months...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30541325/solid-pseudopapillary-tumor-of-the-pancreas-rare-neoplastic-disease-in-20-year-old-woman
#18
Fichtl Jakub, Skalický Tomáš, Vodička Josef, Třeška Vladislav, Tupý Radek, Hes Ondřej
INTRODUCTION: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively rare affliction representing less than 4% of cystic PC. Although the tumor is considered benign, metastasis, especially to the spleen, has been reported in approximately 0.5-4% patients. Despite R0 resection, vascular and perineural invasion is monitored in 20% of cases...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30541324/pituitary-metastasis-in-a-patient-with-pulmonary-adenocarcinoma-presenting-with-a-disturbance-of-consciousness
#19
Cahajlová Radka, Kollerová Jana
BACKGROUND: Brain metastases are one of the main causes of morbidity and mortality of patients with oncological disease. In non-small cell lung carcinoma (NSCLC), the risk of CNS secondary development is 30-50%. An unusual diagnostic and therapeutic problem is the finding of suspicious pituitary lesions. Obtaining a differential diagnosis relies on evaluating the clinical course of the disease (visual disturbances, diabetes insipidus (DI), weakness etc.), and performing endocrinological examinations and imaging analyses (CT, but mainly MRI)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30541323/tumor-to-tumor-metastasis-a-unique-case-of-clear-cell-renal-cell-carcinoma-harboring-metastasis-of-adenocarcinoma-of-unknown-origin
#20
Bartoš Vladimír
BACKGROUND: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin. CASE: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. A histology of lesion in the kidney revealed a conventional clear cell renal cell carcinoma (RCC) harboring multiple metastatic foci of another adenocarcinoma...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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