journal
https://read.qxmd.com/read/38541204/relationship-between-xpa-xpb-ercc3-xpf-ercc4-and-xpg-ercc5-polymorphisms-and-the-susceptibility-to-head-and-neck-carcinoma-a-systematic-review-meta-analysis-and-trial-sequential-analysis
#41
REVIEW
Mohammad Moslem Imani, Masoumeh Basamtabar, Sattar Akbari, Edris Sadeghi, Masoud Sadeghi
Background and Objectives : Nucleotide Excision Repair (NER), the most extensively researched DNA repair mechanism, is responsible for repairing a variety of DNA damages, and Xeroderma Pigmentosum (XP) genes participate in NER. Herein, we aimed to update the previous results with a meta-analysis evaluating the association of XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 polymorphisms with the susceptibility to HNC. Materials and Methods : PubMed/Medline, Web of Science, Scopus, and Cochrane Library databases were searched without any restrictions until 18 November 2023 to find relevant studies...
March 14, 2024: Medicina
https://read.qxmd.com/read/38541203/primary-thyroid-lymphoma-a-retrospective-observational-study-in-a-single-institutional-center
#42
JOURNAL ARTICLE
Octavia Vita, Alis Dema, Robert Barna, Remus Cornea, Dan Brebu, Mihaela Vlad, Oana Popa, Ioana Muntean, Diana Szilagyi, Mihaela Iacob, Maria Iordache, Marioara Cornianu, Dorela Codruta Lazureanu
Background and Objectives : primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. Materials and Methods : this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50-80 years) diagnosed with PTL. Results : nine patients (81.81%) presented a tumor with progressive growth in the anterior cervical region, usually painless and accompanied by local compressive signs...
March 14, 2024: Medicina
https://read.qxmd.com/read/38541202/the-role-of-continuous-glucose-monitoring-in-detecting-early-dysglycemia-and-clinical-outcomes-in-patients-with-cystic-fibrosis
#43
REVIEW
Lora Stanka Kirigin Biloš, Velimir Altabas, Andrea Vukić Dugac, Maja Baretić
Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). CFRD has been correlated with important clinical outcomes, including poor nutrition, reduced pulmonary function, and earlier mortality. However, clinical decline due to abnormalities of blood glucose (dysglycemia) begins early in CF, before the diagnosis of CFRD by the gold-standard oral glucose tolerance test (OGTT). Continuous glucose monitoring (CGM) has been validated in patients with CF and has been recognized as a valuable tool in detecting early glucose abnormalities in patients with CF...
March 14, 2024: Medicina
https://read.qxmd.com/read/38541201/environmental-exposure-to-pesticides-and-the-risk-of-child-neurodevelopmental-disorders
#44
JOURNAL ARTICLE
Rocio Parrón-Carrillo, Bruno José Nievas-Soriano, Tesifón Parrón-Carreño, David Lozano-Paniagua, Rubén Trigueros
Background and Objectives : Neurodevelopment is a fragile brain process necessary for learning from the beginning of childhood to adulthood. During the procedure, several risks could affect it, including environmental factors such as neurotoxic chemicals or environmental pollutants and, within them, exposure to pesticides. Materials and Methods : This ecological descriptive study attempted to assess the association between environmental exposure to pesticides and neurodevelopmental disorders. This study was conducted on 4830 children diagnosed for 11 years in a total population of 119,897 children in three areas: high, medium, and low greenhouse concentrations...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541200/sex-differences-in-insomnia-and-circadian-rhythm-disorders-a-systematic-review
#45
REVIEW
Evelina Pajėdienė, Viltė Urbonavičiūtė, Vita Ramanauskaitė, Lukas Strazdauskas, Ambra Stefani
Insomnia and circadian rhythm disorders are increasingly common in modern society and lead to significant challenges for people's health and well-being. Some studies suggests that men and women differ in neurohormonal secretion, biological processes, and brain morphology. Thus, such differences may affect the etiology, manifestation, and course of sleep disorders, including insomnia and circadian rhythm. This systematic review aims to synthesize the existing literature on sex differences in insomnia and circadian rhythm disorders...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541199/new-perspectives-in-third-molar-auto-transplantation-literature-review-and-a-case-report-of-clinical-financial-and-forensic-implications
#46
REVIEW
Alessandra Putrino, Enrico Marinelli, Alessandro Agrillo, Simona Zaami
Third molar extraction is the most common procedure in oral and maxillofacial surgery. Third molars are considered less functional than other teeth and are often extracted. Sometimes, they are also used for auto-transplantation for the benefit of oral rehabilitation. Since many biological factors are involved in this surgical approach, herein, we outline a review of the biological characteristics of medico-legal/forensic interest, in addition to presenting a successful clinical case. A scoping review of currently available research data (following the principles of PRISMA-ScR or the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) on third molar auto-transplantation was conducted by drawing upon the main databases (Scopus, PubMed, Google Scholar and LILACS) to evaluate biological and clinical characteristics possibly relatable to forensic issues...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541198/italian-survey-on-endoscopic-biliary-drainage-approach-in-patients-with-surgically-altered-anatomy
#47
JOURNAL ARTICLE
Aurelio Mauro, Cecilia Binda, Alessandro Fugazza, Giuseppe Vanella, Vincenzo Giorgio Mirante, Stefano Mazza, Davide Scalvini, Ilaria Tarantino, Carlo Fabbri, Andrea Anderloni, On Behalf Of The I-Eus Group
Background and Objectives : Biliary drainage (BD) in patients with surgically altered anatomy (SAA) could be obtained endoscopically with different techniques or with a percutaneous approach. Every endoscopic technique could be challenging and not clearly superior over another. The aim of this survey is to explore which is the standard BD approach in patients with SAA. Materials and Methods : A 34-question online survey was sent to different Italian tertiary and non-tertiary endoscopic centers performing interventional biliopancreatic endoscopy...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541197/the-effect-of-thyroid-surgery-on-the-accuracy-of-palpation-based-cricothyroid-membrane-identification-in-female-patients-a-prospective-observational-cohort-study
#48
JOURNAL ARTICLE
Jaesik Park, A Rim Yang, Hyunji Lee, Kwangsoon Kim, Min Suk Chae
Background and Objectives : This study examined how a history of thyroid surgery impacts the precision of cricothyroid membrane (CTM) identification through palpation (validated by ultrasound) in female patients visiting the operating room for surgeries unrelated to neck procedures. Materials and Methods : This prospective observational cohort study enrolled adult female patients undergoing elective non-neck surgery, dividing them into control (no thyroid surgery history; n = 40) and experimental (with thyroid surgery history; n = 40) groups...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541196/minimally-invasive-management-and-diagnosis-of-ectopic-splenic-pregnancy
#49
Vestina Strakšytė, Rūta Mikšytė, Ugnė Kulnickaitė, Simas Gudelevičius
This report describes the case of a 32-year-old woman with ectopic pregnancy in the spleen, which was complicated by active bleeding. The patient complained of intermittent pain in her left side and lower abdomen that lasted several days. The serum beta-human chorionic gonadotropin (β-hCG) was increased, but no intrauterine gestational sac was found via transvaginal sonography. A computed tomography (CT) examination revealed the presence of a heterogeneous structure in the left peritoneal cavity, inferior to the spleen; signs of active extravasation; and a large amount of hemorrhagic fluid in the pelvis...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541195/overview-of-cochrane-systematic-reviews-for-rehabilitation-interventions-in-individuals-with-upper-limb-fractures-a-mapping-synthesis
#50
REVIEW
Sara Liguori, Antimo Moretti, Giuseppe Toro, Chiara Arienti, Michele Patrini, Carlotte Kiekens, Stefano Negrini, Giovanni Iolascon, Francesca Gimigliano
Background and Objectives . This overview of Cochrane systematic reviews (CSRs) reports on current evidence on the effectiveness of rehabilitation interventions for persons with upper limb fractures (ULFs), and the quality of the evidence. Materials and Methods . Following the inclusion criteria defined by the World Health Organization, all CSRs tagged in the Cochrane Rehabilitation database that were relevant for persons with ULFs were included. A mapping synthesis was used to group outcomes and comparisons of included CSRs, indicating the effect of rehabilitation interventions and the certainty of evidence...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541194/frequency-of-thyroid-microcarcinoma-in-patients-who-underwent-total-thyroidectomy-with-benign-indication-a-5-year-retrospective-review
#51
JOURNAL ARTICLE
Vasiliki Magra, Kassiani Boulogeorgou, Eleni Paschou, Christina Sevva, Vasiliki Manaki, Ioanna Mpotani, Stylianos Mantalovas, Styliani Laskou, Isaak Kesisoglou, Triantafyllia Koletsa, Konstantinos Sapalidis
Background and Objectives : Incidental thyroid cancers (ITCs) are often microcarcinomas. The most frequent histologic type is a papillary microcarcinoma. Papillary thyroid microcarcinomas are defined as papillary thyroid tumours measuring less than 10 mm at their greatest diameter. They are clinically occult and frequently diagnosed incidentally in histopathology reports after a thyroidectomy. The aim of this study is to evaluate the rate of papillary thyroid microcarcinomas (PTMC) in patients who were thyroidectomised with indications of benign disease...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541193/evaluating-knowledge-self-reported-confidence-levels-and-prescription-patterns-among-dental-practitioners-regarding-analgesics-in-dentistry-a-cross-sectional-study
#52
JOURNAL ARTICLE
Marija Badrov, Antonija Tadin
Background and Objectives : Dental pain is a common problem that often leads to unscheduled dental visits and requires a comprehensive understanding of analgesics, including their indications and contraindications. The aim of this study was to investigate dentists' knowledge, self-reported confidence levels, and prescribing patterns of analgesics in dentistry. Materials and Methods : A nationwide cross-sectional online survey was conducted, resulting in 379 responses. Of these, 68.6% were general dentists, and 31...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541192/metaphedrone-3-methylmethcathinone-pharmacological-clinical-and-toxicological-profile
#53
REVIEW
Igor Kelečević, Ana-Marija Vejnović, Jovan Javorac, Nemanja Gvozdenović, Nataša Janjić, Vesna Mijatović Jovin
Introduction: Synthetic cathinones are a group of novel psychoactive substances used as an alternative to classical recreational drugs. As a result of legal prohibitions on older generations of these compounds, new formulations appeared on the drug market. One of them is metaphedrone (3-methylmethcathinone, 3-MMC), a structural isomer of 4-methylmethcathinone and a psychostimulant drug. Metaphedrone became popular in a large number of countries in a short period of time. The aim: The collection, analysis, and review of relevant research on the subject of metaphedrone in order to present information about the pharmacological, clinical, and toxicological profile of this compound...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541191/diagnostic-challenges-in-inflammatory-choroidal-neovascularization
#54
REVIEW
Izabella Karska-Basta, Weronika Pociej-Marciak, Katarzyna Żuber-Łaskawiec, Anna Markiewicz, Michał Chrząszcz, Bożena Romanowska-Dixon, Agnieszka Kubicka-Trząska
Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesized that its pathogenesis is similar to that of wet age-related macular degeneration (AMD), and involves hypoxia as well as the release of vascular endothelial growth factor, stromal cell-derived factor 1-alpha, and other mediators. Inflammatory CNV develops when inflammation or infection directly involves the retinal pigment epithelium (RPE)-Bruch's membrane complex...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541190/intravenous-vitamin-c-as-an-add-on-therapy-for-the-treatment-of-sepsis-in-an-intensive-care-unit-a-prospective-cohort-study
#55
JOURNAL ARTICLE
Sergio Antonio Gonzalez-Vazquez, Eli Efrain Gomez-Ramirez, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava, Juan Angel Peraza-Zaldivar, Aline Priscilla Santiago-Garcia, Melissa Ramirez-Villafaña, Fabiola Gonzalez-Ponce, Jose Jorge Gomez-Camarena, Ana Miriam Saldaña-Cruz, Norma Alejandra Rodriguez-Jimenez, J Ahuixotl Gutierrez-Aceves, Adriana Jimenez-Lopez, Sylvia Elena Totsuka-Sutto, Ernesto German Cardona-Muñoz, Juan Manuel Ponce-Guarneros
Background and Objectives : According to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), sepsis is defined as "life-threatening organ dysfunction caused by a dysregulated host response to infection". The increased presence of free radicals causes an increase in oxidative stress. Vitamin C is an essential water-soluble vitamin with antioxidant activity and immunoregulatory effects that plays a potential role in the treatment of bacterial infections. Our aim was to evaluate the effectiveness of adding vitamin C to the conventional treatment of sepsis to decrease its mortality rate...
March 12, 2024: Medicina
https://read.qxmd.com/read/38541189/preoperative-age-and-its-impact-on-long-term-renal-functional-decline-after-robotic-assisted-partial-nephrectomy-insights-from-a-tertiary-referral-center
#56
JOURNAL ARTICLE
Cesare Saitta, Giuseppe Garofano, Giovanni Lughezzani, Margaret F Meagher, Kit L Yuen, Vittorio Fasulo, Pietro Diana, Alessandro Uleri, Andrea Piccolini, Stefano Mancon, Paola Arena, Federica Sordelli, Matilde Mantovani, Pier Paolo Avolio, Edoardo Beatrici, Rodolfo F Hurle, Massimo Lazzeri, Alberto Saita, Paolo Casale, Ithaar H Derweesh, Marco Paciotti, Nicolò M Buffi
Background and Objectives : to investigate the impact of age on renal function deterioration after robotic-assisted partial nephrectomy (RAPN) focusing on a decline to moderate and severe forms of chronic kidney disease (CKD). Materials and Methods : This is a single center prospective analysis of patients who underwent RAPN. The outcomes include the development of de novo CKD-S 3a [estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 )] and de novo CKD-S 3b (eGFR < 45 mL/min/1.73/m2 ). Multivariable analysis (MVA) via Cox regression identified predictors for CKD-S 3a/b...
March 11, 2024: Medicina
https://read.qxmd.com/read/38541188/musculoskeletal-pain-physical-activity-muscle-mass-and-mortality-in-older-adults-results-from-the-korean-longitudinal-study-on-health-and-aging-klosha
#57
JOURNAL ARTICLE
Sun-Woo Hwang, Chang-Woo Kim, Yun-Jeong Jang, Chang-Han Lee, Min-Kyun Oh, Ki-Woong Kim, Hak-Chul Jang, Jae-Young Lim, Se-Woong Chun, Seung-Kyu Lim
Background and objectives: Musculoskeletal (MSK) pain significantly impacts physical activity and quality of life in older adults, potentially influencing mortality. This study explored the relationship between MSK pain, physical activity, muscle mass, and mortality among older adults. Material and Methods: We studied 1000 participants in the Korean Longitudinal Study on Health and Aging (KLoSHA), a prospective, population-based cohort study of people aged 65 years or older. Survival status was tracked over a 5-year period...
March 11, 2024: Medicina
https://read.qxmd.com/read/38541187/balloon-pulmonary-angioplasty-for-inoperable-chronic-thromboembolic-pulmonary-hypertension-insights-from-a-pilot-low-volume-centre-study-and-a-comparative-analysis-with-other-centres
#58
JOURNAL ARTICLE
Taida Ivanauskiene, Sigitas Cesna, Egle Grigoniene, Lina Gumbiene, Aurelija Daubaraite, Kaste Ivanauskaite, Sigita Glaveckaite
Background and Objectives : The aim of this study was to evaluate the effectiveness and safety of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) in the Vilnius Pulmonary Hypertension (PH) Referral Centre and to provide a comparative analysis with other centres. Materials and Methods : This study included all BPA procedures performed between 2019 and 2024 in a single tertiary centre. Invasive haemodynamic parameters and clinical variables were assessed at baseline; at the end of invasive treatment; and at the conclusion of follow-up, an average of 8...
March 11, 2024: Medicina
https://read.qxmd.com/read/38541186/ruptured-ovarian-cystic-teratoma-a-rare-diagnosis-easily-to-be-confused-with-peritoneal-carcinomatosis
#59
Dan Costachescu, Alexandru Catalin Motofelea, Daniel Malita, Florica Birsasteanu, Ioana Ionita, Nadica Motofelea, Cristina Ana-Maria Jura, Ioana-Flavia Bacila, Mihai Bacila, Sorin Motoi
Although ovarian cystic teratoma is the most common ovarian tumor, complications are quite rare. However, it is important to be recognized by the radiologist in order to avoid inaccurately diagnosing them as malignant lesions. This case report describes a 61-year-old postmenopausal woman, who presented to the emergency room with abdominal pain following a minor blunt abdominal trauma. In this context, a CT scan was performed, which showed the presence of round, hypodense masses randomly distributed in the peritoneum, with coexisting ascites in moderate amount; ovarian carcinoma with peritoneal carcinomatosis was suspected...
March 10, 2024: Medicina
https://read.qxmd.com/read/38541185/therapeutic-impact-of-aerobic-exercise-on-adolescents-with-obesity-and-its-association-with-expression-of-mirnas-and-cytokines-a-clinical-approach
#60
JOURNAL ARTICLE
Petricia Hillari Raj, Prasanth Subramanian, Mohanraj Nehru, Saravanan Ayyavoo, Nachal Annamalai, Venkataraman Prabhu
Background and Objectives : MicroRNAs are short noncoding RNAs that play an essential role in controlling gene expression at the posttranscriptional level. They can serve as biomarkers in the management of obesity. Circulating miRNAs levels change with exercise, impacting various physiological and biological systems, including structural and functional changes. Aim : The purpose of this study is to evaluate the levels of miRNAs 423-5p and 128-1 in young adolescents with obesity before and after an aerobic exercise programme...
March 10, 2024: Medicina
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