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Journals Journal of the Egyptian Nation...

Journal of the Egyptian National Cancer Institute

https://read.qxmd.com/read/38494582/circmctp2-enhances-the-progression-of-bladder-cancer-by-regulating-the-mir-99a-5p-fzd8-axis
#1
JOURNAL ARTICLE
Yan Liu, Kexin Zhang, Xianxu Yang
BACKGROUND: CircRNAs and miRNAs are involved in the progression of tumor. CircMCTP2 is considered as a novel tumor promoter. However, the exact functions of circMCTP2 in bladder cancer are still unclear. This study was designed to explore the underlying mechanisms of circMCTP2-modulated tumor development in bladder cancer. METHODS: The present study is an original research. The levels of circMCTP2 in a total of 39 bladder cancer specimens and cell lines were determined by RT-qPCR...
March 18, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38462581/molecular-perspectives-on-systemic-priming-and-concomitant-immunity-in-colorectal-carcinoma
#2
REVIEW
Suman Kumar Ray, Sukhes Mukherjee
The progression of metastasis, a complex systemic disease, is facilitated by interactions between tumor cells and their isolated microenvironments. Over the past few decades, researchers have investigated the metastatic spread of cancer extensively, identifying multiple stages in the process, such as intravasation, extravasation, tumor latency, and the development of micrometastasis and macrometastasis. The premetastatic niche is established in target organs by the accumulation of aberrant immune cells and extracellular matrix proteins...
March 11, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38407684/developing-an-efficient-method-for-melanoma-detection-using-cnn-techniques
#3
JOURNAL ARTICLE
Devika Moturi, Ravi Kishan Surapaneni, Venkata Sai Geethika Avanigadda
BACKGROUND: More and more genetic and metabolic abnormalities are now known to cause cancer, which is typically deadly. Any bodily part may become infected by cancerous cells, which can be fatal. Skin cancer is one of the most prevalent types of cancer, and its prevalence is rising across the globe. Squamous and basal cell carcinomas, as well as melanoma, which is clinically aggressive and causes the majority of deaths, are the primary subtypes of skin cancer. Screening for skin cancer is therefore essential...
February 26, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38342816/significance-of-oct3-4-and-sox2-antigens-expression-by-leukemic-blast-cells-in-adult-acute-leukemia
#4
JOURNAL ARTICLE
Salah Aref, Omnyia Khaled, Nadia El Menshawy, Emad Azmy, Mohamed Aref, Osama Salama, Nada Khaled
OBJECTIVE: This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes. METHODS: SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls. RESULTS: Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0...
February 12, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38311646/platelet-to-albumin-ratio-and-radiation-induced-lymphopenia-prognostic-biomarker-for-carcinoma-esophagus
#5
JOURNAL ARTICLE
Adrija Ghosh, Abhilash Dagar, Ram Pukar Bharat, Jaswin Raj, Dyuti Shah, Jyoti Sharma, Akash Kumar, Pritee A Patil, Aman Sharma, Dayanand Sharma, Supriya Mallick
BACKGROUND: Esophageal cancer has a poor survival outcome with 5-year OS at 16.7% despite treatment. Some inflammation-based prognostic indicators like the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously studied as potential biomarker for predicting outcome in esophageal cancer. Recently, platelet-to-albumin ratio (PAR) has been reported as a promising prognostic factor in gastrointestinal malignancies. METHODS: We performed a retrospective analysis of prospectively treated patients of carcinoma esophagus to evaluate the prognostic significance of inflammation-based prognostic indicators-neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and a composite inflammation-nutrition index: platelet-to-albumin ratio (PAR) in esophageal cancer...
February 5, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38285225/pd-l1-expression-and-its-significance-in-advanced-nsclc-real-world-experience-from-a-tertiary-care-center
#6
JOURNAL ARTICLE
Sindhu Kilaru, Soumya Surath Panda, Lalatendu Moharana, Debahuti Mohapatra, Satya Sundar G Mohapatra, Adyakinkar Panda, Spoorthy Kolluri, Suma Devaraj, Ghanashyam Biswas
BACKGROUND: Targeted therapies against programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) have revolutionized the management in recent years. There is paucity of data on the significance of PD-L1 expression in NSCLC from India. We aimed to study the prevalence of PD-L1 expression and its relation with different clinico-pathological parameters in advanced NSCLC from a tertiary care center in Eastern India. METHODS: All consecutive patients with advanced NSCLC diagnosed from January 2020 to December 2021 were prospectively evaluated for PD-L1 expression in formalin fixed-paraffin embedded tumor tissue specimens using immunohistochemistry analysis...
January 29, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38246972/pulmonary-metastatectomy-in-pediatric-cancer-patients-at-national-cancer-institute-egypt-prognostic-factors-and-outcome
#7
JOURNAL ARTICLE
Asmaa Hamoda, Inas Elattar, Heba Mahmoud, Mohamed Abdelrahman, Emad Ebied
BACKGROUND: Metastatic tumors account for 80% of all lung tumors in children. Wilms tumour and osteosarcoma are the most tumors of childhood that produce lung metastases. The aim of the current study is to assess the prognostic factors of pulmonary metastatectomy in pediatric solid tumours as age, number, size, site,laterality, resectability of pulmonary nodules, and number of Thoracotomies. Calculate overall survival among patients who underwent pulmonary metastatectomy. METHODS: It is a retrospective study including all pediatric patients with metastatic solid tumors to lungs treated at pediatric oncology department, National Cancer Institute, Cairo University from 2008 to 2014...
January 22, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38221574/effect-of-combined-kinesiotaping-and-resistive-exercise-on-muscle-strength-and-quality-of-life-in-breast-cancer-survivors-a-randomized-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
Alaa M Ramadan, Abeer M ElDeeb, Ahmed A Ramadan, Dina M Aleshmawy
BACKGROUND: Breast cancer (BC) and its treatment affect women's tissue architecture and physiology, which leads to impaired muscle strength and joint dysfunction, affecting quality of life (QOL). Most evidence has focused on exercises; however, due to the complexity and heterogeneity of patients' rehabilitation needs, further research is required to investigate more adjunctive methods to help optimal rehabilitation according to patients' needs, preferences, and effective interventions...
January 15, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38143264/peripheral-neutrophil-to-lymphocyte-ratio-nlr-a-cogent-clinical-adjunct-for-ki-67-in-breast-cancer
#9
JOURNAL ARTICLE
Radhika Arora, Feroz Alam, Atia Zaka-Ur-Rab, Veena Maheshwari, Kiran Alam, Mahboob Hasan
BACKGROUND: Clinical utility of Ki-67 immunohistochemistry (IHC) in breast cancer (BC) is mainly limited to decide for the use of chemotherapy and estimate prognosis in patients with either Ki-67 index < 5% or > 30%; however, lacunae still exists pertaining to its analytical validity. Neutrophilia is common in cancer with accompanying lymphocytopenia. Neutrophil to lymphocyte ratio (NLR) captures the intricate balance between pro-tumor neutrophilia and anti-tumor lymphocyte immunity...
December 25, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38123741/metabolic-syndrome-and-breast-cancer-risk
#10
JOURNAL ARTICLE
Amira M Mohammed, Hosney B Hamed, Maisa K Noaman, Nelly Alieldin
BACKGROUND: Limited data are available on metabolic syndrome and its relation to breast cancer risk in Egypt. We aimed to study metabolic syndrome and its individual components as risk of breast cancer. METHODS: This case-control study recruited 112 breast cancer cases and 112 age-matched controls from Assiut University. In addition to demographic, clinical, and anthropoemetric characteristics, blood samples were collected from both study groups to evaluate metabolic syndrome and its individual components...
December 21, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38105365/rec8-regulates-neuroblastoma-cell-proliferation-migration-invasion-and-angiogenesis-via-stat3-vegf-signaling
#11
JOURNAL ARTICLE
Qiang Wang, Wei Fan, ZengHui Hao, Bingxue Liang, Meili Fan, Zijian Zhao, Zhaozhu Li
BACKGROUND: Neuroblastoma, one of the most prevalent childhood cancers, is often treated with surgery, radiation, and chemotherapy. However, prognosis and survival are still dismal for children with neuroblastoma at high risk. Consequently, it is vital to identify new and effective treatment targets. As a component of the meiotic cohesion complex, REC8 is involved in a wide range of malignancies. The current work assessed the impact of REC8 knockdown on SH-SY5Y and SK-N-AS neuroblastoma cells and delved into the molecular mechanism behind this effect...
December 18, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38093170/prognosis-of-pancreatic-cancer-with-trousseau-syndrome-a-systematic-review-of-case-reports-in-japanese-literature
#12
Munehiro Wakabayashi, Yoshinori Kikuchi, Kazuhisa Yamaguchi, Takahisa Matsuda
Trousseau syndrome is a paraneoplastic syndrome associated with a risk of poor prognosis. We reviewed the survival time and prognosis of patients with Trousseau syndrome. We identified 40 cases from 28 reports of Trousseau syndrome due to pancreatic cancer. We analyzed 20 cases based on reports providing sufficient information on the stage/location of pancreatic cancer and survival time after Trousseau syndrome. The median survival time was 2.0 months. There was no statistical difference between performance status (PS) 0-1 and PS 4, stages I-III and IV, and pancreatic head and body/tail...
December 14, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38072859/impact-of-family-history-of-cancer-on-colorectal-cancer-screening-%C3%A2-a-propensity-score-matched-analysis-from-the-health-information-national-trends-survey-hints
#13
JOURNAL ARTICLE
Maxwell Akonde, Eric Mishio Bawa, Ottovon Bismark Dakurah, Rajat Das Gupta
BACKGROUND: Early detection of colon cancer leads to better survival outcomes. This can be achieved through colorectal cancer (CRC) screening. People with a family history of cancer (FHC) have increased risk of developing CRC. Increasing screening in this group will reduce CRC mortality. This study evaluated CRC screening in people with FHC. METHODS: The study used data from the Health Information National Trends Survey (HINTS) 5, cycle 3. This is an annual cross-sectional survey with a nationally representative sample of American adults...
December 11, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38060078/distribution-of-high-and-low-risk-human-papillomavirus-genotypes-and-their-prophylactic-vaccination-coverage-among-west-african-women-systematic-review
#14
REVIEW
Rogomenoma Alice Ouedraogo, Ali Kande, Wendyam Marie Christelle Nadembega, Djeneba Ouermi, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Charlemagne Marie Ragnag-Newende Ouedraogo, Olga Mélanie Lompo, Jacques Simpore
INTRODUCTION: The second most deadly gynecological cancer worldwide, cervical cancer is steadily on the rise in sub-Saharan Africa, while vaccination programs are struggling to get off the ground. This systematic review's aim was to assess the prevalence and distribution of high- and low-risk HPV genotypes in West African women. METHODS: Original studies were retrieved from PubMed/Medline, Embase, Scopus, Google Scholar, and Science Direct. In these studies, Human papillomavirus (HPV) DNA was assessed in cervical samples by polymerase chain reaction (PCR), Hybrid capture, and sequencing...
December 7, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38008872/review-of-current-literature-on-gestational-trophoblastic-neoplasia
#15
REVIEW
Mehwish Shahzadi, Saqib Raza Khan, Muhammad Tariq, Sehrish Sarwar Baloch, Aisha Shahid, Munira Moosajee, Zarka Samon
BACKGROUND: Gestational Trophoblastic Neoplasia (GTN) is a disease of the reproductive age group with an incidence rate of <1% among all tumors involving the female reproductive tract. It occurs because of aberrant fertilization. Patients are diagnosed early because of aggravated symptoms during pregnancy. Moreover, patients also bleed from the tumor sites, which leads to early presentation. A cure rate of 100% can be achieved with adequate treatment. MAIN BODY: In this literature review, the authors have brought to attention the risk factors, classification, and various treatment options in GTN patients according to their stratification as per the WHO scoring system...
November 27, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/37981621/targeting-average-length-of-hospital-stay-as-a-control-measure-to-decrease-covid-19-hospital-acquired-infection-in-surgical-cancer-patients
#16
JOURNAL ARTICLE
Sarah S Nasr, Ghada M Sherif, Maha Abdel Wahab, Hatem Aboelkasem
BACKGROUND: The global spread of coronaviruses had a great impact on the economic and social situation of most countries. As the backbone of any society, the health sector made a significant contribution through applying emergency risk management plans in order to control the pandemic. Monitoring the average length of hospital stay (ALOS) was an effective way to release the capacity of the health system during this time. The aim was to evaluate the effect of applying risk assessment/management strategies on ALOS and the impact of this ALOS on COVID-19 infection rates among cancer patients...
November 20, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/37926787/stem-cell-therapy-for-hepatocellular-carcinoma-and-end-stage-liver-disease
#17
REVIEW
Mona S Abdellateif, Abdel-Rahman N Zekri
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a great challenge for clinicians due to the limited chance for liver transplantation, which is the only curative treatment for those patients. Stem cell-based therapy as a part of regenerative medicine represents a promising application for ESLD patients. Many clinical trials were performed to assess the utility of bone marrow-derived stem cells as a potential therapy for patients with liver diseases...
November 6, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/37899408/ameloblastic-fibro-dentinoma-a-rare-mixed-odontogenic-tumor-case-report-with-review-of-literature
#18
REVIEW
Nihal Mohamed Ahmed Darwish, Hatem Wael Abdel-Fattah Amer, Nesma Nabil Mohamed Mahrous
BACKGROUND: Ameloblastic fibro-dentinoma is considered a rare, benign, mixed odontogenic tumor that occurs mainly in the posterior mandible in the 1st-2nd decade of life. Although the clinical behavior of Ameloblastic fibro-dentinoma is similar to that of ameloblastic fibroma, there is a debate about whether Ameloblastic fibro-dentinoma is a developing hamartomatous odontoma or a separate neoplastic odontogenic tumor like ameloblastic fibroma. However, it is important to understand the histopathogenesis of this rare tumor...
October 30, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/37870653/photobiological-modulation-of-hepatoma-cell-lines-and-hepatitis-b-subviral-particles-secretion-in-response-to-650%C3%A2-nm-low-level-laser-treatment
#19
JOURNAL ARTICLE
Ghada M Al-Toukhy, Reda A Suef, Sarah Hassan, Mohamed M S Farag, Tarek A El-Tayeb, Mohamed T M Mansour
BACKGROUND: Chronic hepatitis B virus (HBV) infection is a serious global health concern, with an increased incidence and risk of developing cirrhosis and hepatocellular carcinoma (HCC). Patients chronically infected with HBV are likely to experience chronic oxidative stress, leading to mitochondrial dysfunction. Photobiomodulation is induced by the absorption of low-level laser therapy (LLLT) with a red or infrared laser by cytochrome C oxidase enzyme, resulting in mitochondrial photoactivation...
October 23, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/37779128/immunotherapeutic-strategy-in-the-management-of-gastric-cancer-molecular-profiles-current-practice-and-ongoing-trials
#20
REVIEW
Mengxiao Lu, Yingjie Wu, Yixin Zhang, Yu Yu, ShengJie Wang, Xiaobao Su
Gastric cancer (GC) is the one of the most commonly solid cancer worldwide. Although under the aggressive treatment, the poor clinical outcomes of patients with GCs have not been improved. Current studies emphasized that targeting therapies or immune response-based therapeutic strategy may be a potential approach to improve the clinical outcomes. Moreover, accumulative evidence has reported the increasing expression of PD-L1 expression in GC cells and highlighted its role in the tumor progression. Currently, great development has been established in the immune checkpoint inhibitors (ICIs) and further changed the clinical practice of GC treatment and prognosis...
October 2, 2023: Journal of the Egyptian National Cancer Institute
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