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Journal of the Egyptian National Cancer Institute

Mouna Bellakhdhar, Amira Cheniti, Monia Ghammem, Ahlem Bdioui, Sarra Mestiri, Abir Meherzi, Wassim Kermani, Mohamed Abdelkefi
Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. The larynx is an extremely rare site. We report two cases of 27 and 18 year-old men who developed a synovial sarcoma of the larynx. They presented with hoarseness of voice and hemoptysis. Endoscopy detected a mass in the supraglottic region. The biopsy concluded a synovial sarcoma. Immunohistochemistry conveyed diagnostic certainty...
November 24, 2018: Journal of the Egyptian National Cancer Institute
Abhinav Dewan, Kundan Singh Chufal, Ajay Kumar Dewan, Anjali Pahuja, Krati Mehrotra, Rajpal Singh, Rahul Lal Chaudhary, T Suresh, Maninder Mishra, Abirama V Sundari, Sravya Bommera, Raman Narang, Preeti Pathak, Swarupa Mitra, S K Sharma, Munish Gairola
AIM: To study feasibility of simultaneous integrated boost by intensity modulated radiotherapy (SIB-IMRT) in patients undergoing breast conserving surgery and its impact on cosmesis and dosimetry. PATIENTS AND METHODS: Between January 2014 and June 2017, all breast cancer patients fulfilling inclusion and exclusion criteria were enrolled in a prospective study conducted at a tertiary cancer centre in North India. All patients received adjuvant radiotherapy by simultaneous integrated boost technique following breast conserving surgery...
November 24, 2018: Journal of the Egyptian National Cancer Institute
Mohamed Amr M El-Menoufy, Zeinab I Mourad, Nahla M Farahat
BACKGROUND: Monosomy 7 (-7) or deletion in its long arm [del(7q)] is among the most common chromosomal abnormalities in myeloid malignancies. There are prognostic variations between -7 and del(7q) in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). AIM: To describe the clinical characteristics, response to treatment, and survival of patients with primary AML and MDS having -7 or del(7q) detected by fluorescence in situ hybridization (FISH). PATIENTS AND METHODS: The study was conducted on 53 patients with primary AML and MDS...
November 21, 2018: Journal of the Egyptian National Cancer Institute
Ahmed Mostafa Mahmoud, Yahia M Ismail, Alaadin Hussien, Yasser Debaky, Ihab S Ahmed, Hisham S Wahba Mikhael, Manar Moneer
BACKGROUND: Peritoneal carcinomatosis originating from colorectal cancer (PC-CRC) carries a dismal prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) have been offered to those patients with substantial health and economic burden, nevertheless not all patients are fitting this treatment modality and outcome is generally still poor. OBJECTIVE: To elicit predictive factors associated with the success of CRS and HIPEC in PC-CRC patients...
November 21, 2018: Journal of the Egyptian National Cancer Institute
Magdy Saber, Yahia Ismail, Nelly Alieldin, Iman Loay, Mohamed El Zawahry
BACKGROUND: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carcinoid (TC), intermediate grade atypical carcionid (AC) and high grade, both large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), with extreme differences in management and survival. OBJECTIVE: To study clinicopathologic and prognostic factors affecting survival of lung NETs. PATIENTS AND METHODS: This is a retrospective study evaluating 35 patients with primary lung NETs treated at National Cancer Institute of Egypt (NCI-E) between January 2010 and December 2014...
November 20, 2018: Journal of the Egyptian National Cancer Institute
Mohamed Ibrahim Fahim, Omaya Abdelhamid Nassar, Osman Mohamed Mansour, Abdelmaksoud Mohamed Ali, Ahmed-Mostafa Mahmoud, Rasha Mahmoud Allam, Amr Kamal
BACKGROUND: Complete cytoreduction has been associated with survival benefit in the treatment of recurrent epithelial ovarian cancer (EOC). In this study, the aim is to investigate the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of recurrent EOC. PATIENTS AND METHODS: This is a descriptive (case series) study including 9 patients with recurrent EOC treated by CRS and HIPEC. They were treated and followed up between December 2011 and December 2017...
November 20, 2018: Journal of the Egyptian National Cancer Institute
Dina M El-Guindy, Duaa S Helal, Nesreen M Sabry, Mohamed Abo El-Nasr
Cancer immunotherapy targeting programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway has shown promising results in treatment of non-small cell lung cancer (NSCLC) patients. T cells play a major role in tumor-associated immune response. This study aimed to investigate PD-L1 expression alone and combined with CD8 tumor infiltrating lymphocytes (TILs) density in relation to clinicopathologic parameters and survival in NSCLC patients. Immunohistochemical analysis was used to evaluate PD-L1 expression and CD8 TILs density in 55 NSCLC patients...
October 15, 2018: Journal of the Egyptian National Cancer Institute
Orhan Üreyen, Demet Kocatepe Çavdar, Zehra Hilal Adıbelli, Enver İlhan
AIM OF WORK: This study investigates the factors related to metastasis detection in a sentinel lymph node biopsy (SLN) in patients without clinical axillary involvement. PATIENTS AND METHODS: The medical records of patients who underwent an SLN biopsy after diagnosis with early-stage breast cancer were evaluated retrospectively. The study sample included 64 patients divided into two groups according to the histopathological examination of the SLN biopsy: Group I (positive for axillary metastasis) and Group II (negative for axillary metastasis)...
October 13, 2018: Journal of the Egyptian National Cancer Institute
Mohamed Atef ElKordy, Tarek Sherif ElBaradie, Hisham Ismail ElSebai, Sheriff Mohamed Khairalla, Ayman AbdelWahab Amin
No abstract text is available yet for this article.
September 2018: Journal of the Egyptian National Cancer Institute
Ahmed M Moeen, Ahmed S Safwat, Mohamed M Gadelmoula, Seham M Moeen, Ahmad Elbadry I Abonnoor, Walid M Abbas, Ehab O ElGanainy, Ahmed M El-Taher
OBJECTIVE: To compare quality of life (QoL) after urinary diversion (UD) following radical cystectomy (RC) using validated questionnaires. PATIENTS AND METHODS: Between January 2011 and June 2016, 150 patients (121 men [80.7%] and 29 women [19.3%]) with invasive bladder cancer who underwent RC and UD were included in this prospective study. Patients were divided into 2 groups; group I included the orthotopic neobladder 50 (33.3%) and uretro-sigmoidostomy 41 (27...
September 2018: Journal of the Egyptian National Cancer Institute
Noha E Ezzat, Eman S Abusinna, Nesreen H Hafez, Nelly H Alieldin
PURPOSE: To assess the inter-observer agreement between 3 cytopathologists of thyroid FNAC using Royal College of Pathology reporting system. PATIENTS AND METHODS: The study is a retrospective one conducted on 204 cases retrieved from the archives of the Cytology Unit, Pathology Department, National Cancer Institute, Cairo University during the time period from January 2016 to December 2016. Cases were diagnosed separately by 3 cytopathologists using the Royal College of Pathology classification system (RCPath), where Thy1, nondiagnostic; Thy2, nonneoplastic; Thy3a, atypical, Thy3f, follicular lesion; Thy4, suspicious of malignancy; and Thy5, malignant...
September 2018: Journal of the Egyptian National Cancer Institute
Kareem Sallam, Ahmed Refaat, Marwa Romeih
Ultrasound-guided venous access is becoming a standard technique in many centers worldwide. In small veins and in the pediatric population, successful venous puncture is sometimes followed by resistance in passing the wire. The needle seems to miss the small vein during syringe dismounting, wire mounting and wire advancement through the needle. This work describes a "wire-loaded puncture" technique as a solution for this problem. PATIENTS AND METHODS: Paediatric cancer patients who needed venous access for different indications were included in the study...
September 2018: Journal of the Egyptian National Cancer Institute
Sarthak Tandon, Munish Gairola, Parveen Ahlawat, Sheh Rawat, Archana Aggarwal, Kanika Sharma, Sandeep Tiwari, Ahmad M Karimi, Vinayakumar Muttagi, Nishtha Sachdeva, Manindra Bhushan
OBJECTIVES: Comparison of two fractionation schedules of intensity modulated radiotherapy (IMRT) for locally advanced head and neck cancer - simultaneous integrated boost (SIB-IMRT) and simultaneous modulated accelerated radiotherapy (SMART) boost in terms of toxicity and survival end-point measures. PATIENTS AND METHODS: Sixty patients with locally advanced head and neck cancer were randomized in two treatment arms (SIB-IMRT [control arm] and SMART boost arm [study arm])...
September 2018: Journal of the Egyptian National Cancer Institute
Andrew Fares, Mohamed H Shaaban, Raafat M Reyad, Ahmed S Ragab, Mohga A Sami
INTRODUCTION: About 50% of patients with cancer develop bone metastasis mainly presenting with distressing, drug-resistant pain. AIM OF THE WORK: The study evaluated efficacy and safety of combined cementoplasty and bony radiofrequency ablation in palliation of intractable pain and disability in cancer patients with bony metastases. PATIENTS AND METHODS: The study included 30 adult patients suffering from localized bony metastases causing refractory moderate to severe pain...
September 2018: Journal of the Egyptian National Cancer Institute
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
June 2018: Journal of the Egyptian National Cancer Institute
Alaa Mohamed Maria, Mohamed El-Shebiney, Ayman Mohamed El-Saka, Yomna Zamzam
PURPOSE: The purpose of this work was to assess the truncated form of human epidermal growth factor receptor 2 (HER2) such as p95-HER2 expression in HER2-positive breast cancer (BC) patients who developed metastatic disease after adjuvant treatment with a trastuzumab-containing regimen. PATIENTS AND METHODS: Thirty-two histologically diagnosed HER2-positive BC patients who developed distant failure after treatment with trastuzumab-based chemotherapy (CT) regimen as an adjuvant therapy were included in the study...
June 2018: Journal of the Egyptian National Cancer Institute
Fatma Ashour, Mohammed H Awwad, Hayam E L Sharawy, Mohamed Kamal
BACKGROUND AND OBJECTIVES: Breast cancer (BC) is classified according to estrogen receptor (ER) status into ER+ and ER- tumors. ER+ tumors have a worse response to chemotherapy compared to ER- tumors. BCL-2, TP53, BAX and NF-ΚB are involved in drug resistance in the ER+ tumors. Recently it was shown that Cancer Stem Cells (CSCs) play an important role in drug resistance. In this study we tested the hypothesis that CSCs of the ER+ tumors resist drug through the overexpression of BCL-2, TP53, BAX and NF-ΚB...
June 2018: Journal of the Egyptian National Cancer Institute
Rambha Pandey, Rituparna Biswas, Mukurdipi Ray, Prashant P Ramteke, Ekta Dhamija, Anirban Halder
Myoepithelial carcinoma (MC) is a rare, locally aggressive malignant neoplasm of the salivary glands. Only few evidences on its metastatic behavior are available in the literature. We herein present a unique case of MC of left parotid gland which metastasized to bilateral cavernous sinuses. The patient was successfully treated with palliative radiotherapy and chemotherapy.
June 2018: Journal of the Egyptian National Cancer Institute
Zahra Tolou Ghamari
OBJECTIVE: To describe for the first time period prevalence (PP) and incidence rate (Ir) for patients with lung cancer in Isfahan Province/Iran. DESIGN: Data associated to the Surveillance, Epidemiology, and End Results; (SEER) was collected from the Isfahan Cancer Registry from March 2011 to March 2015. Lung cancer was distinguished by the related established topography code. PP and Ir were calculated and expressed per 100,000 persons. RESULTS: In all, 548 females and 1399 males were identified...
June 2018: Journal of the Egyptian National Cancer Institute
Khalid Abdel Karim, Amr El Shehaby, Reem Emad, Wael Reda, Manal El Mahdy, Ramy Ghali, Ahmed Nabeel
No abstract text is available yet for this article.
June 2018: Journal of the Egyptian National Cancer Institute
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