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Free Radical Research

Yanfeng Gao, Shuang Zhou, Lizhi Pang, Juechen Yang, Han John Li, Xiongwei Huo, Steven Y Qian
The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-related diseases in traditional Chinese medicine. In recent years, celastrol (a natural compound from the root of the thunder god vine) has attracted great interest for its potential anticancer activities. The free radical nitric oxide (NO) is known to play a critical role in colorectal cancer growth by promoting tumour angiogenesis. However, how celastrol influences the NO pathway and its mechanism against colorectal cancer is largely unknown...
February 18, 2019: Free Radical Research
Jun Ma, Ge Jin
Alleviating the oxidant stress associated with myocardial ischemia reperfusion has been demonstrated as a potential therapeutic approach to limit ischemia reperfusion (I/R)-induced cardiac damage. It's reported that EGFR/erbB2 signaling is an important cardiac survival pathway in cardiac function and activation of EGFR has a cardiovascular effect in global ischemia. Epidermal growth factor (EGF), a typical EGFR ligand, was considered to have a significant role in activating EGFR. However, no evidence has been published whether exogenous EGF has protective effects on myocardial ischemia reperfusion...
February 18, 2019: Free Radical Research
Wen-Jing Yang, Ji-Xiang He, Ming-Xing Zhou, Min Huang, Shu-Qi Wang, Xiao-Ning Wang, Hong-Xiang Lou, Dong-Mei Ren, Tao Shen
The nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in regulating the intracellular oxidative stress, and thus activation of Nrf2 by nature-derived molecules effectively alleviates the pathological process of oxidative stress-induced chronic diseases. The isopentenyl-substituted flavonoid norartocarpin (NOR) induced the activity of NAD(P)H: quinone reductase (QR), implying that it might be a potential Nrf2 activator. Further studies indicated that NOR upregulated the protein levels of Nrf2 and its downstream genes, NAD(P)H quinone oxidoreductase 1 (NQO1), and γ-glutamyl cysteine synthetase (GCLM) through facilitating the nuclear translocation of Nrf2 and enhancing Nrf2 protein stability...
February 18, 2019: Free Radical Research
Cestmir Cejka, Sarka Kubinova, Jitka Cejkova
Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Molecular hydrogen (H2 ) is very suitable for this purpose due to its unique properties...
February 18, 2019: Free Radical Research
A L Dorigan de Matos Furlanetto, Caroline Valente, G R Martinez, M E Merlin Rocha, J B B Maurer, S M S C Cadena
Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered those studies by exposing these cells to cold stress (4 ± 1 °C for either 24 or 48 h) and evaluating parameters associated with oxidative stress and alterations in the cellular and mitochondrial responses...
February 14, 2019: Free Radical Research
Hirofumi Fujita, Masahiko Ochi, Mitsuaki Ono, Eriko Aoyama, Tetsuya Ogino, Yoichi Kondo, Hideyo Ohuchi
Chronic inflammation associated with bone tissues often destruct bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It is believed that reactive oxygen species (ROS) are involved in RANK ligand (RANKL)-induced osteoclast differentiation, and, therefore, glutathione (GSH), the most abundant endogenous antioxidant, suppresses osteoclast differentiation and bone resorption by RANKL...
February 10, 2019: Free Radical Research
Hye-Ok Jang, Ha-Na Lee, Jeong-Hwa Woo, Ja-Young Lee, Areumnuri Kim, Jin Kyung Lee, Do-Hee Kim, Young-Joon Surh, Hye-Kyung Na
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyzes the conversion of prostaglandin E2 to a keto metabolite. The downregulation of 15-PGDH is ubiquitously observed in various human malignancies. However, the molecular mechanisms underlying downregulation of 15-PGDH expression remain largely unknown. 15-Deoxy-△12,14 -prostaglandin J2 (15d-PGJ2 ), an endogenous ligand of peroxisome proliferator-activated receptor γ, has been reported to have anti-inflammatory and anticarcinogenic activities...
February 5, 2019: Free Radical Research
Josep A Tur, Claus Jacob, Patrick Chaimbault, Mohammad Tadayyon, Elke Richling, Nina Hermans, Claudia Nunes Dos Santos, Marc Diederich, Linda Giblin, Mourad Elhabiri, Caroline Gaucher, Pierre Andreoletti, Ana Fernandes, Michael Davies, Agnieszka Bartoszek, Mustapha Cherkaoui-Malki
A healthy ageing process is important when it is considered that one third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at older age is not only an important measure of quality of life but also key to participation and productivity. So, the binomial "nutrition and ageing" has different aspects and poses considerable challenges, providing a fertile ground for research and networks...
January 22, 2019: Free Radical Research
Qing-Li Zhao, Hiroko Ito, Takashi Kondo, Takashi Uehara, Masayuki Ikeda, Hitoshi Abe, Jun-Ichi Saitoh, Kyo Noguchi, Michio Suzuki, Masayoshi Kurachi
Antioxidant activity has been reported for some atypical antipsychotic drugs; however, the detailed mechanism is not well known. Here we investigated the effects of atypical antipsychotic drugs on · OH radical formation, intracellular reactive oxygen species (ROS), and apoptosis induced by ionizing radiation. The reaction rate constants with · OH radicals were determined for five antipsychotic drugs as follows, in descending order: olanzapine, aripiprazole, clozapine, haloperidol, and risperidone. Experiments with aminophenyl fluorescein, a fluorescent dye, showed that olanzapine and clozapine could scavenge intracellular ROS...
January 22, 2019: Free Radical Research
Wei He, Peihai Cao, Yiqun Xia, Lin Hong, Tingting Zhang, Xin Shen, Peisen Zheng, Huanpei Shen, Yunjie Zhao, Peng Zou
Thioredoxin reductase 1 (TrxR1) has emerged as a potential target for cancer therapy, because it is overexpressed in several types of cancers and associated with increased tumor growth and poor patient prognosis. Alantolactone (ALT), a natural sesquiterpene lactone originated from traditional folk medicine Inula helenium L., has been reported to exert antitumor activity in various tumors. However, the effect of ALT on human gastric cancer cells and its underlying mechanism remains unknown. In this study, we showed that ALT inhibited cell proliferation and induced cell apoptosis in gastric cancer cells...
January 22, 2019: Free Radical Research
Amel Ben Anes, Hela Ben Nasr, Abdelhamid Garrouche, Sarra Bchir, Zaineb Dhaouefi, Elyes Chabchoub, Zouhair Tabka, Karim Chahed
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. OBJECTIVE: the purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, the influence of these variants on inflammatory and oxidative stress parameters. METHODS: genotyping of superoxide dismutase 1 (SOD1) + 35 A/C ( rs2234694 ), catalase [A-21T ( rs7943316 ), C-262T ( rs1001179 )] and glutathione peroxidase 1 (reduced glutathione (GSH)-Px1) 198Pro/Leu ( rs1050450 ) was carried out in 143 patients with COPD and 216 healthy controls using PCR-RFLP...
January 22, 2019: Free Radical Research
Lu Gan, Jiangwei Duan, Song Zhang, Xin Liu, Devesh Poorun, Xinxin Liu, Xinpei Lu, Xiaoru Duan, Dawei Liu, Hongxiang Chen
Psoriasis is a chronic hyperproliferative skin disease characterised by excessive growth of keratinocytes. Indeed, inducing keratinocyte apoptosis is a key mechanism responsible for psoriatic plaques clearance following some important existing therapies, which display pro-oxidant activity. Cold atmospheric plasma (CAP), acting as a tuneable source of reactive oxygen and nitrogen species (RONS), can controllably transfer RONS to the cellular environment, deliver antiproliferative RONS concentrations and exert antiproliferative and proapoptotic effects...
January 21, 2019: Free Radical Research
Zhifei Chen, Fabian Leinisch, Ines Greco, Wei Zhang, Nan Shu, Christine Y Chuang, Marianne N Lund, Michael J Davies
Modification of proteins in infant milk formula (IF) is of major concern to the dairy industry and consumers. Thermal treatment is required for microbiological safety, but heat, light, metal-ions and other factors may induce oxidative damage, and be a health risk. In this study protein modifications in IFs were quantified. IFs contained both reducible (disulphide) and non-reducible (di-tyrosine, lanthionine, lysinoalanine) protein cross-links. Dehydroalanine and the cross-linked species lanthionine and lysinoalanine were detected...
January 16, 2019: Free Radical Research
Jolanta Czuczejko, Łukasz Sielski, Bartosz Woźniak, Alina Woźniak, Karolina Szewczyk-Golec
Melatonin supplementation has been proved to have antioxidant and anti-inflammatory effects in humans. The aim of the study was to estimate the influence of a 30-day melatonin supplementation on oxidative and inflammatory state in the blood of intense training professional athletes. The study was conducted in 47 football players, 19 rowers, and 15 adults who did not practice sports (control group). Blood samples were taken once from the control group and twice from the athletes: before and after 30-day melatonin administration (5 mg daily before sleep)...
January 16, 2019: Free Radical Research
Atish Barua, Pritha Choudhury, Joy Krishna Maity, Sukhendu Bikash Mandal, Suvra Mandal, Prosenjit Saha
Therapeutic efficacy of nucleoside analogues (NAs) like Gemcitabine, 5-fluorouracil in cancer treatment is already well established. Most of the known NAs are highly toxic to normal cells due to its non-specific action; thus searching for non-toxic NAs are still going on. For that purpose we have synthesised nine different NAs by alteration of their structural and functional groups. The aim of present study is to investigate the therapeutic potential of NAs against mice bearing breast adenocarcinoma cells at IC50 dose for 10 days treatment schedule...
January 9, 2019: Free Radical Research
Sheela Nagarkoti, Samreen Sadaf, Deepika Awasthi, Tulika Chandra, Kumaravelu Jagavelu, Sachin Kumar, Madhu Dikshit
Recent report from this lab has shown role of Rac2 in the translocation of iNOS to the phagosomal compartment of PMNs following phagocytosis of beads. Present study was undertaken to further assess the status and role of tetrahydrobiopterin (BH4 ), a redox sensitive cofactor, and L-arginine, the substrate of NOS, in sustained nitric oxide (.NO) production in killing of phagocytosed microbes ( E.coli ) by human PMNs. Time dependent study revealed consistent. NO and reactive oxygen species (ROS) production in the PMNs following phagocytosis of beads...
January 8, 2019: Free Radical Research
Maryam Radan, Mahin Dianat, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati, Gholamreza Goudarzi
Environmental pollution is one of the risk factors for respiratory diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is the major mechanisms contributing to cellular defense against oxidative damage. Gallic acid (GA) is regarded as potent anti-inflammatory and antioxidant agents. The aim was to evaluate the role of Nrf2 pathway in particulate matter (PM10 ) exposure on lung and epithelial cells with an emphasis on the role of gallic acid. In in vivo part, the rats were divided to: control, GA (30 mg/kg), particulate matter (PM) (0...
December 26, 2018: Free Radical Research
Ping-Fang Chiu, Shih-Li Su, Chun-Chieh Tsai, Chia-Lin Wu, Chen-Ling Kuo, Chew-Teng Kor, Chia-Chu Chang, Chin-San Liu
To find the associations of circulating cyclophilin A (CyP A) and CD147/EMMPRIN with renal outcomes in type 2 diabetes patients and possible pathogenesis involved. Total 131 patients were recruited since 2004. Glycated hemoglobin, blood glucose and urine albumin-creatinine ratio levels at baseline and every 3 months were measured. Plasma CyP A and CD147 were also measured at baseline. Patients were divided into two groups based upon the median level of the baseline plasma CyP A value: < 93.64 ng/mL (group A, n = 65), ≥ 93...
December 20, 2018: Free Radical Research
Yurie Mori, Shinya Kato, Yutaka Fujisawa, Shiho Ohnishi, Yusuke Hiraku, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa
Morin is a potential inhibitor of amyloid β-peptide aggregation. This aggregation is involved in the pathogenesis of Alzheimer's disease. Meanwhile, morin has been found to be mutagenic and exhibits peroxidation of membrane lipids concurrent with DNA strand breaks in the presence of metal ions. To clarify a molecular mechanism of morin-induced DNA damage, we examined the DNA damage and its site specificity on 32 P-5'-end-labeled human DNA fragments treated with morin plus Cu(II). The formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), an indicator of oxidative DNA damage, was also determined in calf thymus DNA treated with morin plus Cu(II)...
December 20, 2018: Free Radical Research
Hyun Ji Park, Kyung Chul Shin, Soon-Kyu Yoou, Myeongsin Kang, Jae Gon Kim, Dong Jun Sung, Wonjong Yu, Youngjin Lee, Sung Hea Kim, Young Min Bae, Sang Woong Park
Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL ) and elevates [Ca2+ ]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequence for arteries are unclear. Here, we examined the hypothesis that hydrogen peroxide (H2 O2 ) regulates membrane potential (Em) by altering Na+ influx through cation channels, which consequently activates VDCCL to induce vasoconstriction in rat mesenteric arteries...
December 10, 2018: Free Radical Research
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