journal
https://read.qxmd.com/read/38996052/central-diabetes-insipidus-vasopressin-deficiency-after-surgery-for-pituitary-tumours-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Athanasios Fountas, Amy Coulden, Silvia Fernández-García, Georgios Tsermoulas, John Allotey, Niki Karavitaki
OBJECTIVE: Central diabetes insipidus or vasopressin deficiency (AVP-D) is the most frequent water balance disorder after transsphenoidal surgery (TSS) with variable prevalence amongst studies. We aimed to determine rates of newly-developed transient or permanent AVP-D in patients with pituitary tumours treated with TSS. DESIGN AND METHODS: We performed systematic review of Medline, Embase and Cochrane Library between 01/01/2000-31/01/2021 for studies reporting on outcomes for pituitary adenoma, craniopharyngioma and Rathke's cleft cyst (RCC) after TSS and providing definition of post-operative AVP-D...
July 12, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38970559/whole-blood-transcriptomic-signature-of-cushing-s-syndrome
#2
JOURNAL ARTICLE
Maria Francesca Birtolo, Roberta Armignacco, Nesrine Benanteur, Bertrand Baussart, Chiara Villa, Daniel De Murat, Laurence Guignat, Lionel Groussin, Rossella Libé, Maria-Christina Zennaro, Meriama Saidi, Karine Perlemoine, Franck Letourneur, Laurence Amar, Jérôme Bertherat, Anne Jouinot, Guillaume Assié
OBJECTIVE: Cushing's syndrome is characterized by high morbidity and mortality with high inter-individual variability. Easily measurable biomarkers, in addition to the hormone assays currently used for diagnosis, could reflect the individual biological impact of glucocorticoids. The aim of this study is to identify such biomarkers through the analysis of whole blood transcriptome. DESIGN: Whole blood transcriptome was evaluated in 57 samples from patients with overt Cushing's syndrome, mild Cushing's syndrome, eucortisolism and adrenal insufficiency...
July 6, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38970525/predicting-fragility-fractures-based-on-frailty-and-bmd-among-rural-community-dwelling-older-adults
#3
JOURNAL ARTICLE
Jeongmin Lee, Jinyoung Kim, Chaiho Jeong, Jeonghoon Ha, Yejee Lim, Ki-Hyun Baek
OBJECTIVE: We aim to investigate the association between bone mineral density (BMD) measurement, and fragility fractures, and assess the predictive value of combining BMD measurement and frailty for fracture risk assessment. METHODS: This retrospective cohort study analyzed data from 5,126 rural Koreans in the Chungju Metabolic Disease Cohort study. Frailty was defined using Fried's frailty phenotype. Fractures were assessed via structured medical interviews. Adjusted odds ratios (OR) were calculated considering age, sex, BMI, behavior, BMD, handgrip strength, medications, and comorbidities...
July 6, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38946089/longterm-outcomes-in-patients-with-cushing-s-disease-vs-non-functioning-pituitary-adenoma-after-pituitary-surgery-an-active-comparator-cohort-study
#4
JOURNAL ARTICLE
Sara Germann, Roxana Wimmer, Rahel Laager, Beat Mueller, Philipp Schuetz, Nina Kaegi-Braun, Alexander Kutz
OBJECTIVE: There is increasing evidence that multisystem morbidity in patients with Cushing's disease (CD) is only partially reversible following treatment. We investigated complications from multiple organs in hospitalized patients with CD compared to patients with non-functioning pituitary adenoma (NFPA) after pituitary surgery. DESIGN: Population-based retrospective cohort study using data from the Swiss Federal Statistical Office between January 2012 and December 2021...
July 1, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38941271/clinical-and-imaging-presentations-are-associated-with-function-in-incidental-adrenocortical-adenomas-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Oksana Hamidi, Muhammad Shah, Catherine D Zhang, Natalia Lazik, Dingfeng Li, Sumitabh Singh, Nicole M Iñiguez-Ariza, Ram Raman, Maria D Hurtado, Lindsay Carafone, Aakanksha Khanna, Qi Yan, Neena Natt, Robert P Hartman, Travis McKenzie, William F Young, Irina Bancos
OBJECTIVE: To assess whether clinical and imaging characteristics predict hormonal subtype, growth, and adrenalectomy for incidental adrenal cortical adenomas (ACA). DESIGN: Single center cohort study. METHODS: Consecutive adult patients with incidental ACA diagnosed between 2000 and 2016. RESULTS: Of 1516 patients with incidental ACA (median age 59 years, 62% women), 699 (46%) had nonfunctioning adenomas (NFA), 482 (31%) had mild autonomous cortisol secretion (MACS), 62 (4%) had primary aldosteronism (PA), 39 (3%) had Cushing syndrome (CS), 18 (1%) had PA and MACS (PA-MACS), and 226 (15%) had incomplete workup...
June 28, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38938059/analysis-of-genetic-and-clinical-characteristics-of-androgen-insensitivity-syndrome-a-cohort-study-including-12-families
#6
JOURNAL ARTICLE
Zheng Yuan, Lijun Fan, Yi Wang, Lele Li, Xiaoya Ren, Shengbin Sui, Yanning Song, Ming Cheng, Bingyan Cao, Chunxiu Gong
CONTEXT: Androgen insensitivity syndrome (AIS) manifests itself as variable symptoms of under-virilization in patients with 46, XY disorders caused by androgen receptor (AR) gene variants. This large-sample study aimed to correlate the genotypes and phenotypes to the fertility of individuals. METHODS: This was a cohort study that analyzed genetic and clinical characteristics of patients with AIS from a single center in China. RESULTS: The 117 patients were divided into 53 with complete AIS (CAIS) and 64 with partial AIS (PAIS)...
June 28, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917410/ucp1-expression-in-human-brown-adipose-tissue-is-inversely-associated-with-cardiometabolic-risk-factors
#7
JOURNAL ARTICLE
T'ng Choong Kwok, Lynne E Ramage, Alexandra Kelman, Karla J Suchacki, Calum Gray, Luke D Boyle, Scott I Semple, Tom MacGillivray, Gillian MacNaught, Dilip Patel, Edwin J R van Beek, Robert K Semple, Sonia J Wakelin, Roland H Stimson
OBJECTIVE: Brown adipose tissue (BAT) is a therapeutic target for obesity. 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is commonly used to quantify human BAT mass and activity. Detectable 18F-FDG uptake by BAT is associated with reduced prevalence of cardiometabolic disease. However, 18F-FDG uptake may not always be a reliable marker of BAT thermogenesis, for example insulin resistance may reduce glucose uptake. Uncoupling protein 1 (UCP1) is the key thermogenic protein in BAT...
June 26, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917356/testosterone-therapy-in-older-men-clinical-implications-of-recent-landmark-trials
#8
JOURNAL ARTICLE
Mathis Grossmann, Bradley D Anawalt, Bu B Yeap
Testosterone therapy for men with hypogonadism due to identifiable hypothalamic-pituitary-testicular (HPT) pathology is uncontroversial. However, the risks and benefits of testosterone for men with clinical features of hypogonadism in the absence of identifiable HPT axis pathology have been uncertain. Recent landmark placebo-controlled trials assessed the benefits and risks of testosterone therapy (≤ 3 years) for middle aged and older men with symptoms and possible signs of hypogonadism or end-organ androgen deficiency, low or low-normal serum testosterone concentrations, but no HPT pathology: testosterone therapy 1) had modest-but clinically significant-benefits on average self-reported energy and mood, sexual function and satisfaction; 2) in conjunction with a lifestyle program, reversed or reduced incident diabetes mellitus type 2 (T2D) in men at high risk of or newly diagnosed with T2D; 3) modestly improved objectively assessed muscle strength and timed walking distance; 4) increased bone density and strength, but did not reduce falls or typical osteoporotic fractures and surprisingly increased the risk of fractures typically attributable to trauma; and 5) did not significantly increase the risk of myocardial infarction, stroke or prostate cancer...
June 26, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38924056/assessment-of-prognostic-factors-in-pediatric-adrenocortical-tumors-the-modified-pediatric-s-gras-score-in-an-international-multicenter-cohort-a-work-from-the-ensat-pact-working-group
#9
JOURNAL ARTICLE
Riedmeier Maria, Agarwal Shipra, Antonini Sonir, Costa Tatiana Ei-Jaick B, Diclehan Orhan, Fassnacht Martin, Figueiredo Bonald C, Guran Tulay, Härtel Christoph, Haubitz Imme, Idkowiak Jan, Kuhlen Michaela, Noronha Lúcia, Parise Ivy Zortéa S, Redlich Antje, Puglisi Soraya, Saniye Ekinci, Schlegel Paul-Gerhardt, Yalcin Bilgehan, Verena Wiegering
OBJECTIVE: Pediatric adrenocortical carcinoma (pACC) is rare, and prognostic stratification remains challenging. We aimed to confirm the prognostic value of the previously published pediatric scoring system (pS-GRAS) in an international multicenter cohort. DESIGN: Analysis of pS-GRAS items of pACC from six countries in collaboration of ENSAT-PACT, GPOH-MET and IC-PACT. METHODS: We received patient data of the pS-GRAS items including survival information from nine centers...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917236/targeted-ngs-molecular-profiling-and-its-clinical-application-in-adrenocortical-cancer
#10
JOURNAL ARTICLE
Francesca Cioppi, Giulia Cantini, Tonino Ercolino, Massimiliano Chetta, Lorenzo Zanatta, Gabriella Nesi, Massimo Mannelli, Mario Maggi, Letizia Canu, Michaela Luconi
OBJECTIVE: Adrenal cortical carcinoma (ACC) is a rare malignancy with a generally poor but heterogeneous prognosis, especially depending on the tumour stage at diagnosis. Identification of somatic gene alterations combined with clinical/histopathological evaluation of the tumour can help improve prognostication. We applied a simplified targeted-NGS panel to characterise the mutational profiles of ACCs, providing potentially relevant information for better patient management. DESIGN AND METHODS: Thirty frozen tumour specimens from a local ACC series were retrospectively analysed by a custom-NGS panel (CDKN2A, CTNNB1, DAXX, MED12, NF1, PRKAR1A, RB1, TERT, TP53, ZNRF3) to detect somatic prioritized single-nucleotide variants...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917234/cognitive-functions-and-the-brain-derived-neurotrophic-factor-in-patients-with-macs
#11
JOURNAL ARTICLE
Tugba Barlas, Muhammed Hakan Aksu, Ethem Turgay Cerit, Mehmet Muhittin Yalcin, Mujde Akturk, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Alev Eroglu Altinova
CONTEXT: The impact of abnormal cortisol secretion on cognitive functions in patients with mild autonomous cortisol secretion (MACS) remains uncertain. OBJECTIVE: To assess cognitive functions, determine serum brain-derived neurotrophic factor (BDNF) concentration in patients with MACS, and association between cognitive subdomains and BDNF. METHODS: We prospectively recruited 84 participants: 28 patients with MACS, 28 patients with nonfunctional adrenal adenoma (NFAA), and 28 control subjects matched for age, gender, body mass index (BMI), visceral adiposity and educational level...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917055/ovarian-neuroendocrine-tumor-metastases-can-induce-estrogen-production-in-postmenopausal-patients
#12
JOURNAL ARTICLE
M C F Mulders, M L F van Velthuysen, E M Roes, L J Hofland, H Sasano, W W de Herder, J Hofland
Neuroendocrine tumors (NET) are malignant neoplasms that can be associated with specific hormonal syndromes. We describe a novel syndrome of postmenopausal vaginal bleeding and ovarian estradiol overproduction due to ovarian NET localizations. An extensive workup was performed for two index patients with ovarian metastases of small bowel neuroendocrine tumors and symptoms of postmenopausal vaginal bleeding. Clinically significant ovarian estrogen production was demonstrated by a combination of ovarian vein sampling and normalization of circulating estrogen levels after oophorectomy...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38917024/variants-in-both-the-n-or-c-terminal-domains-of-ihh-lead-to-defective-secretion-causing-short-stature-and-skeletal-defects
#13
JOURNAL ARTICLE
Francisca Díaz-González, Lucía Sentchordi-Montané, Elsa Lucas Castro, Silvia Modamio-Høybjør, Karen E Heath
BACKGROUND: Heterozygous Indian Hedgehog gene (IHH) variants are associated with brachydactyly type A1 (BDA1). However, in recent years, numerous variants have been identified in patients with short stature and more variable forms of brachydactyly. Many are located in the C-terminal domain of IHH (IHH-C), which lacks signaling activity but is critical for auto-cleavage and activation of the N-terminal (IHH-N) peptide. The absence of functional studies of IHH variants, particularly for those located in IHH-C, has led to these variants being classified as variants of uncertain significance (VUS)...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38916995/risk-of-fractures-following-bariatric-surgery-with-roux-en-y-gastric-bypass-or-sleeve-gastrectomy-a-danish-population-based-cohort-study
#14
JOURNAL ARTICLE
Lotte A Winckelmann, Sigrid B Gribsholt, Katrine Bødkergaard, Lars Rejnmark, Lene R Madsen, Bjørn Richelsen
OBJECTIVES: We examined the association between Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) and fracture risk, including major osteoporotic fractures (MOF), and the use of anti-osteoporosis medication (AOM). While RYGB is associated with impaired bone health and increased fracture risk, it remains uncertain whether SG has a similar impact, and whether this risk is primarily due to MOF or any fracture. DESIGN: We conducted a nationwide cohort study covering patients treated with RYGB (n=16,121, 10...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38916798/igf-i-assay-methods-and-biologic-variability-evaluation-of-acromegaly-treatment-response
#15
JOURNAL ARTICLE
David R Clemmons, Martin Bidlingmaier
Serum insulin-like growth factor (IGF-I) is the primary biochemical measure of disease activity in patients with acromegaly, and 2014 Endocrine Society guidelines recommended normal age-adjusted serum IGF-I as the biochemical target of treatment. However, quantification and interpretation of IGF-I levels are subject to limitations that may affect therapeutic decisions. Techniques for measuring IGF-I have evolved greatly over the past 40 years and continue to do so. Results can vary substantially for different assays, procedures, and laboratories...
June 25, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38872400/ten-things-to-remember-about-propensity-scores
#16
JOURNAL ARTICLE
Rolf H H Groenwold, Olaf M Dekkers, Saskia le Cessie
Propensity score methods are popular to control for confounding in observational biomedical studies of risk factors or medical treatments. This paper focused on aspects of propensity score methods that often remain undiscussed, including unmeasured confounding, missing data, variable selection, statistical efficiency, estimands, the positivity assumption, and predictive performance of the propensity score model.
June 14, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38828659/reply-to-the-utility-of-gallium-68-pet-ct-in-men1-related-parathyroid-disease
#17
EDITORIAL
Iiro Kostiainen, Jukka Schildt, Helka Parviainen, Eeva M Ryhänen, Camilla Schalin-Jäntti
No abstract text is available yet for this article.
June 3, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38798229/response-to-letter-from-dr-al-salameh
#18
EDITORIAL
Richard J Auchus, Suranut Charoensri
No abstract text is available yet for this article.
May 27, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38798228/exploring-the-sex-difference-in-cardiovascular-risk-during-growth-hormone-therapy-in-adults
#19
JOURNAL ARTICLE
Tessa N A Slagboom, Aart Jan van der Lely, Madeleine L Drent, Christa C van Bunderen
OBJECTIVE: Given the previously identified sex differences in cardiovascular morbidity and mortality in patients with growth hormone deficiency (GHD) receiving GH replacement therapy (GHRT), our aim is to investigate sex specific differences in the efficacy of (long-term) GHRT on cardiovascular (CV) risk profile and disease in subjects with GHD. Our hypothesis is that women will experience less beneficial effects than men. DESIGN: Retrospective nationwide cohort study...
May 27, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38798200/comparative-analysis-of-intraoperative-and-imaging-features-of-invasive-growth-in-pituitary-adenomas
#20
JOURNAL ARTICLE
Mirko Hladik, Isabella Nasi-Kordhishti, Lorenz Dörner, Kosmas Kandilaris, Jens Schittenhelm, Benjamin Bender, Jürgen Honegger, Felix Behling
BACKGROUND: Most pituitary adenomas, also termed pituitary neuroendocrine tumors (PitNETs), are benign in nature and can be treated effectively by surgical resection, medical treatment and in special cases by radiotherapy. However, invasive growth can be an important feature of a more aggressive behavior and adverse prognosis. Extension of pituitary adenomas into the cavernous sinus can be categorized according to the Knosp criteria on magnetic resonance imaging (MRI). Comparative analyses of MRI features and intraoperative findings of invasive growth regarding different clinical factors are still scarce...
May 27, 2024: European Journal of Endocrinology
journal
journal
31671
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.