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JOURNAL ARTICLE
Adriana Hogeboom, Óscar Toldos, Huberto García-Muñoz
No abstract text is available yet for this article.
October 5, 2024: Virchows Archiv: An International Journal of Pathology
#2
JOURNAL ARTICLE
Antonia Syrnioti, Kyriakos Chatzopoulos, Darcy A Kerr, Dianne E Torrence, Meera Hameed, Narasimhan P Agaram, Cristina Antonescu, Konstantinos Linos
Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain histogenesis, primarily arising in subcutaneous tissues of the extremities, head and neck, or trunk. Most cases present as well-circumscribed masses with a characteristic morphologic appearance, comprising cytologically bland ovoid cells with fibromyxoid stroma, a peripheral rim of metaplastic bone, and lobulated architecture. Nevertheless, tumors displaying unusual morphologic characteristics pose significant diagnostic challenges, requiring the detection of a pathogenic fusion for a definitive diagnosis...
October 4, 2024: Virchows Archiv: An International Journal of Pathology
#3
REVIEW
Marius Ilié, Vivien Lake, Enrique de Alava, Serena Bonin, Sandra Chlebowski, Aurélie Delort, Elisabeth Dequeker, Raed Al-Dieri, Arjan Diepstra, Olli Carpén, Catarina Eloy, Ambrogio Fassina, Falko Fend, Pedro L Fernandez, Gregor Gorkiewicz, Simon Heeke, Rui Henrique, Gerald Hoefler, Pablo Huertas, Michael Hummel, Karl Kashofer, Jeroen van der Laak, Rocio Martinez de Pablos, Fernando Schmitt, Ed Schuuring, Giorgio Stanta, Wim Timens, Benedikt Westphalen, Paul Hofman
Despite advancements in precision medicine, many cancer patients globally, particularly those in resource-constrained environments, face significant challenges in accessing high-quality molecular testing and targeted therapies. The considerable heterogeneity in molecular testing highlights the urgent need to harmonize practices across Europe and beyond, establishing a more standardized and consistent approach in MP laboratories. Professionals, especially molecular pathologists, must move beyond traditional education to cope with this heterogeneity...
October 2, 2024: Virchows Archiv: An International Journal of Pathology
#4
Vincenzo Guastaferro, Devin N Corbitt, Alessandra Bressan, Bethania Fernandes, Ömer Mintemur, Francesca Magnoli, Susanna Ronchi, Stefano La Rosa, Silvia Uccella, Salvatore Lorenzo Renne
No abstract text is available yet for this article.
October 1, 2024: Virchows Archiv: An International Journal of Pathology
#5
JOURNAL ARTICLE
Marit Bernhardt, Oliver Hommerding, Tobias Kreft, Leonie Weinhold, Matthias Schmid, Glen Kristiansen
The histopathological examination of radical prostatectomy specimens is essential for assessing critical tumor characteristics, including stage, grade, and margins, all of which impact patient prognosis. However, the extent of embedding the prostate has long been a subject of debate, with some advocating partial/selective embedding and others favoring complete embedding. This study establishes a standardized and time-efficient protocol for processing radical prostatectomy specimens with limited embedding while maintaining diagnostic accuracy...
October 1, 2024: Virchows Archiv: An International Journal of Pathology
#6
JOURNAL ARTICLE
Esther Diana Rossi, Shipra Agarwal, Suna Erkilic, Jen-Fan Hang, Jalal B Jalaly, Elham Khanafshar, Alexander Ladenheim, Zubair Baloch
Traditionally, psammoma bodies (PB) have been considered as tale-tell evidence of papillary thyroid carcinoma (PTC) and are frequently encountered in classic and other subtypes of PTCs. However, the presence of PBs in the thyroid gland does not always indicate malignancy. The leading hypothesis on their origin suggests that PB are remnants of papillary structures that have undergone thrombosis, necrosis, and subsequent calcification. From January 2010 to May 2024, 26 patients with psammoma bodies associated with benign thyroid lesions, mainly thyroid follicular nodular disease (TFND), Hashimoto thyroiditis (HT), Graves' disease, and follicular adenomas, were found...
September 30, 2024: Virchows Archiv: An International Journal of Pathology
#7
JOURNAL ARTICLE
Elie Tannous, Shreya Patel, Burak Muratoglu, Andrea R Lightle, Richard R Pacheco, Reza Hosseini, Robert R Pacheco, Peter Kim, Gamze T Cetinkaya, Dilek Ertoy Baydar, Kemal Kosemehmetoglu, Yasemin Yuyucu Karabulut, Sree Appu, Laurence A Galea, Adrien N Bernstein, Mahmut Akgul
Localized cystic disease of the kidney (LCDK) is rare without hereditary background and does not progress. It can mimic neoplastic process, leading to unnecessary surgical intervention. We present 14 patients [male-to-female 9:5; mean age 50.3 years (range: 3-79)] with LCDK in a multinational cohort. Flank pain (n=5) and incidental lesions (n=4) were common. All cases were unilateral (9 right, 5 left), and contralateral kidneys were mostly normal (n=11). No family history was present, and none had extrarenal solid organ cysts...
September 28, 2024: Virchows Archiv: An International Journal of Pathology
#8
LETTER
Takeshi Takahashi
No abstract text is available yet for this article.
September 21, 2024: Virchows Archiv: An International Journal of Pathology
#9
JOURNAL ARTICLE
Ronald A Ghossein, Snjezana Dogan, Marc A Cohen, Nora Katabi, Bin Xu
While high-risk human papillomavirus (HPV) serves as an essential pathogen and an important prognostic and predictive biomarker for oropharyngeal squamous cell carcinoma, it occurs at low frequency (2.2-6%) in oral cavity squamous cell carcinoma (OCSCC). To date, the pathologic features of HPV-associated OCSCC (HPV( +)-OCSCC) have been sparsely reported and its prognosis is not well-defined. We herein described detailed clinicopathologic features and outcomes of a retrospective series of 27 HPV( +)-OCSCC, including 13 from Memorial Sloan Kettering Cancer Center (MSKCC) and 14 from The Cancer Genomic Atlas program (TCGA)...
September 18, 2024: Virchows Archiv: An International Journal of Pathology
#10
JOURNAL ARTICLE
Sambit K Mohanty, Anandi Lobo, Shilpy Jha, Ankur R Sangoi, Mahmut Akgul, Kiril Trpkov, Ondrej Hes, Rohit Mehra, Michelle S Hirsch, Holger Moch, Steven C Smith, Rajal B Shah, Liang Cheng, Mahul B Amin, Jonathan I Epstein, Anil V Parwani, Brett Delahunt, Sangeeta Desai, Christopher G Przybycin, Claudia Manini, Daniel J Luthringer, Deepika Sirohi, Deepika Jain, Divya Midha, Ekta Jain, Fiona Maclean, Giovanna A Giannico, Gladell P Paner, Guido Martignoni, Hikmat A Al-Ahmadie, Jesse McKenney, John R Srigley, Jose Ignacio Lopez, L Priya Kunju, Lisa Browning, Manju Aron, Maria M Picken, Maria Tretiakova, Ming Zhou, Mukund Sable, Naoto Kuroda, Niharika Pattnaik, Nilesh S Gupta, Priya Rao, Samson W Fine, Pritinanda Mishra, Amit K Adhya, Bijal N Kulkarni, Mallika Dixit, Manas R Baisakh, Samriti Arora, Sankalp Sancheti, Santosh Menon, Sara E Wobker, Satish K Tickoo, Seema Kaushal, Shailesh Soni, Shivani Kandukuri, Shivani Sharma, Suvradeep Mitra, Victor E Reuter, Vipra Malik, Vishal Rao, Ying-Bei Chen, Sean R Williamson
Oncocytic renal neoplasms are a major source of diagnostic challenge in genitourinary pathology; however, they are typically nonaggressive in general, raising the question of whether distinguishing different subtypes, including emerging entities, is necessary. Emerging entities recently described include eosinophilic solid and cystic renal cell carcinoma (ESC RCC), low-grade oncocytic tumor (LOT), eosinophilic vacuolated tumor (EVT), and papillary renal neoplasm with reverse polarity (PRNRP). A survey was shared among 65 urologic pathologists using SurveyMonkey...
September 17, 2024: Virchows Archiv: An International Journal of Pathology
#11
JOURNAL ARTICLE
Youcef-Chafik Belgaid, Anissa Moktefi
The publication productivity of residents has been reported in various specialties, mainly in North America, but never in pathology. In France, pathology residents must defend a medical thesis to obtain the title of medical doctor and to practice medicine. The aim of this study was to assess the thesis performance and publication output of a nationwide cohort of pathology residents from six graduating classes in France. Among 231 theses, 110 (48%) resulted in publications, of which 95% were original articles (OA) and 74% were resident first-author publications...
September 17, 2024: Virchows Archiv: An International Journal of Pathology
#12
JOURNAL ARTICLE
Kamilla Németh, László Báthory-Fülöp, Andrea Kohánka, Andrea Simon, Erika Tóth, Zsombor Melegh
No abstract text is available yet for this article.
September 16, 2024: Virchows Archiv: An International Journal of Pathology
#13
JOURNAL ARTICLE
Eisuke Katafuchi, Satoshi Hisano, Satoko Kurata, Kumiko Muta, Noriko Uesugi, Tetsu Miyamoto, Yoshikazu Harada, Shohei Shimajiri, Ritsuko Katafuchi, Toshiyuki Nakayama
Podocyte detachment is a major trigger in pathogenesis of focal segmental glomerulosclerosis (FSGS). Detachment via β1 integrin (ITGB1) endocytosis, associated with endothelial cell injury, has been reported in animal models but remains unknown in human kidneys. The objectives of our study were to examine the difference in ITGB1 dynamics between primary FSGS and minimal change nephrotic syndrome (MCNS), among variants of FSGS, as well as between the presence or absence of cellular lesions (CEL-L) in human kidneys, and to elucidate the pathogenesis of FSGS...
September 13, 2024: Virchows Archiv: An International Journal of Pathology
#14
JOURNAL ARTICLE
Vincenzo Guastafierro, Devin N Corbitt, Alessandra Bressan, Bethania Fernandes, Ömer Mintemur, Francesca Magnoli, Susanna Ronchi, Stefano La Rosa, Silvia Uccella, Salvatore Lorenzo Renne
ChatGPT, an AI capable of processing and generating human-like language, has been studied in medical education and care, yet its potential in histopathological diagnosis remains unexplored. This study evaluates ChatGPT's reliability in addressing pathology-related diagnostic questions across ten subspecialties and its ability to provide scientific references. We crafted five clinico-pathological scenarios per subspecialty, simulating a pathologist using ChatGPT to refine differential diagnoses. Each scenario, aligned with current diagnostic guidelines and validated by expert pathologists, was posed as open-ended or multiple-choice questions, either requesting scientific references or not...
September 13, 2024: Virchows Archiv: An International Journal of Pathology
#15
JOURNAL ARTICLE
M Mauramo, J Tarkkanen, A Skalova, I Leivo
No abstract text is available yet for this article.
September 12, 2024: Virchows Archiv: An International Journal of Pathology
#16
REVIEW
Antonina V Kalmykova, Vira Baranovska-Andrigo, Michael Michal
The section on mesenchymal tumors in the 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutaneous mesenchymal tumors with melanocytic differentiation, and rearrangements of the CRTC1::TRIM11, ACTIN::MITF, and MITF::CREM genes as well as EWSR1::SMAD3-rearranged fibroblastic tumors, superficial CD34-positive fibroblastic tumors, and NTRK-rearranged spindle cell neoplasms...
September 12, 2024: Virchows Archiv: An International Journal of Pathology
#17
JOURNAL ARTICLE
Luisa Di Sciascio, Agnese Orsatti, Francesca Ambrosi, Eugenia Franchini, Francesco Massari, Veronica Mollica, Federico Mineo Bianchi, Maurizio Colecchia, Antonio De Leo, Andres Martin Acosta, João Lobo, Michelangelo Fiorentino, Costantino Ricci
Embryonic-type neuroectodermal tumor (ENT) is a somatic-type malignancy characterized by overgrowth of embryonic-type neuroectodermal tissue (EtNT). In germ cell tumors, EtNT is frequently intermingled with other components that may exhibit significant morphologic overlap [mature neuro-glial tissue (MNGT), nephroblastomatous tissues, and primitive endodermal-type glands]. Therefore, the quantification of EtNT (crucial for the diagnosis of ENT) can be challenging. In this study, we investigated the immunohistochemical profile of ENT, EtNT, and MNGT using a broad immunohistochemical panel...
September 11, 2024: Virchows Archiv: An International Journal of Pathology
#18
JOURNAL ARTICLE
Luiza Dorofte, Sabina Davidsson, Jessica Carlsson, Gabriella Lillsunde Larsson, Mats G Karlsson
Inguinal lymph node surgery is a standard treatment for penile cancer patients with intermediate or high risk for lymph node metastasis (LNM) according to European Association of Urology (EAU) risk grading. We are proposing a more objective histological prognostic grading system for inguinal LNM in these patients. We assessed worst pattern of invasion, lymphocytic host response, lymphovascular invasion, and perineural invasion in a population-based cohort of 306 penile cancer patients. Patients were classified into low, intermediate, and high risk for inguinal LNM...
September 9, 2024: Virchows Archiv: An International Journal of Pathology
#19
JOURNAL ARTICLE
Toshiki Hyodo, Shigeo Hara, Shunsuke Goto, Hideki Fujii, Shinichi Nishi, Akihiro Yoshimoto, Tomoo Itoh
Neural epidermal growth factor-like 1 protein (NELL1) is the second most common target antigen in membranous glomerulonephritis (MGN). However, data regarding the clinicopathological characteristics of NELL1-associated MGN are limited owing to its low prevalence. This study examined the prevalence and clinicopathological characteristics of NELL1-associated MGN in a Japanese cohort. Additionally, we compared the clinicopathological features of NELL1-positive MGN, phospholipase A2 receptor 1 (PLA2R1)-positive MGN, and MGN negative for all three antigens (NELL1, PLA2R1, and thrombospondin type-1 domain-containing 7A)...
September 9, 2024: Virchows Archiv: An International Journal of Pathology
#20
JOURNAL ARTICLE
Abbas Agaimy, Morgan Blakely, Gerben E Breimer, Annett Hölsken, Sjors A Koppes, Norbert Meidenbauer, Johannes A Rijken, Arno Schad, Adrian G Simon, Robert Stoehr, Justin A Bishop, Nasir Ud Din
With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive neoplasms, not fitting any well established WHO entity. Recently, a group of intra-abdominal FET(EWSR1/FUS)::CREB(CREM/ATF1) fused unclassified neoplasms has been reported followed by recent recognition of an analogous extra-abdominal category of unclassified neoplasms carrying EWSR1::ATF1 fusions. We describe 9 additional tumors (5 extra-abdominal and 4 abdominal) carrying an EWSR1::CREM (n = 8) and FUS::CREM (n = 1) fusion...
September 9, 2024: Virchows Archiv: An International Journal of Pathology
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