Journals Virchows Archiv : An Internati...

Virchows Archiv : An International Journal of Pathology
Hirotake Fujii, Yosuke Yamada, Kentaro Yamamura, Yoshihiro Ishida, Marina Tsujimura, Kazuhisa Matsumoto, Satona Tanaka, Hiroshi Date, Tadaaki Nishikawa, Yukihiro Yoshida, Jumpei Kashima, Yasushi Yatabe, Seishi Ogawa, Alexander Marx, Thomas M Ulbright, Hironori Haga
Vasculogenic mesenchymal tumor (VMT), a primitive mesenchymal neoplasm enriched by various-sized atypical vessels, is a new entity that develops in mediastinal germ cell tumors (GCTs) with yolk sac tumor (YST) components after chemotherapy. Notably, patients with VMT in the residual GCT have increased risk of developing sarcomas or hematopoietic malignancies. Here, we report a late-teenage male patient with residual teratoma and high-grade VMT after chemotherapy for a mediastinal mixed GCT, including YST. Whole-exome sequencing revealed biallelic inactivation of TP53 and extensive copy number alterations that suggested whole-genome doubling...
March 21, 2023: Virchows Archiv: An International Journal of Pathology
Dina M El-Guindy, Fatma MKh Ibrahim, Dina A Ali, Hemat El-Sayed El-Horany, Nesreen M Sabry, Rasha A Elkholy, Wael Mansour, Duaa S Helal
Autophagy is a cellular response to diverse stresses within tumor microenvironment (TME) such as hypoxia. It enhances cell survival and triggers resistance to therapy. This study investigated the prognostic importance of HIF-1α and miR-210 in triple negative breast cancer (TNBC). Also, we studied the relation between beclin-1 and Bcl-2 and their prognostic relevance in triple negative breast cancer. Furthermore, the involvement of hypoxia-related markers, beclin-1 and Bcl-2 in mediating resistance to neoadjuvant chemotherapy (NACT) in TNBC was evaluated...
March 20, 2023: Virchows Archiv: An International Journal of Pathology
Grégoire Gessain, Natacha Joyon, Thomas Petit, Sophie Cotteret, Magali Lacroix-Triki
Breast cancer is the most common malignancy in woman, and its associated mortality is still rising worldwide. Among all the different subtypes of breast cancer, invasive lobular carcinoma (ILC) is the second most frequent. Several histological variants of ILC currently exist such as solid, alveolar, pleomorphic, tubulo-lobular, and mixed types. Recently, a new variant of ILC with a papillary growth pattern has been described. Here, we make a review of the literature and report the sixth case of a woman suffering from this very uncommon variant...
March 16, 2023: Virchows Archiv: An International Journal of Pathology
Mary N Sheppard, Allard C van der Wal, Jytte Banner, Giulia d'Amati, Monica De Gaspari, Rosa De Gouveia, Cira Di Gioia, Carla Giordano, Maiken Kudahl Larsen, Matthew J Lynch, Joaquin Lucena, Pilar Molina, Sarah Parsons, M Paz Suarez-Mier, Stefania Rizzo, Simon Kim Suvarna, Wouter P Te Rijdt, Gaetano Thiene, Aryan Vink, Joseph Westaby, Katarzyna Michaud, Cristina Basso
Cardiomyopathies (CMP) comprise a heterogenous group of diseases affecting primarily the myocardium, either genetic and/or acquired in origin. While many classification systems have been proposed in the clinical setting, there is no internationally agreed pathological consensus concerning the diagnostic approach to inherited CMP at autopsy. A document on autopsy diagnosis of CMP is needed because the complexity of the pathologic backgrounds requires proper insight and expertise. In cases presenting with cardiac hypertrophy and/or dilatation/scarring with normal coronary arteries, a suspicion of inherited CMP must be considered, and a histological examination is essential...
March 10, 2023: Virchows Archiv: An International Journal of Pathology
Katsuya Hirose, Yuko Omori, Yusuke Ono, Yusuke Mizukami, Yoshiki Kaneko, Tsunehiko Maruyama, Haruo Ohtani, Toru Furukawa
Detailed genetic and immunohistochemical features of a sarcomatoid carcinoma of the gallbladder were reported. Studied was a resected gallbladder tumor involving the transverse colon, which was consisted of 3 histopathological neoplastic components, i.e., high-grade dysplasia, adenocarcinoma, and sarcomatoid carcinoma. The targeted amplicon sequencing showed somatic mutations in TP53 (p.S90fs) and ARID1A (c.4993 + 1G > T) in all of the 3 components. Copy numbers of CDKN2A and SMAD4 were decreased in the adenocarcinoma and the sarcomatoid component...
March 9, 2023: Virchows Archiv: An International Journal of Pathology
Siba El Hussein, L Jeffrey Medeiros, Stephen K Gruschkus, Peng Wei, Ellen Schlette, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Warren Fiskus, Rashmi Kanagal-Shamanna, Sanam Loghavi, Hong Yang, Shaoying Li, Jie Xu, Zhenya Tang, Beenu Thakral, Nitin Jain, William G Wierda, Keyur Patel, Kapil N Bhalla, Joseph D Khoury
Immune checkpoint inhibitors (PD-1 inhibitors) have shown clinical activity in Richter transformation-diffuse large B-cell lymphoma variant (RT-DLBCL), thus providing for a novel therapeutic approach. The study group consists of 64 patients with RT-DLBCL. Expression of PD-1, PD-L1, CD30, and microsatellite instability (MSI) status (hMLH1, hMSH2, hMSH6, PMS1) was assessed using immunohistochemistry. EBV-encoded RNA (EBER) was evaluated using colorimetric in situ hybridization. PD-1 and PD-L1 expression levels were categorized on the basis of tumor cell expression as follows: negative (< 5%), positive to low-positive (5-50%), or high-positive (> 50%)...
March 3, 2023: Virchows Archiv: An International Journal of Pathology
Tomonori Kawasaki, Tomoaki Tashima, Atsushi Enomoto, Tetsuo Kondo, Hirokazu Nagai, Yasuhiro Nakamura, Jiro Ichikawa, Kiyomi Taniyama, Kyoichi Kaira
No abstract text is available yet for this article.
March 2, 2023: Virchows Archiv: An International Journal of Pathology
Jin Xu, Kay J Park, William M Rehrauer, Paul S Weisman
In general, endometrioid-defining features such as squamoid morular metaplasia are not thought to be associated with mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA). Here, we report a case of FGFR2-mutated ovarian MLA with squamoid morular metaplasia accompanied by aberrant nuclear and cytoplasmic β-catenin expression and CTNNB1 mutation. Histologically, the tumor showed classical MLA histology, including well-formed glands with intraluminal eosinophilic secretions and cells with papillary thyroid carcinoma-like nuclei...
March 1, 2023: Virchows Archiv: An International Journal of Pathology
Maki Ohya, Ayako Tateishi, Yuki Matsumoto, Hidetoshi Satomi, Mikiko Kobayashi
Acute respiratory distress syndrome (ARDS) is a serious complication of systemic inflammatory response syndrome, and diffuse alveolar damage (DAD) is a histological manifestation of ARDS. Endothelial cell injury is mainly responsible for ARDS. Many neutrophils and macrophages/monocytes, which are inflammatory cells that play a role in innate immunity, infiltrate the lung tissue in DAD. In recent years, it has become clear that CD8 plays an important role not only in the acquired immune system, but also in the innate immune system...
February 27, 2023: Virchows Archiv: An International Journal of Pathology
Zhongyi Yang, Xiyue Wang, Jinxi Xiang, Jun Zhang, Sen Yang, Xinran Wang, Wei Yang, Zhongyu Li, Xiao Han, Yueping Liu
Prostate cancer (PCa) is a significant health concern in aging males, and the diagnosis depends primarily on histopathological assessments to determine tumor size and Gleason score. This process is highly time-consuming, subjective, and relies on the extensive experience of the pathologists. Deep learning based artificial intelligence shows an ability to match pathologists on many prostate cancer diagnostic scenarios. However, it is easy to make mistakes on some hard cases with small tumor areas considering the extensively high-resolution of whole slide images (WSIs)...
February 23, 2023: Virchows Archiv: An International Journal of Pathology
Ting Xue, Ru Yan, Zaishang Li, Shengjie Guo, Xiao Xiao, Jietian Jin, Lijuan Jiang, Huali Ma, Chong Wu, Tingyu Liu, Lichao Wei, Longbin Xiong, Fangjian Zhou, Kai Yao, Ranyi Liu, Hui Han
Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC...
February 23, 2023: Virchows Archiv: An International Journal of Pathology
Sebastian Streich, Leonie Frauenfeld, Franziska Otto, Barbara Mankel, Irina Bonzheim, Falko Fend, Leticia Quintanilla-Martinez
Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma (B-NHL) in adults. These lymphomas are classified according to gene expression profiling (GEP) into germinal center B-cell (GCB) and activated B-cell type (ABC). Recent studies have suggested new subtypes of large B-cell lymphoma, based on genetic and molecular alterations, among them is large B-cell lymphoma with IRF4-rearrangement (LBCL-IRF4). We used fluorescence in situ hybridization (FISH), GEP (using the DLBCL COO assay by HTG Molecular Inc), and next generation sequencing (NGS) to comprehensively characterize 30 cases of LBCLs located in Waldeyer's ring in adult patients and to identify LBCL-IRF4...
February 22, 2023: Virchows Archiv: An International Journal of Pathology
Andrej Zupan, Vladka Salapura, Daja Šekoranja, Jože Pižem
Chondromyxoid fibroma (CMF) is a rare benign bone tumour. While CMF located entirely on the surface of a bone (i.e. juxtacortical CMF) has been well characterised, CMF has not so far been convincingly documented to arise in soft tissues without connection to an underlying bone.We report a subcutaneous CMF in a 34-year-old male, located on the distal medial aspect of the right thigh without any connection with the femur. The tumour measured 15 mm, it was well-circumscribed and displayed typical morphological features of a CMF...
February 21, 2023: Virchows Archiv: An International Journal of Pathology
Catarina Eloy, Ana Marques, João Pinto, Jorge Pinheiro, Sofia Campelos, Mónica Curado, João Vale, António Polónia
Paige Prostate is a clinical-grade artificial intelligence tool designed to assist the pathologist in detecting, grading, and quantifying prostate cancer. In this work, a cohort of 105 prostate core needle biopsies (CNBs) was evaluated through digital pathology. Then, we compared the diagnostic performance of four pathologists diagnosing prostatic CNB unaided and, in a second phase, assisted by Paige Prostate. In phase 1, pathologists had a diagnostic accuracy for prostate cancer of 95.00%, maintaining their performance in phase 2 (93...
February 21, 2023: Virchows Archiv: An International Journal of Pathology
Tao Zhang, Xin Zhou, Xiaofei Zhang, Shuang Niu, Hao Chen, Feng Zhou
Differential expression of programmed death-1 ligand (PD-L1) and its clinical significance in primary and metastatic ovarian high-grade serous carcinoma (HGSC) have not been defined. Thus, we investigated the PD-L1 expression of paired ovarian primary and omental metastatic HGSC and its correlation with CD8 + tumor-infiltrating lymphocyte (TILs) and patient survival. A total of 212 cases of ovarian HGSCs with matched primary ovarian and metastatic omental tumors accessioned between 2003 and 2018 were selected for further analysis...
February 21, 2023: Virchows Archiv: An International Journal of Pathology
Valentina Angerilli, Paola Parente, Gianluca Businello, Alessandro Vanoli, Michele Paudice, Giovanni Perrone, Giada Munari, Ilaria Govoni, Giuseppe Neri, Elena Rebellato, Paola Parrella, Federica Grillo, Luca Mastracci, Matteo Fassan
Colorectal adenosquamous carcinoma (ASC) is exceedingly rare, comprising less than 0.1% of all colorectal malignancies, and is characterized by an aggressive disease course, with a higher metastatic rate and worse outcome than conventional colorectal adenocarcinoma. A comprehensive molecular profile of this group of neoplasms is still lacking. A total of 22 cases of colorectal ASCs (with 22 primary lesions and 7 metastases matched with 4 primaries) were subject to NGS targeting 67 cancer-related genes (VariantPlex solid tumor; Archer)...
February 15, 2023: Virchows Archiv: An International Journal of Pathology
Sean M Hacking, Yihong Wang
Do traditional prognostic factors fully account for the diversity of clinical behavior in breast cancer? Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer seen to have a poor prognosis, although there is great variation in clinical outcomes. Most recently, novel approaches have targeted the tumoral microenvironment (TME) to determine prognosis and tumor-associated stroma has become increasingly recognized as a potential biomarker to predict treatment response and prognosis in TNBC...
February 15, 2023: Virchows Archiv: An International Journal of Pathology
Jakob Einhaus, Alexander Rochwarger, Sven Mattern, Brice Gaudillière, Christian M Schürch
High-multiplex tissue imaging (HMTI) approaches comprise several novel immunohistological methods that enable in-depth, spatial single-cell analysis. Over recent years, studies in tumor biology, infectious diseases, and autoimmune conditions have demonstrated the information gain accessible when mapping complex tissues with HMTI. Tumor biology has been a focus of innovative multiparametric approaches, as the tumor microenvironment (TME) contains great informative value for accurate diagnosis and targeted therapeutic approaches: unraveling the cellular composition and structural organization of the TME using sophisticated computational tools for spatial analysis has produced histopathologic biomarkers for outcomes in breast cancer, predictors of positive immunotherapy response in melanoma, and histological subgroups of colorectal carcinoma...
February 9, 2023: Virchows Archiv: An International Journal of Pathology
Hiroshi Kobayashi, Kenji Notohara, Mitsuko Nakashima, Masuo Ujita, Toru Takano, Shunsuke Tsubata, Riuko Ohashi, Hirotomo Saitsu, Souichi Sugitani
Hepatic small vessel neoplasia (HSVN) is a recently recognized hemangioma of the liver with uncertain malignant potential. Almost all the patients are asymptomatic. Budd-Chiari syndrome (BCS) is a rare disorder characterized by noncardiogenic hepatic venous outflow obstruction. Benign hepatocellular nodules have been acknowledged for a long time in the liver with the chronic BCS. However, there has been no case report of BCS associated with HSVN. The patient was diagnosed with BCS 13 years ago. The imaging test initially displayed multiple hepatic nodules that were suspected of benign hepatocellular nodules...
February 9, 2023: Virchows Archiv: An International Journal of Pathology
Irena Antonia Ungureanu, Fleur Cohen-Aubart, Sébastien Héritier, Sylvie Fraitag, Frédéric Charlotte, Hippolyte Lequain, Zofia Hélias-Rodzewicz, Julien Haroche, Jean Donadieu, Jean-François Emile
Diagnosis of histiocytosis can be difficult and one of the biggest challenges is to distinguish between reactive and neoplastic histiocytes on histology alone. Recently, OCT2 nuclear expression was reported in Rosai-Dorfman disease (RDD). Our purpose was to expand the testing of OCT2 on a broader variety of sporadic or H syndrome-related histiocytoses. Cases of histiocytoses were retrieved from the files of Ambroise Paré Pathology Department. All slides and molecular analyses were reviewed, and staining was completed with immunohistochemistry for OCT2...
February 9, 2023: Virchows Archiv: An International Journal of Pathology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.