Michaela Kendall Bártů, Kristýna Němejcová, Romana Michálková, Ivana Stružinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Jan Laco, Radoslav Matěj, Jana Drozenová, Gábor Méhes, Pavel Fabian, Jitka Hausnerová, Marián Švajdler, Petr Škapa, David Cibula, Tomáš Zima, Pavel Dundr
Ovarian clear cell carcinoma (OCCC) is a subtype of ovarian carcinoma characterized by unique biological features and highly malignant characteristics including low chemosensitivity. Therefore, new therapeutic targets are needed. These could include the downstream pathways of receptor tyrosine kinases, especially the human epidermal growth factor receptor 2 (HER2). Our main objective was to characterize the HER2 status using immunohistochemistry (IHC) and FISH on 118 OCCCs, also considering the novel paradigm of HER2-zero and HER2-low status...
September 7, 2023: Virchows Archiv: An International Journal of Pathology