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Journals Virchows Archiv : An Internati...

Virchows Archiv : An International Journal of Pathology

https://read.qxmd.com/read/38879691/a-deep-learning-based-model-for-assessment-of-autoimmune-hepatitis-from-histology-ai-h
#1
JOURNAL ARTICLE
Caner Ercan, Kattayoun Kordy, Anna Knuuttila, Xiaofei Zhou, Darshan Kumar, Ville Koponen, Peter Mesenbrink, Serenella Eppenberger-Castori, Parisa Amini, Marcos C Pedrosa, Luigi M Terracciano
Histological assessment of autoimmune hepatitis (AIH) is challenging. As one of the possible results of these challenges, nonclassical features such as bile-duct injury stays understudied in AIH. We aim to develop a deep learning tool (artificial intelligence for autoimmune hepatitis [AI(H)]) that analyzes the liver biopsies and provides reproducible, quantifiable, and interpretable results directly from routine pathology slides. A total of 123 pre-treatment liver biopsies, whole-slide images with confirmed AIH diagnosis from the archives of the Institute of Pathology at University Hospital Basel, were used to train several convolutional neural network models in the Aiforia artificial intelligence (AI) platform...
June 15, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38877360/papillary-renal-neoplasm-with-reverse-polarity-has-low-frequency-of-alterations-in-chromosomes-7-17-and-y
#2
JOURNAL ARTICLE
Daisuke Kiyozawa, Takeshi Iwasaki, Dai Takamatsu, Kenichi Kohashi, Takumi Miyamoto, Genshiro Fukuchi, Masatoshi Eto, Michifumi Yamashita, Yoshinao Oda
In papillary renal neoplasm with reverse polarity (PRNRP), the status of chromosomal copy number alterations, especially chromosomes 7/17 gain and chromosome Y loss, has remained controversial. In the literatures, there is a discrepancy among the results of chromosomal alteration in PRNRP depending on the analytical methods. Here, we comprehensively analyzed the status of chromosomal abnormalities in PRNRP. Nineteen PRNRP cases were analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), five of which were additionally subjected to array-based comparative genomic hybridization (aCGH) analysis...
June 14, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38877359/obliteration-of-liver-sinusoids-through-platelet-aggregates-associated-to-extramedullary-haematopoiesis-in-myeloid-neoplasms
#3
JOURNAL ARTICLE
Adeline Normand, Yannick Le Bris, Delphine Loussouarn, Jérôme Gournay, Jean-François Mosnier
Herein is reported a series of five patients with myeloid neoplasms presenting hepatic complications in whose liver biopsy revealed obstruction of sinusoids by platelet aggregates associated to liver extramedullary haematopoiesis. Indication of liver biopsies was jaundice, unexplained hepatomegaly or portal hypertension. Haematological disorders were classified according to the World Health Organisation. Molecular profile was established in all cases as well as grade of liver extramedullary haematopoiesis and myelofibrosis...
June 14, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38877358/clear-cell-adult-rhabdomyoma-a-rare-variant-of-an-unusual-tumour
#4
JOURNAL ARTICLE
Ming Liang Oon, Bingcheng Wu, Rachel Lim, Melvin Kang Ming Liew, Fredrik Petersson
No abstract text is available yet for this article.
June 14, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38850328/small-blue-round-cell-tumor-with-focal-epithelial-differentiation-harboring-a-novel-yap1-leutx-fusion-with-poor-prognosis
#5
JOURNAL ARTICLE
Xu-Xi Yang, Feng Gao, Ru Ding, Jia Wei, Xiao-Mei Zhu, Qi-Xing Gong
No abstract text is available yet for this article.
June 8, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38834916/multimodal-integration-of-clinic-pathology-and-genomics-for-a-rare-diagnosis-of-ebv-positive-primary-mediastinal-large-b-cell-lymphoma
#6
JOURNAL ARTICLE
Pierre-Alain Thiebaut, Pierre Isnard, Lucile Couronné, Sophie Kaltenbach, Charles Lepine, David Sibon, Estelle Balducci, Philippe Ruminy, Cécile Badoual, Josette Brière, Olivier Hermine, Vahid Asnafi, Phillippe Gaulard, Julie Bruneau, Thierry Jo Molina
No abstract text is available yet for this article.
June 4, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38833174/-aberrant-expression-of-skeletal-muscle-markers-in-neuroendocrine-carcinomas-a-significant-diagnostic-pitfall
#7
JOURNAL ARTICLE
Guillermo Garcia-Porrero, Faye Wood, Sara Faria, Paul J Kelly, W Glenn McCluggage
In this study, we investigate the expression of muscle markers, including the specific skeletal muscle markers myogenin and myoD1, in neuroendocrine carcinomas (NECs). The study included 23 NECs from various sites (14 small cell NECs and 9 large cell NECs). These were stained with desmin, myogenin and myoD1. Positive staining with at least one muscle marker was observed in 14 cases (61%). 8 (35%), 8 (35%) and 11 (48%) of the cases were positive with desmin, myogenin and myoD1 respectively. In most, but not all, cases positive staining was focal generally involving < 10% of tumour cells...
June 4, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38833173/small-cell-neuroendocrine-carcinoma-and-poorly-differentiated-rhabdomyosarcomas-of-the-urinary-bladder-in-adults-a-comparative-analysis-in-favor-of-a-common-histogenesis
#8
JOURNAL ARTICLE
Veronika Bahlinger, Robert Stoehr, Arndt Hartmann, Ondřej Hes, Abbas Agaimy
Rhabdomyosarcoma (RMS) of the urinary bladder in adults and elderly is an exceptionally rare neoplasm that displays poorly differentiated solid (alveolar-like) small cell pattern, frequently indistinguishable from small cell neuroendocrine carcinoma (SCNEC). However, the histogenesis of RMS and SCNEC and their inter-relationship have not been well studied and remained controversial. We herein analyzed 23 SCNEC and 3 small round cell RMS of the bladder for neuroendocrine (synaptophysin + chromogranin A) and myogenic (desmin + myogenin) marker expression and for TERT promoter mutations...
June 4, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38822175/paediatric-pancreatic-acinar-cell-carcinoma-with-a-novel-sec31a-braf-fusion-gene
#9
JOURNAL ARTICLE
Tingting Li, Yin Cheng, Yixuan Han, Li Yang, Qiang Wei, Xiaosong Yan, Yue Shi, Xin Zhang, Meng Yang, Yanfei Liu
Paediatric pancreatic acinar cell carcinoma (PACC) presents a diagnostic challenge, often confused with pancreatoblastoma (PB) due to its rarity. It is crucial to differentiate between PB and PACC, given their distinct therapeutic strategies and prognoses. Histologically, the absence of squamoid nests and scarcity of tumor mesenchyme support PACC. Conversely, the identification of a BRAF alteration leans towards PACC. Here, we present the case of an 8-year-old girl with a well-defined mass in the pancreas. The tumor exhibited a SEC31A-BRAF fusion gene and amplification of 18p, showcasing unequivocal acinar differentiation and a minor degree of neuroendocrine differentiation...
June 1, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38814477/non-small-cell-lung-carcinoma-with-clear-cell-features-a-clinicopathologic-immunohistochemical-and-molecular-study-of-31-cases
#10
JOURNAL ARTICLE
David I Suster, Natali Ronen, Haider A Mejbel, Shuko Harada, A Craig Mackinnon, Saul Suster
Non-small cell lung carcinoma with predominantly clear cell features is a rare histologic presentation of lung carcinoma. We have examined 31 cases of lung carcinomas showing extensive clear cell features. The patients were 10 women and 21 men aged 47-92 years (mean: 70 years). The tumors showed a predilection for the right upper and lower lobes and measured from 0.8 to 9.5 cm (mean: 4.2 cm). By immunohistochemistry, 9 cases were typed as adenocarcinoma, 19 cases as squamous cell carcinoma, and 3 showed a "null" phenotype with complete loss of markers for adenocarcinoma or squamous cell carcinoma...
May 30, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38805049/morphology-and-multiparameter-flow-cytometry-combined-for-integrated-lymphoma-diagnosis-on-small-volume-samples-possibilities-and-limitations
#11
REVIEW
Mats Ehinger, Marie C Béné
The diagnosis of lymphoma relies mainly on clinical examination and laboratory explorations. Among the latter, morphological and immunohistochemical analysis of a tissue biopsy are the cornerstones for proper identification and classification of the disease. In lymphoma with blood and/or bone marrow involvement, multiparameter flow cytometry is useful. This technique can also be applied to fresh cells released from a biopsy sample. For full comprehension of lymphomas, surgical biopsies are best and indeed recommended by the hematopathological community...
May 28, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38801436/cd34-s100-protein-positive-ntrk1-rearranged-infantile-fibrosarcoma-like-tumors-in-genitourinary-system-two-cases-expanding-the-clinicopathologic-spectrum-and-illustrating-the-diagnostic-dilemma
#12
JOURNAL ARTICLE
Ming Zhao, Jiayun Xu, Jian Wang
Infantile fibrosarcoma (IFS) is malignant fibroblastic tumor of infants characterized genetically by ETV6::NTRK3 fusion. Tumors that show morphology indistinguishable from IFS but harbor alternative genetic alterations are uncommon, which have been designated as IFS-like tumors. We report two cases of IFS-like tumors harboring an NTRK1 rearrangement and arsing from genitourinary system. The patients aged 3 and 14 years. One arose in the kidney and one in the paratesticular region. The tumors measured 13 and 3...
May 27, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38789627/neonatal-spindle-cell-cd34-positive-plaque-like-tumour-a-new-entity-characterised-by-ntrk-gene-fusion
#13
JOURNAL ARTICLE
P Drabent, T Kervarrec, A Tallet, S Fraitag
No abstract text is available yet for this article.
May 24, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38780618/correction-to-digital-pathology-structure-and-deployment-in-veneto-a-proof-of-concept-study
#14
Albino Eccher, Stefano Marletta, Marta Sbaraglia, Angela Guerriero, Mattia Rossi, Giovanni Gambaro, Aldo Scarpa, Angelo Paolo Dei Tos
No abstract text is available yet for this article.
May 23, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38780617/primary-cutaneous-epidermotropic-mycosis-fungoides-like-presentation-critical-appraisal-and-description-of-two-novel-cases-broadening-the-spectrum-of-alk-t-cell-lymphoma
#15
JOURNAL ARTICLE
Giorgio Alberto Croci, Lorena Appio, Caterina Cecchetti, Silvia Tabano, Silvia Alberti-Violetti, Emilio Berti, Daoud Rahal, Francesca Cavallaro, Francesco Onida, Dario Tomasini, Elisabetta Todisco
Leading from a two-case series, including two patients receiving a diagnosis of epidermotropic T-cell lymphoma, featuring a mycosis fungoides (MF)-like clinical pattern and ALK expression and molecular alteration, we performed a critical appraisal of ALK+ primary cutaneous T-cell lymphomas (pcTCL). Considering our patients and the literature, 32 cases were retrieved, 7 of which featured an MF-like clinical picture over a 4-to-20-year period. MF-like cases show distinctive histology, comprising a predominantly epidermotropic infiltration of small-to-large, atypical-to-pleomorphic, with few anaplastic cells, negligible-to-intense CD30-expression, and a CD4+/cytotoxic granule+ phenotype...
May 23, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38780616/shared-chromosome-21q-loss-in-a-mixed-subtype-renal-cell-carcinoma-composite-or-collision-tumor
#16
JOURNAL ARTICLE
Samantha A Stephen, Lauren M Wainman, Joel A Lefferts, Jason R Pettus
Clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC) are the two most frequently encountered subtypes of renal cell carcinoma (RCC). Rarely, these two entities are identified intermingled within the same mass and have been labeled either collision tumors juxtaposed by random chance or composite tumors that have arisen from a common tumorigenic precursor cell. Regarding this distinction, authors have commonly relied upon macroscopic, histologic, and clinicopathologic findings, which may be prone to subjectivity...
May 23, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38771338/pd-l1-expression-tumor-infiltrating-lymphocytes-and-mismatch-repair-proteins-status-in-digestive-neuroendocrine-neoplasms-exploring-their-potential-role-as-theragnostic-and-prognostic-biomarkers
#17
JOURNAL ARTICLE
Eléonore Multone, Stefano La Rosa, Christine Sempoux, Silvia Uccella
Theragnostic biomarkers are still needed to select patients with digestive neuroendocrine neoplasms (NENs) for an optimal management. The PD-1/PD-L1 pathway plays a pivotal role in T cells activation and host immune response to cancer and PD-L1 expression in tumor and/or immune cells is used to identify patients who would benefit of treatment with immune checkpoint inhibitors. However, its role as a biomarker is still unclear in digestive NENs. We investigated PD-L1 expression in 68 well-characterized digestive NENs (32 NETs, 32 NECs and 4 MiNENs) and TPS and CPS scores were calculated...
May 21, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38760594/beyond-histology-a-tissue-algorithm-predictive-of-post-surgical-recurrence-in-hepatocellular-carcinomas-including-tert-promoter-mutation
#18
JOURNAL ARTICLE
Francesco Vasuri, Stefano Chillotti, Thais Maloberti, Elisa Albertini, Giuliana Germinario, Matteo Cescon, Matteo Ravaioli, Dario de Biase, Antonia D'Errico
Surgical resection for hepatocellular carcinoma (HCC) is burdened with a high recurrence rate and a lack of reliable prognostic factors. The aim of this study was to integrate the HCC pathological features with gene mutations to improve the prognostic role of pathological analysis. This is a monocentric prospective study, including 67 patients resected for HCC. All clinical data and histological features were collected, including tumor grade, architecture, margins, microvascular invasion, and microscopic portal vascular invasion (MPVI)...
May 18, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38760593/immunophenotypic-analysis-of-angiomyolipoma-with-epithelial-cysts-comparison-to-mixed-epithelial-and-stromal-tumors-and-epithelial-and-stromal-elements-of-normal-kidney-and-ovaries
#19
JOURNAL ARTICLE
Irem Kilic, Sheila Segura, Thomas M Ulbright, Hector Mesa
Angiomyolipoma with epithelial cysts (AMLEC) is a rare variant of renal angiomyolipoma (AML). It is characterized by a conventional AML component admixed with epithelial cysts within an "ovarian-like" stroma. Mixed epithelial and stromal tumor (MEST) is another renal neoplasm featuring epithelial cysts and "ovarian-like" stroma. While there is consensus that in MEST the epithelial and stromal components are neoplastic, in AMLEC it has been hypothesized that the epithelial component may represent renal tubular entrapment or ovarian-like transdifferentiation of tumor cells...
May 17, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38758231/impact-of-immunohistochemistry-staining-conditions-on-the-incidence-of-human-epidermal-growth-factor-receptor-2-her2-low-breast-cancer
#20
JOURNAL ARTICLE
Min Chong Kim, Sun Young Kwon, Hye Ra Jung, Young Kyung Bae
We investigated frequencies of HER2-low breast cancer (BC) (immunohistochemistry [IHC] 1+ or 2+ without gene amplification) before and after IHC conditions were modified in order to understand the impact of IHC staining conditions on frequencies of HER2-low BC. Primary BC cases diagnosed at the Yeungnam University Hospital (YUH, n = 728) or Keimyung University Dongsan Hospital (KUDH, n = 290) in 2022 were reviewed, and data on HER2 status and IHC conditions were collected (cohort 1). Both institutions used the 4B5 antibody for HER2 IHC but had different staining protocols...
May 17, 2024: Virchows Archiv: An International Journal of Pathology
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