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Virchows Archiv: An International Journal of Pathology

Sho Shiino, Masayuki Yoshida, Kenjiro Jimbo, Sota Asaga, Shin Takayama, Akiko Maeshima, Hitoshi Tsuda, Takayuki Kinoshita, Nobuyoshi Hiraoka
Benign inclusions, such as endosalpingiosis, in an axillary sentinel lymph node (SLN) can be misdiagnosed as metastatic breast carcinoma. However, endosalpingiosis is rare in lymph nodes above the diaphragm. Among 792 patients with breast carcinoma who underwent sentinel lymph node biopsy at our center, 2 patients have experienced benign glandular inclusions in 3 SLNs, and all of these glandular inclusions were lined with columnar and ciliated epithelial cells. Immunohistochemistry revealed that the epithelial cells were positive for Müllerian markers (e...
February 12, 2019: Virchows Archiv: An International Journal of Pathology
Arnaud de la Fouchardière, Claire Caillot, Julien Jacquemus, Emeline Durieux, Aurélie Houlier, Véronique Haddad, Daniel Pissaloux
Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin D1 in these tumors. We assessed nuclear β-catenin immunohistochemical expression in a large group of DPN as well as in the four most frequent differential diagnoses of DPN: "blue" melanocytic tumors, Spitz tumors, nevoid and SSM melanomas, and pigmented epithelioid melanocytomas (PEM)...
February 12, 2019: Virchows Archiv: An International Journal of Pathology
Margaret Ottaviano, Sabino De Placido, Paolo Antonio Ascierto
AbstractSeveral researches have been carried over the last few decades to understand of how cancer evades the immune system and thus to identify therapies that could directly act on patient's immune system in the way of restore or induce a response to cancer. As a consequence, "cancer immunotherapy" is conquering predominantly the modern scenario of the fight against cancer. The recent clinical success of immune checkpoint inhibitors (ICIs) has created an entire new class of anti-cancer drugs and restored interest in the field of immuno-oncology, leading to regulatory approvals of several agents for the treatment of a variety of malignancies...
February 12, 2019: Virchows Archiv: An International Journal of Pathology
Tatiana Franceschi, Emeline Durieux, Anne Pierre Morel, Pierre de Saint Hilaire, Isabelle Ray-Coquard, Alain Puisieux, Mojgan Devouassoux-Shisheboran
Several subtypes of high-grade endometrial carcinomas (ECs) contain an undifferentiated component of non-epithelial morphology, including undifferentiated and dedifferentiated carcinomas and carcinosarcomas (CSs). The mechanism by which an EC undergoes dedifferentiation has been the subject of much debate. The epithelial-mesenchymal transition (EMT) is one of the mechanisms implicated in the transdifferentiation of high-grade carcinomas. To improve our understanding of the role of EMT in these tumors, we studied a series of 89 carcinomas including 14 undifferentiated/dedifferentiated endometrial carcinomas (UECs/DECs), 49 CSs (21 endometrial, 29 tubo-ovarian and peritoneal), 17 endometrioid carcinomas (grade 1-3), and 9 high-grade serous carcinomas of the uterus, using a panel of antibodies targeting known epithelial markers (Pan-Keratin AE1/AE3 and E-cadherin), mesenchymal markers (N-cadherin), EMT transcription factors (TFs) (ZEB1, ZEB2, TWIST1), PAX8, estrogen receptors (ER), progesterone receptors (PR), and the p53 protein...
February 9, 2019: Virchows Archiv: An International Journal of Pathology
Elisa Schmoeckel, Sophie Hofmann, Daniel Fromberger, Miriam Rottmann, Beate Luthardt, Alexander Burges, Udo Jeschke, Thomas Kirchner, Sigurd F Lax, Doris Mayr
Most ovarian carcinomas (OC) are characterized by poor prognosis, particularly the most frequent type high-grade serous carcinoma. Besides PARP inhibitors, target-based therapeutic strategies are not well established. We asked the question which other therapeutic targets could be of potential value and, therefore, analyzed a large cohort of OC for several predictive factors. Two hundred eighty-eight (288) cases of OC including the major histological types were analyzed by immunohistochemistry for PD-L1HER2, ALK, and the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6...
February 7, 2019: Virchows Archiv: An International Journal of Pathology
Kun Jiang, Brian Martens, Logan Meyer, Kim Truong, Gregory Y Lauwers
Invasive primary squamous cell carcinomas involving the anorectal region are challenging to manage. Microsatellite instability has been shown to impact clinical courses and outcomes of patients affected by many types of carcinomas. To the best of our knowledge, there are no reports on microsatellite instability in anorectal squamous cell carcinomas. Here, we report a HPV-negative anorectal squamous cell carcinoma which, despite cisplatin-based chemoradiation therapy, showed progression. Interestingly, after identification of its mismatch repair-deficiency (MLH1/PMS2-absent, MSH2/MSH6-intact), pembrolizumab-based immunotherapy was initiated, leading to a marked clinical response...
February 7, 2019: Virchows Archiv: An International Journal of Pathology
Somboon Keelawat, Andrey Bychkov
Immunophenotype of thyroglossal duct (TGD) cysts, including lining epithelium and thyroid remnants, is scarcely addressed in the literature. There is indirect evidence that C cells may be derived from progenitor cells of the midline thyroid primordium. This is supported by the recent concept of the endodermal origin of lateral thyroid anlagen and several case reports. We aimed to search for neuroendocrine cells in TGD cysts and to characterize immunophenotype of the thyroid follicles and epithelial lining of TGD...
February 7, 2019: Virchows Archiv: An International Journal of Pathology
C Boutanos, M Capdepont, M Svrcek, F Thélu, N Guedj, F Poizat, F Bibeau, B Turlin, A Rousseau, A Bardier, J Selves, M Desrousseaux, F Le Pessot, B Bonhomme, M-H Laverrière, C Julié, R-P Eyremandi, S Stanislas, C Bazille, A Daubech, T Lazure, M-S Bordier, A Demoures, Anne Rullier
The quality of pathologic assessment of rectal cancer specimens is crucial for treatment efficiency and survival. The Royal College of Pathologists (RCP) recommends evaluating the quality of the pathology report in routine practice using three quality indicators (QIs): the number of lymph nodes (LNs) analyzed (≥ 12), the rate of venous invasion (VI ≥ 30%), and peritoneal involvement (pT4a ≥ 10%). In this study, we evaluated the three QIs of the French national pathology reports and compared them with British guidelines and assessed the influence of neoadjuvant radiochemotherapy on QIs...
February 6, 2019: Virchows Archiv: An International Journal of Pathology
Cleo Keppens, Kelly Dufraing, Han J van Krieken, Albert G Siebers, George Kafatos, Kimberly Lowe, Gaston Demonty, Elisabeth M C Dequeker
Biomarker analysis for colorectal cancer has been shown to be reliable in Europe with 97% of samples tested by EQA participants to be correctly classified. This study focuses on errors during the annual EQA assessment. The aim was to explore the causes and actions related to the observed errors and to provide feedback and assess any improvement between 2016 and 2017. An electronic survey was sent to all laboratories with minimum one genotyping error or technical failure on ten tumor samples. A workshop was organized based on 2016 survey responses...
February 5, 2019: Virchows Archiv: An International Journal of Pathology
Dolors Cuevas, Joan Valls, Sònia Gatius, Berta Roman-Canal, Elena Estaran, Eduard Dorca, Maria Santacana, Marta Vaquero, Núria Eritja, Ana Velasco, Xavier Matias-Guiu
The two most frequent types of endometrial cancer (EC) are endometrioid (EEC) and serous carcinomas (SC). Differential diagnosis between them is not always easy. A subset of endometrial cancers shows misleading microscopical features, which cause problems in differential diagnosis, and may be a good scenario for next-generation sequencing. Previous studies have assessed the usefulness of targeted sequencing with panels of generic cancer-associated genes in EC histological typing. Based on the analysis of TCGA (The Cancer Genome Atlas), EEC and SC have different mutational profiles...
February 1, 2019: Virchows Archiv: An International Journal of Pathology
Nicolas Wyvekens, Markus Rechsteiner, Christine Fritz, Ulrich Wagner, Joëlle Tchinda, Carina Wenzel, Friederike Kuithan, Lars-Christian Horn, Holger Moch
The 2016 WHO Classification of Tumors of the Urinary System recognizes microphthalmia transcription factor (MiT) family translocation carcinomas as a separate entity among renal cell carcinomas. TFE3 and transcription factor EB (TFEB) are members of the MiT family for which chromosomal rearrangements have been associated with renal cell carcinoma formation. TFEB translocation renal cell carcinoma is a rare tumor harboring a t(6;11)(p21;q12) translocation. Recently, renal cell carcinomas with TFEB amplification have been identified...
January 31, 2019: Virchows Archiv: An International Journal of Pathology
Anna Luíza Damaceno Araújo, Lady Paola Aristizábal Arboleda, Natalia Rangel Palmier, Jéssica Montenegro Fonsêca, Mariana de Pauli Paglioni, Wagner Gomes-Silva, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão, Luciana Estevam Simonato, Paul M Speight, Felipe Paiva Fonseca, Marcio Ajudarte Lopes, Oslei Paes de Almeida, Pablo Agustin Vargas, Cristhian Camilo Madrid Troconis, Alan Roger Santos-Silva
Validation studies of whole slide imaging (WSI) systems produce evidence regarding digital microscopy (DM). This systematic review aimed to provide information about the performance of WSI devices by evaluating intraobserver agreement reported in previously published studies as the best evidence to elucidate whether DM is reliable for primary diagnostic purposes. In addition, this review delineates the reasons for the occurrence of discordant diagnoses. Scopus, MEDLINE/PubMed, and Embase were searched electronically...
January 26, 2019: Virchows Archiv: An International Journal of Pathology
Thomas Menter, Veronika Ballova, Clemens Caspar, Thomas Wolff, Benjamin Kasenda, Gad Singer, Darius Juskevicius, Alexandar Tzankov, Stefan Dirnhofer
We report on a 73-year-old male patient with recurrent thrombosis of his infrarenal aortic prosthesis. Histologically, the thrombus contained cells of an ALK-negative anaplastic large cell T cell lymphoma (ALCL). Imaging studies were negative for other lymphoma manifestations; however, 3 months before, the patient had developed skin lesions consistent with lymphomatoid papulosis type A (LypA) which were clonally related to the ALCL. Due to recurrent thrombosis of larger peripheral arteries with the presence of ALCL cells in the thrombi, the patient is now referred to systemic chemotherapy...
January 26, 2019: Virchows Archiv: An International Journal of Pathology
Christiane Stuhlmann-Laeisz, Stefan O Schönland, Ute Hegenbart, Ilske Oschlies, Julius-Valentin Baumgart, Sandra Krüger, Christoph Röcken
Immunoglobulin light chain-derived (AL) amyloidosis may occur as a systemic disease usually with dismal prognosis and a localized variant with favorable outcome. We report 29 patients with AL amyloidosis and associated lymphoplasmacytic infiltrate spatially related to amyloid deposits. In 17 cases, the amyloid deposits were classified as ALλ and 12 as ALκ Histopathology in all cases showed relatively sparse plasma cells and B cells without tumor or sheet formation by the lymphoplasmacytic infiltrate. The B cells predominantly showed an immunophenotype of the marginal zone...
January 24, 2019: Virchows Archiv: An International Journal of Pathology
Gwyneth Shook Ting Soon, Kenneth Tou En Chang, Chik Hong Kuick, Fredrik Petersson
We report the first patient (a 13-year-old girl) with a sinonasal low-grade non-intestinal-type adenocarcinoma showing aberrant CDX2 expression both within morular areas and in the tubular component and demonstrate for the first time a SYN2-PPARG gene fusion in this tumor type. The tumor arose from the nasal septum and had not spread beyond the nasal cavity.
January 21, 2019: Virchows Archiv: An International Journal of Pathology
Kazuki Kanayama, Hiroshi Imai, Eri Usugi, Taizo Shiraishi, Yoshifumi S Hirokawa, Masatoshi Watanabe
No abstract text is available yet for this article.
January 19, 2019: Virchows Archiv: An International Journal of Pathology
Ayca Kirmizi, Arzu Ensari
No abstract text is available yet for this article.
January 19, 2019: Virchows Archiv: An International Journal of Pathology
Christopher Pool, Vonn Walter, Darrin Bann, David Goldenberg, James Broach, Max Hennessy, Elizabeth Cottrill, Erik Washburn, Nicole Williams, Henry Crist, Yuka Imamura, Joshua I Warrick
"Follicular variant" papillary thyroid carcinomas (FV-PTC) that do not histologically invade have a miniscule risk of metastasis, and thus been reclassified as a tumor of low malignant potential, the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). There are few molecular studies of this tumor type. We performed gene expression analysis, by RNA sequencing, on a series of FV-PTCs, NIFTPs, and follicular adenomas. A training set comprised tumors from The Cancer Genome Atlas (TCGA) repository (n = 46), digital slides from which were reviewed and classified as invasive or non-invasive FV-PTC...
January 15, 2019: Virchows Archiv: An International Journal of Pathology
Barbara Zanini, Anna Bozzola, Vincenzo Villanacci
No abstract text is available yet for this article.
January 14, 2019: Virchows Archiv: An International Journal of Pathology
Kimiya Sato, Morikazu Miyamoto, Masashi Takano, Kenichi Furuya, Hitoshi Tsuda
L-type amino acid transporter 1 (LAT1) is a Na+ -independent neutral amino acid transporter that plays a key role in cancer cell growth and survival. To determine the significance of LAT1 in prognosis and resistance to chemotherapy in ovarian carcinoma, we investigated the LAT1 expression in 245 ovarian carcinoma patients by immunohistochemistry using tissue microarray. High expression of LAT1 was detected in 85 (34.7%) patients. The ratio of high expression of LAT1 was significantly high in clear cell carcinoma and low in serous carcinoma compared to other histological types (P < 0...
January 13, 2019: Virchows Archiv: An International Journal of Pathology
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