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Journals Virchows Archiv : An Internati...

Virchows Archiv : An International Journal of Pathology

https://read.qxmd.com/read/37733105/correction-to-35-th-european-congress-of-pathology-abstracts
#1
(no author information available yet)
No abstract text is available yet for this article.
September 21, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37733104/correction-to-35-th-european-congress-of-pathology-abstracts
#2
(no author information available yet)
No abstract text is available yet for this article.
September 21, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37731064/novel-gene-fusion-discovery-in-spitz-tumours-and-its-relevance-in-diagnostics
#3
JOURNAL ARTICLE
Louis Delsupehe, Thomas Steelandt, Julie Lemahieu, Pieter-Jan Volders, Ellen Geerdens, Severine Berden, Annick Daniels, Guy Froyen, Brigitte Maes
In addition to morphologic analysis, molecular diagnostic work up of Spitz tumours is often of great value for their accurate diagnosis/classification. Nowadays, next-generation sequencing (NGS) is the predominant screening method in molecular diagnostics. Up to 80% of these melanocytic neoplasms comprise gene fusions as genetic anomalies for which the driver codes for a protein harbouring a kinase domain. However, because of the variety of fusion partners the use of PCR-based targeted enrichment NGS methods is not recommended...
September 21, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37726450/heterogeneity-of-tpit-expression-in-acth-secreting-extra-pituitary-neuroendocrine-tumors-nets-supports-the-existence-of-different-cellular-programs-in-pancreatic-and-pulmonary-nets
#4
JOURNAL ARTICLE
Silvia Uccella, Eleonora Leoni, Simon Kaiser, Roberta Maragliano, Alessandro Valerio, Laura Libera, Maria Laura Tanda, Marco Volante, Dario Diviani, Stefano La Rosa
Extra-pituitary ACTH secretion is associated with a variety of neoplastic conditions and may cause the so-called ectopic ACTH-dependent Cushing syndrome (CS). The clarification of the mechanisms of extra-pituitary ACTH expression would provide potential therapeutic targets for this complex and severe disease. In the adenohypophysis, the transcription factor TPIT, co-operating with other molecules, induces POMC expression and ACTH production. However, no data are currently available on the presence and role of TPIT expression in extra-pituitary ACTH-producing neoplasms...
September 19, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37725208/correction-to-35-th-european-congress-of-pathology-abstracts
#5
(no author information available yet)
No abstract text is available yet for this article.
September 19, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37725207/correction-to-35-th-european-congress-of-pathology-abstracts
#6
(no author information available yet)
No abstract text is available yet for this article.
September 19, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37723345/refining-the-application-of-prame-a-useful-marker-in-high-csd-and-acral-melanoma-subtypes
#7
JOURNAL ARTICLE
Craig Wakefield, Laura O'Keefe, Cynthia C B B Heffron
Pathologic discordance affecting patient management may approach 20% in melanocytic cases following specialist review. The diagnostic utility of PRAME has been highlighted in several studies but interpretative challenges exist including its use in severely dysplastic compound nevi showing progression to melanoma in situ, nevoid melanoma, and coexisting nevi with melanoma. We examine the PRAME status of a broad spectrum of melanocytic lesions including challenging, dysplastic nevi with severe atypia from a large Irish patient cohort...
September 19, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37718335/utility-of-wnt-family-member-9b-wnt9b-immunohistochemistry-in%C3%A2-the-cytologic-diagnosis-of-metastatic-breast-carcinoma
#8
JOURNAL ARTICLE
Yigit Baykara, Shaolei Lu, Dongfang Yang, Yihong Wang, Evgeny Yakirevich, Sean Hacking, Latha Pisharodi, Sara Maleki
Wnt family member 9b (Wnt9b) has been demonstrated as a valuable marker for breast cancer diagnosis in surgical pathology. In this study, we examined the utility of Wnt9b in diagnosing metastatic breast carcinoma in cytology samples. Cell blocks from fine needle aspirations (FNA) and fluid specimens of 96 metastatic breast carcinomas and 123 primary and metastatic non-breast neoplasms from various organ systems were evaluated by Wnt9b and GATA3 immunohistochemistry (IHC). Wnt9b and GATA3 were positive in 81...
September 18, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37713130/kmt2a-rearranged-sarcoma-with-unusual-fusion-gene-cbx6-kmt2a-pygo1
#9
JOURNAL ARTICLE
Harumi Nakamura, Yoji Kukita, Toru Wakamatsu, Satoshi Takenaka, Keiichi Yoshida, Toshinari Yagi
Recently, rare sarcomas harboring KMT2A rearrangements have been reported. They occur in relatively young individuals, exhibit a sclerosing epithelioid fibrosarcoma-like morphology, and often have an aggressive prognosis. YAP1::KMT2A::YAP1 is the most common fusion gene, followed by VIM::KMT2A. We report the case of a 47-year-old man with a spindle cell tumor arising from the subcutaneous tissue of the right anterior chest. The tumor harbored an unusual novel fusion gene, CBX6::KMT2A::PYGO1. Histologically, the tumor consisted of proliferating spindle-shaped cells with uniform nuclei, which varied in cell density and the amount of intervening collagen fibers...
September 15, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37704825/distinct-patterns-of-biomarker-expression-for-atypical-intraductal-proliferations-in-prostate-cancer
#10
JOURNAL ARTICLE
Carmela Martini, Jessica M Logan, Alexandra Sorvina, Sarita Prabhakaran, Benjamin S Y Ung, Ian R D Johnson, Shane M Hickey, Robert D Brooks
High-grade prostatic intraepithelial neoplasia (HGPIN) is a well-characterised precursor lesion in prostate cancer. The term atypical intraductal proliferations (AIP) describes lesions with features that are far too atypical to be considered HGPIN, yet insufficient to be diagnosed as intraductal carcinoma of the prostate (IDCP). Here, a panel of biomarkers was assessed to provide insights into the biological relationship between IDCP, HGPIN, and AIP and their relevance to current clinicopathological recommendations...
September 14, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37704824/three-dimensional-analysis-of-ductular-reactions-and-their-correlation-with-liver-regeneration-and-fibrosis
#11
JOURNAL ARTICLE
Tadashi Yoshizawa, Jae W Lee, Seung-Mo Hong, DongJun Jung, Michaël Noë, Wojciech Zbijewski, Ashley Kiemen, Pei-Hsun Wu, Denis Wirtz, Ralph H Hruban, Laura D Wood, Kiyoko Oshima
The liver has multiple regeneration modes, including hepatocellular hypertrophy and self-renewal of hepatocytes. When hepatocyte proliferation is impaired, hepatic progenitor cells may proliferate through ductular reaction (DR), differentiate into hepatocytes, and contribute to fibrosis. However, the three-dimensional spatial relationship between DR and regenerating hepatocytes and dynamic changes in DR associated with fibrosis remain poorly understood. Here, we performed three-dimensional (3D) imaging of cleared 42 liver explants with chronic and acute liver diseases and 4 normal livers to visualize DR...
September 14, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37704823/myxoid-liposarcoma-with-nuclear-pleomorphism-a-clinicopathological-and-molecular-study
#12
JOURNAL ARTICLE
Naoki Kojima, Takashi Kubo, Taisuke Mori, Kaishi Satomi, Yuko Matsushita, Shintaro Iwata, Yasushi Yatabe, Koichi Ichimura, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
Myxoid liposarcoma (MLS) is a common type of liposarcoma. It is characterized by variably lipogenic uniform cells in myxoid stroma with arborizing capillaries and DDIT3 fusion. Nuclear uniformity is the rule, which is maintained even in high-grade round cell examples. In this study, we conducted an in-depth investigation of four MLS tumors that demonstrated nuclear pleomorphism in three patients. These cases accounted for 2.1% of 142 patients with MLS. All patients were male aged 26, 33, and 49 years. Nuclear pleomorphism was observed in both primary and metastatic tumors in one patient, a primary tumor in one patient, and a metastatic tumor in another patient...
September 13, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37695411/correction-to-the-many-faces-of-nodal-and-splenic-marginal-zone-lymphomas
#13
Alberto Zamò, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
No abstract text is available yet for this article.
September 11, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37695410/androgenetic-biparental-mosaicism-in-a-diploid-mole-like-conceptus-report-of-a-case-with-triple-paternal-contribution
#14
JOURNAL ARTICLE
Marie Donzel, Lucie Gaillot-Durand, Madeleine Joubert, Jacqueline Aziza, Claire Beneteau, Claire Mauduit, Stéphane Ploteau, Touria Hajri, Pierre-Adrien Bolze, Jérôme Massardier, Mojgan Devouassoux-Shisheboran, Lone Sunde, Fabienne Allias
Hydatidiform moles (HMs) are divided into two types: partial hydatidiform mole (PHM) which is most often diandric monogynic triploid and complete hydatidiform mole (CHM) which is most often diploid androgenetic. Morphological features and p57 immunostaining are routinely used to distinguish both entities. Genetic analyses are required in challenging cases to determine the parental origin of the genome and ploidy. Some gestations cannot be accurately classified however. We report a case with atypical pathologic and genetic findings that correspond neither to CHM nor to PHM...
September 11, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37676270/her2-status-as-a-potential-predictive-biomarker-for-ovarian-clear-cell-carcinoma
#15
JOURNAL ARTICLE
Michaela Kendall Bártů, Kristýna Němejcová, Romana Michálková, Ivana Stružinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Jan Laco, Radoslav Matěj, Jana Drozenová, Gábor Méhes, Pavel Fabian, Jitka Hausnerová, Marián Švajdler, Petr Škapa, David Cibula, Tomáš Zima, Pavel Dundr
Ovarian clear cell carcinoma (OCCC) is a subtype of ovarian carcinoma characterized by unique biological features and highly malignant characteristics including low chemosensitivity. Therefore, new therapeutic targets are needed. These could include the downstream pathways of receptor tyrosine kinases, especially the human epidermal growth factor receptor 2 (HER2). Our main objective was to characterize the HER2 status using immunohistochemistry (IHC) and FISH on 118 OCCCs, also considering the novel paradigm of HER2-zero and HER2-low status...
September 7, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37668667/discordance-in-pd-l1-expression-using-22c3-and-sp142-assays-between-primary-and-metastatic-triple-negative-breast-cancer
#16
JOURNAL ARTICLE
Jun Miyakoshi, Shu Yazaki, Tatsunori Shimoi, Mai Onishi, Ayumi Saito, Shosuke Kita, Kasumi Yamamoto, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Kazuki Sudo, Emi Noguchi, Takeshi Murata, Sho Shiino, Shin Takayama, Akihiko Suto, Yasuhiro Fujiwara, Masayuki Yoshida, Kan Yonemori
AIMS: SP142 and 22C3 assays are approved companion diagnostic assays for anti-PD-1/PD-L1 therapy selection in metastatic triple-negative breast cancer (TNBC). The discordance in PD-L1 status between primary and metastatic tumors in the same patient has been poorly characterized. Here, we examined the concordance of PD-L1 status between the two assays and between primary tumors and metastases for each assay. METHODS: We retrospectively evaluated tumor samples from 160 patients with TNBC, including 45 patients with paired primary and metastatic tumors...
September 5, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37658995/molecular-neuropathology-an-essential-and-evolving-toolbox-for-the-diagnosis-and-clinical-management-of-central-nervous-system-tumors
#17
REVIEW
Luca Bertero, Luca Mangherini, Alessia Andrea Ricci, Paola Cassoni, Felix Sahm
Molecular profiling has transformed the diagnostic workflow of CNS tumors during the last years. The latest WHO classification of CNS tumors (5th edition), published in 2021, pushed forward the integration between histopathological features and molecular hallmarks to achieve reproducible and clinically relevant diagnoses. To address these demands, pathologists have to appropriately deal with multiple molecular assays mainly including DNA methylation profiling and DNA/RNA next generation sequencing. Tumor classification by DNA methylation profiling is now a critical tool for many diagnostic tasks in neuropathology including the assessment of complex cases, to evaluate novel tumor types and to perform tumor subgrouping in hetereogenous entities like medulloblastoma or ependymoma...
September 2, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37658196/35-th-european-congress-of-pathology-abstracts
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37656249/the-many-faces-of-nodal-and-splenic-marginal-zone-lymphomas
#19
REVIEW
Alberto Zamò, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Session 3 of the lymphoma workshop of the XXI joint meeting of the European Association for Haematopathology and the Society for Hematopathology took place in Florence, Italy, on September 22, 2022. The topics of this session were splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas and their differential diagnosis as well as related entities. Forty-two cases in these categories were submitted to the workshop, including splenic lymphomas (marginal zone and diffuse red pulp lymphomas), transformed marginal zone lymphomas (splenic and nodal), nodal marginal zone lymphomas with increased TFH-cells, and pediatric nodal marginal zone lymphomas...
September 1, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37653260/minimally-invasive-autopsies-for-the-investigation-of-pulmonary-pathology-of-covid-19-experiences-of-a-longitudinal-series-of-92-patients
#20
JOURNAL ARTICLE
Petar Noack, Claudia Grosse, Jacob Bodingbauer, Marion Almeder, Sylvia Lohfink-Schumm, Helmut J F Salzer, Jens Meier, Bernd Lamprecht, Clemens A Schmitt, Rupert Langer
Minimally invasive autopsies (MIAs) allow the collection of tissue samples for diagnostic and research purposes in special situations, e.g., when there is a high risk of infection which is the case in the context of COVID-19 or restrictions due to legal or personal reasons. We performed MIA to analyze lung tissue from 92 COVID-19 patients (mean age 78 years; range 48-98; 35 women, 57 men), representing 44% of all patients who died from the disease between October 2020 and April 2021. An intercostal approach was used with removal of a 5-cm rib section followed by manual collection of four lung tissue samples (5-8 cm in size)...
September 1, 2023: Virchows Archiv: An International Journal of Pathology
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