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International Journal of Clinical Pharmacology and Therapeutics

https://read.qxmd.com/read/38085095/super-responder-and-clinical-remission-in-patients-with-asthma-on-treatment-with-single-biologic-therapy-or-cycling-therapy-using-dupilumab-in-a-real-world-setting
#21
JOURNAL ARTICLE
Satoshi Hamada, Eriko Ogino, Hirotaka Yasuba
BACKGROUND: Regarding the therapeutic target in asthma, super-responder status (SR) is a status without systemic corticosteroids. Recently, clinical remission (CR), being a status of prolonged absence of asthma symptoms without systemic corticosteroids and/or normal pulmonary function, has gained attention as a new therapeutic target in asthma. Here, we examined the percentage and features of asthma patients on treatment with dupilumab showing SR and CR. MATERIALS AND METHODS: 49 asthma patients used subcutaneous dupilumab for > 1 year between April 2019 and November 2022...
December 12, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38032148/network-target-theory-and-network-pharmacology-next-generation-drug-research-in-medicine-using-ai-models
#22
JOURNAL ARTICLE
Xiaojing Han, Chenghui Wang, Rui Li, Qiuye Wang, Wenbo Lu, Weidong Pan
No abstract text is available yet for this article.
November 30, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38032147/gliptin-induced-bullous-pemphigoid
#23
JOURNAL ARTICLE
Maria Ganeva, Tanya Gancheva, Karen Manuelyan, Evgenya Hristakieva
OBJECTIVES: Bullous pemphigoid (BP) is a rare, autoimmune, blistering disease in elderly patients that can be triggered by external factors including drugs. Drug-induced bullous pemphigoid (DIBP) does not always follow a self-limiting course after the withdrawal of the offending drug. Dipeptidyl peptidase-4 (DPP-4) inhibitors or gliptins seem to be associated with a significant risk of inducing BP. CASE PRESENTATION: We report 2 cases of BP attributed to the DPP-4 inhibitor linagliptin...
November 30, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38032146/pharmacokinetics-and-bioequivalence-of-two-metoprolol-succinate-extended-release-tablets-in-healthy-chinese-subjects-under-fasting-and-fed-conditions
#24
JOURNAL ARTICLE
Xiding Yang, Ronghua Zhu, Xiaojun Chen, Jingjing Li, Guirong Luo, Lingfeng Yang, Xiao Fan, Qiangyong Yan, Wenxing Peng, Pingfei Fang
AIMS: The aims of this study were to evaluate and compare the pharmacokinetic profiles and establish bioequivalence of test and reference metoprolol succinate extended-release (ER) tablets in healthy Chinese subjects under fasting and fed conditions. MATERIALS AND METHODS: Subjects were randomly assigned to either the fasting or the fed group and also to one of the two treatment sequences (test-reference or reference-test), according to which they received a single 47...
November 30, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37997944/-methylobacterium-infection-induced-peritonitis-in-a-patient-with-renal-insufficiency-a-case-report-and-literature-review
#25
JOURNAL ARTICLE
Huiyi Wu, Huanhao Chen, Wenfeng Wu, Ping Zheng, Yilei Li
Clinical pharmacists participated in the drug therapy of peritonitis caused by Methylobacterium infection in a patient with renal insufficiency. Based on the knowledge of clinical pharmacy, the patient's condition and laboratory parameters, the literature, and the pharmacokinetic/pharmacodynamic characteristics of antibiotics, amikacin in combination with ciprofloxacin was suggested for anti-infection therapy. During the treatment, clinical pharmacists timely evaluated the efficacy of antibiotics, monitored the adverse reactions, and provided individualized pharmaceutical care in the patient...
November 24, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969097/is-compressed-colchicine-tablet-superior-to-other-colchicine-preparations-in-patients-with-familial-mediterranean-fever
#26
JOURNAL ARTICLE
İbrahim Vasi, Rıza Can Kardaş, Derya Yıldırım, Burcugül Kaya, Rahime Duran, Hazan Karadeniz, Aslıhan Avanoğlu Güler, Abdulsamet Erden, Hamit Küçük, Berna Göker, Abdurrahman Tufan, Mehmet Akif Öztürk
AIMS: The aim of our study is to evaluate the differences in effectiveness, dosage, and side effect profiles in the use of colchicine preparations and evaluate the superiority of compressed colchicine tablets in familial Mediterranean fever (FMF) patients with resistance or intolerance to coated colchicine tablets. MATERIALS AND METHODS: Patients who were diagnosed with FMF according to the Tel Hashomer criteria, aged 18 years and older, and switched from compressed colchicine to coated colchicine tablets in the rheumatology clinic of Gazi University were identified...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969096/effect-of-pre-treatment-of-egfr-tkis-on-immune-checkpoint-inhibitor-associated-interstitial-lung-disease-in-lung-cancer-patients-analysis-using-a-japanese-claims-database
#27
JOURNAL ARTICLE
Naoto Okada, Hirofumi Hamano, Kenta Yagi, Takahiro Niimura, Fuka Aizawa, Mitsuhiro Goda, Yoshito Zamami, Takashi Kitahara, Keisuke Ishizawa
BACKGROUND: Immune checkpoint inhibitors (ICI) and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are key drugs for the treatment of EGFR mutation-positive lung cancer. While previous studies reported that the concomitant use of these drugs increases the risk of interstitial lung disease (ILD), the impact of sequential treatment on ILD risk is unknown. This study aimed to analyze the impact of EGFR-TKI pre-treatment on the risk of developing ILD after subsequent ICI administration...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969095/monitoring-of-blood-levels-in-patients-administered-cyp3a4-inhibitor-during-the-maintenance-phase-of-venetoclax-administration
#28
JOURNAL ARTICLE
Toshiki Kubo, Shunsuke Matsuo, Rintaro Sogawa, Takeo Yasu, Toshiaki Nagaie, Sho Okamoto, Shinya Kimura, Chisato Shimanoe
OBJECTIVE: Venetoclax, an oral B-cell lymphoma-2 inhibitor, necessitates dose adjustment when combined with a CYP3A4 inhibitor; however, the dosing regimen remains unclear on adding a CYP3A4 inhibitor after venetoclax administration. CASE SUMMARY: We present a case report of a patient who was simultaneously treated with a CYP3A4 inhibitor and a steady daily dose of venetoclax. A 30-year-old male diagnosed with acute myeloid leukemia received a combination of venetoclax and azacitidine as remission induction therapy...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969094/german-longitudinal-prescription-database-lrx-description-of%C3%A2-characteristics-use-in-pharmacoepidemiological-research-and-limitations
#29
JOURNAL ARTICLE
Karel Kostev, Ying Wang, Robert Singh, Matthias Kalder, Sven H Loosen, Christoph Roderburg, Marcel Konrad, Louis Jacob
Large databases have played a critical role in pharmacoepidemiological research in the last decade, with this role likely to gain further importance in the future. The aim of the present paper is to describe the characteristics, the recent use, and the limitations of the German longitudinal prescription (LRx) database. The LRx database contains patient-level data on prescriptions collected in retail pharmacies, corresponding to ~ 80% of prescriptions reimbursed by statutory health insurance funds in Germany...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969093/venlafaxine-aggravating-interstitial-pneumonia-a-case-report
#30
JOURNAL ARTICLE
Xia Wu, Lutao Zhang, Chuanping Wang
A 70-year-old male taking venlafaxine for depression developed interstitial pneumonia and was admitted with shortness of breath and dyspnea. A computed tomography (CT) chest scan showed diffuse multiple lung lesions in both lungs, suggesting interstitial changes with inflammation or exudation. Compared with the CT chest scan 1 month earlier, there were significant progresses and new findings. The clinical diagnosis was interstitial pneumonia with pulmonary infection. The patient had been treated with fluvoxamine 100 mg/day, duloxetine 60 mg/day, venlafaxine 75 mg/day for depression over the past 4 months...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37969092/predictors-for-non-attainment-of-meropenem-target-concentrations-when-treating-infections-in-critically-ill-patients
#31
JOURNAL ARTICLE
Shao Jun Zheng, Yifan Xu, Nai Dong Chen, Jing Wen Hao, Yubing Zhu, Qiong Jie
BACKGROUND: Failure to achieve target concentrations of β-lactam antibiotics is not uncommon despite administration of high doses. The objective of this study was to identify risk factors predicting non-attainment of β-lactams target concentration in critically ill patients receiving meropenem as an intravenous infusion. MATERIALS AND METHODS: The retrospective study included adult patients receiving meropenem by intravenous infusion and undergoing therapeutic drug monitoring (TDM) in the intensive care units (ICU) at Nanjing First Hospital...
November 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37942928/analysis-of-risk-factors-for-hypoglycemia-in-patients-with-gastrointestinal-bleeding-induced-by-somatostatin-for-injection-and-establishment-of-the-prediction-model
#32
JOURNAL ARTICLE
Hong Zhang, Lei Chen, Xiaoying Wang, Qi Wang, Guangli Li, Xiaojuan Wang
OBJECTIVES: This study aimed to explore the risk factors of hypoglycemia in patients with gastrointestinal bleeding caused by somatostatin for injection and to establish a prediction model based on logistic regression combined with receiver operating characteristic (ROC) curve. MATERIALS AND METHODS: This retrospective study analyzed patients diagnosed with gastrointestinal bleeding and treated with somatostatin from January 2022 to May 2023 and collected hypoglycemic events...
November 9, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37942927/phillyrin-sensitizes-lung-cancer-cells-to-ferroptosis-through-inhibiting-fth1-slc7a11-axis
#33
JOURNAL ARTICLE
Xu Tang, Jiajia Teng, Keyin Lu
Ferroptosis is a newly found form of non-apoptotic regulated cell death that is essential for cancer progression. Phillyrin (PHN), an effective lignan glycoside of Forsythia suspensa , has been explored as a potential anticancer agent in some cancer types. However, it is unclear whether and how PHN could promote the death of non-small cell lung cancer (NSCLC) cells by inducing ferroptosis. Our study showed for the first time that PHN induced cell death and attenuated cell proliferation in NSCLC cells in vitro and in vivo...
November 9, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37942926/leukopenia-associated-with-lamotrigine-initiation-after-covid-19-vaccine-booster-a-case-report-and-literature-review
#34
JOURNAL ARTICLE
Tsukasa Murata, Katsuaki Uno, Miki Ito, Takahiko Nagamine
Adverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia...
November 9, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37877293/potential-drug-drug-interactions-in-a-multi-center-study-of-death-cases-of-covid-19-the-significance-of-appropriate-drug-choice
#35
JOURNAL ARTICLE
Ayda Esmaeili, Zahra Niazkhani, Khadijeh Makhdoomi, Iraj Mohebbi, Javad Aghazadeh-Attari, Ebrahim Hassani, Seyed Jalil Mousavi, Naser Gharebaghi, Rahim Nejadrahim, Mohammad Mirza-Aghzadeh, Aysan Esmaeili, Mojgan Cheshmekaboodi, Yasaman Nader-Babaei, Habibollah Pirnejad
OBJECTIVES: The prevalence, types, severity, risk ratings, and common pairs of involved drugs, and the most important potential drug-drug interactions (pDDIs) in coronavirus disease 2019 (-COVID-19) deceased cases were evaluated. MATERIALS AND METHODS: We reviewed the medical records of 157 confirmed COVID-19 deceased cases hospitalized in 27 province-wide hospitals. Patients' demographics and clinical data (including comorbidities, vital signs, length of in-hospital survival, electrocardiograms (ECGs), medications, and lab test results) were extracted...
October 25, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37877292/porcine-antilymphocyte-globulin-versus-rabbit-antithymocyte-globulin-for-intensive-immunosuppressive-therapy-of-acquired-aplastic-anemia-a-meta-analysis-and-systematic-review
#36
JOURNAL ARTICLE
Jinsong Jia, Shasha Wang, Ying Kang, Xiujuan Liu, Lanping Xu
OBJECTIVE: Several studies have reported that porcine antilymphocyte globulin (pALG) has a significant effect on aplastic anemia (AA), but their conclusions are inconsistent. To objectively evaluate its efficacy and safety, a meta-analysis was conducted. MATERIALS AND METHODS: We systematically searched the relevant literature on pALG vs. rabbit antithymocyte globulin (rATG) as the first-line treatment in AA patients until August 31, 2022, in electronic databases: PubMed, Cochrane Library, Web of Science, etc...
October 25, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37840522/pharmacokinetics-and-safety-of-injected-ornidazole-compared-to-its-enantiomer-levornidazole-in-healthy-chinese-subjects
#37
JOURNAL ARTICLE
Yue Liu, Ying Zhang, Wei Xue, Juan Wang, Wenjing Bai, Tingting Wang, Yao Liu, Kaitian Tang, Jie Qin, Kexin Li, Xin Wang
OBJECTIVE: To compare the pharmacokinetics of levornidazole and ornidazole in healthy Chinese subjects after a single intravenous injection, and to determine whether the chiral inversion of levornidazole occurs in vivo. MATERIALS AND METHODS: The study was a randomized, open-label, two-period crossover, single-dose design. A total of 12 subjects were enrolled in this study. Subjects received an intravenous injection of either levornidazole sodium chloride injection (200 mL: 0...
October 16, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37796147/self-reported-urinary-urgency-in-association-with-vitamin-d-and-psychiatric-symptoms-among-patients-with-musculoskeletal-pain
#38
JOURNAL ARTICLE
Osama Y Alshogran, Khalid K Abdul-Razzak, Aseel Y Altahrawi
OBJECTIVES: Urinary urgency (UU) is linked to musculoskeletal pain (MSP), and it is associated with mental health conditions. This study examined the prevalence of UU morbidity among outpatients with MSP, and the possible association of UU with psychological symptoms and vitamin D deficiency. MATERIALS AND METHODS: A cross-sectional study was conducted among 169 participants recruited from outpatient clinics at King Abdullah University Hospital in Jordan. Participants completed self-guided questionnaires that included information about MSP and UU...
October 5, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37779441/management-of-patients-after-total-knee-arthroplasty-using-mechanical-prophylaxis-and-reduced-doses-of-edoxaban-a-retrospective-cohort-study
#39
JOURNAL ARTICLE
Dai Tsurusaki, Masako Kuriki, Toshiya Fukataki, Takahisa Kimura, Mitsuki Takubo, Motoki Arakawa, Shinji Hidaka
OBJECTIVE: Edoxaban is given as pharmacologic prophylaxis alone or in combination with mechanical prophylaxis for venous thromboembolism after total knee arthroplasty. Several choices are made regarding edoxaban dosages when used in combination with mechanical prophylaxis. This study aimed to compare efficacy and safety in patients who received edoxaban with elastic stockings after total knee arthroplasty between those who received the standard dose, including those who received a reduced dose after meeting dose reduction criteria, and those who received reduced doses without dose reduction criteria...
October 2, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37548459/risk-factors-for-amiodarone-induced-liver-injury-a-retrospective-analysis-of-medical-records
#40
JOURNAL ARTICLE
Hinoo Nagai, Takahiro Amemiya, Hiroshi Suzuki
OBJECTIVE: This study identified risk factors for drug-induced liver injury (DILI) based on patient information before the administration of amiodarone. MATERIALS AND METHODS: A retrospective analysis was performed on patients who had received amiodarone treatment. Data from patients with and without DILI were compared immediately before the start of amiodarone treatment. RESULTS: An elevated C-reactive protein level (odds ratio (OR) 1.119; 95% confidence interval (CI) 1...
October 2023: International Journal of Clinical Pharmacology and Therapeutics
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