journal
https://read.qxmd.com/read/36917961/immediate-and-delayed-salivary-cytokine-responses-during-repeated-exposures-to-cold-pressor-stress
#21
JOURNAL ARTICLE
Mauro Larra, Silvia Capellino, Elena Schwendich, Leon von Haugwitz, Jörg Reinders, Edmund Wascher
Introduction Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies and monitoring such stress related effects could aid prevention. The measurement of salivary markers of inflammation is emerging as a promising tool to non-invasively quantify stress' effects on immune processes in everyday life and thereby detect early aberrations before the manifestation of serious health problems. However, more laboratory-controlled research is needed in order to establish the timescale and determinants of salivary cytokine responses to acute stress...
March 14, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/36858024/mir-124-reduced-neuroinflammation-after-traumatic-brain-injury-by-inhibiting-traf6
#22
JOURNAL ARTICLE
Yongxiang Yang, Yuqin Ye, Kexia Fan, Jianing Luo, Yongjian Yang, Yuan Ma
INTRODUCTION: Neuroinflammation contributes to secondary injury after traumatic brain injury (TBI), which has been mainly mediated by the microglia. MiR-124 was reported to play an important role in the polarization of microglia by targeting TLR4 signaling pathway. However, the role and mechanism of miR-124 in neuroinflammation mediated by microglia after TBI is unclear. To clarify this, we performed this research. METHODS: The expression of miR-124 was first measured by RT-PCR in the injured brain at 1/3/7 days post-TBI...
March 1, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/36780882/aberrant-dendritic-cell-subsets-in-patients-with-myasthenia-gravis-and-related-clinical-features
#23
JOURNAL ARTICLE
Yan Song, Chunye Xing, Tianyang Lu, Chen Liu, Wei Wang, Shaoqiang Wang, Xungang Feng, Jianzhong Bi, Qian Wang, Chao Lai
INTRODUCTION: Dendritic cells (DCs) play critical roles in the pathogenesis of myasthenia gravis (MG), and a series of DC-based experimental strategies for MG have recently been developed. However, the definite roles of different DC subsets in the mechanism of MG have scarcely been covered by previous studies. The present study aimed to investigate the levels of three main DC subsets, plasmacytoid DCs (pDCs) (CD303 positive) and two distinct subsets of conventional DCs (cDCs), namely CD1c+ cDCs and CD141+ cDCs, in MG patients and analyze related clinical features...
February 13, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/36657415/myrtenol-ameliorates-recognition-memories-impairment-and-anxiety-like-behaviors-induced-by-asthma-by-mitigating-hippocampal-inflammation-and-oxidative-stress-in-rats
#24
JOURNAL ARTICLE
Mohammad Abbas Bejeshk, Amir Hashem Aminizadeh, Elham Jafari, Sina Motamedi, Iman Zangiabadi, Ahmad Ghasemi, Mazyar Fathi, Akram Nezhadi, Faezeh Akhgarandouz, Fatemeh Bejeshk, Leila Mohammadi, Fatemeh Mohammadi, Mohammad Amin Rajizadeh
INTRODUCTION: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation, and oxidative stress in the hippocampus of asthmatic rats. METHODS: Rats were allocated to five groups: control, asthma, asthma/vehicle, asthma/myrtenol, and asthma/budesonide...
January 19, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/36599309/integrated-proteomic-and-phosphoproteomic-analysis-of-the-hippocampus-in-a-mouse-model-of-early-life-inflammation
#25
JOURNAL ARTICLE
Xin-Miao Wu, Yu-Zhu Gao, Ting-Ting Zhu, Han-Wen Gu, Jian-Hua Tong, Jie Sun, Jian-Jun Yang, Mu-Huo Ji
INTRODUCTION: Inflammation in early life is a risk factor for the development of neuropsychiatric diseases later in adolescence and adulthood, yet the underlying mechanism remains elusive. In the present study, we performed an integrated proteomic and phosphoproteomic analysis of the hippocampus to identify potential molecular mechanisms of early life inflammation-induced cognitive impairment. METHODS: Both female and male mice received a single intraperitoneal injection of 100 μg/kg lipopolysaccharide (LPS) on postnatal day 10 (P10)...
January 4, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/38142672/retraction-statement
#26
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37972578/olfactory-cues-of-naturally-occurring-systemic-inflammation-a-pilot-study-of-seasonal-allergy
#27
JOURNAL ARTICLE
Arnaud Tognetti, Supreet Saluja, Nathalie Lybert, Julie Lasselin, Sandra Tamm, Catarina Lensmar, Bianka Karshikoff, Simon Cervenka, Mats Lekander, Mats J Olsson
INTRODUCTION: In an attempt to avoid contact with infectious individuals, humans likely respond to generalized rather than specific markers of disease. Humans may thus perceive a noninfectious individual as socially less attractive if they look (e.g., have facial discolouration), move (e.g., have a slower walking pace), or sound (e.g., sneeze) sick. This pilot study tested whether humans are averse to the body odour of noninfectious individuals with a low-grade systemic inflammation. METHODS: We collected the axillary body odour of individuals with severe seasonal allergy (N = 14) and healthy controls (N = 10) during and outside the allergy season and measured serum levels of two inflammatory cytokines (tumour necrosis factor-α and interleukin-5)...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37952531/ageing-affects-thymopoiesis-and-experimental-autoimmune-encephalomyelitis-development-in-a-strain-dependent-manner
#28
JOURNAL ARTICLE
Zorica Stojić-Vukanić, Marija Petrušić, Ivan Pilipović, Gordana Leposavić
INTRODUCTION: Considering significance of mechanisms of central tolerance for development of autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), and suppressive influence of circulating proinflammatory cytokines and alterations in brain-thymus communication, characteristic for the central nervous system (CNS) autoimmune diseases, on thymopoiesis, the study interogated putative strain-based thymus-related specificities relevant for the opposite effects of ageing on susceptibility of Dark Agouti (DA) and Albino Oxford (AO) rats to EAE...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37926077/inhibition-of-galectin-3-in-a-rat-model-of-epilepsy-and-kainate-activated-bv2-cells-limits-microglial-activation-through-the-nlrp3-pyroptosis-pathway
#29
JOURNAL ARTICLE
Weiwei Sun, Ying Hao, Chunxiang Li, Yuanyuan Zhao, Haishao Yu, Lin Wang
INTRODUCTION: This study aimed to investigate the possible role of galectin-3 in epilepsy and further explore its underlying mechanisms. METHODS: Sprague-Dawley rats were intraperitoneally injected with 30 mg/kg pilocarpine to induce an animal model of epilepsy. To inhibit galectin-3, the epilepsy model of rats was intraperitoneally injected with TD139. The severity of the seizure was graded according to the Racine score. The pathological changes in hippocampal CA1 regions were observed by hematoxylin and eosin and Nissl staining...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37899033/transcrocetin-meglumine-salt-inhibits-spinal-glial-cell-mediated-proinflammatory-cytokines-and-attenuates-complete-freund-s-adjuvant-induced-inflammatory-pain
#30
JOURNAL ARTICLE
Qing Qiao, Dandan Yao, Yongjie Wang, Shuxia Zhang, Gang Chen
INTRODUCTION: Inflammatory pain is a significant global clinical challenge that involves both unpleasant sensory and emotional experiences. The treatment of pain is imminent, and we are committed to seeking new analgesics for pain relief. Transcrocetin meglumine salt (TCMS), a saffron metabolite derived from the crocin apocarotenoids, has exhibited the ability to cross the blood-brain barrier and exert neuroprotective effects. In this study, we aimed to investigate whether TCMS could ameliorate complete Freund's adjuvant (CFA)-induced inflammatory pain in mice and elucidate its underlying mechanisms...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37852199/chronic-stress-exacerbates-hyperglycemia-induced-affective-symptoms-in-male-mice
#31
JOURNAL ARTICLE
Riley G McCready, Kayla R Gilley, Laura E Kusumo, Grace M Hall, Elisabeth G Vichaya
INTRODUCTION: Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression and anxiety. The mechanisms underlying stress-induced affective dysregulation are likely distinct from those induced by diabetes. A direct comparison between stress- and hyperglycemia-induced affective dysregulation could provide insight into distinct mechanistic targets for depression/anxiety associated with these different conditions...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37827142/age-dependent-effects-of-transgenic-2d2-mice-used-to-induce-passive-experimental-autoimmune-encephalomyelitis-in-c57bl-6-mice
#32
JOURNAL ARTICLE
James M Nichols, Barbara L F Kaplan
INTRODUCTION: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that worsens with age. Here, we examined the influence of age on passive experimental autoimmune encephalomyelitis (P-EAE), a model to study MS, using young and mature adult 2D2 transgenic donor mice to induce pathology in WT C57BL6/J mice. METHODS: Lymphocytes from young adult (i.e., 10-week-old) or mature adult (i.e., 6-month-old) transgenic donor mice were characterized by flow cytometry prior to injection of cultured leukocytes into adult female WT recipient mice, with a special focus on transgenic T cell phenotypes...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37797598/how-can-experimental-endotoxemia-contribute-to-our-understanding-of-pain-a-narrative-review
#33
REVIEW
Sven Benson, Bianka Karshikoff
The immune system and the central nervous system exchange information continuously. This communication is a prerequisite for adaptive responses to physiological and psychological stressors. While the implicate relationship between inflammation and pain is increasingly recognized in clinical cohorts, the underlying mechanisms and the possibilities for pharmacological and psychological approaches aimed at neuro-immune communication in pain are not fully understood yet. This calls for preclinical models which build a bridge from clinical research to laboratory research...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37797587/endotoxin-induced-physiological-and-psychological-sickness-responses-in-healthy-humans-insights-into-the-post-acute-phase
#34
RANDOMIZED CONTROLLED TRIAL
Harald Engler, Alexandra Brinkhoff, Benjamin Wilde, Andreas Kribben, Hana Rohn, Oliver Witzke, Manfred Schedlowski, Sven Benson
INTRODUCTION: Experimental endotoxemia is a translational model of systemic inflammation that has contributed significantly to our current understanding of sickness behavior and inflammation-associated depression. Previous studies using this model revealed a strong association between cytokine levels, endocrine changes, and psychological sickness symptoms during the acute phase of inflammation. The objective of this randomized, double-blind, placebo-controlled crossover study was to gain insight into potential post-acute physiological and psychological consequences of endotoxin administration that may either persist or newly emerge between 24 and 72 h after injection...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37769638/olfactory-bulbs-in-arthritis-model-mouse-persistently-express-interleukin-6-before-the-onset-of-arthritis-relationship-to-food-intake
#35
JOURNAL ARTICLE
Kazuhiro Otani, Masayuki Yoshiga, Masashi Hirano, Takayuki Matsushita, Kentaro Noda, Daitaro Kurosaka
INTRODUCTION: Rheumatoid arthritis (RA) can be comorbid with psychiatric symptoms. Brain abnormalities in RA patients and in arthritis models have been reported. However, it remains unclear when these abnormalities occur and where they are distributed. In this study, we analyzed spatiotemporal changes in gene expression in the brains of mice with collagen-induced arthritis (CIA). METHODS: Mice were divided into three groups: (i) CIA (all mice developed arthritis on day 35): complete Freund's adjuvant (CFA) and type II collagen at initial immunization, and incomplete Freund's adjuvant (IFA) and type II collagen at booster immunization; (ii) C(+/-) (50% mice developed arthritis on day 35): only IFA at booster immunization; and (iii) C(-/-) (no arthritis): only CFA at initial immunization and only IFA at booster immunization...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37757765/neuropsychiatric-outcomes-and-sleep-dysfunction-in-covid-19-patients-risk-factors-and-mechanisms
#36
REVIEW
Aliki Karkala, Asterios Tzinas, Seraphim Kotoulas, Athanasios Zacharias, Evdokia Sourla, Athanasia Pataka
The ongoing global health crisis due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has significantly impacted all aspects of life. While the majority of early research following the coronavirus disease caused by SARS-CoV-2 (COVID-19) has focused on the physiological effects of the virus, a substantial body of subsequent studies has shown that the psychological burden of the infection is also considerable. Patients, even without mental illness history, were at increased susceptibility to developing mental health and sleep disturbances during or after the COVID-19 infection...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37729881/modulation-of-neuroinflammation-advances-in-roles-and-mechanisms-of-the-il-33-st2-axis-involved-in-ischemic-stroke
#37
REVIEW
Shuang Guo, Chengli Qian, Wenfeng Li, Zhikun Zeng, Junlong Cai, Yi Luo
Interleukin (IL)-33 was initially recognized as a constituent of the IL-1 cytokine family in 2005. It exerts pleiotropic effects by regulating immune responses via its binding to the receptor ST2 (IL-33R). The IL-33/ST2 pathway has been linked to several inflammatory disorders. In human and rodents, the broad expression of IL-33 in spinal cord tissues and brain indicates its central nervous system-specific functions. Growing evidence supports the protective effects of the IL-33/ST2 pathway in ischemic stroke, along with a better understanding of the underlying mechanisms...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37725949/15th-conference-of-the-german-endocrine-brain-immune-network-gebin-ulm-germany-september-28-september-30-2023
#38
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37703857/hypothalamic-pituitary-axis-function-and-adrenal-insufficiency-in-covid-19-patients
#39
REVIEW
Emre Durcan, Aysa Hacioglu, Zuleyha Karaca, Kursad Unluhizarci, Mustafa Sait Gonen, Fahrettin Kelestimur
The outbreak of COVID-19 has affected more than half a billion people worldwide and caused more than 6 million deaths since 2019. The responsible virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affects the lungs, but it has multisystemic effects. It is well known that dysfunction of multiple endocrine organs may occur during or after COVID-19. Impairment of the hypothalamic-pituitary-adrenal (HPA) axis is of utmost importance as it may lead to death if went undiagnosed. SARS-CoV-2 may cause both primary and secondary adrenal insufficiencies (AIs)...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37604137/2nd-european-psychoneuroimmunology-network-autumn-school-the-skin-brain-axis-and-the-breaking-of-barriers
#40
EDITORIAL
Eva Peters, Adriana Del Rey, Karsten Krüger, Christoph Rummel
No abstract text is available yet for this article.
2023: Neuroimmunomodulation
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