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Hadi Zarif, Agnès Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Catherine Heurteaux, Nicolas Glaichenhaus, Joëlle Chabry, Alice Guyon, Agnès Petit-Paitel
BACKGROUND: Others and we have shown that T cells have an important role in hippocampal synaptic plasticity, including neurogenesis in the dentate gyrus, spinogenesis, and glutamatergic synaptic function in the CA of the hippocampus. Hippocampus plasticity is particularly involved in the brain effects of the enriched environment (EE), and interestingly CD4+ and CD8+ T cells play essential and differential roles in these effects. However, the precise mechanisms by which they act on the brain remain elusive...
January 31, 2019: Neuroimmunomodulation
Yu-Ling Cao, Wei Dong, Yu-Zhi Li, Wei Han
OBJECTIVES: Myasthenia gravis (MG) is an organ-specific autoimmune neuromuscular disorder that occurs as a result of the impairment in neuromuscular junction and autoantibody attack on the postsynaptic receptors. Increasing evidence suggests that microRNAs (miRs) might be involved in the development of MG. Therefore, the present study aimed to investigate the regulatory function of miR-653 on MG and its relationship with tripartite motif 9 (TRIM9). METHODS: The thymic tissues obtained from MG patients with thymic hyperplasia were prepared for establishing an MG mouse model in BALB/c mice...
January 31, 2019: Neuroimmunomodulation
Cai Song, Yih-Shyuan Wu, Zhi-You Yang, Allan V Kalueff, Yin-Yin Tsao, Yilong Dong, Kuan-Pin Su
OBJECTIVE: Both excitotoxicity and neurotrophin deficiency may contribute to the etiology of depression and neurodegeneration. Astrocytes not only regulate glutamate metabolism and clearance, they also produce neurotrophins in the brain. However, the direct interaction between neurons and astrocytes remains unknown. METHODS: This study evaluated the cellular mechanisms by which astrocyte-conditioned medium (ACM) protects prefrontal cortical neurons from glutamate-induced death by measuring cell viability and morphology as well as mRNA and protein expression of brain-derived neurotrophic factor (BDNF), BDNF receptors, glial cell line-derived neurotrophic factor (GDNF), and the proinflammatory cytokine, tumor necrosis factor (TNF)-α...
January 30, 2019: Neuroimmunomodulation
Yongxiang Yang, Yuqin Ye, Chen Chen, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng He
OBJECTIVE: Traumatic brain injury (TBI) induces immunosuppression in the acute phase, and the activation of the sympathetic nervous system (SNS) might play a role in this process, but the mechanism involved is unknown. Herein, we explored the impact of acute (a)TBI on the peripheral immune system and its correlation with the SNS and the T cell exhaustion marker, PD-1 (programmed cell death-1). METHODS: Flow cytometry (FCM) was performed to analyze the expression of T cell markers and intracellular cytokines, interferon-γ and tumor necrosis factor-α, and the T cell exhaustion marker, PD-1, in the peripheral blood mononuclear cells (PBMCs) of TBI rats...
January 29, 2019: Neuroimmunomodulation
Shuang Zhang, Xu Ma, Jin Fu
OBJECTIVE: Multiple sclerosis (MS), also called disseminated sclerosis or encephalomyelitis disseminate, is an inflammatory disorder in which the insulating covers of brain nerve cells and the spinal cord are impaired. Emerging evidence has highlighted leukocyte immunoglobulin-like receptor A1 (LILRA1) and its ability to suppress the secretion of various inflammatory factors. METHOD: During this study, we explored cell viability, apoptosis, and levels of certain inflammatory factors when silencing LILRA1 in cultured spinal cord cells obtained from mice with MS...
January 23, 2019: Neuroimmunomodulation
Roberta Foster, Mauro Vaisberg, André Luis Lacerda Bachi, Juliana de Melo Batista Dos Santos, Rodolfo de Paula Vieira, Luiz Antonio Luna-Junior, Maita Poli Araújo, Tathiana Rebizzi Parmigiano, Fernanda Borges, Zsuzsanna I K J Di-Bella
OBJECTIVE: To evaluate the relationship between the inflammatory profile and mood states in the different phases of the menstrual cycle in soccer players with and without premenstrual syndrome (PMS). METHODS: Data on the menstrual cycle and mood states were collected using the Daily Symptom Report and the Brunel Mood Scale. Cytokine and stress hormone concentrations were measured in urine by flow cytometry before and after a game in the luteal phase and in the follicular phase of one menstrual cycle...
January 17, 2019: Neuroimmunomodulation
Carmem Gottfried, Victorio Bambini-Junior
No abstract text is available yet for this article.
January 15, 2019: Neuroimmunomodulation
Priscila Vianna, Julia do Amaral Gomes, Juliano André Boquett, Lucas Rosa Fraga, Jaqueline Bohrer Schuch, Fernanda Sales Luiz Vianna, Lavínia Schuler-Faccini
The recent outbreak of the Zika virus (ZIKV) and the discovery that perinatal Zika exposure can lead to the Congenital Zika Syndrome has promoted a call for prevention measures. Due to the increased number of babies born with microcephaly, structural brain abnormalities, and neurological alterations in regions affected by ZIKV, investigations were carried out in order to better understand this process. The maternal immune system directly influences the fetal central nervous system, and complications during pregnancy have been associated with neurodevelopmental disorders...
January 10, 2019: Neuroimmunomodulation
Ye Hua, Nanfei Xu, Tao Ma, Yumin Liu, Hong Xu, Yunnan Lu
OBJECTIVE: Spinal cord ischemia/reperfusion injury (SCII) is a devastating complication following thoracoabdominal aortic surgeries, often leading to severe neurological deficits. We sought to examine the effects of lycopene, a naturally existing carotenoid with anti-inflammatory properties, in the treatment against SCII. METHODS: Rats were assigned into four treatment groups: Sham (sham operation), SCII (SCII-induction), LY25, and LY50 (lycopene treatment at 25 or 50 mg/kg following SCII induction, respectively)...
January 9, 2019: Neuroimmunomodulation
Isabella R Grifasi, Scot E McIntosh, Rhiannon D Thomas, Donald T Lysle, Todd E Thiele, S Alex Marshall
OBJECTIVES: Alcohol dependence leads to dysregulation of the neuroimmune system, but the effects of excessive alcohol consumption on key players of the neuroimmune response after episodic binge drinking in nondependence has not been readily assessed. These studies seek to determine how the neuroimmune system within the hippocampus responds to binge-like consumption prior to dependence or evidence of brain damage. METHODS: C57BL/6J mice underwent the drinking in the dark (DID) paradigm to recapitulate binge consumption...
January 9, 2019: Neuroimmunomodulation
Yuzhen Wei, Haoxiao Chang, Xindi Li, Huabing Wang, Li Du, Heng Zhou, Wangshu Xu, Yuetao Ma, Linlin Yin, Xinghu Zhang
OBJECTIVE: We investigated the contribution of several cytokines in the pathogenesis of first-onset neuromyelitis optica spectrum disorder (NMOSD) and determined the differences between aquaporin 4 immunoglobulin G (AQP4-IgG)-positive and AQP4-IgG-negative subtypes. METHODS: We enrolled 18 NMOSD (10 AQP4-IgG-positive and 8 AQP4-IgG-negative) and 8 multiple sclerosis (MS) patients, whose serum and cerebrospinal fluid (CSF) samples were collected during the acute phase of the first onset before immunotherapy...
December 13, 2018: Neuroimmunomodulation
Ana Clara Liberman, Emiliano Trias, Luana da Silva Chagas, Pablo Trindade, Marissol Dos Santos Pereira, Damian Refojo, Cecilia Hedin-Pereira, Claudio A Serfaty
An extensive microglial-astrocyte-monocyte-neuronal cross talk seems to be crucial for normal brain function, development, and recovery. However, under certain conditions neuroinflammatory interactions between brain cells and neuroimmune cells influence disease outcome and brain pathology. Microglial cells express a range of functional states with dynamically pleomorphic profiles from a surveilling status of synaptic transmission to an active player in major events of development such as synaptic elimination, regeneration, and repair...
December 5, 2018: Neuroimmunomodulation
Vahid Bagheri, Hossein Khorramdelazad, Gholamhossein Hassanshahi, Amir Moghadam-Ahmadi, Alireza Vakilian
OBJECTIVE: The role of CXCL12 and its receptor CXCR4 has not been fully examined in Parkinson's disease (PD). The purpose of this study was to investigate the role of CXCL12/CXCR4 in the peripheral blood of patients with PD and healthy controls. METHODS: CXCL12 serum levels and CXCR4 mRNA levels were measured in 30 PD patients and 40 controls using ELISA and real-time PCR, respectively. RESULTS: CXCL12 serum levels were significantly higher in PD patients compared to controls (p < 0...
November 14, 2018: Neuroimmunomodulation
Baozhu Liu, Xiaonan Zhong, Zhengqi Lu, Wei Qiu, Xueqiang Hu, Honghao Wang
OBJECT: CD27 belongs to the tumor necrosis factor receptor family and is constitutively expressed on T cells. The concentration of cerebrospinal fluid (CSF) soluble (s)CD27 is elevated in patients with multiple sclerosis (MS). However, whether the level of CSF sCD27 is elevated in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. The aim of this study was to measure the CSF concentration of sCD27 and to determine its relationship with NMOSD disease activity. METHODS: CSF CXCL13 was measured by ELISA in neuromyelitis optica (NMO) (n = 31) and MS (n = 23) patients and in controls (CTLs) (n = 22)...
November 13, 2018: Neuroimmunomodulation
Samarah Cook, Vanessa Hung, Kelli A Duncan
OBJECTIVES: Characterized by neuroinflammation, traumatic brain injury (TBI) induces neuropathological changes and cognitive deficits. Estrogens are neuroprotective by increasing cell survival and this increase is mediated by a decrease in neuroinflammation. To further explore the relationship between estrogens, brain injury, and neuroinflammation, we examined the expression of the IKK/NFκB complex. The IKK/NFκB complex is a pleiotropic regulator of many cellular signaling pathways linked to inflammation, as well as three major cytokines (IL-1β, IL-6, and TNF-α)...
November 13, 2018: Neuroimmunomodulation
Sharon L Hollins, Luke Brock, Rafael Barreto, Lauren Harms, Ariel Dunn, Pedro Garcia-Sobrinho, Jessica Bruce, Phillip W Dickson, Marjorie M Walker, Simon Keely, Deborah M Hodgson
OBJECTIVES: Gastrointestinal (GI) inflammation and GI integrity deficits are common comorbidities of neuropsychiatric disorders. Ongoing research suggests that these aberrations may be contributing to heightened immune signals that have the potential to disrupt neuronal homeostasis and exacerbate behavioural deficits. The current study aimed to determine whether the well-characterized animal model of neuropsychopathology, the maternal immune activation (MIA) model, produced GI inflammation and integrity disruptions in association with anxiety-like behaviour...
November 9, 2018: Neuroimmunomodulation
Laura S Redwine, Meredith A Pung, Kathleen Wilson, Kelly Chinh, Allyson R Duffy
OBJECTIVE: Cognitive deficits are common in patients with heart failure (HF), and can negatively affect self-care, predict rehospitalizations, and increase mortality rates 5-fold. Inflammation can produce vascular pathology, reducing cerebral blood flow to brain regions necessary for optimal cognitive function. The purpose of the investigation was to identify a pattern of peripheral blood inflammation-related biomarkers associated with cognitive impairment in patients with HF. METHODS: Forty-five outpatients (median age = 67 years, SD = 9...
October 23, 2018: Neuroimmunomodulation
Jalil Mehrzad, Saman Hosseinkhani, Amir Mohammad Malvandi
OBJECTIVE: Knowledge regarding interactions of AFB1 with the human nervous system and how a naturally occurring level of AFB1 could potentially induce neuroimmune dysregulation is very limited. To assess the cellular effects of AFB1 on the human brain, we used the human microglia cell line CHME5 as a model to pinpoint its potential in vivo translation. METHODS: We used the CHME5 cell line culture system, multiplex qPCR, (chemi)bioluminescence, Luminex ELISA, and flow cytometry assays to evaluate the toxic effects of a naturally occurring level of AFB1 on human microglia...
October 18, 2018: Neuroimmunomodulation
Eleonora Sacchinelli, Fabrizio Piras, Maria Donata Orfei, Nerisa Banaj, Francesca Salani, Antonio Ciaramella, Carlo Caltagirone, Gianfranco Spalletta, Paola Bossù
OBJECTIVE: Interaction between the nervous and immune systems may influence emotions, ultimately affecting human health. Cytokines may play a role in developing emotional dysregulation as in alexithymia, a personality construct characterized by the subclinical inability to identify and describe emotions, often associated with several psychiatric and psychosomatic disorders. The proinflammatory cytokine IL-18, with a recognized role in brain functions, may influence serotonin metabolism and appears to be associated with alexithymia...
October 16, 2018: Neuroimmunomodulation
José L Arias, Andrea C Mayordomo, Juan E Silva, Juan A V Ragusa, Gabriel A Rabinovich, Ana C Anzulovich, María S Di Genaro
OBJECTIVE: Circadian rhythms are generated by the suprachiasmatic nucleus of the hypothalamus and involve rhythmic expression of clock genes and proteins. This rhythmicity is transferred to peripheral tissues by neural and hormonal signals. Late pregnancy is considered a state of inflammation which impacts on peripheral tissues such as joints. Tumor necrosis factor (TNF) mediates inflammatory and circadian responses through its p55 receptor (TNFRp55). Neuroimmunoendocrine interactions in joints have not been studied completely...
October 10, 2018: Neuroimmunomodulation
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