Maurizio Cutolo, Emanuele Gotelli
No abstract text is available yet for this article.
February 6, 2024: Neuroimmunomodulation
Daniella Arêas Mendes-da-Cruz, Elizabeth Pinto Belorio, Vinicius Cotta-de-Almeida
BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematologic disease caused by the transformation and uncontrolled proliferation of T-cell precursors. T-ALL is generally thought to originate in the thymus since lymphoblasts express phenotypic markers comparable to those described in thymocytes in distinct stages of development. Although around 50% of T-ALL patients present a thymic mass, T-ALL is characterized by peripheral blood and bone marrow involvement, and central nervous system (CNS) infiltration is one of the most severe complications of the disease...
January 25, 2024: Neuroimmunomodulation
Rainer H Straub, Dario Boschiero
Introduction Patients often go to the physician with medically unexplained symptoms (MUS). MUS can be autonomic nervous system-related 'unspecific' symptoms, such as palpitations, hearth rhythm alterations, tempera-ture dysregulation (hand, feet), anxiety or MUS can be depressive manifestations, fatigue, somnolence, nausea, hyperalgesia with varying pains and aches, dizziness, etc. Methods In this real-world study, we investigated MUS in a cohort of unselected outpatients from general practi-tioners in Italy...
January 12, 2024: Neuroimmunomodulation
Maryam Salari, Khadijeh Esmaeilpour, Lily Mohammadipoor-Ghasemabad, Farahnaz Taheri, Mahmoud Hosseini, Vahid Sheibani
INTRODUCTION: Both sleep deprivation (SD) and inflammation can negatively affect cognitive function. This study aimed to investigate how SD impacts the brain's inflammatory response to lipopolysaccharide (LPS) and its subsequent effects on cognitive functions. METHODS: To this end, male rats were tested through a Morris water maze (MWM) to assess their spatial learning and memory. Also, in vivo field potential recordings (to evaluate synaptic plasticity) were done in Saline, SD, LPS1 (1mg/kg/7 days), and LPS1+SD groups...
December 27, 2023: Neuroimmunomodulation
Carolina Francelin, Alexandre Borin, Jessica Funari, Fernando Pradella, Leonilda M B Santos, Wilson Savino, Alessandro S Fariasa
The thymus is the primary lymphoid organ responsible for normal T-cell development. Yet, in abnormal metabolic conditions as well as an acute infection, the organ exhibits morphological and cellular alterations. It is well established that the immune system is in a tidy connection and dependent on the central nervous system (CNS), which regulates thymic function by means of innervation and neurotransmitters. Sympathetic innervation leaves the CNS and spreads through thymic tissue, where nerve endings interact directly or indirectly with thymic cells contributing to their maintenance and development...
December 21, 2023: Neuroimmunomodulation
Adriana Del Rey, Hugo Besedovsky
BACKGROUND: The neuro-endocrine regulation of immune functions is based on a complex network of interactions. As part of this series of articles, we refer here to immune-sympathetic interactions that are triggered by different types of immune challenge. SUMMARY: We mention the initial hypothesis that led to the proposal that the sympathetic nervous system (SNS) is involved in immunoregulation. We next refer mainly to our initial work performed at a time when most immunologist were concentrated in clarifying aspects of the immune system that are essential for its regulation from within...
November 26, 2023: Neuroimmunomodulation
(no author information available yet)
No abstract text is available yet for this article.
September 18, 2023: Neuroimmunomodulation
Karina Alejandra Pedroza-García, Denisse Calderón-Vallejo, Daniel Cervantes-García, Andrés Quintanar-Stephano, Eva Salinas, J Luis Quintanar
BACKGROUND: Mild hypoxic-ischemic encephalopathy (HIE) is a condition that predisposes to negative outcomes such as neuroanatomical injury, mood disorders, and motor or cognitive disabilities. The neuroinflammation plays an important role in the neurological damage, therefore reducing it could provide neuroprotection. The leuprolide acetate (LA) has shown to have neuroregenerative and immunomodulator properties in other nervous system injuries. OBJECTIVE: The aim of this study was to evaluate the immunomodulatory effect of LA in the acute phase of mild HIE and its effects in motor activity and behavior in a subacute phase...
August 22, 2023: Neuroimmunomodulation
Emanuele Gotelli, Stefano Soldano, Elvis Hysa, Andrea Casabella, Andrea Cere, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
Calcitriol and hydroxyderivatives of lumisterol and tachisterol are secosteroid hormones with immunomodulatory and anti-inflammatory properties. Since the beginning of the COVID-19 pandemic, several studies have correlated deficient serum concentrations of vitamin D3 (calcifediol) with increased severity of the course of SARS-CoV-2 infection. Among systemic complications, subjective (anosmia, ageusia, depression, dizziness) and objective (ischemic stroke, meningo-encephalitis, myelitis, seizures, Guillain-Barré syndrome) neurological symptoms have been reported in up to 80% of severe COVID-19 patients...
August 9, 2023: Neuroimmunomodulation
Rebecca Sohn, Zsuzsa Jenei-Lanzl
The sympathetic nervous system (SNS) is a major regulatory mediator connecting the brain and the immune system that influences accordingly inflammatory processes within the entire body. In the periphery, the SNS exerts its effects mainly via its neurotransmitters norepinephrine (NE) and epinephrine (E), which are released by peripheral nerve endings in lymphatic organs and other tissues. Depending on their concentration, NE and E bind to specific α- and β-adrenergic receptor (AR) subtypes and can cause both pro- and anti-inflammatory cellular responses...
July 10, 2023: Neuroimmunomodulation
Muhammad Mubashshir, Nabeel Ahmad, Tripti Negi, Renu Rawal, Nirjara Singhvi, Hina Khatoon, Vijya Laxmi, Om Dubey, Renu Bala Sharma, Ganga Negi, Mohd Ovais
The assumption of the pineal hormone melatonin as a therapeutic use for COVID-19 affected people seems promising. It's intake has shown significant improvement in the patients' conditions. Higher melatonin titres in children may provide a protective shield against this disease. The hormone melatonin works as an anti-inflammatory, antioxidant, immunomodulator and strategically slows down the cytokine release which is observed in the COVID-19 disease, thereby improving the overall health of afflicted patients...
June 19, 2023: Neuroimmunomodulation
Alessandra Occhinegro, Robin M McAllen, Michael J McKinley, Davide Martelli
In this review we will try to convince the readers that the immune system is controlled by an endogenous neural reflex, termed inflammatory reflex, that inhibits the acute immune response during the course of a systemic immune challenge. We will analyse here the contribution of different sympathetic nerves as possible efferent arms of the inflammatory reflex. We will discuss the evidence that demonstrates that neither the splenic sympathetic nerves nor the hepatic sympathetic nerves are necessary for the endogenous neural reflex inhibition of inflammation...
June 9, 2023: Neuroimmunomodulation
Georg Pongratz, Rainer H Straub
The immune system is embedded in a network of regulatory systems to keep homeostasis in case of an immunologic challenge. Neuroendocrine immunologic research revealed several aspects of these interactions over the past decades, e.g. between the autonomic nervous system and the immune system. This review will focus on evidence revealing the role of the sympathetic nervous system (SNS) in chronic inflammation, like colitis, multiple sclerosis, systemic sclerosis, lupus erythematodes, and arthritis with a focus on animal models supported by human data...
May 18, 2023: Neuroimmunomodulation
Helio Salgado Cesar, Fernanda Brognara, Aline Barbosa Ribeiro, Renata Maria Lataro, Jaci Airton Castania, Luis Ulloa, Alexandre Kanashiro
Bioelectronic medicine is a novel field in modern medicine based on specific neuronal stimulation to control organ function and cardiovascular and immune homeostasis. However, most studies addressing neuromodulation of the immune system have been conducted on anesthetized animals, which can affect the nervous system and neuromodulation. Here we review recent studies involving conscious experimental rodents (rats and mice) to better understand the functional organization of neural control of immune homeostasis...
May 5, 2023: Neuroimmunomodulation
Julian Philipp, Christoph G Baerwald, Olga Seifert
INTRODUCTION: In the present work, the frequency of inherited polymorphisms of the beta 2 adrenergic receptor (β2AR) gene and their association with fatigue in patients with rheumatoid arthritis (RA) was examined. METHODS: An allele-specific polymerase chain reaction was used to determine the common variants of the β2AR at position 16, 27, and 164 in 92 German RA outpatients. Health Assessment Questionnaire (HAQ-DI), Beck Depression Inventory (BDI), Perceived Stress Questionnaire (PSQ-30), Multidimensional Fatigue Inventory (MFI-20) were utilized...
April 21, 2023: Neuroimmunomodulation
Mauro Larra, Silvia Capellino, Elena Schwendich, Leon von Haugwitz, Jörg Reinders, Edmund Wascher
Introduction Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies and monitoring such stress related effects could aid prevention. The measurement of salivary markers of inflammation is emerging as a promising tool to non-invasively quantify stress' effects on immune processes in everyday life and thereby detect early aberrations before the manifestation of serious health problems. However, more laboratory-controlled research is needed in order to establish the timescale and determinants of salivary cytokine responses to acute stress...
March 14, 2023: Neuroimmunomodulation
Yongxiang Yang, Yuqin Ye, Kexia Fan, Jianing Luo, Yongjian Yang, Yuan Ma
INTRODUCTION: Neuroinflammation contributes to secondary injury after traumatic brain injury (TBI), which has been mainly mediated by the microglia. MiR-124 was reported to play an important role in the polarization of microglia by targeting TLR4 signaling pathway. However, the role and mechanism of miR-124 in neuroinflammation mediated by microglia after TBI is unclear. To clarify this, we performed this research. METHODS: The expression of miR-124 was first measured by RT-PCR in the injured brain at 1/3/7 days post-TBI...
March 1, 2023: Neuroimmunomodulation
Yan Song, Chunye Xing, Tianyang Lu, Chen Liu, Wei Wang, Shaoqiang Wang, Xungang Feng, Jianzhong Bi, Qian Wang, Chao Lai
INTRODUCTION: Dendritic cells (DCs) play critical roles in the pathogenesis of myasthenia gravis (MG), and a series of DC-based experimental strategies for MG have recently been developed. However, the definite roles of different DC subsets in the mechanism of MG have scarcely been covered by previous studies. The present study aimed to investigate the levels of three main DC subsets, plasmacytoid DCs (pDCs) (CD303 positive) and two distinct subsets of conventional DCs (cDCs), namely CD1c+ cDCs and CD141+ cDCs, in MG patients and analyze related clinical features...
February 13, 2023: Neuroimmunomodulation
Mohammad Abbas Bejeshk, Amir Hashem Aminizadeh, Elham Jafari, Sina Motamedi, Iman Zangiabadi, Ahmad Ghasemi, Mazyar Fathi, Akram Nezhadi, Faezeh Akhgarandouz, Fatemeh Bejeshk, Leila Mohammadi, Fatemeh Mohammadi, Mohammad Amin Rajizadeh
INTRODUCTION: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation, and oxidative stress in the hippocampus of asthmatic rats. METHODS: Rats were allocated to five groups: control, asthma, asthma/vehicle, asthma/myrtenol, and asthma/budesonide...
January 19, 2023: Neuroimmunomodulation
Xin-Miao Wu, Yu-Zhu Gao, Ting-Ting Zhu, Han-Wen Gu, Jian-Hua Tong, Jie Sun, Jian-Jun Yang, Mu-Huo Ji
INTRODUCTION: Inflammation in early life is a risk factor for the development of neuropsychiatric diseases later in adolescence and adulthood, yet the underlying mechanism remains elusive. In the present study, we performed an integrated proteomic and phosphoproteomic analysis of the hippocampus to identify potential molecular mechanisms of early life inflammation-induced cognitive impairment. METHODS: Both female and male mice received a single intraperitoneal injection of 100 μg/kg lipopolysaccharide (LPS) on postnatal day 10 (P10)...
January 4, 2023: Neuroimmunomodulation
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