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Oncology Reports

Rui Zhang, Qi Deng, Yan-Yu Jiang, Hai-Bo Zhu, Jia Wang, Ming-Feng Zhao
CD19 chimeric antigen receptor (CAR) T cell therapy has changed the outcomes of relapsed/refractory B‑cell leukemia and lymphoma. However, its efficacy in patients with relapsed/refractory non‑Hodgkin lymphoma (NHL) has been less impressive compared with that in patients with acute lymphoid leukemia. Furthermore, immune checkpoints have a critical role in the immune system. Several clinical trials have confirmed the dramatic effects of programmed death‑1/programmed death‑ligand 1 (PD‑1/PD‑L1) inhibitors in numerous malignancies, but the immune‑associated adverse events of PD‑1/PD‑L1 inhibitors may occur in a number of systems...
April 3, 2019: Oncology Reports
Can Shi, Yijun Yang, Lei Zhang, Ting Zhang, Juanpeng Yu, Shanshan Qin, Yingchun Gao
Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. MicroRNAs (miRNAs) significantly differentially expressed between early‑ and advanced‑stage samples were identified by expression analysis. An optimal subset of signature miRNAs for pathologic stage prediction was delineated using the random forest algorithm and was used for the construction of a cervical cancer‑specific support vector machine (SVM) classifier...
April 3, 2019: Oncology Reports
Ye Gi Han, Miyong Yun, Minji Choi, Seok-Geun Lee, Hongtae Kim
Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential role of tumor necrosis factor receptor‑associated factor‑interacting protein (TRAIP) in regulating its modification in lung adenocarcinoma...
April 2, 2019: Oncology Reports
Chunni Fan, Ning Liu
Triple‑negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with limited treatment options combined with poor rates of survival. Given the lack of appropriate prognostic biomarkers for TNBC patients, the present study aimed to identify potential dysregulated miRNAs capable of providing a diagnosis and predicting overall survival for TNBC patients. A total of 289 miRNAs were aberrantly regulated in TNBC tissue compared to adjacent, non‑cancerous tissues and 96 microRNAs (miRNAs) in TNBC compared with non‑triple‑negative breast cancer (nTNBC) samples...
April 2, 2019: Oncology Reports
Li-Min Liu, Peng Lin, Hong Yang, Yi-Wu Dang, Gang Chen
Nitidine chloride (NC), an inartificial bioactive alkaloid present in the root of Zanthoxylum nitidum (Roxb.) DC, is known for its versatile anti‑inflammation and anticancer capabilities. The molecular mechanisms underlying its anticancer properties, however, remain obscure. The authors of the present study demonstrated the tumor suppressive effects of NC in a human liver cancer cell line using an MTT assay. The tumor suppressive capacity of NC was also analysed in a tumor xenograft nude mouse model. Changes in tumor cell gene expression profiles following NC treatment were detected by microarray; bioinformatics analysis demonstrated that differentially expressed genes were enriched in several cancer‑associated pathways, including those initiated by transforming growth factor‑β and phosphatidylinositol 4,5‑bisphosphate 3‑kinase/RAC‑α serine/threonine‑protein kinase signaling...
April 2, 2019: Oncology Reports
Binbin Li, Nansong Xu, Zheng Wan, Li Ma, Huahui Li, Weijie Cai, Xiumei Chen, Zunnan Huang, Zhiwei He
Aberrant activation of the extracellular signal‑regulated kinases (ERKs)/ribosomal S6 kinase 2 (RSK2) signaling pathway is frequently determined in various human tumor types, including liver cancer, and has been considered as a promising target for cancer chemoprevention and therapy. In the present study, using computer‑aided virtual screening and molecular docking, isobavachalcone (IBC), a natural chalcone compound, was identified to be an ATP‑competitive inhibitor targeting ERK1/2 and RSK2. Cell Counting Kit‑8, EdU incorporation and colony formation assays were used to detect the effects of IBC on cell viability and proliferation, and the results demonstrated that IBC effectively inhibited the proliferation of liver cancer HepG2 and Hep3B cells, whereas it had no notable cytotoxic effect on immortal liver L02 cells...
April 2, 2019: Oncology Reports
Sara M Ibrahim, Sherin Bakhashab, Asad M Ilyas, Peter N Pushparaj, Sajjad Karim, Jalaluddin A Khan, Adel M Abuzenadah, Adeel G Chaudhary, Muhammed H Al-Qahtani, Farid Ahmed
Multidrug resistance (MDR) is a major reason for the failure of acute myeloid leukemia (AML) therapy. Agents that reverse MDR and sensitize AML cells to chemotherapy are of great clinical significance. The present study developed Adriamycin (Adr)‑resistant cell lines, namely K562/Adr200 and K562/Adr500, which exhibited MDR. The upregulation of ATP‑binding cassette subfamily B member 1 (ABCB1) was confirmed as the mechanism of resistance by reverse transcription‑quantitative polymerase chain reaction and western blot analyses...
April 2, 2019: Oncology Reports
Pei-Bin Lin, Juan Shen, Pei-Yu Ou, Ling-Yan Liu, Zhi-Yu Chen, Fu-Jiang Chu, Jie Wang, Xiao-Bao Jin
Serratia marcescens are considered to be abundant and optimal resources for obtaining prodigiosin, which can be isolated from soil, water, plants and air but rarely from insects. In the present study, a strain of Serratia marcescens named WA12‑1‑18 was isolated from the gut of Periplaneta americana, which was capable of producing high levels of pigment reaching 2.77 g/l via solid fermentation and was identified as prodigiosin by ultraviolet, high performance liquid chromatography (LC), Fourier‑transform infrared spectroscopy, LC‑mass spectroscopy and nuclear magnetic resonance...
April 2, 2019: Oncology Reports
Yan Zou, Mu Chen, Shuai Zhang, Zeng'li Miao, Jing Wang, Xiao'jie Lu, Xu'dong Zhao
Temozolomide (TMZ) is the first choice chemotherapy agent against glioblastoma, but the TMZ chemotherapy resistance has restricted the clinical application. Although autophagy is considered an adaptive response for cell survival under the pressure of chemotherapy and associated with chemotherapy resistance, its initiator and the precise molecular mechanism remains unknown. In the present study, it was determined that TMZ increases the transient receptor potential cation channel subfamily C member 5 (TRPC5) protein expression and the basal autophagy level, and the upregulation of autophagy is mediated by TRPC5 in glioma cells...
April 2, 2019: Oncology Reports
Yanmin Zhang, Yusen Zhang, Minghua Li, Fanhua Meng, Zhendong Yu, Yun Chen, Guanghui Cui
Epithelial‑mesenchymal transition (EMT) plays an important role in cancer progression, metastasis and drug resistance, and recent studies have revealed that neoplastic epithelial cells regain the stem cell state through EMT. Single‑agent targeted cancer therapy frequently fails due to acquired drug resistance. Therefore, multi‑agent targeted therapy exhibits advantages in fighting cancer cells. In the present study, small molecule inhibitors SB431542 (ALK inhibitor), CHIR99021 (GSK3 pathway inhibitor), PD0325901 (MEK/ERK inhibitor) and valproic acid (VPA; HDAC inhibitor) were applied individually or in combination to HeLa uterine cervix carcinoma cells, 5637 bladder cancer cells and SCC‑15 squamous cell carcinoma cells to clarify their potential effects on cancer cells...
April 1, 2019: Oncology Reports
Jian Wu, An-Quan Shang, Chu Chen, Wei-Wei Wang, Cun-Quan Xiong, Nai-Zhou Guo
The authors wish to retract their research article entitled 'Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2', published in Oncology Reports 40, 3033‑3039, 2018. After the publication of this article, the authors have become concerned that there were flaws in their study design that have called into question the reported results. On repeating certain of the experiments, the authors found that the Nrf2‑Keap1‑ARE signaling pathway only has a role in the lung epithelial cell injury model, whereas it does not serve a role in the A549 model...
March 29, 2019: Oncology Reports
Yang Yang, Chun-Li Yang, Zhen-Jiang Zhao, Xiao-Xiao Zuo, Tian-Song Liang, Ya Yang, Sheng-Lin Ma, Dao-Ke Yang
The pleiotropic effects of hyperthermia on cancer cells have been well documented, and microwave hyperthermia (MWHT) has been widely applied for multifarious cancer treatment. However, the mechanisms underlying the anticancer effect of MWHT combined with gemcitabine (GEM) remain poorly understood. The aim of the present study was to investigate the role of autophagy in the thermo‑chemotherapy of human squamous cell lung carcinoma cells. It was observed that MWHT combined with GEM potently suppressed the viability of NCI‑H2170 and NCI‑H1703 cells, and induced G0/G1 cell cycle arrest...
March 22, 2019: Oncology Reports
Jingjing Lu, Xia Gu, Fanglei Liu, Zhuanghua Rui, Ming Liu, Liming Zhao
Lung cancer is the most common and lethal cancer worldwide, especially in developing countries. Non‑small cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer. In aprevious study, the protein expression of ubiquitin conjugating enzyme E2 C (UBE2C/UbcH10) in NSCLC tissues and cells was found to be significantly higher than that in adjacent tissues and normal lung epithelial cells. Further study revealed that the aberrant expression of UbcH10 in NSCLC tumors or cancer cells was caused by inactivation of the post‑transcriptional regulation mechanism, and thus microRNAs (miRNAs) may play an important...
March 21, 2019: Oncology Reports
Wenwei Qian, Yifei Feng, Jie Li, Wen Peng, Qiou Gu, Zhiyuan Zhang, Dongjian Ji, Qingyuan Wang, Dongsheng Zhang, Yueming Sun
Although colon cancer is often referred to as a homogeneous entity, an increasing number of studies have revealed that colon cancer can be divided according to the anatomic site of the cancer. However, few studies have reported the difference between distal and proximal colon cancer with regard to molecular mechanism, and especially non‑coding RNA molecules. In the present study, the data of 186 colon tumour tissues and 17 adjacent non‑tumour colon tissues in the left colon and 229 colon tumour tissues and 21 adjacent non‑tumour colon tissues in the right colon were obtained from The Cancer Genome Atlas (TCGA)...
March 21, 2019: Oncology Reports
M A Frassanito, I Saltarella, A Vinella, L Lo Muzio, G Pannone, R Fumarulo, A Vacca, M A Mariggiò
Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of apoptosis protein (IAP) family, namely survivin, is selectively overexpressed in tumors, including HNSCC, but not in normal tissues. Thus, it is considered a tumor biomarker. Here, we reviewed survivin expression and function in tumor progression focusing on its nodal role in the regulation of cell apoptosis and autophagy...
March 21, 2019: Oncology Reports
Taylor Banh, Deena Snoke, Rachel M Cole, Austin Angelotti, Patrick M Schnell, Martha A Belury
Cachexia is responsible for nearly 20% of all cancer‑related deaths, yet effective therapies to prevent or treat the disease are lacking. Clinical studies have shown that male patients lose weight at a faster rate than females. Additionally, an 'obesity paradox' may exist where excess adiposity may confer survival to patients with cancer cachexia. To further explore these phenomena, the aim of this study was to evaluate the role of changes of adipose tissue mass, sex status, and tumor mass on outcomes of male, female and ovariectomized (OVX) mice with C‑26 adenocarcinoma‑induced cachexia...
March 20, 2019: Oncology Reports
Susumu Tanaka, Yoshiko Honda, Shizuka Takaku, Taro Koike, Souichi Oe, Yukie Hirahara, Takashi Yoshida, Nae Takizawa, Yasuharu Takamori, Kiyoshi Kurokawa, Tohru Kodama, Hisao Yamada
The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑finger transcription factor, occurs in hypocretin neuron‑ablated transgenic mice, suggesting that PLAGL1 is co‑expressed in hypocretin neurons and regulates hypocretin transcription. The present study examined whether canonical prepro‑hypocretin transcription is functionally modulated by PLAGL1...
March 20, 2019: Oncology Reports
Shengfei Wang, Xiaomin Niu, Xiao Bao, Qin Wang, Jianping Zhang, Shun Lu, Yongjun Wang, Ling Xu, Mingwei Wang, Jie Zhang
Non‑small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide‑3‑kinase (PI3K) signalling promotes the growth of PI3K‑dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects of a PI3K inhibitor on NSCLC growth in bone and osteoclast formation, and aimed to determine whether it could control symptoms associated with bone metastasis. A bone metastasis xenograft model was established by implanting NCI‑H460‑luc2 lung cancer cells, which contain a phosphatidylinositol‑​4,5‑bisphosphate 3‑kinase catalytic subunit α mutation, into the right tibiae of mice...
March 20, 2019: Oncology Reports
Fan He, Long Fang, Qingshui Yin
PDZ domain containing 2 (PDZD2) is a multi-PDZ domain protein that promotes the proliferation of insulinoma cells, and is upregulated during prostate tumorigenesis. However, the function of PDZD2 in other cancers, including osteosarcoma (OS), remains unclear. Dysregulation of microRNAs (miRNAs) contributes to tumor initiation, proliferation and metastasis, via the regulation of their target genes. The present study investigated the functions of miR-363 and PDZD2 in MG-63 OS cells. The results revealed that MG-63 cells contained low levels of miR-363, and that overexpression of miR-363 in MG-63 cells significantly inhibited the vitality, proliferation, and colony formation ability of the cells, but promoted their apoptosis and G1/S arrest by regulating proliferating cell nuclear antigen (PCNA) and caspase-3 expression...
March 19, 2019: Oncology Reports
Xiandong Lin, Yan Xia, Dan Hu, Qiao Mao, Zongyang Yu, Hejun Zhang, Chao Li, Gang Chen, Fen Liu, Weifeng Zhu, Yi Shi, Huihao Zhang, Jianming Zheng, Tao Sun, Jianying Xu, Herta H Chao, Xiongwei Zheng, Xingguang Luο
Piwi‑interacting RNAs (piRNAs) comprise the largest class of non‑coding RNAs. They represent a molecular feature shared by all non‑aging biological systems, including germline and somatic cancer stem cells, which display an indefinite capacity of renewal and proliferation and are potentially immortal. They have been identified in animal stomachs, but their relationship with human gastric cancers remains largely unclear. The present study aimed to identify the piRNAs associated with human gastric cancers across the whole transcriptome...
March 18, 2019: Oncology Reports
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