Lucas B Lopes, Guilherme B Pintarelli, Raul Guedert, Daniella L L S Andrade, Afrânio C Antonio, Clara T S Ramos, Jéssica R da Silva, Marcelo M M Rangel, Daniela O H Suzuki
Electrochemotherapy is a cancer treatment in which local pulsed electric fields are delivered through electrodes. The effectiveness of the treatment depends on exposing the tumor to a threshold electric field. Electrode geometry plays an important role in the resulting electric field distribution, especially in hard-to-reach areas and deep-seated tumors. We designed and developed a novel tetrapolar single-needle electrode for proper treatment in bone cavities. In silico and in vitro experiments were performed to evaluate the electric field and electric current produced by the electrode...
March 2024: Medical Engineering & Physics