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Journals Revista de Investigación Cl...

Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

https://read.qxmd.com/read/36898012/a-simple-painless-solution-to-detach-different-materials-from-the-skin-of-patients
#21
JOURNAL ARTICLE
Huberman-Wajsman Alberto
No abstract text is available yet for this article.
March 10, 2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/36652613/low-expression-of-e-cadherin-and-cdh1-variants-associated-with-diffuse-gastric-cancer
#22
JOURNAL ARTICLE
Azaria García-Ruvalcaba, Katia C Vázquez-Ibarra, María T Magaña-Torres, Lourdes Del C Rizo de-la-Torre, Lennon Meléndez-Aranda, Gabriela López-Armas, José A Cruz-Ramos, Jorge Peregrina-Sandoval, Esther Espinoza-Jiménez, María E Rosales-Gradilla, Josefina Y Sánchez-López
BACKGROUND: Reduced or null expression of E-cadherin protein is a frequent cause of diffuse gastric cancer (DGC). More than 50% of patients with DGC present somatic variants in CDH1 gene. OBJECTIVES: The objectives of this study were to study E-cadherin expression and identify variants in the CDH1 gene in gastric tumors of patients with DGC. METHODS: We studied 18 Mexican DGC patients who attended a hospital of the Mexican Social Security Institute; E-cadherin expression was determined by immunohistochemistry, and variants were identified by Sanger sequencing in promoter and coding regions...
January 18, 2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38154458/advances-in-hemodialysis-in-the-last-decade-in-latin-america
#23
JOURNAL ARTICLE
María C González-Bedat, Guillermo Rosa-Diez, Ricardo Correa-Rotter
Kidney replacement therapy (KRT) initiated in Latin America towards the second half of the 20th century, starting with dialytic therapies and, shortly thereafter, with kidney transplant. By the end of 2021, close to half a million Latin Americans were under KRT, with an overall unadjusted prevalence of 872 per million persons (pmp), yet with significant heterogeneity between nations. By treatment modality, 68% of prevalent patients were treated with hemodialysis (HD), 9% with peritoneal dialysis (PD), and 23% were living with a functioning kidney graft (LFG)...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38154128/hybrid-therapies-for-supporting-critically-ill-patients-with-acute-kidney-injury-when-how-and-for-whom
#24
JOURNAL ARTICLE
Alejandro Ferreiro-Fuentes, Ana Guerisoli, Olynka Vega-Vega
Acute kidney injury (AKI) is common in critically ill patients. There is no specific pharmacological treatment for established severe AKI. Therefore, the conventional therapeutic strategy is limited to the use of kidney replacement therapy (KRT) to maintain homeostasis. Hybrid therapies optimize the advantages of intermittent and continuous modalities of KRT, combining lower hourly efficiency, longer application time, at lesser cost, but also adding different physicochemical principles of extracorporeal clearance...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38154126/advances-in-peritoneal-dialysis-in-acute-kidney-injury
#25
REVIEW
Daniela Ponce, Welder Zamoner, Dayana Bitencourt Dias, Vanessa Banin, Andre Luis Balbi
In the 1970s, acute peritoneal dialysis (PD) was widely accepted for the treatment of acute kidney injury (AKI), but this practice has declined in favor of extracorporeal therapies, mainly in developed world. The lack of familiarity with the use of PD in critically ill patients has also led to a lack of use even among those receiving maintenance PD. Renewed interest in the use of PD for AKI therapy has emerged due to its increasing use in low- and middle-income countries due to its lower cost and minimal infrastructural requirements...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38154125/continuous-renal-replacement-therapy-what-have-we-learned-and-what-are-key-milestones-for-the-years-to-come
#26
JOURNAL ARTICLE
Pablo Galindo, Javier A Neyra
Continuous renal replacement therapy (CRRT) is the main extracorporeal kidney support therapy used in critical ill patients in the intensive care unit (ICU). Since its conceptualization ~50 years ago, there have been major improvements in its technology and utilization. The last decade, and particularly since the COVID-19 pandemic, has been marked by a growing interest and demand of CRRT in worldwide ICUs. This has underpinned the need for improvements in nomenclature and process standardization, optimization of CRRT deliverables, and the development and validation of key performance indicators...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38147578/preface-advances-in-dialysis-in-the-last-decade
#27
JOURNAL ARTICLE
Olynka Vega-Vega, Noemí Del Toro-Cisneros
No abstract text is available yet for this article.
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918014/tumor-promoting-effects-of-microrna-421-4-aminobutyrate-aminotransferase-axis-in-hepatocellular-carcinoma
#28
JOURNAL ARTICLE
Yuanguang Liu, Ran Cheng, Yijie Wu, Chunmei Liu, Yang Liu, Qing Chang, Jun Yin
Background: MicroRNA-421 (miR-421) has been implicated in hepatocellular carcinoma (HCC), but its potential mechanism in HCC remains unclear. Objectives: The study aimed to study the potential mechanism of miR-421 in HCC which is necessary. Methods: The downstream target genes of miR-421 were screened in HCC tissues and cells using miDIP, Targetscan, and starBase databases. Differential analysis, survival analysis, and Pearson correlation analysis were performed between miR-421 and its downstream target genes...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918013/multivariate-prognostic-models-for-patients-with-stages-i-and-ii-colon-carcinoma-a-strobe-compliant-retrospective-cohort-study
#29
RANDOMIZED CONTROLLED TRIAL
Luis F Oñate-Ocaña, Roberto Herrera-Goepfert, Alejandro Avilés-Salas, Carlo C Cortés, Sagrario González-Trejo, José F Carrillo, Erika Ruiz-García, Francisco J Ochoa-Carrillo, Vincenzo Aiello-Crocifoglio, Claudia M García-Cuellar
Background: Colorectal cancer is the most frequent gastrointestinal malignancy worldwide. The value of adjuvant treatment is controversial in Stages I and II. Objective: The aim of this study was to construct post-operative prognostic models applicable to patients with stages I-II colon carcinoma (CC). Methods: This is a retrospective cohort study of patients with Stage I-II CC treated over a 25-year period. Exposure was defined as clinical, histopathological, and immunohistochemical factors (including CDX2 and MUC2 expression)...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918012/predictive-performance-of-triglyceride-glucose-index-on-asymptomatic-multiple-organ-damage-in-patients-with-newly-diagnosed-hypertension
#30
JOURNAL ARTICLE
Ahmet Kivrak, Alp Yildirim
Background: Insulin resistance (IR) contributes to the development of hypertension and mediated organ damage (HMOD) through various mechanisms. Objectives: The objective of the study was to assess the diagnostic performance of the triglyceride-glucose (TyG) index, a surrogate marker of IR, in predicting the presence and severity of HMOD in newly diagnosed untreated hypertensive patients from an academic training and research hospital. Methods: The study included 438 patients with newly diagnosed, untreated hypertension...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918011/anti-hla-donor-specific-antibodies-are-associated-to-infection-and-not-to-the-engraftment-rate-in-outpatient-haploidentical-hematopoietic-cell-transplantation
#31
JOURNAL ARTICLE
José C Jaime-Pérez, María L Ruiz-De La Cruz, Sandra I Mendoza-Ibarra, Nidia K Moncada-Saucedo, David Gómez-Almaguer
Background: Recipients of a related haploidentical stem cell transplant (haplo-SCT) can have preformed antibodies to HLA donor's antigens. Objective: The aim of the study was to evaluate the engraftment rate and major clinical associations of anti-HLA donor-specific antibodies (DSA) at two mean fluorescence intensity (MFI) thresholds in recipients of an outpatient haplo-SCT. Methods: Seventy haplo-HCT recipients were analyzed. A virtual crossmatch was performed using the donor HLA typing and the recipient's anti-HLA DSA test results...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607036/type-2-diabetes-mellitus-and-nonvalvular-atrial-fibrillation-in-mexico-national-registries-raise-a-red-flag
#32
JOURNAL ARTICLE
Manlio F Márquez-Murillo, Eduardo Brenner-Muslera, Diana L Rodríguez-Carrillo, César A Chua-López, Margarita Torres-Tamayo
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and is highly prevalent in Mexico, as 10.2% of the adult population harbors this condition. T2DM is usually associated with cardiovascular comorbidities, including arrhythmias. Metabolic impairment is one of the mechanisms that contribute to tissue remodeling that affects atrial structure, and concomitant, the cardiac conduction system, both could result in atrial fibrillation (AF). AF is estimated to affect more than a half million Mexicans, and its incidence is expected to keep rising...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607031/meta-analysis-to-implement-alpha-synuclein-in-extracellular-vesicles-as-a-potential-biomarker-for-parkinsons-disease
#33
JOURNAL ARTICLE
Víctor H Juárez-Vaquera, Marcos F Rosetti-Sciutto, Valeria Morales-Ruiz, Laura V Adalid-Peralta
Background: In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker. Objective: Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency. Methods: Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis. Results: Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607027/new-onset-geriatric-epilepsy-in-a-latin-american-country-a-multi-centric-study-from-mexico
#34
JOURNAL ARTICLE
Roberto A Suástegui Román, Ángel Lee, Laura E Hernández Vanegas, Gerónimo Pacheco-Aispuro, Brigham Bowles, Christopher Mader, Elizabeth Aveleyra Ojeda
Background: In Latin America, epilepsy in the elderly is a neglected issue that has never been studied. The epidemiological transition has significantly altered the demographics of epilepsy, and therefore, we would like to draw attention to this topic. Objective: We require local real-world evidence, as the literature often depicts a different scenario, including pharmacological management. Methods: From 2007 to 2018, we recruited all patients with new-onset geriatric epilepsy (first seizure after the age of 60) tracked from ten Mexican hospitals, adding them to patients with similar characteristics from a previously published study...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37603449/the-predictive-value-of-r-wave-peak-time-to-detect-thrombus-burden-in-st-segment-elevation-myocardial-infarction-a-retrospective-cohort-study-in-a-tertiary-medical-center
#35
JOURNAL ARTICLE
Zehra Güven-Çetin, Bekir Demirtaş, Ahmet Balun, Hülya Çiçekçioğlu, Kerem Özbek, Mustafa Çetin
Background: Patients with higher thrombus burden have higher procedural complications and more long-term adverse cardiac events. Detecting patients with high thrombus burden (HTB) before coronary intervention could help avoid procedural complications. Objective: The research aimed to analyze the R wave peak time (RWPT) on the electrocardiogram to predict thrombus burden before coronary angiography in patients with acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: A total of 159 patients with STEMI were included in the study conducted at a tertiary medical center...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441771/fentanyl-and-other-new-psychoactive-synthetic-opioids-challenges-to-prevention-and-treatment
#36
JOURNAL ARTICLE
Damaris Albores-García, Silvia L Cruz
Synthetic opioids have played a significant role in the current opioid crisis in the United States (U.S.) and Canada and are a matter of concern worldwide. New psychoactive opioids (NPOs) are classified in the internationally recognized new psychoactive substances (NPSs) category. This group comprises compounds that may have been synthesized decades ago but appeared only recently in the illicit drug market. Such is the case of fentanyl, fentanyl analogs, and non-fentanyl opioids. Most NPOs have effects similar to morphine, including euphoria and analgesia, and can produce fatal respiratory depression...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441770/amphetamine-type-stimulants-novel-insights-into-their-actions-and-use-patterns
#37
REVIEW
Miguel I Paz-Ramos, Silvia L Cruz, Valeria Violante-Soria
This review focuses on the effects and mechanisms of action of amphetamine-type stimulants (ATS) and their adverse effects on the cardiovascular, nervous, and immune systems. ATS include amphetamine (AMPH), methamphetamine (METH, "crystalmeth," or "ice"), methylenedioxymethamphetamine (MDMA, "ecstasy," or "Molly"), MDMA derivatives (e.g., methylenedioxyamphetamine [MDA] and methylenedioxy-N-ethylamphetamine [MDEA]), khat, and synthetic cathinones. The first section of this paper presents an overview of the historical aspects of ATS use, their initial clinical use, and regulations...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441767/preface-special-issue-on-challenges-and-new-findings-on-misused-psychoactive-drugs
#38
JOURNAL ARTICLE
Silvia L Cruz
No abstract text is available yet for this article.
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441766/-cannabis-drug-of-abuse-and-therapeutic-agent-two-sides-of-the-same-coin
#39
JOURNAL ARTICLE
Ana Canseco-Alba, Gabriela Rodríguez-Manzo
The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating, and spiritual) due to its psychoactive effects, can be traced back to ancient times. Cannabis is the most used illicit drug worldwide; however, its legal status is changing rapidly. Cannabis regulation will allow a better understanding of its effects as a misused drug, including new challenges, such as the availability of highly potent Cannabis extracts . Furthermore, scientific research is making significant efforts to take advantage of the potential therapeutic uses of Cannabis active compounds...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441764/alcohol-immunomodulatory-effects-and-cancer
#40
JOURNAL ARTICLE
Juan C Molina, Jesús D Guerrero-Morán, Claudia González-Espinosa
Alcohol consumption has been linked to numerous pathologic conditions, including infectious diseases and several types of cancer. Alcohol exerts its modulatory effects on the immune system (IS) in a dose- and time-dependent manner. Numerous studies indicate that these alterations affect responses such as peripheral inflammation or decreased antibody production and promote chronic inflammation, leading to cell death. The molecular mechanisms underlying these effects involve generating an oxidative tissue environment, producing cell damage-associated molecular patterns (DAMPs), and activating pattern recognition receptors...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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