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Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

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https://read.qxmd.com/read/30532115/the-effect-of-single-dose-intraperitoneal-bevacizumab-on-peritoneal-adhesion-formation
#1
Gokce Acun, Hakan Ozdemir, Oguzhan Sunamak, Zehra Unal Ozdemir, Emel Baskan, Mete Yazi, Berna Savas, Ugur Berberoglu
Background: Intra-abdominal adhesions and their complications following abdominal surgery are serious problems, with an incidence of 67-93%. Prevention of peritoneal adhesion formation may eliminate the need for surgical intervention, decreasing complications, morbidity, and cost. Bevacizumab is a recombinant monoclonal antibody which specifically binds vascular endothelial growth factor, an important cytokine in adhesion formation, and neutralizes its biological activity. We developed an experimental model in rats to determine the effect of bevacizumab in preventing adhesion formation and analyzed its effect both micro- and macroscopically...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532112/the-role-of-stents-as-bridge-to-surgery-for-acute-left-sided-obstructive-colorectal-cancer-meta-analysis-of-randomized-controlled-trials
#2
Ping Yang, Xiu-Feng Lin, Kai Lin, Wei Li
Background: The role of self-expanding metallic stents (SEMS) as a bridge to surgery for acute left-sided obstructive colorectal cancer has remained controversial. Objective: To study the efficacy of this approach, we performed a meta-analysis at the gastrointestinal surgery center of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital (Eastern Hospital). Methods: Two PubMed and science-direct electronic databases were searched up to December 30, 2017...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532110/integrative-view-of-the-mechanisms-that-induce-acute-kidney-injury-and-its-transition-to-chronic-kidney-disease
#3
Luis Enrique García-Ortuño, Norma Araceli Bobadilla
There is ample evidence showing that acute kidney injury (AKI) increases the risk of developing chronic kidney disease (CKD). Although considerable efforts have been undertaken in recent years to elucidate the mechanisms responsible for the AKI to CKD transition, many questions remain to be answered. In this review, we address most of the latest studies elucidating the mechanisms involved in this transition. Based on recent studies, the consensus to date is that endothelial and proximal tubular epithelium injury along with the activation of inflammatory processes occurring after an AKI episode, not only establish a close interrelation but also trigger a series of signaling pathways that culminate in the generation of tubulointerstitial fibrosis and chronic hypoxia, which lead to the progressive deterioration of functional tissue...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532098/diagnostic-utility-of-11c-dtbz-positron-emission-tomography-in-clinically-uncertain-parkinsonism-experience-of-a-single-tertiary-center
#4
Christian Pérez-Lohman, Nora E Kerik, Ivan E Díaz-Meneses, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante
Background: The use of single-photon emission computed tomography and positron emission tomography (PET) has proven to be helpful in differentiating Parkinson's disease (PD) from other movement disorders with a sensitivity of up to 95%. Objective: The objective of this study was to determine the accuracy of [11C]DTBZ PET imaging in patients with clinically uncertain parkinsonism from a tertiary referral center in Mexico City. Materials and Methods: Patients who underwent [11C]DTBZ PET brain scan due to clinically uncertain parkinsonism where divided into two groups: PD or non-PD...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532096/type-2-diabetes-mellitus-is-associated-with-carotid-artery-plaques-in-patients-with-premature-coronary-heart-disease
#5
J Gabriel Juárez-Rojas, Carlos Posadas-Romero, Rocío Martínez-Alvarado, Esteban Jorge-Galarza, Juan Reyes-Barrera, L Gabriela Sánchez-Lozada, Margarita Torres-Tamayo, Aida X Medina-Urrutia
Background: In subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events. Objective: The objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients. Methods: Premature CHD was considered before the age of 55 years in men and before 65 in women...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532091/calculated-versus-measured-urine-osmolarity-accuracy-of-estimated-urine-density
#6
José de Jesús Vidal-Mayo, Antonio Olivas-Martínez, Iván Pérez-Díaz, Juan M López-Navarro, Elizabet Sánchez-Landa, Eduardo Carrillo-Maravilla, Martha Portillo-González, Reynerio Fagundo-Sierra, Mario Andrés de Jesús Leal-Villareal
Background: Urine osmolarity (OsmU) is the gold standard for the evaluation of the kidney's urine concentration capacity; nevertheless, urinary density (UD) is often used as a surrogate for its estimation. Objective: The objective of this study was to analyze the accuracy of UD in estimating OsmU. Materials and Methods: A transversal study including patients with simultaneous determination of UD measured with refractometry and OsmU measured by osmometer (OsmUm)...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30532087/oncological-implications-of-lymph-nodes-retrieval-and-perineural-invasion-in-colorectal-cancer-outcomes-from-a-referral-center
#7
Omar Vergara-Fernandez, Adolfo Navarro-Navarro, Hugo Antonio Rangel-Ríos, Noel Salgado-Nesme, José Aristeo Reyes-Monroy, David Velázquez-Fernández
Background: In colorectal cancer (CRC), regional lymphadenectomy provides prognostic information and guides management. The current consensus states that at least 12 lymph nodes (LN) should be evaluated. The aims of this study were to identify whether the number of LN is a predictor for survival and recurrence, and to reveal the role of LN ratio (LNR) and perineural invasion (PNI) in predicting prognosis after curative resection of CRC. Methods: We included all patients who underwent surgery for CRC between 2000 and 2016 in an academic medical center in Mexico...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307448/genomics-and-systems-biology-approaches-in-the-study-of-lipid-disorders
#8
Alejandra Rodríguez, Päivi Pajukanta
Cardiovascular disease (CVD) is a broad definition for diseases of the heart and blood vessels with high mortality and morbidity worldwide. Atherosclerosis and hypertension are the most common causes of CVD, and multiple factors confer the susceptibility. Some of the predisposing factors are modifiable such as diet, smoking, and exercise, whereas others, including age, sex, and individual's genetic variations contributing to the CVD composition traits, are non-modifiable. This latter group includes serum lipid traits...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307447/new-biotechnological-treatments-for-lipid-disorders
#9
Natalia Valencia-Enciso, Carlos O Mendivil
Disorders of lipid and lipoprotein metabolism play a central role in the pathogenesis of atherosclerotic cardiovascular diseases (CVDs). Despite the widespread use of efficacious lipid-modifying therapies, the residual risk of CVD remains unacceptably high. The purpose of this manuscript is to review the application of new technologies in the treatment of lipid disorders. New therapies work mostly at the gene expression level and are, therefore, different from traditional small-molecule drugs that work mainly by inhibiting already synthesized proteins...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307446/familial-combined-hyperlipidemia-current-knowledge-perspectives-and-controversies
#10
REVIEW
Omar Yaxmehen Bello-Chavolla, Anuar Kuri-García, Monserratte Ríos-Ríos, Arsenio Vargas-Vázquez, Jorge Eduardo Cortés-Arroyo, Gabriela Tapia-González, Ivette Cruz-Bautista, Carlos Alberto Aguilar-Salinas
Familial combined hyperlipidemia (FCHL) is the most prevalent primary dyslipidemia; however, it frequently remains undiagnosed and its precise definition is a subject of controversy. FCHL is characterized by fluctuations in serum lipid concentrations and may present as mixed hyperlipidemia, isolated hypercholesterolemia, hypertriglyceridemia, or as a normal serum lipid profile in combination with abnormally elevated levels of apolipoprotein B. FCHL is an oligogenic primary lipid disorder, which can occur due to the interaction of several contributing variants and mutations along with environmental triggers...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307445/controversial-issues-in-the-treatment-of-dyslipidemias-in-patients-with-diabetes-mellitus
#11
Klaus G Parhofer
Patients with diabetes mellitus have an elevated cardiovascular risk. Lipid-lowering therapy is a successful strategy to prevent atherosclerotic events in these patients. Therefore, almost all professional societies recommend statin therapy for patients with diabetes under certain conditions. Despite this broad consensus, a number of controversial issues remain. Thus, it remains unclear in which patients the lipid parameters should be determined in the fasting state and in which postprandial values are sufficient...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307444/dyslipidemia-in-mexico-a-call-for-action
#12
Bernardette Rivas-Gomez, Paloma Almeda-Valdés, María Teresa Tussié-Luna, Carlos A Aguilar-Salinas
The purpose of this manuscript is to highlight the peculiarities of the Mexican population regarding the clinical expression, genetics, and treatment of lipid disorders. Furthermore, it is a call for action to address the existing gaps in care and research of dyslipidemias. The Mexican Mestizos are highly susceptible to metabolic disorders (i.e., low high-density lipoprotein cholesterol concentrations, hypertriglyceridemia, abdominal obesity, and type 2 diabetes); these conditions are associated with ethnic-specific genetic variants...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30307443/lipid-disorders-advances-in-research-and-challenges-in-clinical-practice
#13
Carlos A Aguilar-Salinas, María Teresa Tussié-Luna, Paloma Almeda-Valdés
No abstract text is available yet for this article.
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067729/-combined-preimplantation-genetic-testing-for-aneuploidy-and-monogenic-disease-in-a-mexican-family-affected-by-x-linked-hypohidrotic-ectodermal-dysplasia
#14
Raul Eduardo Piña-Aguilar, Claudia González-Ortega, Anna Calull-Bago, María Cristina Lanuza-López, Patricia Cancino-Villarreal, Ana Mireya Gutiérrez-Gamiño, Antonio Martin Gutiérrez-Gutiérrez
Background: Hypohidrotic ectodermal dysplasia (HED) is a genetic skin condition presenting as hypohidrosis, hypodontia, and hypotrichosis, resulting in an important burden for affected families. The most common form of HED has an X-linked inheritance and female carriers have the option of prenatal or preimplantation genetic testing (PGT) to avoid transmission of the disease. A combined PGT for a mutation in EDA gene and aneuploidies in a Mexican carrier of X-linked HED is reported. Materials and Methods: Ovarian stimulation and assisted reproduction procedures were performed in a private academic medical center...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067728/-roles-of-donor-recipient-body-surface-area-ratio-and-donor-kidney-glomerular-filtration-rate-in-kidney-selection-for-living-transplantation-from-family-members
#15
Youqing Zheng, Yawei Guan, Zhihui Li, Guohui Zhang, Yanjie Guo, Xing Ai
Background: Accurate assessing donor renal function is crucial to the success of living kidney transplants. We studied the roles of donor kidney glomerular filtration rate (GFR) and donor/recipient body surface area (BSA) ratio in kidney selection for living transplantation from family members. Methods: We included 204 recipients who were subjected to living kidney transplantation from family members in our hospital from February 2011 to February 2015 and followed up for over 2 years...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067727/-primary-tumors-of-the-central-nervous-system-clinical-experience-at-a-third-level-center
#16
Alan Hernández-Hernández, Ignacio Reyes-Moreno, Axayácatl Gutiérrez-Aceves, Vicente Guerrero-Juárez, José Santos-Zambrano, Manuel López-Martínez, Elvira Castro-Martínez, Bernardo Cacho-Díaz, Javier Avendaño Méndez-Padilla, Alberto González-Aguilar
Background: Central nervous system (CNS) tumors are a group of neoplasms that originate from various cells in the CNS. The increasing incidence and prevalence of this type of tumor in developing countries are striking; however, there are few current studies in Latin America including Mexico estimating the impact of these pathological entities on the general population. Objective: The objective of the study was to study the characteristics of primary CNS tumors over a period of 52 years...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067725/-prediction-of-molecular-signature-potential-biomarkers-and-molecular-pathways-associated-with-membranous-nephropathy-based-on-protein-protein-interactions
#17
Amir Taherkhani, Shiva Kalantari, Mohsen Nafar
Background: Membranous nephropathy (MN) is one of the causes of nephrotic syndrome in adults that lead to end-stage renal disease with an unknown molecular signature. The current diagnosis is based on renal biopsy, which is an invasive method and has several complications and challenges. Thus, identification of the novel biomarker candidates, as well as impaired pathways, will be helpful for non-invasive molecular-based diagnosis. Objectives: We aimed to study the molecular signature of MN and facilitate the systematic discovery of diagnostic candidate biomarkers, molecular pathway, and potential therapeutic targets using bioinformatics predictions...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067724/-association-of-notified-cases-and-treatment-success-rates-in-pulmonary-tuberculosis
#18
Alfonso Vallejos-Parás, David Alejandro Cabrera-Gaytán, Rosario Padilla-Velázquez, Lumumba Arriaga-Nieto, Gabriel Valle-Alvarado, Concepción Grajales-Muñiz, Teresita Rojas-Mendoza, María Del Rosario Niebla-Fuentes
Background: Tuberculosis has long been recognized as a public health problem in large cities. The goals of the "Stop TB" strategy of the WHO specifically promote its study at the subnational level. Therefore, we aimed to describe the state of pulmonary tuberculosis (PTB) at the municipality level in Mexico. Methods: We obtained data on new cases of PTB and treatment success rates (TSRs) per municipality from each state in Mexico, reported by the Mexican Social Security Institute to the National Epidemiological Surveillance System during 2013...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067723/-multimorbidity-depressive-symptoms-and-self-reported-health-in-older-adults-a-secondary-analysis-of-the-sabe-bogota-study
#19
Sandy Camargo-Casas, Silvia Suarez-Monsalve, Mario Ulises Pérez Zepeda, Carmen García-Peña, Carlos Alberto Cano-Gutierrez
Background: Multimorbidity and depressive symptoms (DSs) are common in older adults. Self-rated health (SRH) allows detection of elderly adults with a high burden of multimorbidity plus depression. The aim of this study was to test the association of groups of multimorbidity and DS on SRH in Colombian older adults. Methods: We conducted a cross-sectional study in 2012 in Bogotá, Colombia, called "Salud, Bienestar y Envejecimiento" (Health, Well-being, and Aging), including 2000 community-dwelling adults 60 years of age or older...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/30067721/-clinical-applications-of-next-generation-sequencing
#20
Rosa Gloria Rebollar-Vega, Cristian Arriaga-Canon, Inti Alberto de la Rosa-Velázquez
The significant drop in sequencing costs boosted by chemistries optimization and sample multiplexation has resulted in an immense growth within the field of next-generation sequencing (NGS) in the last decade. This has allowed a diversification of techniques, promoting a rapid advance in knowledge on the molecular basis of human disease. Due to the applicability and importance of this technology in basic research, it has quickly migrated to the clinical setting. NGS enables clinicians to make improved diagnostic and treatment decisions, which ultimately may influence precision medicine...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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