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Clinical Chemistry

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https://read.qxmd.com/read/30770377/measurement-of-treatment-effects-require-instruments-responsive-to-change-based-on-the-minimal-important-difference
#1
Bradley C Johnston, Gordon H Guyatt
No abstract text is available yet for this article.
February 15, 2019: Clinical Chemistry
https://read.qxmd.com/read/30770376/increased-clinical-sensitivity-and-specificity-of-plasma-protein-n-glycan-profiling-for-diagnosing-congenital-disorders-of-glycosylation-by-use-of-flow-injection-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#2
Jie Chen, Xueli Li, Andrew Edmondson, Gail Ditewig Meyers, Kosuke Izumi, Amanda M Ackermann, Eva Morava-Kozicz, Can Ficicioglu, Michael J Bennett, Miao He
BACKGROUND: Congenital disorders of glycosylation (CDG) represent 1 of the largest groups of metabolic disorders with >130 subtypes identified to date. The majority of CDG subtypes are disorders of N -linked glycosylation, in which carbohydrate residues, namely, N -glycans, are posttranslationally linked to asparagine molecules in peptides. To improve the diagnostic capability for CDG, we developed and validated a plasma N -glycan assay using flow injection-electrospray ionization-quadrupole time-of-flight mass spectrometry...
February 15, 2019: Clinical Chemistry
https://read.qxmd.com/read/30770375/technology-meets-opportunity-high-sensitivity-troponin-testing-for-screening-apparently-healthy-adults
#3
James A de Lemos
No abstract text is available yet for this article.
February 15, 2019: Clinical Chemistry
https://read.qxmd.com/read/30770374/performance-of-the-masspec-pen-for-rapid-diagnosis-of-ovarian-cancer
#4
Marta Sans, Jialing Zhang, John Q Lin, Clara L Feider, Noah Giese, Michael T Breen, Katherine Sebastian, Jinsong Liu, Anil K Sood, Livia S Eberlin
BACKGROUND: Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems...
February 15, 2019: Clinical Chemistry
https://read.qxmd.com/read/30755401/room-temperature-detection-of-plasma-epstein-barr-virus-dna-with-crispr-cas13
#5
LETTER
Yetao Wu, Shang-Xin Liu, Fang Wang, Mu-Sheng Zeng
No abstract text is available yet for this article.
February 12, 2019: Clinical Chemistry
https://read.qxmd.com/read/30745290/low-hdl-cholesterol-and-high-risk-of-autoimmune-disease-two-population-based-cohort-studies-including-117341-individuals
#6
Christian M Madsen, Anette Varbo, Børge G Nordestgaard
BACKGROUND: HDL is quantitatively the most important lipoprotein in most species and mechanistic evidence points toward a role for HDL in normal immune function. We tested the hypothesis that concentrations of HDL cholesterol are associated with risk of autoimmune disease. METHODS: From 2 studies of the general population- the Copenhagen General Population Study and the Co-penhagen City Heart study-we included 107954 and 9387 individuals with baseline measurements of HDL cholesterol...
February 11, 2019: Clinical Chemistry
https://read.qxmd.com/read/30737207/advancing-point-of-care-diagnostics-of-metabolites-through-engineering-semisynthetic-proteins
#7
JingJing Zhang, Yi Lu
No abstract text is available yet for this article.
February 8, 2019: Clinical Chemistry
https://read.qxmd.com/read/30737206/high-sensitivity-generation-5-cardiac-troponin-t-sex-and-age-specific-99th-percentiles-in-the-caliper-cohort-of-healthy-children-and-adolescents
#8
LETTER
Mary Kathryn Bohn, Victoria Higgins, Peter Kavsak, Barry Hoffman, Khosrow Adeli
No abstract text is available yet for this article.
February 8, 2019: Clinical Chemistry
https://read.qxmd.com/read/30737205/label-free-enrichment-and-molecular-characterization-of-viable-circulating-tumor-cells-from-diagnostic-leukapheresis-products
#9
André Franken, Christiane Driemel, Bianca Behrens, Franziska Meier-Stiegen, Volker Endris, Albrecht Stenzinger, Dieter Niederacher, Johannes C Fischer, Nikolas H Stoecklein, Eugen Ruckhaeberle, Tanja Fehm, Hans Neubauer
INTRODUCTION: Circulating tumor cells (CTCs)5 may be used to improve cancer diagnosis, prognosis, and treatment. However, because knowledge regarding CTC biology is limited and the numbers of CTCs and CTC-positive cancer patients are low, progress in this field is slow. We addressed this limitation by combining diagnostic leukapheresis (DLA) and microfluidic enrichment to obtain large numbers of viable CTCs from metastasized breast cancer patients. METHODS: DLA was applied to 9 patients, and 7...
February 8, 2019: Clinical Chemistry
https://read.qxmd.com/read/30737204/mass-spectrometry-based-tissue-imaging-the-next-frontier-in-clinical-diagnostics
#10
Felix Leung, Livia S Eberlin, Kristina Schwamborn, Ron M A Heeren, Nicholas Winograd, R Graham Cooks
No abstract text is available yet for this article.
February 8, 2019: Clinical Chemistry
https://read.qxmd.com/read/30737203/novel-assay-for-quantitative-analysis-of-dna-methylation-at-single-base-resolution
#11
Huichuan Yu, Liangliang Bai, Guannan Tang, Xiaolin Wang, Meijin Huang, Guangwen Cao, Jianping Wang, Yanxin Luo
BACKGROUND: The DNA methylation profile provides valuable biological information with potential clinical utility. Several methods, such as quantitative methylation-specific PCR (qMSP), have been developed to examine methylation of specific CpG sites. Existing qMSP-based techniques fail to examine the genomic methylation at a single-base resolution, particularly for loci in gene bodies or extensive CpG open seas lacking flanking CpGs. Therefore, we established a novel assay for quantitative analysis of single-base methylation...
February 8, 2019: Clinical Chemistry
https://read.qxmd.com/read/30728149/independent-validation-of-a-diagnostic-noninvasive-3-microrna-ratio-model-ucap-for-prostate-cancer-in-cell-free-urine
#12
Jacob Fredsøe, Anne K I Rasmussen, Emma B Laursen, Yunpeng Cai, Kenneth A Howard, Bodil G Pedersen, Michael Borre, Peter Mouritzen, Torben Òrntoft, Karina D Sørensen
BACKGROUND: Detection of prostate cancer (PC) based on serum prostate-specific antigen (PSA) testing leads to many unnecessary prostate biopsies, overdiagnosis, and overtreatment of clinically insignificant tumors. Thus, novel and more accurate molecular biomarkers are required. METHODS: Using reverse transcription quantitative PCR, we measured the concentrations of 45 preselected microRNAs (miRNAs) in extracellular vesicle-enriched cell-free urine samples from 4 independent patient cohorts from Spain and Denmark, including 758 patients with clinically localized PC, 289 noncancer controls with benign prostatic hyperplasia (BPH), and 233 patients undergoing initial transrectal ultrasound (TRUS)-guided prostate biopsy owing to PC suspicion (101 with benign and 132 with malignant outcome)...
February 6, 2019: Clinical Chemistry
https://read.qxmd.com/read/30709812/immunoglobulin-like-domain-of-hs-fc%C3%AE-r-as-a-capture-molecule-for-detection-of-crimean-congo-hemorrhagic-fever-virus-and-zika-virus-specific-igm-antibodies
#13
Anne Rackow, Christa Ehmen, Ronald von Possel, Raquel Medialdea-Carrera, David Brown, Ana Maria Bispo de Filippis, Patrícia Carvalho de Sequeira, Rita Maria Ribeiro Nogueira, Barie Halili, Xhevat Jakupi, Lindita Berisha, Salih Ahmeti, Kurtesh Sherifi, Jonas Schmidt-Chanasit, Herbert Schmitz, Angela Mika, Petra Emmerich, Christina Deschermeier
BACKGROUND: The cellular surface molecule Hs TOSO/FAIM3/ Hs Fcμ R has been identified as an IgM-specific Fc receptor expressed on lymphocytes. Here, we show that its extracellular immunoglobulin-like domain ( Hs Fcμ R-Igl) specifically binds to IgM/antigen immune complexes (ICs) and exploit this property for the development of novel detection systems for IgM antibodies directed against Crimean-Congo hemorrhagic fever virus (CCHFV) and Zika virus (ZIKV). METHODS: His-tagged Hs Fcμ R-Igl was expressed in Escherichia coli and purified by affinity chromatography, oxidative refolding, and size-exclusion chromatography...
February 1, 2019: Clinical Chemistry
https://read.qxmd.com/read/30692117/can-mendelian-randomization-shift-into-reverse-gear
#14
EDITORIAL
Michael V Holmes, George Davey Smith
No abstract text is available yet for this article.
January 28, 2019: Clinical Chemistry
https://read.qxmd.com/read/30692116/estimates-of-within-subject-biological-variation-derived-from-pathology-databases-an-approach-to-allow-assessment-of-the-effects-of-age-sex-time-between-sample-collections-and-analyte-concentration-on-reference-change-values
#15
Graham Ross Dallas Jones
BACKGROUND: Within-subject biological variation data (CVI ) are used to establish quality requirements for assays and allow calculation of the reference change value (RCV) for quantitative clinical laboratory tests. The CVI is generally determined using a large number of samples from a small number of individuals under controlled conditions. The approach presented here is to use a small number of samples (n = 2) that have been collected for routine clinical purposes from a large number of individuals...
January 28, 2019: Clinical Chemistry
https://read.qxmd.com/read/30692115/protein-detection-by-counting-molecules
#16
David C Duffy, David R Walt
No abstract text is available yet for this article.
January 28, 2019: Clinical Chemistry
https://read.qxmd.com/read/30679169/increased-growth-differentiation-factor-15-is-associated-with-unfavorable-clinical-outcomes-of-acute-ischemic-stroke
#17
Jieyun Yin, Zhengbao Zhu, Daoxia Guo, Aili Wang, Nimei Zeng, Xiaowei Zheng, Yanbo Peng, Chongke Zhong, Guangli Wang, Yiting Zhou, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND: Growth differentiation factor 15 (GDF-15), a stress-responsive biomarker, is known to be independently associated with mortality and cardiovascular events in different disease settings, but data on the prognostic value of GDF-15 after stroke are limited. METHODS: Baseline serum GDF-15 was measured in 3066 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The primary outcome was a composite of death and major disability within 3 months...
January 24, 2019: Clinical Chemistry
https://read.qxmd.com/read/30651228/quality-monitoring-of-a-fit-based-colorectal-cancer-screening-program
#18
Esther Toes-Zoutendijk, Johannes M G Bonfrer, Christian Ramakers, Marc Thelen, Manon C W Spaander, Evelien Dekker, Miriam P van der Meulen, Maaike Buskermolen, Anneke J van Vuuren, Ernst J Kuipers, Folkert J van Kemenade, Marie-Louise F van Velthuysen, Maarten G J Thomeer, Harriët van Veldhuizen, Marjolein van Ballegooijen, Harry J de Koning, Monique E van Leerdam, Iris Lansdorp-Vogelaar
BACKGROUND: Quality assessment is crucial for consistent program performance of colorectal cancer (CRC)11 screening programs using fecal immunochemical test for hemoglobin (FIT). However, literature on the consistency of FIT performance in laboratory medicine was lacking. This study examined the consistency of FIT in testing positive or detecting advanced neoplasia (AN) for different specimen collection devices, lot reagents, and laboratories. METHODS: All participants with a FIT sample with a cutoff concentration of 47 μ g Hb/g feces in the Dutch CRC screening program in 2014 and 2015 were included in the analyses...
January 16, 2019: Clinical Chemistry
https://read.qxmd.com/read/30647125/which-methods-for-determining-glomerular-filtration-rate-most-strongly-associate-with-risk-of-progression-of-kidney-disease
#19
EDITORIAL
Anders H Berg, Jennifer Van Eyk
No abstract text is available yet for this article.
January 15, 2019: Clinical Chemistry
https://read.qxmd.com/read/30647124/how-does-the-analytical-quality-of-the-high-sensitivity-cardiac-troponin-t-assay-affect-the-esc-rule-out-algorithm-for-nstemi
#20
LETTER
Kristin Haagensen, Paul Collinson, Arne Åsberg, Kristin M Aakre
No abstract text is available yet for this article.
January 15, 2019: Clinical Chemistry
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