Sheetal S Buddhadev, Kevinkumar C Garala, Saisivam S, Mohamed Rahamathulla, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Ismail Pasha
The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a quality-by-design (QbD)-based paradigm. Utilizing Labrafil M 2125 CS, Kolliphor EL, and Transcutol P, the BD-S-SNEDDS were created. The central composite design was adopted to optimize numerous components. Zeta potential, drug concentration, resistance to dilution, pH, refractive index, viscosity, thermodynamic stability, and cloud point were further investigated in the most efficient formulation, BD14, which had a globule size of 156...
December 2024: Drug Delivery