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Colloids and Surfaces. B, Biointerfaces

Gregory Marslin, Ann Mary Revina, Vinoth Kumar Megraj Khandelwal, Krishnamoorthy Balakumar, Caroline J Sheeba, Gregory Franklin
No abstract text is available yet for this article.
February 12, 2019: Colloids and Surfaces. B, Biointerfaces
Jianhua Zhou, Yannan Li, Hong Li, Hongtao Yao
Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion was successfully synthesized via RAFT-assisted Pickering emulsion process using modified cellulose nanocrystals as particle stabilizers. The cellulose nanocrystals were organically modified by linear triblock copolymer poly(2-(dimethylamino) ethyl methacrylate)-b-poly(glycidyl methacrylate)-b-poly(2,2,3,4,4,4-Hexafluorobutyl acrylate) (PDMAEMA-b-PGMA-b-PHFBA) with reactive trithiocarbonate group. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analyses showed that modified cellulose nanocrystals were armored on the surface of spherical particles...
February 10, 2019: Colloids and Surfaces. B, Biointerfaces
Nurettin Sahiner, Selin S Suner, Ramesh S Ayyala
Porous and degradable hyaluronic acid (HA) microparticles was synthesized in a single step using different ratio of crosslinker, divinylsulfone (DVS) ranging between 2.5 and 100% mole ratio of HA repeating unit. HA particles less than 25% (≤10%) crosslinker ratio were found to be mesoporous and provided the highest surface area, calculated as 21.54±10.31 m2 /g for 2.5% crosslinked HA particles via BET analysis. Hydrolytic degradation of 2.5% crosslinked HA microparticles in PBS (pH 7.4) and at 37.5 ºC revealed a linear weight loss up to 20 days and 94...
February 8, 2019: Colloids and Surfaces. B, Biointerfaces
Bailong Tao, Yiman Deng, Liying Song, Wenwen Ma, Ying Qian, Chuanchuan Lin, Zhang Yuan, Lu Lu, Maowen Chen, Xin Yang, Kaiyong Cai
Bacterial infection and surface biointertness are two main causes for titanium (Ti)-based orthopedic implants failure. To improve the antibacterial ability and enhance poor osteogenic property of Ti substrates, in this work, we employed titania nanotubes (TNTs) as Bone Morphogenetic Protein 2 (BMP2) carrier, and a pH-responsive multilayer film composed of alginate dialdehyde-gentamicin (ADA-Gen) and chitosan (Chi) was constructed onto BMP2-loaded TNTs substrates through layer-by-layer (LBL) assembly technique, resulting in TNT-BMP2-LBLg samples...
February 7, 2019: Colloids and Surfaces. B, Biointerfaces
Zhenhua Li, Yuping Liu, Xuejin Huang, Changming Hu, Hongwei Wang, Lin Yuan, John L Brash, Hong Chen
Gene transfection, as an effective treatment for inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, has evolved as a promising therapeutic strategy for cancer and other intractable diseases. Non-target-specific vectors will affect normal cells as well as pathogenic cells, resulting in a relative decrease in transfection efficiency and unnecessary cytotoxicity. In the present work, gold nanoparticles (AuNPs) functionalized with folate (FA)-modified polyethylenimine (PEI-FA) were prepared by a single step method (without additional reducing agent) for targeted gene transfection in tumor cells...
February 6, 2019: Colloids and Surfaces. B, Biointerfaces
I T Mendes, A L M Ruela, F C Carvalho, J T J Freitas, R Bonfilio, G R Pereira
Donepezil is one of the main compounds used in the therapy of Alzheimer's disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for donepezil delivery is important. The aim of this study was to prepare and to evaluate nanostructured lipid carrier-based gels (NLC gel) able to improve the skin delivery of donepezil free base (DPB). The components of nanostructured lipid carriers (NLCs) were selected after evaluating their enhancing effects using in vitro DPB skin delivery assays...
February 6, 2019: Colloids and Surfaces. B, Biointerfaces
Nélio Drumond, Sven Stegemann
Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired swallowing functions in certain diseases, multimorbidity and advanced age, predictive in vitro methods for the oro-esophageal gliding behavior of SODF would be very useful. The gliding performance of different SODF polymer films was investigated across an artificial mucous layer using a versatile in vitro gliding system...
February 6, 2019: Colloids and Surfaces. B, Biointerfaces
João Victor Brandt, Rodolfo Debone Piazza, Caio Carvalho Dos Santos, Jaime Vega-Chacón, Bruno Estevam Amantéa, Gabriel Cardoso Pinto, Marina Magnani, Henrique Luís Piva, Antonio Claudio Tedesco, Fernando Lucas Primo, Miguel Jafelicci, Rodrigo Fernando Costa Marques
Hydrophobic drugs, such as methotrexate, are not easily delivered into the human body. Therefore, the use of amphiphilic nanoplatforms to the transport of these drugs through the bloodstream is a challenge. While the hydrophobic region interacts with the drug, the hydrophilic outer layer enhances its bioavailability and circulation time. Poly (ethylene glycol)-block-poly(ε-caprolactone) PEG-b-PCL micelles are biodegradable and biocompatible, allowing its use as a nanocarrier for drug delivery systems. The stealth property of PEG that composes the outer layer of nanoplatforms, makes the micelle unperceivable to phagocytic cells, increasing the circulation time in the human body...
February 6, 2019: Colloids and Surfaces. B, Biointerfaces
Hsin-Hung Chen, I-Lin Lu, Te-I Liu, Yuan-Chung Tsai, Wen-Hsuan Chiang, Sung-Chyr Lin, Hsin-Cheng Chiu
To overcome low therapeutic efficacy of chemotherapy against multidrug resistance (MDR) breast cancer, a combination therapy system based upon functionalized polymer nanoparticles comprising poly(γ-glutamic acid)-g-poly(lactic-co-glycolic acid) (γ-PGA-g-PLGA) as the major component was developed. The NPs were loaded with doxorubicin (DOX) and indocyanine green (ICG) for dual modality cancer treatment and coated with cholesterol-PEG (C-PEG) for MDR abrogation in treatment of human MDR breast cancer. The in vitro cellular uptake of the DOX/ICG loaded nanoparticles (DI-NPs) by MDR cancer cells was significantly enhanced owing to effective inhibition of the P-gp activity by C-PEG and γ-PGA receptor-mediated endocytosis...
February 5, 2019: Colloids and Surfaces. B, Biointerfaces
Bin Cai, Luning Yu, Savanna R Sharum, Kai Zhang, Jiajie Diao
Functions of the proteins involved in membrane tethering, a crucial step in membrane trafficking, remain elusive due to the lack of effective tools to investigate protein-lipid interaction. To address this challenge, we introduce a method to study protein-induced membrane tethering via in vitro reconstitution of lipid vesicles, including detailed steps from the preparation of the PEGylated slides to the imaging of single vesicles. Furthermore, we demonstrate the measurement of protein-vesicle interaction in tethered vesicle pairs using two representative proteins, the cytoplasmic domain of synaptotagmin-1 (C2AB) and α-synuclein...
February 5, 2019: Colloids and Surfaces. B, Biointerfaces
Jian Li, Qi Zhu, Yingying Su, Dongdong Wang, Zipeng Xing, Lei Fang
After depositing nano zinc oxide on the surface of red mud granule material by one-step hydrothermal method, a layer of cationic polyelectrolyte diallyldimethylammonium chloride is coated to obtain nano zinc oxide-cation polyelectrolyte diallyl dimethylammonium chloride (PDDA) modified red mud granule material. The modified granule material were characterized and tested. The results showed that the modified granule material has significant antibacterial activity against E. coli. And maintain a good antibacterial effect in multiple rounds of antibacterial cycle experiments...
February 5, 2019: Colloids and Surfaces. B, Biointerfaces
Mingliang Pei, Guoping Li, Kangwei Ma, Jianan Li, Yuanfan Wang, Peng Liu
Theranostic nanoplatforms have been recognized for imaging-guided diagnosis and chemotherapy of cancer by integrating imaging function into the drug delivery systems (DDSs). Here, a facile approach was developed for the fabrication of polymeric prodrug microspheres by introducing pH sensitive "off-on" fluorochrome Rhodamine 6G into bioreducible cleavable bisulfide crosslinked PEGylated poly(glycidyl methacrylate) (PEG-PGMA) microspheres, followed with chemical conjugation of doxorubicin (DOX) via an acid-labile hydrazone linkage...
February 4, 2019: Colloids and Surfaces. B, Biointerfaces
Carlos Caro, David Egea-Benavente, Rocio Polvillo, Jose Luis Royo, Manuel Pernia Leal, María Luisa García-Martín
Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last decade the number of studies published in this field has grown exponentially. However, the clinical translation achieved so far has been very limited. This situation is likely related to the fact that most studies are focused on the in vitro characterization of these new nanomaterials, and very few provide an exhaustive in vivo characterization, where key aspects, such as pharmacokinetics, bioavailability, and, most importantly, toxicity, are properly evaluated...
February 3, 2019: Colloids and Surfaces. B, Biointerfaces
Bing-Qiong Yu, Jian-Cheng Jin, Han-Feng Zou, Bei-Bei Wang, Huan He, Peng Jiang, Feng-Lei Jiang, Yi Liu
Intracellular reactive oxygen species (ROS) generation are associated with many diseases. Lots of studies focus on the detection of intracellular ROS by small fluorescent molecules. However, ROS recognized by biocompatible nanoparticles are relatively less reported. It is widely known that albumin-based nanomaterials possess unique advantages in biomedical applications because they are biodegradable and biocompatible. Herein, fluorescent protein nanoparticles (PNPs) were prepared using BSA as a starting material without introducing extra fluorescent molecules...
February 1, 2019: Colloids and Surfaces. B, Biointerfaces
Rajesh Kumar Saini, Laxami Prasad Bagri, A K Bajpai
In the present study macroporous three dimensional spongy scaffolds composed of gelatin, alginate, and poly (vinyl alcohol) were prepared by cryogelation technique and silver hydroxyapatite was reinforced into the 3 D matrix. The polymer nanocomposite materials were characterized by analytical techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and x-ray diffraction (XRD) analysis. The nanocomposite scaffolds were studied for their porous nature, water sorption capacity, and mechanical behavior...
January 31, 2019: Colloids and Surfaces. B, Biointerfaces
Iris R Ribeiro, Maira F Immich, Dan Lundberg, Fernanda Poletto, Watson Loh
Dispersed systems of bicontinuous cubic phases, called cubosomes, show a drug release rate faster than those obtained using other liquid-crystalline phases. To minimize side effects associated with the accelerated release of incorporated drugs, compounds may be added in the dispersions to produce systems of slow initial release and then fast release only in the desired action region. This paper addresses the addition of 10.0% (w/w) of decyl betainate chloride (DBC), a cleavable surfactant, into phytantriol/Pluronic-based dispersions to generate lamellar-to-cubic-to-hexagonal phase transitions...
January 31, 2019: Colloids and Surfaces. B, Biointerfaces
Gary Bryant, Matthew B Taylor, Tamim A Darwish, Anwen M Krause-Heuer, Ben Kent, Christopher J Garvey
Deuteration of phospholipids is a common practice to elucidate membrane structure, dynamics and function, by providing selective visualisation in neutron scattering, nuclear magnetic resonance and vibrational spectroscopy. It is generally assumed that the properties of the deuterated lipids are identical to those of the protiated lipids, and while a number of papers have compared the properties of different forms, to date this has been no systematic study of the effects over a range of conditions. Here we present a study of the effects of deuteration on the organisation and phase behaviour of four common phospholipids (DSPC, DPPC, DMPC, DOPC), observing the effect of chain deuteration and headgroup deuteration on lipid structure and phase behaviour...
January 31, 2019: Colloids and Surfaces. B, Biointerfaces
Wenjuan Huang, Tinghong Zhang, Pengzhong Shi, Dejun Yang, Shan Luo, Brigitte Voit, Dietmar Appelhans, Xingjie Zan, Hao Chen
Constructing intracellular degradable drug delivery vehicles is critical to fully exert the function of loaded drugs. Considering the poly (amino acid) is sensitively degradable to acid and enzyme which indwell in the mature lysosome, we here presented the poly(amino acid) capsules constructed by the synthetic poly(amino acid), (poly-glutamic acid, PGA and poly-ornithine, POR). The fabrication of Dox loaded poly (amino acid) capsules was demonstrated, and was thoroughly characterized by various techniques, including Zetasizer, SEM, TEM, fluorescent microscopy, and confocal laser scan microscopy...
January 31, 2019: Colloids and Surfaces. B, Biointerfaces
Xiang Di, Yanke Kang, Feifan Li, Rui Yao, Qin Chen, Chen Hang, Yue Xu, Yanming Wang, Pingchuan Sun, Guolin Wu
Conducting hydrogels have attracted attention as a special functional class of smart soft materials and have found applications in various advanced fields. However, acquiring all the characteristics such as conductivity, adequate adhesiveness, self-healing ability, stretchability, biocompatibility, and stimulating deformation responsiveness still remains a challenge. Inspired by the mechanism of bioadhesion in marine mussels, a multifunctional nanocomposite hydrogel with excellent adhesiveness to a broad range of substrates including human skin was developed with the help of synergistic multiple coordination bonds between clay, poly(N-isopropylacrylamide) (PNIPAM), and polydopamine nanoparticles (PDA-NPs)...
January 29, 2019: Colloids and Surfaces. B, Biointerfaces
María Del Pilar Chantada-Vázquez, Antonio Castro López, Susana B Bravo, Sergio Vázquez-Estévez, Benigno Acea-Nebril, Cristina Núñez
Adsorption of biomolecules onto nanoparticles surface in biological samples led to the formation of a bio-corona, it could modified the "identity" of nanoparticles, contributing to the determination of their toxicity and biocompatibility. Gel electrophoresis in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to qualitatively analyze and identify the human serum proteins adsorbed on the surface of three different nanomaterials stabilized with citrate: 10.02 ± 0...
January 29, 2019: Colloids and Surfaces. B, Biointerfaces
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