Florian N Loch, Carsten Kamphues, Freschta Rieger, Katharina Beyer, Wael Rayya, Christian Schineis, Frederick Klauschen, David Horst, Simon Schallenberg, Mihnea P Dragomir
The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective study included specimens from 75 patients who underwent oncological resection of pancreatic head PDAC between February 2013 and July 2020. Two pathologists independently re-measured the distance between tumors and the multiple RMs. The impact of RM involvement for DMI, tumor cells within ≤1 mm, in general, and for individual RMs on overall survival (OS) and development of distant pulmonary (PM) and hepatic (HM) metastasis was analyzed...
February 1, 2024: International Journal of Surgical Pathology