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https://read.qxmd.com/read/24140652/atf3-expression-is-induced-by-low-glucose-in-pancreatic-%C3%A3-%C3%A2-and-%C3%A3-%C3%A2-cells-and-regulates-glucagon-but-not-insulin-gene-transcription
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JOURNAL ARTICLE
Yong-Soo Lee, Masaki Kobayashi, Osamu Kikuchi, Tsutomu Sasaki, Hiromi Yokota-Hashimoto, Vina Yanti Susanti, Yukari Ido Kitamura, Tadahiro Kitamura
The pancreas is critical for maintaining glucose homeostasis. Activating transcription factor 3 (ATF3) is an adaptive response transcription factor. There are major discrepancies in previous reports on pancreatic ATF3; therefore, its role in the pancreas is unclear. To better elucidate the role of ATF3 in the pancreas, we conducted in vitro studies using pancreatic α and β cell lines, and also evaluated the use of ATF3 antibodies for immunohistochemistry. We determined ATF3 expression was increased by low glucose and decreased by high glucose in both αTC-1...
2014: Endocrine Journal
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