journal
https://read.qxmd.com/read/38252517/harnessing-the-synergistic-potential-of-nk1r-antagonists-and-selective-cox-2-inhibitors-for-simultaneous-targeting-of-tnbc-cells-and-cancer-stem-cells
#21
REVIEW
Madhu Tanya Singh, Praveen ThaggikuppeKrishnamurthy, Sai Varshini M
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to endocrine therapy and HER2 targeted treatments. Though certain chemotherapeutics targeting the cell cycle have shown efficacy to a certain extent, the presence of chemotherapy-resistant cancer stem cells (CSCs) presents a significant challenge in tackling TNBC. Multiple lines of evidence suggest the upregulation of neuropeptide Substance P (SP), its NK-1 receptor (NK1R) and the Cyclooxygenase-2 (COX-2) enzyme in TNBC patients...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38252035/therapeutic-and-diagnostic-applications-of-carbon-nanotubes-in-cancer-recent-advances-and-challenges
#22
REVIEW
Muskan Sharma, Parodi Alessandro, Sanith Cheriyamundath, Manu Lopus
Carbon nanotubes (CNTs) are tubular allotropes of carbon, composed of carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure, facilitates their drug carrying capacity. Therefore, CNTs have been intensively explored for several biomedical applications including cancer. By incorporating smart fabrication strategies, CNTs can be designed to specifically target cancer cells. This targeted drug delivery approach not only maximizes the therapeutic benefits of CNTs but also minimizes any potential side effects...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38251986/elements-in-trace-amount-with-a-significant-role-in-human-physiology-a-tumor-pathophysiological-and-diagnostic-aspects
#23
REVIEW
Manish Dwivedi, Divya Jindal, Sandra Jose, Saba Hasan, Pradeep Nayak
Cancer has a devastating impact globally regardless of gender, age, and community, which continues its severity to the population due to the lack of efficient strategy for the cancer diagnosis and treatment. According to the World Health Organization report, one out of six people dies due to this deadly cancer and we need effective strategies to regulate it. In this context, trace element has a very hidden and unexplored role and require more attention from investigators. The variation in concentration of trace elements was observed during comparative studies on a cancer patient and a healthy person making them an effective target for cancer regulation...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38251656/nano-medicine-therapy-reprogramming-metabolic-network-of-tumor-microenvironment-new-opportunity-for-cancer-therapies
#24
REVIEW
Xiaojie Zhang, Min An, Juntao Zhang, Yumeng Zhao, Yanhua Liu
Metabolic heterogeneity is one of the characteristics of tumor cells. In order to adapt to the tumor microenvironment of hypoxia, acidity and nutritional deficiency, tumor cells have undergone extensive metabolic reprogramming. Metabolites involved in tumor cell metabolism are also very different from normal cells, such as a large number of lactate and adenosine. Metabolites play an important role in regulating the whole tumor microenvironment. Taking metabolites as the target, it aims to change the metabolic pattern of tumor cells again, destroy the energy balance it maintains, activate the immune system, and finally kill tumor cells...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38217526/current-targeting-strategies-and-advanced-nanoplatforms-for-atherosclerosis-therapy
#25
REVIEW
Yingchao Li, Qixiang Feng, Luyue Wang, Xi Gao, Yanwei Xi, Lei Ye, Jianbo Ji, Xiaoye Yang, Guangxi Zhai
Atherosclerosis is one of the major causes of death worldwide, and it is closely related to many cardiovascular diseases, such as stroke, myocardial infraction and angina. Although traditional surgical and pharmacological interventions can effectively retard or slow down the progression of atherosclerosis, it is very difficult to prevent or even reverse this disease. In recent years, with the rapid development of nanotechnology, various nanoagents have been designed and applied to different diseases including atherosclerosis...
January 13, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38174845/factors-of-faecal-microbiota-transplantation-applied-to-cancer-management
#26
REVIEW
Yi-Huang Liu, Juan Chen, Xiang Chen, Hong Liu
The homeostasis of the microbiota is essential for human health. In particular, the gut microbiota plays a critical role in the regulation of the immune system. Thus, faecal microbiota transplantation (FMT), a technology that has rapidly developed in the last decade, has specifically been utilised for the treatment of intestinal inflammation and has recently been found to be able to treat tumours in combination with immunotherapy. FMT has become a breakthrough in enhancing the response rate to immunotherapy in cancer patients by altering the composition of the patient's gut microbiota...
January 4, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38164940/development-and-characterization-of-a-novel-neutralizing-scfv-vectored-immunoprophylaxis-against-botulinum-toxin-type-a
#27
JOURNAL ARTICLE
Yongpeng Wei, Guangyao Li, Zhuo Wang, Kewen Qian, Shuyi Zhang, Lingling Zhang, Changhai Lei, Shi Hu
Botulinum toxin is a protein toxin secreted by Clostridium botulinum that is strongly neurotoxic. Due to its characteristics of being super toxic, quick acting, and difficult to prevent, the currently reported antiviral studies focusing on monoclonal antibodies have limited effectiveness. Therefore, for the sake of effectively prevention and treatment of botulism and to maintain country biosecurity as well as the health of the population, in this study, we intend to establish a single chain antibody (scFv) targeting the carboxyl terminal binding functional domain of the botulinum neurotoxin heavy chain (BONT/AHc) of botulinum neurotoxin type A, and explore the value of a new passive immune method in antiviral research which based on adeno-associated virus (AAV) mediated vector immunoprophylaxis (VIP) strategy...
January 2, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38164658/pharmaceutical-cocrystals-a-rising-star-in-drug-delivery-applications
#28
REVIEW
Prabhakar Panzade, Anita Wagh, Pratiksha Harale, Sumeet Bhilwade
Pharmaceutical cocrystals owing to their manifold applications are acting as bridge between drug discovery and pharmaceutical product development. The ability to scale up pharmaceutical cocrystals through continuous manufacturing approaches offer superior and economic pharmaceutical products. Moreover, cocrystals can be aid for the nanoparticulate systems to solve the issues related to scale-up and cost. Cocrystals grabbed attention of academic researchers and pharmaceutical scientist due to their potential to target various diseases like cancer...
January 2, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38252514/overview-of-role-of-survivin-in-cancer-expression-regulation-functions-and-its-potential-as-a-therapeutic-target
#29
REVIEW
Xian-Long Fang, Xue-Ping Cao, Jun Xiao, Yun Hu, Mian Chen, Hafiz Khuram Raza, Huai-Yuan Wang, Xu He, Jin-Fa Gu, Kang-Jian Zhang
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP) family due to its predominant expression in tumours rather than normal terminally differentiated adult tissues. The high expression level of survivin in tumours is closely linked to chemotherapy resistance, heightened tumour recurrence, and increased tumour aggressiveness and serves as a negative prognostic factor for cancer patients. Consequently, survivin has emerged as a promising therapeutic target for cancer treatment...
December 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38009711/clinical-evaluation-of-liposome-based-gel-formulation-containing-glycolic-acid-for-the-treatment-of-photodamaged-skin
#30
JOURNAL ARTICLE
Eskandar Moghimipour, Ali Gorji, Reza Yaghoobi, Anayatollah Salimi, Mahmoud Latifi, Maryam Aghakouchakzadeh, Somayeh Handali
Background: Long contact of UV causes skin damage. Glycolic acid (GA) as an alpha hydroxy acid is used to treat photodamaged skin. However, GA leads to side effects including; burning, erythema and peeling. Purpose: The aim of this study was to develop a controlled delivery systems loading GA in order to increasing its efficacy and lowering its side effects. Methods: Liposomes were evaluated for encapsulation efficiency, size and morphology. Optimized formulation was dispersed in HPMC gel bases and drug release kinetics were also studied...
December 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38155427/the-combined-treatment-of-gold-nanoparticles-associated-with-photobiomodulation-accelerate-the-healing-of-dermonecrotic-lesion
#31
JOURNAL ARTICLE
Daysiane de Oliveira, Gabriel Paulino Luiz, Rahisa Scussel, Mirian Ivens Fagundes, Nathália Coral Galvani, Jessica da Silva Abel, Rubya Pereira Zaccaron, Gustavo de Bem Silveira, Thiago Antônio Moretti de Andrade, Paulo Cesar Lock Silveira, Ricardo Andrez Machado-de-Ávila
Introduction: The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis , is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion...
December 28, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38153328/molecular-mechanism-of-wilms-tumor-1-associated-protein-in-diabetes-related-dry-eye-disease-by-mediating-m6a-methylation-modification-of-lncrna-neat1
#32
JOURNAL ARTICLE
Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao
Dry eye disease (DED) is often secondary to diabetes mellitus (DM). We explored the action of Wilms tumor 1-associated protein (WTAP) in DM-DED via lncRNA NEAT1 m6A methylation. DM-DED mouse models were treated with sh-WTAP/sh-NEAT1 plasmid, followed by assessment of corneal epithelial damage/histopathological changes. HCE-2 cells were exposed to hyperosmotic conditions to establish in vitro DED models and treated with oe-NEAT1/sh-NEAT1/sh-WTAP/nigericin (an NLRP3 inflammasome inducer). Cell viability/apoptosis were evaluated by CCK-8/TUNEL...
December 28, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38133596/colon-targeted-delivery-of-niclosamide-from-solid-dispersion-employing-a-ph-dependent-polymer-via-hotmelt-extrusion-for-the-treatment-of-ulcerative-colitis-in-mice
#33
JOURNAL ARTICLE
Sakshi Arjun, Uttam Kulhari, Amruta Prabhakar Padakanti, Bidya Dhar Sahu, Naveen Chella
Niclosamide (NCL) is repurposed to treat inflammatory bowel disease due to its anti-inflammatory properties and potential to reduce oxidative stress. This therapeutic activity remains challenging if administered directly due to its low solubility and high recrystallization tendency in gastric pH. Solid dispersions using pH-dependent polymer will be a better idea to improve the solubility, dissolution, and targeted delivery at the colon. Hot melt extrusion was used to formulate a solid dispersion with 30% NCL utilizing Hydroxypropyl methylcellulose acetate succinate as a pH-dependent polymer...
December 22, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38133515/a-cisplatin-and-disulfiram-co-loaded-inclusion-complex-overcomes-drug-resistance-by-inhibiting-cancer-cell-stemness-in-non-small-cell-lung-cancer
#34
JOURNAL ARTICLE
Wenhui Ye, Huaiyou Lv, Qinxiu Zhang, Jianxiong Zhao, Xin Zhao, Guozhi Zhao, Chongzheng Yan, Fengqin Sun, Zhongxi Zhao, Xiumei Jia
Non-small cell lung cancer (NSCLC) accounting for about 80-85% of all lung cancer cases is one of the fastest-growing malignancies in terms of incidence and mortality worldwide and is commonly treated with cisplatin (DDP). Although treatment may initially be effective, the DDP therapy often leads to the development of chemoresistance and treatment failure. Disulfiram (DSF), an old alcohol-aversion drug, has been revealed to help reverse drug resistance in several cancers. In addition, several studies have shown a close relationship between drug resistance and cancer cell stemness...
December 22, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38105766/enhanced-neuroprotective-activity-of-ophthalmic-delivered-nerve-growth-factor-conjugated-with-cell-penetrating-peptide-against-optic-nerve-injury
#35
JOURNAL ARTICLE
Danni Zhu, Yao Li, Jinlong Zhang, Yi Chen, Xiaohong Song, Wei Chen, Shipo Wu, Lihua Hou
Nerve growth factor is a well characterized neurotrophic factor that play a critical role in the survival, growth, and differentiation of neurons both in central and peripheral nervous system. However, it is difficult for the conventional exogenous nerve growth factor administration delivery to the central nervous system due to the biological barrier in human bodies. Here, we validated a series of cell penetrating peptides and found that L-PenetraMax significantly enhanced the efficiency of recombinant human nerve growth factor entry into the rat retina...
December 18, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38096045/a-paradigm-use-of-monoclonal-antibodies-conjugated-nanoparticles-in-breast-cancer-treatment-current-status-and-potential-approaches
#36
REVIEW
Anmar Al-Taie, Ece Özcan Bülbül
Monoclonal antibodies (mAbs) are integral to cancer treatment over conventional non-specific therapy methods. This study provides a scoping review of the clinically approved mAbs, focusing on the current application of different nanocarrier technologies as drug delivery targets for mAb-conjugated nanoparticles as potential features for breast cancer treatment. An extensive literature search was conducted between the years 2000 and 2023 using various sources of databases. The first part covered mAb classification, types, and mechanisms of action, pharmacokinetics, and clinical applications in breast cancer...
December 14, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38095181/cancer-stem-cell-biomarkers-and-related-signaling-pathways
#37
REVIEW
Zhe Wang, Rui Li, Guilin Yang, Yijin Wang
Cancer stem cells (CSCs) represent a distinct subset of neoplastic cells characterized by their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of cancer metastasis, recurrence, and resistance to conventional therapeutic interventions. Extensive scientific research has been devoted to the identification of biomarkers and the elucidation of molecular mechanisms in order to improve targeted therapeutic approaches. Accurate identification of cancer stem cells based on biomarkers can provide a theoretical basis for drug combinations of malignant tumors...
December 14, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38088811/ghrelin-inhibits-myocardial-pyroptosis-in-diabetic-cardiomyopathy-by-regulating-ers-and-nlrp3-inflammasome-crosstalk-through-the-pi3k-akt-pathway
#38
JOURNAL ARTICLE
Fan Wang, Jingzhi Wang, Xinfang Liang, Zixuan Wu, Jiaxin Xue, Lingyu Yin, Lai Wei, Xiaohui Zhang
Aims: Endoplasmic reticulum stress(ERS) can induce inflammation mediated by NLRP3 inflammatory bodies and link inflammation with oxidative stress in myocardial tissue. Ghrelin is an endogenous growth hormone-releasing peptide that has been proven to have multiple effects, such as regulating energy metabolism and inhibiting inflammation. However, the role of ghrelin in myocardial injury in diabetic rats and the mechanism have not been reported. Results: We found that ghrelin could improve endoplasmic reticulum stress and inflammatory pyroptosis in the myocardial tissue of diabetic rats and reduce ERS and NLRP3 inflammasome crosstalk in H9 C2 cardiomyocytes...
December 13, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38044844/design-and-preparation-naringenin-loaded-functional-biomimetic-nano-drug-delivery-system-for-alzheimer-s-disease
#39
JOURNAL ARTICLE
Chang Yan, Jinlian Gu, Shun Yin, Hao Wu, Xia Lei, Fang Geng, Ning Zhang, Xiaodan Wu
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as blood-brain barrier (BBB) impedes most drugs to reach brain. To overcome this obstacle, we developed a novel TGN decorated erythrocyte membrane-coated poly (lactic-co-glycolic acid) nanoparticle (TRNNs). The nanoparticle significantly boosted the penetration (7.3 times) in a U-118MG and HCMEC/D3 cell co-culture BBB model in vitro. Living image was performed to assess the TRNNs distribution in vivo...
December 4, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/37772906/the-activation-of-sirt1-by-resveratrol-reduces-breast-cancer-metastasis-to-lung-through-inhibiting-neutrophil-extracellular-traps
#40
JOURNAL ARTICLE
Wenyan Yu, Zhuning Wang, Ping Dai, Jing Sun, Jian Li, Wei Han, Kaichun Li
Neutrophil extracellular traps (NETs) play a crucial role in breast cancer metastasis. However, the therapeutic target of NETs in breast cancer metastasis is still unknown. Using a natural metabolite library and single-cell sequencing data analysis, we identified resveratrol (RES), a polyphenolic natural phytoalexin, and agonist of silent information regulator-1 (SIRT1) that suppressed NETs formation after cathepsin C (CTSC) treatment. In vivo , RES significantly hindered breast cancer metastasis in a murine orthotopic 4T1 breast cancer model...
December 2023: Journal of Drug Targeting
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