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Journal of Drug Targeting

Sifiso S Makhathini, Rahul S Kalhapure, Mahantesh Jadhav, Ayman Y Waddad, Ramesh Gannimani, Calvin A Omolo, Sanjeev Rambharose, Chunderika Mocktar, Thirumala Govender
The development of bacterial resistance against antibiotics is attributed to poor localization of lethal antibiotic dose at the infection site. This study reports on the synthesis and use of novel two chain fatty acid-based lipids (FAL) containing amino acid head groups in the formulation of pH-responsive liposomes for the targeted delivery of vancomycin (VAN). The formulated liposomes were characterized for their size, polydispersity index (PDI), surface charge and morphology. The drug loading capacity, drug release, cell viability, and in vitro and in vivo efficacy of the formulations were investigated...
March 22, 2019: Journal of Drug Targeting
Parvaneh Eskandari, Bahare Bigdeli, Mohammad Porgham Daryasari, Hadi Baharifar, Behroz Bazri, Mostafa Shourian, Amir Amani, Armin Sadighi, Bahram Goliaei, Mehdi Khoobi, Jie Shen, Ali A Saboury
A Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of controlled drug delivery systems. In this study, a MSN-based nanocarriers was fabricated and gold nanoparticle (GNP)-biotin conjugates were successfully grafted onto the pore outlets of the prepared MSN. This bioconjugate served as a capping agent with a peptide-cleavable linker sensitive to matrix metalloproteinases (MMPs), which are overexpressed extracellular proteolytic enzymes in cancerous tissue. The prepared nanocarriers was fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and thermo gravimetric analysis (TGA)...
March 22, 2019: Journal of Drug Targeting
Yingli Wei, Ning Shang, Hai Jin, Yan He, Yuwei Pan, Nina Xiao, Jinglu Wei, Shuyi Xiao, Liping Chen, Jianhua Liu
Ultrasound combined with microbubbles (USMB) has been extensively applied to enhance drug and gene targeting delivery. However, the accumulation and distribution of particle size in the range of 5-30 nm (nano drug) to the tumour and the effects of intratumoral vascular density on permeability have been rarely reported. This study investigated Evans blue (EB) and fluorescein isothiocyanate-labelled dextran (FITC-dextran) distribution in tumour tissue upon USMB with various molecular sizes (3.7 nm and 30...
March 20, 2019: Journal of Drug Targeting
Christine Vauthier
Starting in the late 1970s, the pioneering work of Patrick Couvreur gave birth to the first biodegradable nanoparticles composed of a biodegradable synthetic polymer. These nanoparticles, made of poly(alkylcyanoacrylate) (PACA), were the first synthetic polymer-based nanoparticulate drug carriers undergoing a phase III clinical trial so far. Analyzing the journey from the birth of PACA nanoparticles to their clinical evaluation, this paper highlights their remarkable adaptability to bypass various drug delivery challenges found on the way...
March 19, 2019: Journal of Drug Targeting
Sisi Li, Hongqiang Shen, Qiang Shu
CD79α protein together with the related CD79β protein forms the B-cell antigen receptor (BCR). It remains present when B cells transform into active plasma cells, and is also present in virtually all B cell neoplasms. Monoclonal antibody (mAb) S3 (S3Ab) is a novel anti-CD79α antibody generated by using Raji cells as an immunogen. Herein, we conducted a study on S3Ab using various cellular and immunocytological techniques. The results showed that S3Ab could recognise CD79α in living cells. The molecular weights of the heavy and the light chains of S3Ab were 55 and 26 kDa, respectively...
March 11, 2019: Journal of Drug Targeting
Chuan-Jin Wang, Heng-Zhi Wang, Wei Li
To facilitate targeting drug delivery and combined therapy, we constructed a novel drug carrier, in which oridonin-liposome containing microbubbles (LUMO) are covalently adhered to folic acid-conjugated multiwalled carbon nanotubes loaded with protohemin (FMTP) to form a novel conjugate (FMTP-LUMO). Oridonin (ORI) is used as a chemotherapeutic drug for chemotherapy (CHT), whereas protohemin (Ph) is applied in the field of sonodynamic therapy (SDT) as a sonosensitizer. In vitro release properties, cellular uptake and cytotoxicity in HepG-2 cells as well as in vivo antitumour effects in HepG-2 cell tumour-bearing mice submitted to chemo-sonodynamic therapy, SDT alone and CHT alone were evaluated upon ultrasound exposure...
March 6, 2019: Journal of Drug Targeting
Saghir Akhtar
No abstract text is available yet for this article.
February 28, 2019: Journal of Drug Targeting
Pravin Shende, Sajal Jain
Currently, nanotechnology-based products are gaining tremendous interest in development of nanocarriers for drug delivery and nano-diagnostic devices. Nanodroplets emerge as novel carriers for delivery of gases and actives with wide range of applications in fields of theranostics, drug delivery and diagnostic devices. Nanodroplets are multifunctional carriers composed of an outer shell of drug and polymer that encapsulates inner core of gases and liquid molecules. This review focuses on properties of nanodroplets, mathematical theories, different polymers used in the preparation of nanodroplets, characterization, animal models, toxicity and applications of nanodroplets...
February 27, 2019: Journal of Drug Targeting
Pankaj Bidve, Namrata Prajapati, Kiran Kalia, Rakesh Tekade, Vinod Tiwari
Neuropathic Pain (NeP) is a complex chronic pain condition associated with nerve injury. Approximately, 7-10% of the general population across the globe is suffering from this traumatic condition, but the existing treatment strategies are inadequate to deliver pain relief and are associated with severe adverse effects. To overcome these limitations lot of research is focused on developing new molecules with high potency and fewer side effects, novel cell, and gene-based therapies and modification of the previously approved drugs by different formulation aspects...
February 25, 2019: Journal of Drug Targeting
Marie Rouquette, Karine Ser-Le Roux, Mélanie Polrot, Claudie Bourgaux, Jean-Philippe Michel, Fabienne Testard, Frédéric Gobeaux, Sinda Lepetre-Mouelhi
Squalene-adenosine (SQAd) nanoparticles (NPs) were found to display promising pharmacological activity similar to many other nanomedicines, but their long-term stability was still limited, and their preparation required specific know-how and material. These drawbacks represented important restrictions for their potential use in the clinic. Freeze-drying nanoparticles is commonly presented as a solution to allow colloidal stability, but this process needs to be adapted to each nanoformulation. Hence, we aimed at developing a specific protocol for freeze-drying SQAd NPs while preserving their structural features...
February 21, 2019: Journal of Drug Targeting
Christopher J Lowe, Keana R Mirmajlesi, Emily T DiMartini, Adam J Gormley, David I Shreiber
Targeted drug delivery is a promising approach to enhance the accumulation of therapies in diseased tissues while limiting off-site effects. Ligand-receptor interactions are traditionally identified to deliver therapies, and although specific, this can be costly and often suffers from limited sensitivity. An emerging approach is to target intermediary species that modulate disease progression. Here, we propose novel methods of targeting therapies by using native free radicals as a homing signal. Elevated concentrations of free radicals are a characteristic comorbidity of many different diseases...
February 20, 2019: Journal of Drug Targeting
Baiying Li, Wenyue Gu, Xinhai Zhu
Development of paclitaxel-resistance is a main problem during non-small cell lung cancer (NSCLC) chemotherapy. Nuclear paraspeckle assembly transcript 1 (NEAT1) is an oncogenic long non-coding RNA (lncRNA) which has been proved to be aberrantly upregulated in many human malignancies. In this study, we investigated the mechanism by which NEAT1 contributed to paclitaxel-resistance in NSCLC. NEAT1 was upregulated significantly in paclitaxel-resistant NSCLC cell line, compared with other NSCLC cell lines and normal bronchial epithelial (BE) cell line...
February 20, 2019: Journal of Drug Targeting
Thi Nhu Quynh Phan, Bao Le-Vinh, Nuri Ari Efiana, Andreas Bernkop-Schnürch
OBJECTIVE: The aim of this study was to develop self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins through hydrophobic ion pairing. METHOD: Horseradish peroxidase (HRP), a model protein, was ion paired with sodium docusate to increase its hydrophobicity. The formed enzyme - surfactant complex was incorporated into SEDDS, followed by permeation studies across Caco-2 cell monolayer and freshly excised rat intestine. RESULTS: Hydrophobic ion pairs (HIP) were formed between HRP and sodium docusate with the efficiency of 87...
February 19, 2019: Journal of Drug Targeting
Badar Ul Islam, Nasimudeen R Jabir, Shams Tabrez
Alzheimer's disease (AD) is a complex, progressive, irreversible neurodegenerative disorder. Recent reports suggest that it affects more than 36 million people worldwide and accounts 60-80% of all cases of dementia. It is characterized by aberrations of multiple interactive systems and pathways, which ultimately lead to memory loss and cognitive dysfunction. The exact mechanisms and initial trigging factors that underpin the known pathological defects in AD remain to be fully elucidated. In addition, an effective treatment strategy to reduce the progression of AD is yet to be achieved...
February 18, 2019: Journal of Drug Targeting
Maria B C de Matos, Bárbara S Miranda, Yudha Rizky Nuari, Gert Storm, Gero Leneweit, Raymond M Schiffelers, Robbert J Kok
Asymmetrical lipid nanoparticles are interesting nanocarriers for charged molecules, like nucleic acids. They promise control over inner and outer charge. High charge density on the inside is favorable for efficient condensation and charge neutralization of highly charged biopharmaceuticals, while a neutral or slightly negative outer layer promotes biocompatibility. The main goal of this work was the development and characterization of asymmetric liposomes, prepared using water in oil (w/o) nanoemulsions of phospholipids and squalene in a centrifugal field...
February 12, 2019: Journal of Drug Targeting
Anitha Vadekeetil, Sanjay Chhibber, Kusum Harjai
Pseudomonas aeruginosa biofilm-associated pyelonephritis is a severe infection that can lead to mortality. There are no strategies that can effectively manage this infection since the pathogenesis is controlled by quorum sensing (QS) regulated virulence and recalcitrant biofilms. QS inhibitors (QSIs) are emerging therapeutics against such infections but are associated with cytotoxicity or low bioactivity. Hence, we developed novel quorum sensing inhibitor loaded nanoparticles (QSINPs) using the biopolymers, chitosan (CS) and dextran sulphate (DS) and were intravesically targeted against biofilm-associated murine pyelonephritis...
February 11, 2019: Journal of Drug Targeting
Elias Fattal
No abstract text is available yet for this article.
February 7, 2019: Journal of Drug Targeting
Nzungize Lambert, Md Kaisar Ali, Xiaoyu Wang, Xue Huang, Wenmin Yang, Xiangke Duan, Shuangquan Yan, Chunyan Li, Abualgasim Elgaili Abdalla, Ponmani Jeyakkumar, Jianping Xie
Tuberculosis, especially multidrug resistant cases, remains an enormous public health threat. Mycobacterium tuberculosis metC (Rv3340) an enzyme involved in methionine biosynthesis was identified and characterized for antimicrobial susceptibility. We reported that the overexpression of Rv3340 in Mycobacterium smegmatis (Ms_Rv3340) produces hydrogen sulfide (H2 S) for its energy in harsh conditions. The produced H2 S sustained Ms_Rv3340 against streptomycin whereas the chemical inhibition of H2 S caused streptomycin lethality to Ms_Rv3340...
February 7, 2019: Journal of Drug Targeting
Simona Mura, Elias Fattal, Julien Nicolas
The present review article covers the most important steps of the pioneering work of Patrick Couvreur and tries to shed light on his outstanding career that has been a source of inspiration for many decades. His discovery of the biodegradable poly(alkyl cyanoacrylate) (PACA) nanoparticles has opened large perspectives in nanomedicine. Indeed, nanoparticles made from different types of PACA monomers have been used in different applications such as the treatment of intracellular infections or the treatment of multidrug resistant hepatocarcinoma...
February 5, 2019: Journal of Drug Targeting
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2019: Journal of Drug Targeting
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