Mohan Li, Sijia Gao, Yu Wen, Liang Yong, Liming Tao
PURPOSE: Uveitis is a common, sight-threatening inflammatory ocular disease and is the main cause of blindness, which is caused by autoimmune response, infection, and injury. The contribution of 14-3-3ζ in uveitis remains obscure. This study aims to investigate the role of 14-3-3ζ in regulating ferroptosis in retinal inflammation and its contribution to uveitis. METHODS: A lipopolysaccharide (LPS)-induced uveitis mouse model and BV-2 cell line were used to examine the effect of LPS stimulation on the expression of 14-3-3ζ and ferroptosis in microglia...
April 12, 2024: Ocular Immunology and Inflammation
Vidya S Mooss, Vinaya Kumar Konana, Kalpana Babu Murthy
PURPOSE: To document vascular changes in eyes with post-fever retinitis (PFR) pre and post treatment demonstrated using optical coherence tomography angiography (OCTA). METHODS: This is a retrospective observational case series wherein patients with PFR were retrospectively evaluated for changes in the retinal vasculature during the course of disease using OCTA. RESULTS: At presentation, OCTA revealed flow void areas in superficial and deep capillary plexus (SCP and DCP) corresponding to the areas of retinitis...
April 12, 2024: Ocular Immunology and Inflammation
R Fitoussi, P Gascon, D Denis, T Mathis, N Tieulé, C Schneider-Rouhaud, R Attia, T David, N Stolowy
INTRODUCTION: Uveitis may occur during approximately 1-3% of MS patients, corresponding to 10 times higher than in the general population. The development of uveitis is not currently considered as an inflammatory relapse of MS. There are no clinical guidelines for treating. MS with concomitant uveitis requiring systemic treatment. PURPOSES: To analyze clinical and therapeutic characteristics of uveitis in patients with MS and the impact of MS treatment on the progression of uveitis...
April 11, 2024: Ocular Immunology and Inflammation
Matthew Camacho, Yoseph Sayegh, Sander R Dubovy
PURPOSE: The aim of this study was to describe the clinical presentation, histopathologic characteristics, and management of phacolytic glaucoma. PATIENTS AND METHODS: The database at the Florida Lions Ocular Pathology Laboratory was searched for surgical specimens at the Bascom Palmer Eye Institute. Patients with a diagnosis of "phacolytic glaucoma" on cytopathology between the years of 1997 and 2023 were included ( n  = 15). Patient demographics, anatomic site, laterality, clinical features, and ocular examination findings were obtained from available medical records...
April 9, 2024: Ocular Immunology and Inflammation
Sofia Romero-Santos, Daniela Parra-Tanoux, Carlos Cifuentes-González, Juliana Muñoz-Ortiz, Germán Mejía-Salgado, Alejandra de-la-Torre
PURPOSE: To present an atypical case of severe bilateral ocular toxoplasmosis with systemic involvement that initially mimicked an autoimmune etiology, posing challenges to its diagnosis and treatment. CASE REPORT: A 39-year-old immunocompetent male was admitted to the hospital due to a presumed pulmonary thromboembolism concomitant with an abrupt onset of vision loss. Initial differential diagnoses included antiphospholipid syndrome and systemic lupus erythematosus, prompting the administration of corticosteroid pulses and rituximab...
April 9, 2024: Ocular Immunology and Inflammation
Berru Yargi-Ozkocak, Cigdem Altan, Burcu Kemer-Atik, Berna Basarir, Muhittin Taskapili
PURPOSE: To investigate the association of clinical findings and indocyanine green angiography (ICGA) score with inflammatory markers derived from complete blood count (CBC) parameters in patients with Vogt-Koyanagi-Harada (VKH) to determine the diagnostic and predictive role. METHODS: Demographic characteristics, presenting complaints, ocular findings, optical coherence tomography findings, ICGA scores and best corrected visual acuity were recorded in treatment-naive VKH patients at presentation...
April 9, 2024: Ocular Immunology and Inflammation
Lusine Kambulyan, Armine Chopikyan, Sevan Iritsyan, Armen Mkhitaryan, Anna Hovakimyan
PURPOSE: To study the role of the complement system's C3 and C4 fractions in the pathogenesis of different types of uveitis. METHODS: A prospective case-control study. 118 patients were enrolled. The control group comprised 60 patients who were otherwise healthy people undergoing cataract or pterygium surgery, whereas the uveitis patients group consisted of 58 people. The levels of C3 and C4 fractions in the blood and in the aqueous humor for both groups were evaluated and compared...
April 8, 2024: Ocular Immunology and Inflammation
Pierre-Maurice Herr, Victor Brantl, Siegfried Georg Priglinger, Paul Foerster, Stephan Thurau
We report two patients who displayed evidence of localized ocular inflammation after CAR T-cell infusion. To manage the resulting severe visual impairment, systemic corticosteroids were administered to both patients. This treatment led to a reduction in local inflammation and restored vision in one of the patients.
April 5, 2024: Ocular Immunology and Inflammation
Laura Zarate-Pinzón, Gabriela Flórez-Esparza, Camilo Andrés Rodríguez-Rodríguez, Luis A Diez-Bahamón, Germán Mejía-Salgado, Carlos Cifuentes-González, Alejandra de-la-Torre
PURPOSE: To report two cases of non-granulomatous unilateral anterior uveitis in two female patients associated with autoimmune liver diseases (ALD), emphasizing the possibility of this rare coexistence as a polyautoimmunity phenomenon. CASE DESCRIPTIONS: Case 1: An 18-year-old female with a history of congenital renal hypoplasia and metabolic syndrome presented with anterior uveitis in OS and a history of jaundice, blood elevated hepatic enzymes, and cholangioresonance compatible with primary sclerosing cholangitis (PSC)...
April 2, 2024: Ocular Immunology and Inflammation
Sevde Akcay Usta, Mehmet Icoz
AIM: To assess the relationship between systemic inflammation markers and ocular surface parameters in hazelnut harvesters. MATERIAL AND METHOD: This prospective study included 30 patients presenting with moderate ocular surface diseases during the hazelnut harvesting season. A detailed ophthalmological examination was performed during the harvesting season and the first month after the end of treatment (control). Schirmer test, tear break-up time (TBUT), and ocular surface disease index (OSDI) scores were determined...
April 1, 2024: Ocular Immunology and Inflammation
Nazima Ali, Joanne Sims, Rachael Niederer
PURPOSE: To examine the real-world management and outcomes of uveitic cystoid macular oedema (CME). DESIGN: Retrospective study. METHODS: Patients with uveitic CME were identified from the Inflammatory Eye Disease database. 248 eyes of 218 patients with uveitic CME were identified. Main Outcome Measures : Time to resolution, time to recurrence and vision loss. RESULTS: Median age at time of CME was 51.7 years [IQR 37...
March 28, 2024: Ocular Immunology and Inflammation
William Gil, Hassan Lagrib, Louis Olagne, Céline Tilignac, Maud Perie, Frédéric Taithe, Xavier Moisset, Frederic Chiambaretta, Pierre Clavelou, Marc Andre, Ludovic Trefond
PURPOSE: To report a case of uveitis associated with multiple sclerosis (MS) that was refractory to multiple lines of therapy but achieved remission with tocilizumab. METHODS: We conducted a retrospective analysis of the patient's medical record including clinical, biological and imaging data. RESULTS: A 33-year-old female patient with a history of MS inactive for 5 years on teriflunomide, and no significant medical or ophthalmological history, presented with bilateral granulomatous panuveitis...
March 28, 2024: Ocular Immunology and Inflammation
Saban Gonul, Serhat Eker
PURPOSE: Atypical hemolytic uremic syndrome (aHUS) is a rare progressive thrombotic microangiopathy caused by overactivation in the alternative complement pathway. A wide spectrum of environmental triggers, such as viruses, vaccination, drugs, pregnancy, neoplasms, transplant, and autoimmune diseases can cause aHUS in genetically susceptible individuals. In this report, the diagnosis and treatment process of aHUS and bilateral retinal venous occlusion (RVO) will be presented. METHODS: Single-case, retrospective management of ophthalmological and systemic manifestations...
March 27, 2024: Ocular Immunology and Inflammation
Nagwa Hussein Abdelmageed, Anas Adi, Samy Abo El-Khair, Maha Shahin, Doaa Mosad Mosa, Dalia Sabry, Amgad El Nokrashy
PURPOSE: Pediatric uveitis poses unique challenges, characterized by difficulties in performing comprehensive examinations, potential delays in diagnosis, and a heightened risk of ocular complications. This study evaluate the etiologic and clinical characteristics of uveitis in children presenting to the Mansoura Ophthalmic Center, Mansoura, Egypt. METHODS: A cross-sectional observational study was undertaken involving children diagnosed with uveitis attending the uveitis outpatient clinic at Mansoura University Ophthalmic Center...
March 25, 2024: Ocular Immunology and Inflammation
Anna-Karina B Maier, Daniel Mandrossa, Emanuel Reitemeyer, Sibylle Winterhalter, Anne Rübsam, Uwe Pleyer
PURPOSE: To investigate differences in the retinal vessel area density (VAD) on optical coherence tomography angiography (OCTA) between eyes with unilateral herpetic viral anterior uveitis (VAU) (herpes-simplex virus (HSV) and varicella-zoster virus (VZV)) and the non-affected fellow eye. METHODS: In this monocentric, observational, prospective case series we analyzed the VAD of the macula, optic disc, and peripapillary region in affected and non-affected eyes of 22 patients with HSV-positive and 22 patients with VZV-positive VAU using OCTA...
March 22, 2024: Ocular Immunology and Inflammation
Ipsita Muni, Smruti Rekha Priyadarshini, Srikant Kumar Sahu, Sujata Das
PURPOSE: To elucidate a distinctive clinical feature in cases of microsporidial stromal keratitis (MSK). METHOD: A retrospective observational study of cases with a histopathological and/or microbiological diagnosis of MSK on corneal biopsy or host corneal button between 2016 and 2022 was conducted. RESULTS: Eighteen cases with a confirmed histopathological and/or microbiological diagnosis of MSK were detected. Careful review of slit-lamp photographs revealed the presence of pigmented keratic precipitates (KPs) beyond the area of stromal keratitis in five out of eighteen cases (27...
March 21, 2024: Ocular Immunology and Inflammation
Ali Ceylan, Irem Onal, Fahri Onur Aydin, Burak Mergen, Yusuf Yildirim
PURPOSE: The objective of this study was to illustrate the changes in ocular findings, meibography, and tear break-up time (TBUT) values in pediatric patients with ocular rosacea following a standardized treatment. METHODS: The study included consecutive patients diagnosed with ocular rosacea, referred to a tertiary hospital between 2021 and 2023. Each patient underwent biomicroscopic examinations, non-invasive TBUT assessments, corneal fluorescein staining (evaluated using the Oxford scoring system), and meibography...
March 21, 2024: Ocular Immunology and Inflammation
Jonathan E Lu, Connor Ross, Alexander Ivanov, Nathan Hall, Alice Lorch, Joan Miller, Michael K Yoon
PURPOSE: The current study queries the American Academy of Ophthalmology (AAO) Intelligent Research in Sight (IRIS) registry for data on the epidemiology, work-up, and management patterns of autoimmune orbital inflammation. METHODS: Analysis and description of patient data from the IRIS registry between 2013 and 2019 reviewing patients with autoimmune or idiopathic orbital inflammation with filters based on International Classification of Disease (ICD) and Current Procedural Terminology (CPT) codes...
March 15, 2024: Ocular Immunology and Inflammation
Dayron F Martínez-Pulgarin, Juan D Arias, Carlos M Córdoba-Ortega, Carlos M Rangel, Clara L Varón, Eduardo Villareal, Donaldo Villareal
PURPOSE: We aimed to compare the visual outcomes after pars plana vitrectomy (PPV) versus tap and inject (T&I) in fungal endophthalmitis (FE) reported in the literature and to compare the findings from the literature with data from a reference centre. METHODS: We performed a systematic review and meta-analysis of studies reporting the use of PPV versus T&I in FE. We also performed a retrospective review of the clinical records of patients with endophthalmitis from a reference centre in Colombia...
March 15, 2024: Ocular Immunology and Inflammation
Raz Gepstein, Tamar Laytman Klein, Liron Naftali Ben Haim, Avner Belkin
PURPOSE: To assess the risk of gonioscopy-assisted transluminal trabeculotomy (GATT) inducing an uveitic flare-up in patients with uveitic glaucoma (UG). METHODS: This retrospective study included consecutive UG patients who underwent GATT at a single medical center between June 2020 and September 2022. The main outcome measure was the occurrence of a surgery-related uveitic complication defined as either an uveitic flare-up defined by the Standardization of Uveitis Nomenclature (SUN) criteria, or the appearance of cystoid macular edema (CME) from 2 weeks to 3 months after surgery...
March 12, 2024: Ocular Immunology and Inflammation
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