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Ocular Immunology and Inflammation

Elvan Kucukkomurcu, Ali Ugur Unal, Fehim Esen, Gulsen Ozen, Haner Direskeneli, Haluk Kazokoglu
PURPOSE: To describe posterior segment findings of antiphospholipid syndrome (APS) and compare them with systemic lupus erythematosus (SLE). METHODS: A total of 11 patients with primary APS, 29 secondary APS patients, and 29 SLE patients without APS were included. All patients were referred from rheumatology clinic for detailed ophthalmologic examination. When patients had suspicious lesions, fundus fluorescein angiography was performed (n = 56). RESULTS: The most common retinal examination finding was peripheral venous tortuosity (17...
December 17, 2018: Ocular Immunology and Inflammation
Jay M Stewart
The dexamethasone intravitreal implant poses a risk to the cornea if it migrates into the anterior chamber. Because it tends to fracture if grasped with surgical instruments, no-touch techniques represent the most successful means of removing the device from the eye. The present report describes a new approach in which the implant is aspirated into the lumen of a needle, providing the surgeon with greater control in accessing the device within the anterior chamber.
December 17, 2018: Ocular Immunology and Inflammation
Sukru Cekic, Ozgur Yalcinbayir, Sara Sebnem Kilic
PURPOSE: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS). MATERIALS AND METHODS: Nine patients with MWS were included in this study. Each study participant underwent a systemic evaluation, comprehensive ophthalmic examination, and auxillary testings. RESULTS: In this study, conjunctivitis was the most prominent ocular finding...
December 17, 2018: Ocular Immunology and Inflammation
Mehmed Uğur Işık, Nilüfer Yalcındag
PURPOSE: This study aims to compare the spectral domain optical coherence tomography (SD OCT) findings and laser flare photometry (LFP) measurements in Behçet's disease (BD). METHODS: This study was composed of 4 groups as follows: "Group 1: Healthy volunteers, Group 2: Volunteers with BD and no eye involvement, Group 3: Patients with active uveitis with BD, Group 4: Patients with BD in quiescent phase of uveitis". Laser Flare Photometry (Kowa FM-600, Kowa Acculas, San Jose, CA, USA), SD-OCT and Enhanced Depth Imaging protocol (EDI) (Spectralis®, Heidelberg Engineering Inc...
December 17, 2018: Ocular Immunology and Inflammation
Reema Bansal, Nitin Kumar Menia, Amod Gupta
PURPOSE: To report two unique cases of spontaneous uveal effusion syndrome (UES) from the same family. METHODS: The patients included father (54 years old) and a daughter (23 years old). The father presented 7 years ago with bilateral exudative retinal detachment, nanophthalmic eyes (axial length 16.11 mm and 16.43 mm in right and left eyes, respectively) with hypermetropia, and a thickened sclera on MRI. The daughter presented with left eye peripheral exudative annular retinal detachment with bilateral nanophthalmos (axial length 20...
December 17, 2018: Ocular Immunology and Inflammation
Ji Hwan Lee, Sung Chul Lee, Seo Jin Park, Christopher Seungkyu Lee
PURPOSE: To describe the clinical features and outcomes of punctate inner choroidopathy (PIC) in Korean patients Methods: We retrospectively reviewed the medical records of patients with PIC between 2004 and 2015. The main outcome measures included best-corrected visual acuity (BCVA), presence of choroidal neovascularization (CNV), and optical coherence tomography findings. Patients with and without CNV were compared. RESULTS: Forty eyes of 26 patients were included...
December 14, 2018: Ocular Immunology and Inflammation
Thomas Maldiney, Clémence Deschasse, Philip Bielefeld
PURPOSE: To discuss the use of tocilizumab in mild to severe Graves' ophthalmopathy as corticosteroid-adjunctive therapy. METHODS: Retrospective case reports. RESULTS: Three patients with corticosteroid-resistant or advanced diplopia-associated Graves' ophthalmopathy were subsequently treated with monthly intravenous tocilizumab at a dose of 8 mg/kg. None reported a past or present history of dysthyroidism. The adjunction of interleukin-6-receptor monoclonal antibody treatment was associated with a significant improvement in ocular symptoms, notably diplopia and proptosis, and functional prognosis in all patients, with one relapse approximately two months after the end of the treatment...
November 20, 2018: Ocular Immunology and Inflammation
Ji Won Kim, JaeSang Ko, JinJoo Kim, Jin Sook Yoon
PURPOSE: Early detection and control of inflammation are important to manage Graves' orbitopathy (GO). We investigated the effects of calprotectin (S100A8/A9) on orbital fibroblast inflammation and GO pathogenesis. METHODS: We measured serum calprotectin, S100A8 and S100A9 mRNA expression in orbital fat/connective tissue from GO patients and healthy controls, and proinflammatory cytokines in primary cultured orbital fibroblasts. RESULTS: The serum levels of S100A8/A9 and the expression of S100A8/A9 mRNA in orbital tissue were higher in the GO patients than in the healthy controls...
November 19, 2018: Ocular Immunology and Inflammation
L M Hassman, M M Chung, M Gonzalez, A P Bessette
PURPOSE: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2). METHODS: Case report. RESULTS: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Her disease progressed despite antibiotic and steroid treatment, and HSV-2 was ultimately identified in the vitreous...
November 16, 2018: Ocular Immunology and Inflammation
Zoltan Griger, Katalin Danko, Levente Bodoki, Zsuzsa Aszalos, Gabor Nemeth, Hassan Ziad, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke
PURPOSE: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls. METHODS: A total of 43 PM and 32 DM patients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Objective clinical tests of dry eye disease (DED) were also performed. RESULTS: All pachymetric measurements and corneal volumes (CVs) proved to be significantly lower both in PM and DM patients...
November 16, 2018: Ocular Immunology and Inflammation
Andrew R Osborn, Sejoon Jun, Douglas C Miller, Bokkwan Jun
PURPOSE: To describe a case of p-ANCA associated vasculitis in a patient with bilateral vision loss with no systemic symptoms or signsMethods: A descriptive review of a caseResults: We report a case of bilateral sequential vision loss in a 73-year-old woman who had no constitutional symptoms except headache and was found to have positive p-ANCA and lymphocytic infiltration on bilateral temporal artery biopsy. Despite the early administration of systemic corticosteroids, the visual outcome was unfavorable...
November 14, 2018: Ocular Immunology and Inflammation
F Groen-Hakan, A A Van Der Eijk, A Rothova
PURPOSE: To determine characteristics of patients with laboratory findings indicative of intraocular Epstein-Barr-virus (EBV) infection and to establish the usefulness of the laboratory analysis in patients with uveitis. METHODS: Retrospective study of patients who underwent diagnostic aqueous fluid analysis. Diverse demographic data of patients were registered. RESULTS: EBV-PCR tested positive in 3/201 (1%) and EBV-GWC in 22/245 (9%). The prevalence of immunosuppression was similar in EBV positive (by PCR/GWC) and EBV negative patients (7/25; 28% vs...
November 13, 2018: Ocular Immunology and Inflammation
Anna-Maria Haas, Martin Stattin, Daniel Ahmed, Ilse Krebs, Siamak Ansari-Shahrezaei
PURPOSE: To elaborate a case of focal choroidal excavation (FCE) in punctate inner choroidopathy (PIC) complicated by secondary choroidal neovascularization (CNV) based on multimodal imaging findings. METHODS: In this retrospective case report, multimodal imaging including near-infrared reflectance, blue peak autofluorescence, spectral domain-optical coherence tomography (OCT), fluorescein and indocyanine green angiography (Heidelberg Engineering GmbH, Germany), and swept source-OCT angiography (SS-OCTA; Topcon Corporation, Japan) was performed...
November 13, 2018: Ocular Immunology and Inflammation
Enver Mirza, Refik Oltulu, Zeynep Katipoğlu, Günsu Deniz Mirza, Ahmet Özkağnıcı
PURPOSE: To evaluate the association between monocyte count/high-density lipoprotein (HDL) ratio (MHR) and lymphocyte count/monocyte count ratio (LMR) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG). MATERIALS AND METHODS: A total of 63 participants included in the study. Participants were divided into three groups. Twenty-one patients with PEXS regarded as group 1, 21 patients with PEXG regarded as group 2 and 21 participants without PEXS or PEXG regarded as the control group...
November 13, 2018: Ocular Immunology and Inflammation
Eiman Abd El Latif, Mouamen M Seleet, Hazem El Hennawi, Mohamed Abdulbadiea Rashed, Hossameldeen Elbarbary, Karim Sabry, Mohamed Abdelmonagy Ibrahim
PURPOSE: To report the clinical experience with scleritis at four Egyptian tertiary care eye centers. METHODS: Multicenter retrospective chart review of all patients with scleritis visiting four ocular inflammation referral clinics in Egypt between January 2013 and October 2017. RESULTS: A total of 303 scleritis patients were enrolled. These included 76 male and 227 female patients. The most frequent subtype of scleritis was nodular anterior scleritis (44...
November 9, 2018: Ocular Immunology and Inflammation
Simar Rajan Singh, Mohit Dogra, Savleen Kaur, Priya Bajgai, Basavaraj Tigari, Sabia Handa, Deeksha Katoch, Vishali Gupta, Mangat R Dogra, Aman Sharma, Ramandeep Singh
PURPOSE: To characterize the presenting features of cytomegalovirus (CMV) retinitis in HIV-positive patients in a developing country in the HAART era. METHODS: Retrospective chart review of all patients with CMV retinitis seen at a tertiary-care referral center between January 2006 to June 2017. Demographic and clinical data were collected to study the presenting features and risk factors for blindness. RESULTS: Fifty-five patients with treatment-naïve CMV retinitis were enrolled; 75% were males...
November 5, 2018: Ocular Immunology and Inflammation
Julien Rohmer, Jérôme Hadjadj, Amina Bouzerara, Sawsen Salah, Romain Paule, Matthieu Groh, Philippe Blanche, Luc Mouthon, Dominique Monnet, Claire Le Jeunne, Jean Guibourdenche, Antoine Brézin, Benjamin Terrier
PURPOSE: The diagnostic workup of uveitis is challenging, with 30 to 50% of cases remaining of undetermined etiology despite multiple investigations. Sarcoid granuloma-related increase of 1,25(OH)2 D levels could be helpful for the diagnosis of ocular sarcoidosis. METHODS: Monocentric retrospective cohort study of patients for whom serum 25(OH)D and 1,25(OH)2 D levels were measured during the etiologic workup of unexplained uveitis in a tertiary referral center...
November 5, 2018: Ocular Immunology and Inflammation
Tomoko Ohno, Akira Meguro, Masaki Takeuchi, Takahiro Yamane, Takeshi Teshigawara, Nobuyoshi Kitaichi, Yukihiro Horie, Kenichi Namba, Shigeaki Ohno, Kumiko Nakao, Taiji Sakamoto, Tsutomu Sakai, Tadashi Nakano, Hiroshi Keino, Annabelle A Okada, Atsunobu Takeda, Takako Fukuhara, Hisashi Mashimo, Nobuyuki Ohguro, Shinichirou Oono, Hiroshi Enaida, Satoshi Okinami, Nobuhisa Mizuki
PURPOSE: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. METHODS: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. RESULTS: We observed an increased frequency of the A allele of rs28690417 in patients compared with controls (P = 0...
November 5, 2018: Ocular Immunology and Inflammation
Victor Llorenç, Gibet Benejam, Marina Mesquida, Maite Sainz de la Maza, Blanca Molins, Carmen Alba, Laura Pelegrin, Jose Antonio Martínez, Alfredo Adán
PURPOSE: To study the risk factors for visual loss in presumed tuberculosis-related uveitis (TRU). METHODS: Retrospective observational cohort study of patients with TRU, either treated or not for tuberculosis, from January 2005 to January 2017. Clinical and demographic variables were recorded. Main outcome measure was a loss of visual acuity (VA) of ≥2 Snellen lines. A Generalized Estimation Equation was used to control between-eyes bias. A backward stepwise logistic regression multivariate analysis was conducted to elucidate independent risk factors...
November 5, 2018: Ocular Immunology and Inflammation
Yu-Qin Wang, Xiao-Dan Dai, Yun Ran, Ying Cao, Chun-Lin Lan, Ji-Tian Guan, Chang Liu, Feng-Mei Yang, Yi-Jing Gan, Bai-Jing Liu, Ai-Wu Fang, Dan Lin, Xian-Hui Gong, Ren-Zhe Cui, Zi-Bing Jin, Jia Qu, Fan Lu, Zai-Long Chi
PURPOSE: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. METHODS: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. RESULTS: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0...
November 5, 2018: Ocular Immunology and Inflammation
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