journal
https://read.qxmd.com/read/37722842/evaluating-the-diagnostic-accuracy-and-management-recommendations-of-chatgpt-in-uveitis
#1
JOURNAL ARTICLE
William Rojas-Carabali, Carlos Cifuentes-González, Xin Wei, Ikhwanuliman Putera, Alok Sen, Zheng Xian Thng, Rajdeep Agrawal, Tobias Elze, Lucia Sobrin, John H Kempen, Bernett Lee, Jyotirmay Biswas, Quan Dong Nguyen, Vishali Gupta, Alejandra de-la-Torre, Rupesh Agrawal
INTRODUCTION: Accurate diagnosis and timely management are vital for favorable uveitis outcomes. Artificial Intelligence (AI) holds promise in medical decision-making, particularly in ophthalmology. Yet, the diagnostic precision and management advice from AI-based uveitis chatbots lack assessment. METHODS: We appraised diagnostic accuracy and management suggestions of an AI-based chatbot, ChatGPT, versus five uveitis-trained ophthalmologists, using 25 standard cases aligned with new Uveitis Nomenclature guidelines...
September 18, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37722841/in-vivo-visualization-of-macrophage-like-cells-in-patients-with-uveitis-by-use-of-en-face-swept-source-optical-coherence-tomography
#2
JOURNAL ARTICLE
Francesco Pichi, Piergiorgio Neri, Shaikha Aljeneibi, Steven Hay, Hannah Chaudhry, Maria Carmela Saturno, Ester Carreno
AIMS: To detect macrophage-like cells (MLCs) in uveitis patients and describe their characteristics compared to healthy subjects by using en face SS-OCTA. METHODS: Fifteen consecutive patients with "active" uveitis and 11 healthy participants underwent 6 macular scans of 6×6mm using SS-OCTA. The 3μm en face OCT slabs on inner limiting membrane were used to visualize the MLCs. RESULTS: In healthy subjects there was an average of 478...
September 18, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37722824/correction
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 18, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37722802/quantitative-ocular-surface-changes-in-patients-undergoing-immune-checkpoint-inhibitor-therapy
#4
JOURNAL ARTICLE
Kevin Chen, Maria Carolina Ibañez Bruron, Sebastian Mondaca, Gonzalo Pizarro, Paulina Liberman, Meghan K Berkenstock
PURPOSE: To describe the clinical course and evaluate treatment of ocular surface changes in patients receiving immune checkpoint inhibitor (ICI) therapy. METHODS: Multiple markers of ocular surface dryness were evaluated in 16 patients on ICI therapy. The Wilcoxon rank-sum test was used to determine the significant change in the initial and final ocular surface indices. RESULTS: Fifty percent of the eyes demonstrated worsening Schirmer I scores; 29% showed an increase in lissamine green staining...
September 18, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37713536/epidemiology-and-clinical-course-of-pediatric-uveitis-in-a-tertiary-referral-center-in-northeastern-iran
#5
JOURNAL ARTICLE
Sahel Khazaei, Elham Bakhtiari, Mohammad Reza Ansari Astaneh, Seyedeh Maryam Hosseini
PURPOSE: To describe the distribution, clinical findings, treatment, complications, and visual outcomes of pediatric uveitis at a tertiary referral ophthalmic center. METHODS: The medical records of all patients ≤18 years diagnosed with and managed as uveitis from August 2016 to August 2021 were reviewed retrospectively. RESULTS: Of the 97 patients, 52.6% were female, and the mean age at the onset was 10.5 ± 4...
September 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37713271/psychosocial-well-being-and-quality-of-life-in-uveitis-a-review
#6
JOURNAL ARTICLE
Zheting Zhang, Konstadina Griva, William Rojas-Carabali, Gazal Patnaik, Renee Liu, Lucia Sobrin, John H Kempen, Robert P Finger, Vishali Gupta, Bryan Ang, Rupesh Agrawal
PURPOSE: As a potentially sight-threatening disease with ocular, systemic, and treatment-related complications, uveitis diminishes quality of life (QOL) and affects psychosocial well-being. This review summarizes the existing tools for evaluating psychosocial well-being and/or QOL in patients with uveitis, explores the biological and non-biological factors affecting psychosocial well-being and/or QOL, and proposes future directions for incorporating these tools into clinical practice...
September 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37712945/acute-and-chronic-manifestations-of-sympathetic-ophthalmia-on-multimodal-imaging
#7
JOURNAL ARTICLE
Alessandro Marchese, Federica Filipello, Maria Vittoria Cicinelli, Francesca Sanvito, Federica Pedica, Francesco Bandello, Giulio Modorati, Elisabetta Miserocchi
PURPOSE: To report the clinical and multimodal imaging features of sympathetic ophthalmia in the acute and chronic phases. METHODS: Retrospective cohort study of consecutive patients with sympathetic ophthalmia seen at a tertiary referral center. Charts, imaging studies, and histopathological specimens were reviewed. The clinical features and multimodal imaging in the sympathizing eye were analyzed by sorting features into those seen in the acute and chronic phase...
September 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37703505/steroid-dependency-in-posner-schlossman-syndrome-a-suggested-topical-2-ganciclovir-and-gradual-decrement-of-topical-steroid-combination-therapy-from-shanghai-pss-study
#8
JOURNAL ARTICLE
Yue Ying, Yanan Sun, Qilian Sheng, Ruyi Zhai, Xintong Fan, Xiangmei Kong
PURPOSE: This study focused on the prevalence, unique features, and required treatment of steroid-dependent Posner-Schlossman syndrome (SD-PSS), and analyzed the outcome of 2% Ganciclovir and gradual decrement steroid combination therapy in SD-PSS patients. METHODS: Retrospective comparative and interventional study. SD-PSS was defined as PSS patients with continuous steroid use for over 3 months and relapsed within 2 weeks after steroid withdrawal or tapered dosage...
September 13, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37703496/bilateral-panuveitis-in-an-adolescent-with-autoimmune-lymphoproliferative-syndrome-due-to-ctla4-haploinsufficiency
#9
JOURNAL ARTICLE
Richmond Woodward, Andrew Gross, Grant A Justin, Glenn J Jaffe, Dilraj S Grewal
PURPOSE: To describe a case of bilateral panuveitis in an 11-year-old girl with autoimmune lymphoproliferative syndrome (ALPS) due to CTLA4 haploinsufficiency. CASE DESCRIPTION: A 5-year-old girl developed cervical adenopathy, and autoimmune hemolytic anemia and thrombocytopenia consistent with Evan's Syndrome. She was subsequently diagnosed with autosomal dominant CTLA4 haploinsuffciency and treated with immunosuppressants. Ocular symptoms developed 6 years later when she complained of blurry vision and photophobia...
September 13, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37699175/seasonal-hyperacute-panuveitis-shapu-outbreak-amidst-covid-19-pandemic
#10
JOURNAL ARTICLE
Haramaya Gurung, Ranju Kharel Sitaula, Pratap Karki, Gyanendra Lamichhane, Sweta Singh, Eliya Shrestha, Anadi Khatri, Amrit Banstola, Pursottam Joshi, Hira Nath Dahal, Ananda K Sharma, Sagun Narayan Joshi, Madan Prasad Upadhaya
PURPOSE: To document the demographic profile of the SHAPU outbreak amidst the COVID-19 pandemic. METHODS: A multicentric cross-sectional study of the 2021 SHAPU outbreak during the second phase of the COVID-19 outbreak. RESULTS: A total of 135 patients were diagnosed with SHAPU from August to December 2021, 77 (57%) were children <16 years, males 54.8% and 34.8% had direct physical contact with white moths and 41.5% had severe type of SHAPU...
September 12, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37699166/diagnosis-and-characteristics-of-presentation-of-tubulointerstitial-nephritis-and-uveitis-syndrome-during-the-covid-2019-pandemic
#11
JOURNAL ARTICLE
Lingling Huang, David Ta Kim, Christopher R Rosenberg, Phoebe Lin, Eric Suhler
PURPOSE: To compare the diagnosis and clinical features of tubulointerstitial nephritis and uveitis syndrome (TINU) before and during the COVID-19 pandemic. METHODS: Retrospective chart review. RESULTS: Before the COVID-19 pandemic (March 2017 to March 2019), 1/561 (0.18%) new patient was diagnosed with TINU. During the pandemic (March 2020 to March 2022), 15/581 (2.58%) new patients were diagnosed with TINU. We found a significant increase in TINU cases during the pandemic (P=0...
September 12, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37656834/long-term-results-of-0-19mg-fluocinolone-acetonide-insert-for-treatment-of-non-infectious-uveitis-in-clinical-practice
#12
JOURNAL ARTICLE
Lara Buhl, Valerie Schmelter, Benedikt Schworm, Stephan Thurau, Christoph Kern
PURPOSE: To evaluate the long-term outcomes of patients with non-infectious uveitis treated with 0.19 mg fluocinolone acetonide insert (FAi) for up to 36 months in clinical practice. METHODS: A retrospective study conducted at a single uveitis center. RESULTS: Fifty eyes of 39 patients were included. Mean best corrected visual acuity (BCVA) and central retinal thickness (CRT) remained stable until month 36 after FAi implantation (61...
September 1, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37652695/bilateral-acute-iris-transillumination-associated-with-moxifloxacin-antibiotic-use
#13
JOURNAL ARTICLE
Gabriela A Gorbea Fuxench, Sofía C Ayala Rodríguez, Gabriel Guardiola, Fabiola Ramos, Mariella Pappaterra-Rodríguez, Guillermo A Requejo Figueroa, Stephanie M Llop, Luis A Santiago, Carmen Santos, Armando L Oliver
PURPOSE: To describe the clinical and demographic characteristics and associated factors leading to bilateral acute iris transillumination (BAIT) syndrome. METHODS: A retrospective review of patients with BAIT syndrome was performed. RESULTS: Thirty-five patients with a diagnosis of BAIT were identified. The median age at presentation was 53 years; 80% of the patients were female. Twenty-six patients (74%) had recent histories of systemic antibiotic treatment...
August 31, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37616557/intraocular-inflammation-and-palpable-purpura-in-a-patient-with-interstitial-pasteurella-multocida-pneumonia
#14
JOURNAL ARTICLE
Antonio Pinna, Nicola Castiglia, Maria Antonia Montesu, Lorenza Ronchi, Rita Serra, Giacomo Boscia, Stefano Dore
PURPOSE: We describe a case of intraocular inflammation and palpable purpura in a patient with Pasteurella multocida pneumonia. METHODS: A 75-year-old pseudophakic woman with type-2 diabetes and chronic obstructive pulmonary disease complained of lower limb palpable purpura and right vision loss of five-day duration. On admission, right visual acuity was hand motion. Slit-lamp examination disclosed severe conjunctival and ciliary injection, corneal oedema, 3-mm hypopyon with heavy fibrin accumulation and blood clots, and synechiae to the IOL...
August 24, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37590885/multimodal-imaging-features-of-the-posterior-segment-in-ocular-syphilis-and-hiv-co-infection-a-single-center-case-series
#15
JOURNAL ARTICLE
Sergio Emilio Sifuentes Rentería, Paulina Rodríguez Badillo, Teresa Valdez González
OBJECTIVE: To analyze the frequent multimodal imaging features in posterior syphilitic uveitis. PURPOSE: Syphilis infection has re-emerged as a global health problem. Multimodal imaging approach has been proposed for diagnosis and follow-up; there are not previous reports dedicated to the anatomic and visual outcomes in patients diagnosed with ocular syphilis and concomitant HIV infection. METHODS: All demographic information was recovered; a complete ophthalmological examination and multimodal imaging evaluation (retinal fluorescein angiography (FA), autofluorescence (AF), optical coherence tomography (OCT)) were performed on initial visit and 1 month after antibiotic therapy...
August 17, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37585678/outbreak-of-rift-valley-fever-retinitis-in-rwanda-novel-imaging-findings-and-response-to-treatment-with-corticosteroids
#16
JOURNAL ARTICLE
Ivo De Clerck
PURPOSE: To describe the clinical and epidemiological characteristics of the first epidemic of Rift Valley Fever retinitis in Rwanda and to report novel imaging findings and a possible role for corticosteroids. METHODS: Retrospective analysis of all patients who presented with presumed Rift Valley Fever retinitis at the Rwanda Charity Eye Hospital over a period of 4 months in 2022. Multimodal images are reviewed including optical coherence tomography, fluorescein angiography, color, infrared, red-free, and autofluorescence photography...
August 16, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37582248/efficacy-of-biosimilar-infliximab-dyyb-in-non-infectious-uveitis
#17
JOURNAL ARTICLE
Fatma Zaguia, Edward L Randerson, Ramana S Moorthy, Debra A Goldstein
PURPOSE: To describe the frequency of uveitis recurrences in patients with non-infectious uveitis treated with the biosimilar infliximab-dyyb. DESIGN: Retrospective case series. METHODS: Records of uveitis patients treated with the biosimilar infliximab-dyyb between 2016 and 2022 at two institutions were reviewed. Data extracted included patient demographics, diagnosis, previous originator infliximab use, additional immunosuppression medications, infliximab-dyyb use, reason for switch, disease activity, and follow-up time...
August 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37582226/acute-retinal-necrosis-experience-in-a-reference-center-in-santander-colombia
#18
JOURNAL ARTICLE
Carlos Mario Rangel, Marcos Restrepo-Arango, Germán Mejía-Salgado, María Alejandra Gómez-Rocha, Maira Gómez Velasco, María Fernanda García, Juan José Moreno
INTRODUCTION: Acute retinal necrosis (ARN) is a severe eye disease demanding swift treatment to prevent blindness. Early action involving antiviral medications and corticosteroids is crucial for optimal visual outcomes. OBJECTIVE: We present an ARN case series showcasing treatment experience and results. METHODOLOGY: Patients diagnosed with ARN based on SUN Working Group 2021 criteria were included; all underwent comprehensive eye exams, PCR analysis, and imaging...
August 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37582224/intravenous-ceftriaxone-on-an-outpatient-basis-in-the-treatment-of-ocular-syphilis
#19
JOURNAL ARTICLE
Amanda Gomes E Silva, Leticia Alcântara Pedroso, Flavia Veiga Costa, Raissa de Moraes Perlingeiro, Priscila Peixoto de Castro Oliveira, Ana Luisa Biancardi Barreto, Andre Luiz Land Curi
PURPOSE: The goal of this study is to describe the clinical and laboratory outcomes of patients with syphilitic uveitis treated with 2 g intravenous Ceftriaxone daily on an outpatient treatment basis for 14 days, in the setting of the COVID pandemic and lack of hospitalization availability. METHODS: This study included a review of the clinical records from patients from January 2020 to December 2021 and who were then followed for 6 months at the Research Laboratory of Infectious Diseases in Ophthalmology of the National Institute of Infectious Diseases Evandro Chagas (INI) FIOCRUZ, Rio de Janeiro, Brazil...
August 15, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37579245/limited-utility-of-keratic-precipitate-morphology-as-an-indicator-of-underlying-diagnosis-in-ocular-inflammation
#20
JOURNAL ARTICLE
Katherine Terence, Olivia Cundy, Salomey Kellett, Andrew D Dick, Jugnoo Rahi, Ameenat Lola Solebo
OBJECTIVES: We aimed to establish the degree of consensus among clinicians on descriptors of KP morphology. METHODS: A web-based exercise in which respondents associated KP descriptors, as identified through a scoping review of the published literature, to images from different disorders. Inter-observer agreement was assessed using the Krippendorff kappa alpha metric. RESULTS: Of the 76 descriptive terms identified by the scoping review, the most used included "mutton-fat" ( n  = 93 articles, 36%), "fine/dust" ( n  = 76, 29%), "stellate" ( n  = 40, 15%), "large" ( n  = 33, 12%), and "medium" ( n  = 33, 12%)...
August 14, 2023: Ocular Immunology and Inflammation
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