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Biological & Pharmaceutical Bulletin

https://read.qxmd.com/read/38538325/effect-of-chronic-ethanol-consumption-on-exogenous-glucose-metabolism-in-rats-using-1-13-c-2-13-c-and-3-13-c-glucose-breath-tests
#1
JOURNAL ARTICLE
Naoyasu Kashima, Yosuke Sasaki, Naoyuki Kawagoe, Tomoyuki Shigeta, Fumiya Komatsu, Yoshihisa Urita
The C3 carbon of glucose molecules becomes the C1 carbon of pyruvate molecules during glycolysis, and the C1 and C2 carbons of glucose molecules are metabolized in the tricarboxylic acid (TCA) cycle. Utilizing this position-dependent metabolism of C atoms in glucose molecules, [1-13 C], [2-13 C], and [3-13 C] glucose breath tests are used to evaluate glucose metabolism. However, the effects of chronic ethanol consumption remain incompletely understood. Therefore, we evaluated glucose metabolism in ethanol-fed rats using [1-13 C], [2-13 C], and [3-13 C]glucose breath tests...
March 26, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432946/protective-effect-of-pemafibrate-treatment-against-diabetic-retinopathy-in-spontaneously-diabetic-torii-fatty-rats
#2
JOURNAL ARTICLE
Yoshiaki Tanaka, Rina Takagi, Shingen Mitou, Machiko Shimmura, Tetsuya Hasegawa, Jota Amarume, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Takeshi Ohta, Shin-Ichi Muramatsu, Akihiro Kakehashi, Toshikatsu Kaburaki
Diabetic retinopathy (DR) can cause visual impairment and blindness, and the increasing global prevalence of diabetes underscores the need for effective therapies to prevent and treat DR. Therefore, this study aimed to evaluate the protective effect of pemafibrate treatment against DR, using a Spontaneously Diabetic Torii (SDT) fatty rat model of obese type 2 diabetes. SDT fatty rats were fed either a diet supplemented with pemafibrate (0.3 mg/kg/day) for 16 weeks, starting at 8 weeks of age (Pf SDT fatty: study group), or normal chow (SDT fatty: controls)...
March 1, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38417893/comparing-the-efficacy-of-fosnetupitant-an-nk-1-receptor-antagonist-in-cddp-based-regimens-with-that-of-fosaprepitant-and-aprepitant-a-retrospective-observational-study
#3
JOURNAL ARTICLE
Hiroshi Inano, Yoshihito Morimoto, Kanata Kitagawa, Akito Shibuya, Kozue Nakagomi, Tomohiro Ota, Yuri Anzo, Rika Miyauchi, Aiko Shono, Kazuhiro Watanabe, Katsuya Otori
Existing antiemetic therapy against emetic-risk agents across malignancies 24 h post-dose in the acute period in CDDP-based regimens yields a satisfactory complete response (CR) rate of ≥ 90%. However, the control rate after 24 h in the delayed period is unsatisfactory. This study compared the efficacy of fosnetupitant (F-NTP), a neurokinin 1 receptor antagonist, with that of fosaprepitant (F-APR) and aprepitant (APR) in the treatment of patients with cancer at high emetic risk due to chemotherapy. In this retrospective case-control study involving patients receiving cisplatin-containing regimens and neurokinin 1 receptor antagonists, patients were divided into three groups based on prophylactic antiemetic therapy: F-NTP, F-APR, and APR...
February 28, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38220208/icariin-regulates-emt-and-stem-cell-like-character-in-breast-cancer-through-modulating-lncrna-neat1-tgf%C3%AE-smad2-signaling-pathway
#4
JOURNAL ARTICLE
Bo Song, Fuxia Wei, Jiehao Peng, Xiuhong Wei, Mingran Liu, Zhongbiao Nie, Yanmiao Ma, Tao Peng
Metastases and drug resistance are the major risk factors associated with breast cancer (BC), which is the most common type of tumor affecting females. Icariin (ICA) is a traditional Chinese medicine compound that possesses significant anticancer properties. Long non-coding RNAs (lncRNAs) are involved in a wide variety of biological and pathological processes and have been shown to modulate the effectiveness of certain drugs in cancer. The purpose of this study was to examine the potential effect of ICA on epithelial mesenchymal transition (EMT) and stemness articulation in BC cells, as well as the possible relationship between its inhibitory action on EMT and stemness with the NEAT1/TGFβ/SMAD2 pathway...
January 13, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38199251/loureirin-a-promotes-cell-differentiation-and-suppresses-migration-and-invasion-of-melanoma-cells-via-wnt-and-akt-mtor-signaling-pathways
#5
JOURNAL ARTICLE
Zi-Yi Xia, Ling Liu, Chiu-Fai Kuok, Xue-Li Wang, Dan Shi, Quan Ma, Xiao-Yang Cheng, Guo-Li Wang, Min-Jing Li, Qiu-Sheng Zheng, Xiao-Na Liu, De-Fang Li, Bo-Han Li
Resina Draconis is a traditional Chinese medicine, with the in-depth research, its medicinal value in anti-tumor has been revealed. Loureirin A is extracted from Resina Draconis, however, research on the anti-tumor efficacy of Loureirin A is rare. Herein, we investigated the function of Loureirin A in melanoma. Our research demonstrated that Loureirin A inhibited the proliferation of and caused G0/G1 cell cycle arrest in melanoma cells in a concentration-dependent manner. Further study showed that the melanin content and tyrosinase activity was enhanced after Loureirin A treatment, demonstrated that Loureirin A promoted melanoma cell differentiation, which was accompanied with the reduce of WNT signaling pathway...
January 10, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38296488/a-morpholine-derivative-n-4-morpholinomethylene-ethanesulfonamide-induces-ferroptosis-in-tumor-cells-by-targeting-nrf2
#6
JOURNAL ARTICLE
Bingchun Sun, Ligang Zhang, Binhua Wu, Xiping Luo
Small molecule drugs containing morpholine-based moieties have become crucial candidates in the tumor targeted therapy strategies, but the specific molecular mechanisms of these drugs causing tumor cell death require further investigation. The morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide (MESA) was used to stimulate prostate and ovarian cancer cells and we focused on the ferroptosis effects, including the target molecule and signal pathways mediated by MESA. The results showed that MESA could induce ferroptosis to cause the proliferation inhibition and apoptosis effects of tumor cells according to the identification of ferroptosis inhibitor fer-1 and other cell death inhibitors...
February 14, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38538335/effect-of-lipid-composition-on-the-interaction-of-liposomes-with-thp-1-derived-macrophages
#7
JOURNAL ARTICLE
Ryoya Ibuki, Takashi Tokui, Masaya Kuriyama, Kanji Hosoda, Hiroshi Tomoda, Kumiko Sakai-Kato
Recently, liposomal formulations that target macrophages have been used to treat lung diseases. However, the detailed mechanism of the cellular uptake must be elucidated to identify a formulation with excellent cellular uptake efficiency to treat non-tuberculous mycobacterial lung disease. We studied the effect of lipid composition on the cellular uptake of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/cholesterol (Chol) liposomes with a size of approximately 200 nm into THP-1-derived macrophages...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38538324/changes-in-pharmacy-students-awareness-of-hepatitis-b-patients-through-patient-lectures-as-humanity-education-findings-from-questionnaire-surveys-of-face-to-face-and-simultaneous-remote-classes
#8
JOURNAL ARTICLE
Ayano Iwazaki, Tomomichi Sone, Shuji Okumura, Ryota Maki, Takeyuki Kohno
In 2020, the coronavirus disease 2019 (COVID-19) pandemic made social distancing compulsory. In patient lectures by hepatitis B patients (Patient Lectures)-a humanity education initiative that had traditionally been delivered face-to-face to assembled students-it was necessary to divide the students into two groups, one that attended the Patient Lectures in person (face-to-face group) and another that assembled in a separate room to view the delivered lecture simultaneously and remotely via a teleconferencing platform (remote group)...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38538323/lymphatic-endothelial-cells-produce-chemokines-in-response-to-the-lipid-nanoparticles-used-in-rna-vaccines
#9
JOURNAL ARTICLE
Yi Liu, Miho Suzuoki, Hiroki Tanaka, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita
RNA vaccines based on Lipid nanoparticles (LNP) were put into practical use within only one year after the global outbreak of the coronavirus disease 2019 (COVID-19). This success of RNA vaccine highlights the utility of an mRNA delivery system as a vaccination strategy. Potent immunostimulatory activity of LNPs (i.e., inflammation occurring at the injection site and the production of inflammatory cytokines) have recently been reported. However, we have only limited knowledge concerning which cells are responsible for responding to the LNPs...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38522942/therapeutic-potential-of-danyankang-capsule-in-high-fat-diet-induced-cholelithiasis-and-its-impact-on-liver-fxr-signaling-and-gut-microbiota
#10
JOURNAL ARTICLE
Lin Zhou, Chu-Ling Zhang, Kun Jiang, Hong-Yu Cheng, Wen-Wen Xiong, Ji-Xiao Zhu
Cholelithiasis, commonly known as gallstones, represents a prevalent hepatobiliary disorder. This study aimed to elucidate the therapeutic role and mechanism of Danyankang capsulein treating cholelithiasis induced by a high-fat diet in C57BL/6 mice. The therapeutical potential of Danyankang was assessed through biochemical analyses, histopathological examinations, protein detection, and 16S rDNA sequencing. A high-fat diet resulted in cholelithiasis manifestation in mice, with discernable abnormal serum biochemical indices and disrupted biliary cholesterol homeostasis...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38508765/osteoblastgenic-and-osteogenic-effects-of-ky-273-with-cdk8-19-inhibitory-activity-in-bone-marrow-mesenchymal-stem-cells-and-female-rats
#11
JOURNAL ARTICLE
Megumi Yamamoto, Yui Shibata, Yuma Ito, Masaki Fukui, Hikaru Kioka, Yoshimichi Shoji, Tatsuya Kitao, Hiroaki Shirahase, Eiichi Hinoi
Osteoporosis is caused by imbalance between osteogenesis and bone resorption, thus, osteogenic drugs and resorption inhibitors are used for treatment of osteoporosis. The present study examined the effects of (R)-4-(1-hydroxyethyl)-3-{4-[2-(tetrahydropyran-4-yloxy)ethoxy]phenoxy}benzamide (KY-273), a diphenyl ether derivative, on CDK8/19 activity, osteoblast differentiation and femoral bone using micro-computed tomography in female rats. KY-273 potently inhibited CDK8/19 activity, promoted osteoblast differentiation with an increase in alkaline phosphatase (ALP) activity, and gene expression of type I collagen, ALP and BMP-4 in mesenchymal stem cells (ST2 cells)...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38508745/platelets-affect-the-activity-of-amino-acid-transporter-snat4-in-huh-7-human-hepatoma-cells
#12
JOURNAL ARTICLE
Hitoshi Kashiwagi, Yuki Sato, Shunsuke Nashimoto, Shungo Imai, Yoh Takekuma, Mitsuru Sugawara
Platelets have been reported to exert diverse actions besides hemostasis and thrombus formation in the body. However, whether platelets affect transporter activity remains to be determined. In this study, we examined the effects of platelets on the activity of amino acid transporter system A, which is known to be changed by various factors, and we clarified the mechanism by which platelets affect system A activity. Among system A subtypes, we found that sodium-coupled neutral amino acid transporter (SNAT) 4 played a central role in the transport activity of system A in HuH-7 human hepatoma cells...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38508744/oxidized-ldl-induces-metabolic-dysfunction-in-retinal-pigment-epithelial-cells
#13
JOURNAL ARTICLE
Manami Tomomatsu, Naoto Imamura, Hoshimi Izumi, Masatsugu Watanabe, Masataka Ikeda, Tomomi Ide, Shohei Uchinomiya, Akio Ojida, Mirinthorn Jutanom, Kazushi Morimoto, Ken-Ichi Yamada
Recently, mitochondrial dysfunction has gained attention as a causative factor in the pathogenesis and progression of age-related macular degeneration (AMD). Mitochondrial damage plays a key role in metabolism and disrupts the balance of intracellular metabolic pathways, such as oxidative phosphorylation (OXPHOS) and glycolysis. In this study, we focused on oxidized low-density lipoprotein (ox-LDL), a major constituent of drusen that accumulates in the retina of patients with AMD, and investigated whether it could be a causative factor for metabolic alterations in retinal pigment epithelial (RPE) cells...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38508741/spasmolytic-effect-of-flopropione-does-not-involve-catechol-o-methyltransferase-comt-inhibition
#14
JOURNAL ARTICLE
Yoko Amagase, Mari Hoshiyama, Shiho Hasegawa, Miwa Kanbara, Yumiko Mizukawa, Tetsuro Urushidani
Flopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494736/modeled-hepatic-plasma-exposures-of-fluvastatin-prescribed-alone-in-subjects-with-impaired-cytochrome-p450-2c9-3-as-one-of-possible-determinant-factors-likely-associated-with-hepatic-toxicity-reported-in-a-japanese-adverse-event-database
#15
JOURNAL ARTICLE
Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Makiko Shimizu, Hiroshi Yamazaki
Fluvastatin is a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor that competitively inhibits human cytochrome P450 (P450) 2C9 in vitro. Drug interactions between a variety of P450 2C9 substrates/inhibitors and fluvastatin can increase the incidence of fluvastatin-related hepatic or skeletal muscle toxicity in vivo. In this survey, the prescribed dosage of fluvastatin was reduced or discontinued in 133 of 164 patients receiving fluvastatin alone, as recorded in the Japanese Adverse Drug Event Report database of spontaneously reported events...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494735/ketogenic-diet-alleviates-mechanical-allodynia-in-the-models-of-inflammatory-and-neuropathic-pain-in-male-mice
#16
JOURNAL ARTICLE
Kei Eto, Masanori Ogata, Yoshitaka Toyooka, Toru Hayashi, Hitoshi Ishibashi
Inflammation is involved in the induction of chronic inflammatory and neuropathic pain. Moreover, the ketogenic diet, a high-fat, low-carbohydrate, and adequate protein diet, has an anti-inflammatory effect. Thus, we hypothesized that a ketogenic diet has a therapeutic effect on both types of chronic pain. In the present study, we investigated the effect of a ketogenic diet on mechanical allodynia, a chronic pain symptom, in formalin-induced chronic inflammatory pain and nerve injury-induced neuropathic pain models using adult male mice...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479886/structural-impact-assessment-of-cytochrome-p450-2a13-polymorphisms-using-molecular-dynamics-simulations
#17
JOURNAL ARTICLE
Koichi Kato, Tomoki Nakayoshi, Sho Hioki, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda
One of the members of CYP, a monooxygenase, CYP2A13 is involved in the metabolism of nicotine, coumarin, and tobacco-specific nitrosamine. Genetic polymorphisms have been identified in CYP2A13, with reported loss or reduction in enzymatic activity in CYP2A13 allelic variants. This study aimed to unravel the mechanism underlying the diminished enzymatic activity of CYP2A13 variants by investigating their three-dimensional structures through molecular dynamics (MD) simulations. For each variant, MD simulations of 1000 ns were performed, and the obtained results were compared with those of the wild type...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479885/streamlining-considerations-for-safety-measures-a-predictive-model-for-addition-of-clinically-significant-adverse-reactions-to-japanese-drug-package-inserts
#18
JOURNAL ARTICLE
Takashi Watanabe, Kaori Ambe, Masahiro Tohkin
The addition of clinically significant adverse reactions (CSARs) to Japanese package inserts (PIs) is an important safety measure that can be used to inform medical personnel of potential health risks; however, determining the necessity of their addition can be lengthy and complex. Therefore, we aimed to construct a machine learning-based model that can predict the addition of CSARs at an early stage due to the accumulation of both Japanese and overseas adverse drug reaction (ADR) cases. The target comprised CSARs added to PIs from August 2011 to March 2022...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38462492/causes-of-sex-differences-in-serum-cholesterol-and-triglyceride-levels-in-meishan-pigs
#19
JOURNAL ARTICLE
Misaki Kojima, Masakuni Degawa
To clarify the causes of sex differences (male < female) in the serum total cholesterol (TCHO) and triglyceride (TG) levels in Meishan pigs, we examined the sex differences in mRNA levels of key hepatic enzymes involved in the biosynthesis/metabolism of cholesterol and TG using real-time RT-PCR. There were no sex differences in mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase and CYP51A1 for cholesterol biosynthesis, or of the rate-limiting enzyme CYP7A1 for bile acid synthesis from cholesterol...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38447992/temperature-dependent-upregulation-of-per2-protein-expression-is-mediated-by-eif2%C3%AE-kinases-perk-and-pkr-through-pi3k-activation
#20
JOURNAL ARTICLE
Xinyan Shao, Takahito Miyake, Yuichi Inoue, Emi Hasegawa, Masao Doi
Temperature-dependent translational control of the core clock gene Per2 plays an important role in establishing entrainment of the circadian clock to physiological body temperature cycles. Previously, we found an involvement of the phosphatidylinositol 3-kinase (PI3K) in causing Per2 protein expression in response to a warm temperature shift (WTS) within a physiological range (from 35 to 38.5 °C). However, signaling pathway mediating the Per2 protein expression in response to WTS is only sparsely understood...
2024: Biological & Pharmaceutical Bulletin
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