journal
Journals Biological & Pharmaceutical Bu...

Biological & Pharmaceutical Bulletin

https://read.qxmd.com/read/38866477/epigallocatechin-3-gallate-alleviates-ethanol-induced-endothelia-cells-injury-partly-through-alteration-of-nf-%C3%AE%C2%BAb-translocation-and-activation-of-the-nrf2-signaling-pathway
#1
JOURNAL ARTICLE
Jie Xu, Shouzhu Xu, Jiayin Luo, Shihao Zhang, Dongdong Wu, Qifan Yang, Rourou Fang, Chuandao Shi, Qiling Liu, Jing Zhao
Ethanol (alcohol) is a risk factor that contributes to non-communicable diseases. Chronic abuse of ethanol is toxic to both the heart and overall health, and even results in death. Ethanol and its byproduct acetaldehyde can harm the cardiovascular system by impairing mitochondrial function, causing oxidative damage, and reducing contractile proteins. Endothelial cells are essential components of the cardiovascular system, are highly susceptible to ethanol, either through direct or indirect exposure. Thus, protection against endothelial injury is of great importance for persons who chronic abuse of ethanol...
June 12, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38644204/detoxification-and-activating-blood-circulation-decoction-promotes-reendothelialization-of-damaged-blood-vessels-via-vegf-signaling-pathway-activation-by-mirna-126
#2
JOURNAL ARTICLE
Zhiming Liu, Guangmie Xie, Zuwei Li, Hanbin Luo, Jianhong Zhou, Jie Cheng, Xiaolin Wang, Xiaoyan Huang, Guohui Zou
The occurrence of in-stent restenosis (ISR) poses a significant challenge for percutaneous coronary intervention (PCI). Thus, the promotion of vascular reendothelialization is essential to inhibit endothelial proliferation. In this study, we clarified the mechanism by which Detoxification and Activating Blood Circulation Decoction (DABCD) promotes vascular reendothelialization to avoid ISR by miRNA-126-mediated modulation of the vascular endothelial growth factor (VEGF) signaling pathway. A rat model of post-PCI restenosis was established by balloon injury...
April 20, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38631865/the-influence-of-emodin-succinyl-ethyl-ester-on-non-alcoholic-steatohepatitis-induced-by-a-diet-high-in-fructose-cholesterol-and-fat-in-mice
#3
JOURNAL ARTICLE
Yanxue Wang, Liang Li, Lingling Chen, Jinlei Xia, Tongli Wang, Lei Han, Liang Cao, Zhenzhong Wang, Wei Xiao, Shan Jiang
Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis and evidence of hepatocyte injury (ballooning) and inflammation, with or without liver fibrosis. In this study, after 12 weeks of induction, the mice were treated with emodin succinyl ethyl ester (ESEE) for four weeks at doses of 10/30/90 mg/kg/day. The blood analysis of experimental endpoints showed that ESEE exhibited significant therapeutic effects on the progression of disorders of glycolipid metabolism and the induced liver injury in the model animals...
April 18, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38538325/effect-of-chronic-ethanol-consumption-on-exogenous-glucose-metabolism-in-rats-using-1-13-c-2-13-c-and-3-13-c-glucose-breath-tests
#4
JOURNAL ARTICLE
Naoyasu Kashima, Yosuke Sasaki, Naoyuki Kawagoe, Tomoyuki Shigeta, Fumiya Komatsu, Yoshihisa Urita
The C3 carbon of glucose molecules becomes the C1 carbon of pyruvate molecules during glycolysis, and the C1 and C2 carbons of glucose molecules are metabolized in the tricarboxylic acid (TCA) cycle. Utilizing this position-dependent metabolism of C atoms in glucose molecules, [1-13 C], [2-13 C], and [3-13 C] glucose breath tests are used to evaluate glucose metabolism. However, the effects of chronic ethanol consumption remain incompletely understood. Therefore, we evaluated glucose metabolism in ethanol-fed rats using [1-13 C], [2-13 C], and [3-13 C]glucose breath tests...
March 26, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432946/protective-effect-of-pemafibrate-treatment-against-diabetic-retinopathy-in-spontaneously-diabetic-torii-fatty-rats
#5
JOURNAL ARTICLE
Yoshiaki Tanaka, Rina Takagi, Shingen Mitou, Machiko Shimmura, Tetsuya Hasegawa, Jota Amarume, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Takeshi Ohta, Shin-Ichi Muramatsu, Akihiro Kakehashi, Toshikatsu Kaburaki
Diabetic retinopathy (DR) can cause visual impairment and blindness, and the increasing global prevalence of diabetes underscores the need for effective therapies to prevent and treat DR. Therefore, this study aimed to evaluate the protective effect of pemafibrate treatment against DR, using a Spontaneously Diabetic Torii (SDT) fatty rat model of obese type 2 diabetes. SDT fatty rats were fed either a diet supplemented with pemafibrate (0.3 mg/kg/day) for 16 weeks, starting at 8 weeks of age (Pf SDT fatty: study group), or normal chow (SDT fatty: controls)...
March 1, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38417893/comparing-the-efficacy-of-fosnetupitant-an-nk-1-receptor-antagonist-in-cddp-based-regimens-with-that-of-fosaprepitant-and-aprepitant-a-retrospective-observational-study
#6
JOURNAL ARTICLE
Hiroshi Inano, Yoshihito Morimoto, Kanata Kitagawa, Akito Shibuya, Kozue Nakagomi, Tomohiro Ota, Yuri Anzo, Rika Miyauchi, Aiko Shono, Kazuhiro Watanabe, Katsuya Otori
Existing antiemetic therapy against emetic-risk agents across malignancies 24 h post-dose in the acute period in CDDP-based regimens yields a satisfactory complete response (CR) rate of ≥ 90%. However, the control rate after 24 h in the delayed period is unsatisfactory. This study compared the efficacy of fosnetupitant (F-NTP), a neurokinin 1 receptor antagonist, with that of fosaprepitant (F-APR) and aprepitant (APR) in the treatment of patients with cancer at high emetic risk due to chemotherapy. In this retrospective case-control study involving patients receiving cisplatin-containing regimens and neurokinin 1 receptor antagonists, patients were divided into three groups based on prophylactic antiemetic therapy: F-NTP, F-APR, and APR...
February 28, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38296488/a-morpholine-derivative-n-4-morpholinomethylene-ethanesulfonamide-induces-ferroptosis-in-tumor-cells-by-targeting-nrf2
#7
JOURNAL ARTICLE
Bingchun Sun, Ligang Zhang, Binhua Wu, Xiping Luo
Small molecule drugs containing morpholine-based moieties have become crucial candidates in the tumor targeted therapy strategies, but the specific molecular mechanisms of these drugs causing tumor cell death require further investigation. The morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide (MESA) was used to stimulate prostate and ovarian cancer cells and we focused on the ferroptosis effects, including the target molecule and signal pathways mediated by MESA. The results showed that MESA could induce ferroptosis to cause the proliferation inhibition and apoptosis effects of tumor cells according to the identification of ferroptosis inhibitor fer-1 and other cell death inhibitors...
February 14, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38220208/icariin-regulates-emt-and-stem-cell-like-character-in-breast-cancer-through-modulating-lncrna-neat1-tgf%C3%AE-smad2-signaling-pathway
#8
JOURNAL ARTICLE
Bo Song, Fuxia Wei, Jiehao Peng, Xiuhong Wei, Mingran Liu, Zhongbiao Nie, Yanmiao Ma, Tao Peng
Metastases and drug resistance are the major risk factors associated with breast cancer (BC), which is the most common type of tumor affecting females. Icariin (ICA) is a traditional Chinese medicine compound that possesses significant anticancer properties. Long non-coding RNAs (lncRNAs) are involved in a wide variety of biological and pathological processes and have been shown to modulate the effectiveness of certain drugs in cancer. The purpose of this study was to examine the potential effect of ICA on epithelial mesenchymal transition (EMT) and stemness articulation in BC cells, as well as the possible relationship between its inhibitory action on EMT and stemness with the NEAT1/TGFβ/SMAD2 pathway...
January 13, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38199251/loureirin-a-promotes-cell-differentiation-and-suppresses-migration-and-invasion-of-melanoma-cells-via-wnt-and-akt-mtor-signaling-pathways
#9
JOURNAL ARTICLE
Zi-Yi Xia, Ling Liu, Chiu-Fai Kuok, Xue-Li Wang, Dan Shi, Quan Ma, Xiao-Yang Cheng, Guo-Li Wang, Min-Jing Li, Qiu-Sheng Zheng, Xiao-Na Liu, De-Fang Li, Bo-Han Li
Resina Draconis is a traditional Chinese medicine, with the in-depth research, its medicinal value in anti-tumor has been revealed. Loureirin A is extracted from Resina Draconis, however, research on the anti-tumor efficacy of Loureirin A is rare. Herein, we investigated the function of Loureirin A in melanoma. Our research demonstrated that Loureirin A inhibited the proliferation of and caused G0/G1 cell cycle arrest in melanoma cells in a concentration-dependent manner. Further study showed that the melanin content and tyrosinase activity was enhanced after Loureirin A treatment, demonstrated that Loureirin A promoted melanoma cell differentiation, which was accompanied with the reduce of WNT signaling pathway...
January 10, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38987177/application-of-a-fluorescence-recovery-based-polo-like-kinase-1-binding-assay-to-polo-like-kinase-2-and-polo-like-kinase-3
#10
JOURNAL ARTICLE
Kohei Tsuji, Hirokazu Tamamura, Terrence R Burke
Assay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a protein family can be extremely important and for this reason it is critical to have methods for evaluating selectivity. We have previously reported a fluorescence recovery assay that employs a fluorescein-labelled probe to determine IC50 values of ATP-competitive type 1 inhibitors of polo-like kinase 1 (Plk1). This probe is based on the potent Plk1 inhibitor BI2536 [fluorescein isothiocyanate (FITC)-polyethylene glycol (PEG)-lysine (Lys) (BI2536) 1]...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38987176/inhibition-of-uracil-dna-glycosylase-alters-frequency-and-spectrum-of-action-at-a-distance-mutations-induced-by-8-oxo-7-8-dihydroguanine
#11
JOURNAL ARTICLE
Tetsuya Suzuki, Saho Yoshida, Hiroyuki Kamiya
The generation of DNA damage causes mutations and consequently cancer. Reactive oxygen species are important sources of DNA damage and some mutation signatures found in human cancers. 8-Oxo-7,8-dihydroguanine (GO , 8-hydroxyguanine) is one of the most abundant oxidized bases and induces a G→T transversion mutation at the modified site. The damaged G base also causes untargeted base substitution mutations at the G bases of 5'-GpA-3' dinucleotides (action-at-a-distance mutations) in human cells, and the cytosine deaminase apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) is involved in the mutation process...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38987175/the-beneficial-effect-of-brazilian-propolis-for-liver-damage-through-endoplasmic-reticulum-stress
#12
JOURNAL ARTICLE
Tomohiro Ogawa, Takumi Terada
There is evidence that propolis exhibits anti-inflammatory, anticancer, and antioxidant properties. We assessed the potential beneficial effects of Brazilian propolis on liver injury in nonalcoholic fatty liver disease (NAFLD). Our findings demonstrate that Brazilian propolis suppresses inflammation and fibrosis in the liver of mice with NAFLD by inhibiting the expression of genes involved in endoplasmic reticulum (ER) stress. Additionally, Brazilian propolis also suppressed the expression of ER stress-related genes in HepG2 cells treated with an excess of free fatty acids, leading to cell apoptosis...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38972750/alantolactone-induced-apoptosis-and-dna-damage-of-cervical-cancer-through-atm-chk2-signaling-pathway
#13
JOURNAL ARTICLE
Yan Zhang, Heyue Li, Yunfang Wei, Linxia Li
Traditional Chinese Medicine, known for its minimal side effects and significant clinical efficacy, has attracted considerable interest for its potential in cancer therapy. In particular, Inula helenium L. has demonstrated effectiveness in inhibiting a variety of cancers. This study focuses on alantolactone (ALT), a prominent compound from Inula helenium L., recognized for its anti-cancer capabilities across multiple cancer types. The primary objective of this study is to examine the influence of ALT on the proliferation, apoptosis, cell cycle, and tumor growth of cervical cancer (CC) cells, along with its associated signaling pathways...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38945944/errata-for-biological-and-pharmaceutical-bulletin
#14
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38945943/errata-for-biological-and-pharmaceutical-bulletin
#15
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38945897/suppression-of-the-epithelial-mesenchymal-transition-and-maintenance-of-the-liver-functions-in-primary-hepatocytes-through-dispersion-culture-within-a-dome-shaped-collagen-matrix
#16
JOURNAL ARTICLE
Yoshino Tonooka, Tomoyuki Takaku, Manabu Toyoshima, Yasuhiko Takahashi, Sachiko Kitamoto
Primary hepatocytes are valuable for studying liver diseases, drug-induced liver injury, and drug metabolism. However, when cultured in a two-dimensional (2D) environment, primary hepatocytes undergo rapid dedifferentiation via an epithelial-mesenchymal transition (EMT) and lose their liver-specific functions. On the other hand, a three-dimensional (3D) culture of primary hepatocyte organoids presents challenges for analyzing cellular functions and molecular behaviors due to strong cell-cell adhesion among heterogeneous cells...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38945844/sphingolipid-enriched-porcine-placental-extract-promotes-the-expression-of-structural-genes-and-desquamation-enzyme-genes-in-cultured-human-keratinocytes
#17
JOURNAL ARTICLE
Masahiko Tebakari, Yuki Daigo, Hiroaki Takemoto, Kiyomitsu Nemoto, Fumihide Takano
Porcine placental extract (PPE) is commonly used in various health foods and cosmetics. PPE use in cosmetics predominantly consist of the water-soluble fraction derived from the entire placenta. In this report, we examined the effect of the hydrophobic constituents of the PPE, specifically the sphingolipid-enriched fraction designated as the sphingolipid-enriched porcine placental extract (SLPPE), on the expression of genes associated with skin function in cultured normal human epidermal keratinocytes. Using quantitative RT-PCR (qRT-PCR) analysis, we found that SLPPE concentrations ranging from 25 to 100 µg/mL upregulated the gene expression of key components associated with the cornified envelope structure (filaggrin (FLG), involucrin (IVL) and loricrin (LOR)), cornification enzymes (transglutaminase 1 (TGM1) and TGM5) and the desquamation enzymes (kallikrein 5 (KLK5) and KLK7)...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38925923/preparation-and-application-of-decanoic-acid-arginine-hydrogels-to-a-transdermal-formulation
#18
JOURNAL ARTICLE
Ryuichiro Mochizuki, Naoyuki Fukumoto, Kenichiro Ise, Kohsuke Shibasaki, Kaname Hashizaki, Makiko Fujii, Hiroyuki Taguchi
We prepared a supramolecular hydrogel composed of decanoic acid and arginine (C10/Arg gel) and evaluated its application to a transdermal formulation. C10/Arg gel adjusted to pH 7 with 1 M NaOH aq or 1 M HCl aq provided a translucent hydrogel with a lamellar liquid crystal structure in the concentration region of decanoic acid ≥12% and arginine ≤9%. Rheological measurements showed that C10/Arg gel is a viscoelastic material with both solid and liquid properties, with elasticity being dominant over viscosity in the low shear stress region...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38925922/omeprazole-induces-cyp3a4-mrna-expression-but-not-cyp3a4-protein-expression-in-heparg-cells
#19
JOURNAL ARTICLE
Yuto Fujita, Takahito Miyake, Xinyan Shao, Yuto Aoki, Emi Hasegawa, Masao Doi
Unknown interactions between drugs remain the limiting factor for clinical application of drugs, and the induction and inhibition of drug-metabolizing CYP enzymes are considered the key to examining the drug-drug interaction (DDI). In this study, using human HepaRG cells as an in vitro model system, we analyzed the potential DDI based on the expression levels of CYP3A4 and CYP1A2. Rifampicin and omeprazole, the potent inducers for CYP3A4 and CYP1A2, respectively, induce expression of the corresponding CYP enzymes at both the mRNA and protein levels...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38925921/heterogenous-gene-expression-of-bicellular-and-tricellular-tight-junction-sealing-components-in-the-human-intestinal-tract
#20
JOURNAL ARTICLE
Keisuke Tachibana, Lin Bai, Sayaka Sugimura, Hijiri Fujioka, Wataru Kishimoto, Hiroyuki Mizuguchi, Hiroshi Nakase, Masuo Kondoh
A major site for the absorption of orally administered drugs is the intestinal tract, where the mucosal epithelium functions as a barrier separating the inside body from the outer environment. The intercellular spaces between adjacent epithelial cells are sealed by bicellular and tricellular tight junctions (TJs). Although one strategy for enhancing intestinal drug absorption is to modulate these TJs, comprehensive gene (mRNA) expression analysis of the TJs components has never been fully carried out in humans...
2024: Biological & Pharmaceutical Bulletin
journal
journal
31411
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.