Tyler Coye, Elizabeth Ansert, Mehmet A Suludere, Jayer Chung, Gu Eon Kang, Lawrence A Lavery
Transmetatarsal amputation (TMA) is a common surgical procedure for addressing severe forefoot pathologies, such as peripheral vascular disease and diabetic foot infections. Variability in research methodologies and findings within the existing literature has hindered a comprehensive understanding of healing rates and complications following TMA. This meta-analysis and systematic review aims to consolidate available evidence, synthesising data from multiple studies to assess healing rates and complications associated with closed TMA procedures...
December 18, 2023: Wound Repair and Regeneration
Adam Whitley, Peter Baláž, Jan Kavalírek, Jitka Hanusová, Robert Gürlich
StopBac is an innovative silver-impregnated antimicrobial dressing specifically designed to reduce surgical site infections and enhance healing. The primary objective of this study was to compare infection rate and healing rate at the 30 days after surgery between primarily closed surgical wounds covered with StopBac and those covered with Cosmorpor, a standard surgical dressing. Between 1.3.2023 and 30.4.2023, we conducted a prospective screening of all patients undergoing surgical operations within a single surgical department...
December 18, 2023: Wound Repair and Regeneration
Allison N Ramey-Ward, Howard P Walthall, Shakesia Smith, Thomas H Barrows
A wide variety of biomaterials have been developed to assist in wound healing, including acellular animal and human-derived protein matrices. However, millions of patients worldwide still suffer from non-healing chronic wounds, demonstrating a need for further innovation in wound care. To address this need, a novel biomaterial, the human keratin matrix (HKM), was developed, characterized, and tested in vitro and in vivo. HKM was found to be degradation-resistant, and a proteomics analysis showed it to be greater than 99% human keratin proteins...
December 18, 2023: Wound Repair and Regeneration
(no author information available yet)
No abstract text is available yet for this article.
December 14, 2023: Wound Repair and Regeneration
Chaonan Yin, Fang Tang, Jiahui Lao, Yang Yang, Mingzhuo Li, Jia Cao, Ru Song, Peng Wu, Yibing Wang
The aim of this case-control study was to explore the potential risk factors for venous ulceration in patients with varicose veins of lower extremities and to establish a simplified diagnostic score model. Seventy subjects with varicose veins of lower extremities and venous ulceration were compared with 1164 controls with varicose veins of lower extremities and no history of venous ulceration. Stepwise multivariate logistic regression analysis was used to identify the risk factors for venous ulceration. The steps in developing the diagnostic score model were based on the Framingham Heart study...
December 12, 2023: Wound Repair and Regeneration
M Graça Pereira, Margarida Vilaça, Diogo Braga, Ana Madureira, Jéssica Da Silva, Diana Santos, Eugénia Carvalho
Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic, and social challenges. Therefore, early identification of patients with a high-risk profile would be important to prompt adequate treatment and more successful health outcomes. This study explores risk assessment profiles for DFU healing and healing prognosis, using machine learning predictive approaches and decision trees algorithms...
December 10, 2023: Wound Repair and Regeneration
Paulina Mościcka, Justyna Cwajda-Białasik, Arkadiusz Jawień, Wojciech Jaraczewski, Maria T Szewczyk
The process of healing venous ulcers is complex and influenced by many factors. By identifying the risk factors that influence a slower healing process, it is possible to predict impending delays and plan an individualized care plan. We analyzed our database of patients with venous ulcers and identified clinical and demographic factors that delay the healing process. The research analyzed the medical records of 754 patients with VLUs at Chronic Wound Treatment Unit of the University Hospital treated between 2001 and 2019...
December 10, 2023: Wound Repair and Regeneration
Odette Hart, Qiantai Hong, Khai Tuck Lee, Sinead Gormley, Peta Tehan, Jill Sommerset, Manar Khashram
Rest pain, ulceration, and gangrene are hallmark features of chronic limb-threatening ischaemia (CLTI). Wound healing can be challenging, and this is compounded by an inability to measure lower limb perfusion via non-invasive tools such as toe pressure (TP). Novel perfusion tests, such as pedal acceleration time (PAT), may overcome some limitations. This study aimed to quantify the proportion of patients with CLTI that were unable to undergo TP measurement. Over a three-year duration, 344 consecutive patients with CLTI underwent PAT assessment (403 limbs)...
December 6, 2023: Wound Repair and Regeneration
Lawrence A Lavery, Mehmet A Suludere, Chris E Attinger, Matthew Malone, Gu Eon Kang, Peter A Crisologo, Edgar J Peters, Lee C Rogers
No abstract text is available yet for this article.
2024: Wound Repair and Regeneration
(no author information available yet)
No abstract text is available yet for this article.
December 2023: Wound Repair and Regeneration
Juliana Girón Bastidas, Natasha Maurmann, Juliete Nathali Scholl, Augusto Ferreira Weber, Raíssa Padilha Silveira, Fabricio Figueiró, Marco Augusto Stimamiglio, Bruna Marcon, Alejandro Correa, Patricia Pranke
Therapies for wound healing using the secretome and extracellular vesicles (EVs) of mesenchymal stem/stromal cells have been shown to be successful in preclinical studies. This study aimed to characterize the protein content of the secretome from stem cells from human exfoliated deciduous teeth (SHED) and analyze the in vitro effects of SHED-conditioned medium (SHED-CM) and SHED extracellular vesicles (SHED-EVs) on keratinocytes. Extracellular vesicles were isolated and characterized. The keratinocyte viability and migration of cells treated with SHED-EVs and conditioned medium (CM) were evaluated...
December 1, 2023: Wound Repair and Regeneration
Masood Mazaheri, Raoul F Crooijmans, Maya Vereen, Eveline M L Corten
This study was aimed to review Virtual Reality's (VR) impact on pain, anxiety, opioid usage, physiological and behavioural responses, and patients' experience during wound care (WC) in adults. We searched multiple databases (Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, CINAHL, Scopus and Google Scholar) from inception until January 27th, 2023. Included studies compared VR alone or as an adjunct to standard WC with standard WC or other distraction methods, in adults with burn or non-burn-related wounds...
November 23, 2023: Wound Repair and Regeneration
Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Balaji Manohar, Sukhbir Singh Chopra
No abstract text is available yet for this article.
November 20, 2023: Wound Repair and Regeneration
Lisa J Gould, Jenny Alderden, Rummana Aslam, Adrian Barbul, Kath M Bogie, Mohamed El Masry, Letitia Y Graves, E Foy White-Chu, Amany Ahmed, KerriAnn Boanca, Jessica Brash, Katie R Brooks, Wendy Cockron, Susan M Kennerly, Aaron K Livingston, Jeni Page, Catherine Stephens, Velena West, Tracey L Yap
The major populations at risk for developing pressure ulcers are older adults who have multiple risk factors that increase their vulnerability, people who are critically ill and those with spinal cord injury/disease. The reported prevalence of pressure ulcers in the United States is 2.5 million. However, this estimate is derived from acute care facilities and does not include people who are living at home or in nursing facilities. Despite the implementation of hospital and facility-based preventive measures, the incidence of pressure ulcers has not decreased in decades...
November 16, 2023: Wound Repair and Regeneration
K Benabdderrahmane, J Stirnemann, S Ramtani, C Falentin-Daudré
Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although midtrimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly minimizing maternal and fetal risks. Several studies have proposed an alternative approach to surgical repair, by covering the defect with a patch and protect the exposed neural tissue...
November 13, 2023: Wound Repair and Regeneration
Francisco J Álvaro-Afonso, Sebastián Flores-Escobar, David Sevillano-Fernández, Yolanda García-Álvarez, Marta García-Madrid, José L Lázaro-Martínez
The current study aimed to evaluate the dispersal of solution and microbes (aerosol) in the clinic environment during treatment with Low-frequency contact ultrasonic debridement (LFCUD) with or without suction attachment in patients with diabetic foot ulcers (DFUs). We performed 20 treatments in 10 patients divided into two groups to receive the proposed LFCUD modalities. We measured the microbial load of the environment pre-treatment (sample M1), during treatment with each LFCUD modality (sample M2), and post-treatment (sample M3)...
November 13, 2023: Wound Repair and Regeneration
Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi
In the current study, Gold Nanoparticles were loaded into poly (ε-caprolactone)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of poly (ε-caprolactone)/Gelatin solution supplemented with synthesized Gold Nanoparticles (200 ppm, 400 ppm, and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test, and cellular response...
November 13, 2023: Wound Repair and Regeneration
Alexander Paping, Clara Basler, Loreen Ehrlich, Carlo Fasting, Kerstin Melchior, Thomas Ziska, Mario Thiele, Georg N Duda, Sara Timm, Matthias Ochs, Rebecca C Rancourt, Wolfgang Henrich, Thorsten Braun
Uterine rupture during a trial of labor after cesarean delivery (CD) is a serious complication for mother and fetus. The lack of knowledge on histological features and molecular pathways of uterine wound healing has hindered research in this area from evolving over time. We analyzed collagen content and turnover in uterine scars on a histological, molecular and ultrastructural level. Therefore, tissue samples from the lower uterine segment were obtained during CD from 16 pregnant women with at least one previous CD, from 16 pregnant women without previous CD, and from 16 non-pregnant premenopausal women after hysterectomy for a benign disease...
November 13, 2023: Wound Repair and Regeneration
Daijiro Haba, Takafumi Ohmiya, Masaki Sekino, Qi Qin, Chihiro Takizawa, Sanai Tomida, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Local low-frequency vibration promotes blood flow and wound healing in hard-to-heal diabetic foot ulcers (DFUs). However, vibration treatment is challenging in patients with DFUs due to wound management difficulties and low adherence. Consequently, developing wearable self-care devices becomes imperative for effective wound healing. This study introduces a wearable vibration dressing and assesses its impact on wound healing in hyperglycemic rats. Low-frequency vibration at 52 Hz was applied to the wound for 40 min/day in awake rats...
November 11, 2023: Wound Repair and Regeneration
Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery
The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM) or soft tissue infection based on bone culture and/or histology. We evaluated the diagnostic accuracy of CRP, ESR, albumin, CRP/albumin and ESR/albumin as biomarkers to diagnose OM in persons with diabetes...
October 16, 2023: Wound Repair and Regeneration
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