Odette Hart, Qiantai Hong, Khai Tuck Lee, Sinead Gormley, Peta Tehan, Jill Sommerset, Manar Khashram
Rest pain, ulceration, and gangrene are hallmark features of chronic limb-threatening ischaemia (CLTI). Wound healing can be challenging, and this is compounded by an inability to measure lower limb perfusion via non-invasive tools such as toe pressure (TP). Novel perfusion tests, such as pedal acceleration time (PAT), may overcome some limitations. This study aimed to quantify the proportion of patients with CLTI that were unable to undergo TP measurement. Over a three-year duration, 344 consecutive patients with CLTI underwent PAT assessment (403 limbs)...
December 6, 2023: Wound Repair and Regeneration
Juliana Girón Bastidas, Natasha Maurmann, Juliete Nathali Scholl, Augusto Ferreira Weber, Raíssa Padilha Silveira, Fabricio Figueiró, Marco Augusto Stimamiglio, Bruna Marcon, Alejandro Correa, Patricia Pranke
Therapies for wound healing using the secretome and extracellular vesicles (EVs) of mesenchymal stem/stromal cells have been shown to be successful in preclinical studies. This study aimed to characterize the protein content of the secretome from stem cells from human exfoliated deciduous teeth (SHED) and analyze the in vitro effects of SHED-conditioned medium (SHED-CM) and SHED extracellular vesicles (SHED-EVs) on keratinocytes. Extracellular vesicles were isolated and characterized. The keratinocyte viability and migration of cells treated with SHED-EVs and conditioned medium (CM) were evaluated...
December 1, 2023: Wound Repair and Regeneration
Lawrence A Lavery, Mehmet A Suludere, Chris E Attinger, Matthew Malone, Gu Eon Kang, Peter A Crisologo, Edgar J Peters, Lee C Rogers
No abstract text is available yet for this article.
November 30, 2023: Wound Repair and Regeneration
Masood Mazaheri, Raoul F Crooijmans, Maya Vereen, Eveline M L Corten
This study was aimed to review Virtual Reality's (VR) impact on pain, anxiety, opioid usage, physiological and behavioral responses, and patients' experience during wound care (WC) in adults. We searched multiple databases (Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, CINAHL, Scopus and Google Scholar) from inception until January 27th , 2023. Included studies compared VR alone or as an adjunct to standard WC with standard WC or other distraction methods, in adults with burn or non-burn-related wounds...
November 23, 2023: Wound Repair and Regeneration
Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Balaji Manohar, Sukhbir Singh Chopra
No abstract text is available yet for this article.
November 20, 2023: Wound Repair and Regeneration
Lisa J Gould, Jenny Alderden, Rummana Aslam, Adrian Barbul, Kath M Bogie, Mohamed El Masry, Letitia Y Graves, E Foy White-Chu, Amany Ahmed, KerriAnn Boanca, Jessica Brash, Katie R Brooks, Wendy Cockron, Susan M Kennerly, Aaron K Livingston, Jeni Page, Catherine Stephens, Velena West, Tracey L Yap
The major populations at risk for developing pressure ulcers are older adults who have multiple risk factors that increase their vulnerability, people who are critically ill and those with spinal cord injury/disease. The reported prevalence of pressure ulcers in the US is 2.5 million. However, this estimate is derived from acute care facilities and does not include people who are living at home or in nursing facilities. Despite implementation of hospital and facility based preventive measures, the incidence of pressure ulcers has not decreased in decades...
November 16, 2023: Wound Repair and Regeneration
K Benabdderrahmane, J Stirnemann, S Ramtani, C Falentin-Daudré
Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although midtrimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly minimizing maternal and fetal risks. Several studies have proposed an alternative approach to surgical repair, by covering the defect with a patch and protect the exposed neural tissue...
November 13, 2023: Wound Repair and Regeneration
Francisco J Álvaro-Afonso, Sebastián Flores-Escobar, David Sevillano-Fernández, Yolanda García-Álvarez, Marta García-Madrid, José L Lázaro-Martínez
The current study aimed to evaluate the dispersal of solution and microbes (aerosol) in the clinic environment during treatment with Low-frequency contact ultrasonic debridement (LFCUD) with or without suction attachment in patients with diabetic foot ulcers (DFUs). We performed 20 treatments in 10 patients divided into two groups to receive the proposed LFCUD modalities. We measured the microbial load of the environment pre-treatment (sample M1), during treatment with each LFCUD modality (sample M2), and post-treatment (sample M3)...
November 13, 2023: Wound Repair and Regeneration
Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi
In the current study, Gold Nanoparticles were loaded into poly (ε-caprolactone)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of poly (ε-caprolactone)/Gelatin solution supplemented with synthesized Gold Nanoparticles (200 ppm, 400 ppm, and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test, and cellular response...
November 13, 2023: Wound Repair and Regeneration
Alexander Paping, Clara Basler, Loreen Ehrlich, Carlo Fasting, Kerstin Melchior, Thomas Ziska, Mario Thiele, Georg N Duda, Sara Timm, Matthias Ochs, Rebecca C Rancourt, Wolfgang Henrich, Thorsten Braun
Uterine rupture during a trial of labor after cesarean delivery (CD) is a serious complication for mother and fetus. The lack of knowledge on histological features and molecular pathways of uterine wound healing has hindered research in this area from evolving over time. We analyzed collagen content and turnover in uterine scars on a histological, molecular and ultrastructural level. Therefore, tissue samples from the lower uterine segment were obtained during CD from 16 pregnant women with at least one previous CD, from 16 pregnant women without previous CD, and from 16 non-pregnant premenopausal women after hysterectomy for a benign disease...
November 13, 2023: Wound Repair and Regeneration
Daijiro Haba, Takafumi Ohmiya, Masaki Sekino, Qi Qin, Chihiro Takizawa, Sanai Tomida, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Local low-frequency vibration promotes blood flow and wound healing in hard-to-heal diabetic foot ulcers (DFUs). However, vibration treatment is challenging in patients with DFUs due to wound management difficulties and low adherence. Consequently, developing wearable self-care devices becomes imperative for effective wound healing. This study introduces a wearable vibration dressing and assesses its impact on wound healing in hyperglycemic rats. Low-frequency vibration at 52 Hz was applied to the wound for 40 min/day in awake rats...
November 11, 2023: Wound Repair and Regeneration
Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery
The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM) or soft tissue infection based on bone culture and/or histology. We evaluated the diagnostic accuracy of CRP, ESR, albumin, CRP/albumin and ESR/albumin as biomarkers to diagnose OM in persons with diabetes...
October 16, 2023: Wound Repair and Regeneration
Wuliang Diao, Peiting Li, Xilin Jiang, Jianda Zhou, Songbo Yang
Chronic wounds have become the leading cause of death, particularly among diabetic patients. Chronic wounds affect approximately 6.5 million patients each year, according to statistics, and wound care and management incur significant financial costs. The rising prevalence of chronic wounds, combined with the limitations of current treatments, necessitates the development of new and innovative approaches to accelerate wound healing. Copper has been extensively studied for its antibacterial and anti-inflammatory activities...
October 11, 2023: Wound Repair and Regeneration
Stuti P Garg, Tokoya Williams, Iulianna C Taritsa, Rou Wan, Chirag Goel, Raiven Harris, Kristin Huffman, Robert D Galiano
Across scar studies, there is a lack of dark-skinned individuals, who have a predisposition for keloid formation, altered pigmentation, and poorer quality-of-life. There is a need for patients-of-color to be included in scar scale development and validation. In this study, we evaluate the racial diversity of patients included in the validation of scar assessment scales. A systematic review was conducted for articles reporting on the validation of a scar assessment tool. Racial, ethnic, and Fitzpatrick skin type(FST) data was extracted...
September 28, 2023: Wound Repair and Regeneration
Xilin Ye, Enshuo Zhang, Yaqin Huang, Feng Tian, Jiajia Xue
Wound management for acute and chronic wounds has become a serious clinical problem worldwide, placing considerable pressure on public health systems. Owing to the high-precision, adjustable pore structure, and repeatable manufacturing process, 3D-printed electrospun fiber (3DP-ESF) has attracted widespread attention for fabricating wound dressing. In addition, in comparison with 2D electrospun fiber membranes fabricated by traditional electrospinning, the 3D structures provide additional guidance on cell behavior...
September 27, 2023: Wound Repair and Regeneration
Magnus S Ågren, Boris Hinz, Konstantinos Kalogeropoulos, Christopher M Overall, Hans Smola, Sabine Werner
No abstract text is available yet for this article.
September 20, 2023: Wound Repair and Regeneration
Eskandar Qaed, Marwan Almoiliqy, Bandar Al-Hamyari, Abdullah Qaid, Haneen Aalademy, Ahmed Al-Maamari, Eman Alyafeai, Zhaohong Geng, Zeyao Tang, Xiaodong Ma
Diabetes mellitus (DM) is a complex disease with alarming worldwide health implications and high mortality rates, largely due to its complications such as cardiovascular disease, nephropathy, neuropathy, and retinopathy. Recent research has shown that Procyanidins (PC), a type of flavonoid, have strong antioxidant and free radical elimination effects, and may be useful in improving glucose metabolism, enhancing pancreatic islet cell activity, and decreasing the prevalence of DM complications. This review article presents a systematic search for peer-reviewed articles on the use of PC in the treatment of DM, without any language restrictions...
August 8, 2023: Wound Repair and Regeneration
Xinghan Chen, Xiujun Shi, Haitao Xiao, Dongqin Xiao, Xuewen Xu
Chronic wounds have been confirmed as a vital health problem facing people in the global population aging process. While significant progress has been achieved in the study of chronic wounds, the treatment effect should be further improved. The number of publications regarding chronic wounds has been rising rapidly. In this study, bibliometric analysis was conducted to explore the hotspots and trends in the research on chronic wounds. All relevant studies on chronic wounds between 2013 and 2022 were collected from the PubMed database of the Web of Science (WOS) and the National Center for Biotechnology Information (NCBI)...
August 8, 2023: Wound Repair and Regeneration
Sydney E Browder, Avital Yohann, Teresa R Filipowicz, Nikki L B Freeman, William A Marston, Stephen Heisler, Mark A Farber, Shrunjay R Patel, Jacob C Wood, Katharine L McGinigle
Chronic limb-threatening ischemia (CLTI) is associated with significant morbidity, including major limb amputation, and mortality. Healing ischemic wounds is necessary to optimize vascular outcomes and can be facilitated by dedicated appointments at a wound clinic. This study aimed to estimate the association between successful wound care initiation and 6-month wound healing, with specific attention to differences by race/ethnicity. This retrospective study included 398 patients with CLTI and at least one ischemic wound who scheduled an appointment at our wound clinic between January 2015 and July 2020...
August 3, 2023: Wound Repair and Regeneration
Kenichi Arai, Kohei Yamamoto, Takaaki Suzuki, Yuki Shiko, Yohei Kawasaki, Nobuyuki Mitsukawa, Ituko Ishii
Polypharmacy, which refers to the situation of a patient taking more medications than is clinically necessary, has become a major problem in recent years. Although the effects of medications on pressure ulcers have been reported, there are no reports on the impact of the total number of medications on pressure ulcers. The purpose of this study was to investigate the effect of number of medications on the severity of pressure ulcers. Participants included 94 patients who were admitted to Chiba University Hospital with pressure ulcers between April 2013 and March 2021...
July 30, 2023: Wound Repair and Regeneration
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.