Dario Costa, Antonietta Picascia, Vincenzo Grimaldi, Cristiano Amarelli, Andrea Petraio, Anna Levi, Mario Di Donato, Anna Virginia Adriana Pirozzi, Carmela Fiorito, Giusi Moccia, Aurora Gallo, Mariagrazia Strozziero, Claudio Marra, Marisa De Feo, Francesco Cacciatore, Ciro Maiello, Claudio Napoli
Although there are different data supporting benefits of HLA matching in kidney transplantation, its role in heart transplantation is still unclear. HLA mismatch (MM) between donor and recipient can lead to the development of donor-specific antibodies (DSA) which produces negative events on the outcome of heart transplantation. Moreover, DSAs are involved in the development of antibody-mediated rejection (AMR) and are associated with an increase in cardiac allograft vasculopathy (CAV). In this study it is analyzed retrospectively the influence of HLA matching and anti-HLA antibodies on overall survival, AMR and CAV in heart transplantation...
February 23, 2024: Transplant Immunology