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Transplant Immunology

Ming-Xiang Cheng, Jin-Zheng Li, Yong Chen, Ding Cao, Jian-Ping Gong, Bing Tu
BACKGROUND: Vascular endothelial growth factor receptor-3 (VEGFR-3) / vascular endothelial growth factor -c (VEGF-C) signaling is reported to negatively regulate TLR4-triggered inflammation of macrophages. This study aims to clarify whether the VEGFR-3/VEGF-C signaling can suppress Kupffer cells (KCs) activation and attenuate hepatic ischemia-reperfusion injury (IRI) after liver transplantation. METHODS: A rat model of liver transplantation was performed. Donor livers were perfused with VEGF-C injection via portal vein during cold preservation, and controls were perfused with UW solution...
February 13, 2019: Transplant Immunology
Lai Xingqiang, Ning Fen, Yao Zhongpeng, Wang Tiantian, Zhang Lei, Fang Jiali, Ma Junjie, Li Guanghui, Xu Lu, Guo Yuhe, Chen Zheng
Infusion of ethylene carbodiimide-fixed donor splenocytes (ECDI-SPs) is an effective method to induce donor-specific protection to allografts. However, the ischemia reperfusion (I/R) injury during transplant leads to abundant of pro-inflammatory cytokines, which negates the effect of ECDI-SPs. Therefore, suppressing pro-inflammatory cytokine secretion while promoting anti-inflammatory cytokine release would enhance the graft protective efficacy of ECDI-SPs. In this study, we aimed to determine the effect of ECDI-SPs combined with a short course of cordycepin (an anti-inflammatory agent) on the long-term outcomes of mice cardiac allografts...
February 8, 2019: Transplant Immunology
Nicholas J Geraghty, Lisa Belfiore, Sam R Adhikary, Stephen I Alexander, Ronald Sluyter, Debbie Watson
Graft-versus-host disease (GVHD) is a frequent complication following allogeneic hematopoietic stem cell transplantation (HSCT) with current therapies limited to general immunosuppression. Humanized mouse models of GVHD are emerging as valuable intermediaries to allow translation of findings from allogeneic mouse models to humans to prevent and treat this disease, but such models require further characterization. In this study, humanized mice were generated by injecting immunodeficient non-obese diabetic severe combined immunodeficiency interleukin-2 receptor γ common chain null (NSG) mice with human peripheral blood mononuclear cells (hPBMCs)...
February 8, 2019: Transplant Immunology
Jérôme Dumortier, Tomas Dedic, Domitille Erard-Poinsot, Christine Rivet, Olivier Guillaud, Christine Chambon-Augoyard, Alexie Bosch, Alain Lachaux, Eduardo Couchonnal, Olivier Thaunat, Olivier Boillot, Valérie Dubois
BACKGROUND: Risk factors for the development of anti-HLA antibodies include blood transfusion, organ transplantation, and pregnancy. Humoral rejection, mediated by donor-specific anti-HLA antibodies (DSA), has been studied in all kind of solid organ transplantations, and several studies have suggested that post-liver transplantation (LT) DSA may play a role in acute and chronic rejection. OBJECTIVE: The aim of the present study was to assess the impact of pregnancy on the occurrence of DSA and the impact of DSA in a large population of young female LT recipients...
February 8, 2019: Transplant Immunology
Kelly Cristine Santos Roballo, Jared Bushman
Allogeneic peripheral nerve (PN) transplants are an effective bridge for stimulating regeneration of segmental PN defects, but there are currently no detailed studies about the timeline and scope of the immunological response for PN allografting. In this study, the cellular immune response in PN allografts and autograft was studied during the acute and chronic phases of a 1.0 cm critical size defect in the rat sciatic nerve at 3, 7, 14, 28 and 98 days after grafting autologous or allogeneic nerves without any immunosuppressive treatment...
February 5, 2019: Transplant Immunology
Michał Czerewaty, Maciej Tarnowski, Krzysztof Safranow, Leszek Domanski, Andrzej Pawlik
Mannose-binding lectin (MBL) is one of the pattern-recognition soluble receptors and is responsible for complement activation via the lectin pathway, so it plays an important role in kidney transplantation. The aim of the study was to examine the association between MBL gene polymorphisms and acute rejection of the kidney allograft. This study enrolled 266 Caucasian deceased-donor renal transplant recipients - 69 with diagnosed acute graft rejection, 197 with stable graft function. A 969 bp DNA fragment, from chromosome 10, including promoter region and exon 1 of MBL2 gene was sequenced...
January 30, 2019: Transplant Immunology
Jin Deng, Yue Xia, Qin Zhou, Xin Wang, Chongxiang Xiong, Xiaofei Shao, Mengjiao Shao, Hequn Zou
BACKGROUND: Chronic renal allograft dysfunction (CRAD) is the main condition affecting the long-term survival of renal allografts. Rosiglitazone, which is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been shown to exert antifibrotic and anti-inflammatory effects on some renal diseases. The present paper investigates the effect of rosiglitazone on CRAD using a murine model. METHODS: The CRAD group received classical orthotopic F344-Lewis kidney transplantation...
January 22, 2019: Transplant Immunology
Shivaprakash Gangappa, Jens Wrammert, David Wang, Zhu-Nan Li, Justine S Liepkalns, Weiping Cao, Jufu Chen, Min Z Levine, James Stevens, Suryaprakash Sambhara, Beth Begley, Aneesh Mehta, Thomas C Pearson, Rafi Ahmed, Christian P Larsen
Annual vaccination is routinely used in organ transplant recipients for immunization against seasonal influenza. However, detailed analysis of the kinetics of vaccine-induced immune responses in this population is lacking. In this study, we investigated the kinetics of vaccine strains-specific antibody responses to trivalent influenza vaccine in a group of renal transplant recipients and a control group. First, we found that the geometric mean hemagglutination inhibition titer against all 3 vaccine strains in the transplant cohort was significantly low when compared to control subjects...
January 18, 2019: Transplant Immunology
Martine J Jager, Anneke Brand, Frans H J Claas
A single observation in a patient with an unusual transfusion reaction led to a life-long fascination with immunogenetics, and a strong wish to improve the care for patients needing a transplantation. In 2017, Jon van Rood, one of the pioneers in the field of HLA and immunogenetics of transplantation, passed away. Several obituaries have appeared describing some of the highlights of his career. However, the details of the early developments leading among others to the routine use of HLA as an important parameter for donor selection in organ- and hematopoietic stem cell transplantation are largely unknown to the community...
January 4, 2019: Transplant Immunology
Slawomir C Zmonarski, Katarzyna Madziarska, Tomasz Golebiowski, Miroslaw Banasik, Oktawia Mazanowska, Marcin Madziarski, Magdalena Krajewska
BACKGROUND: A small percentage of peripheral blood mononuclear cells (PBMCs) circulating during the kidney transplantation (KT) period remain in the blood long after transplantation. A part of the PBMCs penetrates the graft. AIM: To examine if the choice of immunosuppression may change TLR4ex and how TLR4ex affects the transplant function in the future. MATERIAL: The study population-143 transplanted patients (pts) (55 females, 88 males), mean age on recruitment day 50...
December 25, 2018: Transplant Immunology
John Jeongseok Yang, Sang-Hyun Hwang, Dae-Hyun Ko, Eul-Ju Seo, Heung-Bum Oh
INTRODUCTION: Chimerism is defined as coexistence of different cell lines in an individual. 46,XX/46,XY chimerism is very rare and exhibits broad range of clinical phenotypes. Most cases are detected at infancy or younger age due to disorders of sex development, while phenotypically normal cases are incidentally discovered through abnormal blood grouping results or multiple genotypes in HLA. OBJECTIVE: Aim was to determine the genetic expression of numerous HLA alleles detected in phenotypically normal 46,XX/46,XY chimerism...
December 21, 2018: Transplant Immunology
Tetsuo Koshizuka, Yasushi Matsuda, Hirotoshi Suzuki, Ryoko Kanno, Kazufumi Ikuta, Takahiro Kobayashi, Takashi Kondo, Yoshinori Okada, Tatsuo Suzutani
Transplant recipients become immunocompromised through the use of immunosuppressive therapy to prevent allograft rejection. These recipients readily experience human cytomegalovirus (CMV) infection or reactivation. Therefore, CMV represents a life-threatening pathogen in transplant recipients. To demonstrate the serostatus and course of IgG maturation against CMV in transplant patients, we measured the transition of anti-CMV IgG and its affinity (avidity index; AI) as criteria for antibody maturation. Among 31 lung transplant recipients, 26 were infected with CMV before transplantation and maintained anti-CMV IgG and high AI values throughout the study period...
December 12, 2018: Transplant Immunology
Shosaku Nomura, Tomoki Ito, Yuta Katayama, Shuichi Ota, Kunio Hayashi, Shinya Fujita, Atsushi Satake, Kazuyoshi Ishii
BACKGROUND: Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulatory functions. METHODS: We measured interleukin (IL)-10, transforming growth factor (TGF)β1 , and soluble HLA-G (sHLA-G) in HSCT patients and examined the relationship between sHLA-G levels and acute GVHD (aGVHD)...
December 10, 2018: Transplant Immunology
Takao Shigenobu, Takashi Ohtsuka, Masayuki Shimoda
Bronchiolitis obliterans (BO), which begins with lymphocytic bronchiolitis (LB), is the most serious manifestations of chronic rejection following lung transplantation. We have evaluated the effects of intraperitoneal administration of pioglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist, on LB in mice tracheal transplant model. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Animals were divided into three groups (n = 8), isograft (IG) and allograft with (AGP) or without (AGN) pioglitazone...
December 10, 2018: Transplant Immunology
Shinkichi Takamori, Fumihiro Shoji, Tatsuro Okamoto, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Yoshihiko Maehara
BACKGROUND: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28)...
December 1, 2018: Transplant Immunology
David Solar-Cafaggi, Lluvia Marino, Norma Uribe-Uribe, Luis Eduardo Morales-Buenrostro
BACKGROUND: Antibody-mediated rejection (ABMR) is the leading cause of kidney graft loss worldwide. Criteria for acute humoral rejection (currently labeled active humoral rejection) established by the 2007 Banff classification are highly specific but lack sensitivity. Modifications to the Banff classification were introduced for its 2013 and 2017 versions in order to identify more cases of this entity. PURPOSE: We intend to demonstrate that, compared to its 2007 version, the 2017 Banff classification bears an improved capacity for graft loss prediction when histologic criteria for active ABMR are met...
December 2018: Transplant Immunology
Takayuki Yamamoto, Qi Li, Hidetaka Hara, Liaoran Wang, Hongmin Zhou, Juan Li, Devin E Eckhoff, A Joseph Tector, Edwin C Klein, Ray Lovingood, Mohamed Ezzelarab, David Ayares, Yi Wang, David K C Cooper, Hayato Iwase
BACKGROUND: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from an α1,3-galactosyltransferase gene-knockout (GTKO) pig elicits a significant anti-nonGal IgG response, indicating sensitization to the graft. A costimulation blockade-based regimen, e.g., anti-CD154mAb or anti-CD40mAb, prevents sensitization. However, neither of these agents is currently FDA-approved. The aim of the present study was to determine the efficacy of FDA-approved agents on the T and B cell responses...
December 2018: Transplant Immunology
Amey Sonavane, Sanjiv Saigal
Graft versus Host Disease (GVHD) after orthotopic liver transplant (OLT), although rare, carries >80% mortality. Early diagnosis, prompt treatment, and aggressive supportive care are imperative to potentially reverse this otherwise fatal ailment. We describe a case of severe diarrhoea post living donor OLT who was diagnosed with acute GVHD. Addition of oral budesonide therapy to systemic corticosteroid therapy controlled the symptoms of diarrhoea.
November 22, 2018: Transplant Immunology
Qi Jiang, Yawei Ru, Yang Yu, Keqiu Li, Yaqing Jing, Jianhai Wang, Guang Li
Liver transplantation (LT) is the most effective treatment method for advanced stage liver disease but acute cellular rejection (ACR) seriously affects the prognosis of LT. To discover novel diagnostic biomarkers of ACR after LT, Isobaric Tags for Relative and Absolute Quantitation (iTRAQ)-based mass spectrometry was performed to characterize alterations of serum proteins among patients validated to be pathologically ACR or pathologically no-ACR after LT and healthy controls. As a result, 10 differentially expressed proteins were found out between the ACR group and the No-ACR group; 88 differentially expressed proteins were found out between the ACR group and the Healthy Control group; 39 differentially expressed proteins were found out between No-ACR group and Healthy Control group...
November 22, 2018: Transplant Immunology
Min Yang, Gen Chen, Xue Zhang, Zuochuan Ding, Yan Miao, Yang Yang, Sheng Chang, Ping Zhou
BACKGROUND: After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse model to examine the effects of a newtype of innate immune inhibitor, TJ-M2010-5. METHODS: Syngeneic tracheal grafts were transplanted heterotopically from C57BL/6 mice to C57BL/6 mice...
November 22, 2018: Transplant Immunology
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